Category: 192810-12-1

Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM was written by Park, Kaapjoo;Lee, Byoung Moon;Hyun, Kwan Hoon;Han, Taedong;Lee, Dong Hoon;Choi, Hyun Ho. And the article was included in ACS Medicinal Chemistry Letters in 2015.Related Products of 192810-12-1 This article mentions the following:

Novel acetylenyl-containing benzamide derivatives were synthesized and screened using an in vitro assay measuring increases in glucokinase activity stimulated by 10 mM glucose concentration and glucose uptake in rat hepatocytes. Lead optimization of an acetylenyl benzamide series led to the discovery of several active compounds via in vitro enzyme assays (EC₅₀ < 40 nM) and in vivo OGTT assays (AUC reduction > 40% at 50 mg/kg). Of the active compounds tested, 3-(3-amino-phenylethynyl)-5-(2-methoxy-1-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide I was identified as a potent glucokinase activator exhibiting an EC₅₀ of 27 nM and eliciting a 2.16-fold increase in glucose uptake. Compound I caused a glucose AUC reduction of 47.4% (30 mg/kg) in an OGTT study in C57BL/6J mice compared to 22.6% for sitagliptin (30 mg/kg). Single treatment of compound I in C57BL/6J mice elicited basal glucose lowering activity without any significant evidence for hypoglycemia risk. Compound I was therefore selected as a candidate for further preclin. development for the treatment of type 2 diabetes. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Related Products of 192810-12-1).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 192810-12-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mechanically axially chiral catenanes and noncanonical mechanically axially chiral rotaxanes was written by Maynard, John R. J.;Gallagher, Peter;Lozano, David;Butler, Patrick;Goldup, Stephen M.. And the article was included in Nature Chemistry in 2022.Computed Properties of C8H7BrO3 This article mentions the following:

The symmetry properties of these mols. and in doing so identify a straightforward route to access them from simple chiral building blocks was re-examined This anal. also led us to identify an analogous but previously unremarked upon rotaxane stereogenic unit, which also yielded to our co-conformational auxiliary approach. With methods to access mech. axially chiral mols. in hand, their properties and applications can now be explored. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Computed Properties of C8H7BrO3).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C8H7BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Evaluation of Novel Auxin Mimic Herbicides was written by Do-Thanh, Chi-Linh;Vargas, Jose J.;Thomas, Joseph W.;Armel, Gregory R.;Best, Michael D.. And the article was included in Journal of Agricultural and Food Chemistry in 2016.Application In Synthesis of Methyl 3-bromo-5-hydroxybenzoate This article mentions the following:

Due to the key roles of auxins as master regulators of plant growth, there is considerable interest in the development of compounds with auxin-like properties for growth management and weed control applications. Herein, we describe the design and multistep synthesis of ten compounds bearing combinations of functional groups commonly associated with auxin-type properties. Following synthesis, these compounds were tested against multiple weed species as well as sweet corn. In general, while these structures were not quite as active as com. auxin mimic herbicides, multiple compounds exhibited broadleaf weed activity with concurrent selectivity in sweet corn (Zea mays L. var. saccharum). In addition, differential results were observed upon subtle changes to structure, providing insights into the structural properties required for activity. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Application In Synthesis of Methyl 3-bromo-5-hydroxybenzoate).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of Methyl 3-bromo-5-hydroxybenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-Catalyzed Regioselective Synthesis of 1-Hydroxycarbazoles Under Aerobic Conditions was written by Youn, So Won;Kim, Young Ho;Jo, Yoon Hyung. And the article was included in Advanced Synthesis & Catalysis in 2019.Recommanded Product: 192810-12-1 This article mentions the following:

A palladium-catalyzed aerobic C-H amidation of N-Ts-2-amino-3′-hydroxylbiaryls was developed to afford a diverse range of 1-hydroxycarbazoles with high regioselectivity and efficiency. This protocol benefits from operational simplicity, robustness, and sustainability using ambient air as the sole terminal oxidant. Further elaboration of the products obtained from this process provides facile access to various carbazole alkaloids including carbazolequinones and biscarbazoles. A mechanism involving dual directing group-assisted regioselective C-H activation at the more sterically hindered C2′-position of 2-amino-3′-hydroxylbiaryls is proposed. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Recommanded Product: 192810-12-1).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 192810-12-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM was written by Park, Kaapjoo;Lee, Byoung Moon;Hyun, Kwan Hoon;Han, Taedong;Lee, Dong Hoon;Choi, Hyun Ho. And the article was included in ACS Medicinal Chemistry Letters in 2015.Related Products of 192810-12-1 This article mentions the following:

Novel acetylenyl-containing benzamide derivatives were synthesized and screened using an in vitro assay measuring increases in glucokinase activity stimulated by 10 mM glucose concentration and glucose uptake in rat hepatocytes. Lead optimization of an acetylenyl benzamide series led to the discovery of several active compounds via in vitro enzyme assays (EC₅₀ < 40 nM) and in vivo OGTT assays (AUC reduction > 40% at 50 mg/kg). Of the active compounds tested, 3-(3-amino-phenylethynyl)-5-(2-methoxy-1-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide I was identified as a potent glucokinase activator exhibiting an EC₅₀ of 27 nM and eliciting a 2.16-fold increase in glucose uptake. Compound I caused a glucose AUC reduction of 47.4% (30 mg/kg) in an OGTT study in C57BL/6J mice compared to 22.6% for sitagliptin (30 mg/kg). Single treatment of compound I in C57BL/6J mice elicited basal glucose lowering activity without any significant evidence for hypoglycemia risk. Compound I was therefore selected as a candidate for further preclin. development for the treatment of type 2 diabetes. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Related Products of 192810-12-1).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 192810-12-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mechanically axially chiral catenanes and noncanonical mechanically axially chiral rotaxanes was written by Maynard, John R. J.;Gallagher, Peter;Lozano, David;Butler, Patrick;Goldup, Stephen M.. And the article was included in Nature Chemistry in 2022.Computed Properties of C8H7BrO3 This article mentions the following:

The symmetry properties of these mols. and in doing so identify a straightforward route to access them from simple chiral building blocks was re-examined This anal. also led us to identify an analogous but previously unremarked upon rotaxane stereogenic unit, which also yielded to our co-conformational auxiliary approach. With methods to access mech. axially chiral mols. in hand, their properties and applications can now be explored. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Computed Properties of C8H7BrO3).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C8H7BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, Synthesis, and Evaluation of Novel Auxin Mimic Herbicides was written by Do-Thanh, Chi-Linh;Vargas, Jose J.;Thomas, Joseph W.;Armel, Gregory R.;Best, Michael D.. And the article was included in Journal of Agricultural and Food Chemistry in 2016.Application In Synthesis of Methyl 3-bromo-5-hydroxybenzoate This article mentions the following:

Due to the key roles of auxins as master regulators of plant growth, there is considerable interest in the development of compounds with auxin-like properties for growth management and weed control applications. Herein, we describe the design and multistep synthesis of ten compounds bearing combinations of functional groups commonly associated with auxin-type properties. Following synthesis, these compounds were tested against multiple weed species as well as sweet corn. In general, while these structures were not quite as active as com. auxin mimic herbicides, multiple compounds exhibited broadleaf weed activity with concurrent selectivity in sweet corn (Zea mays L. var. saccharum). In addition, differential results were observed upon subtle changes to structure, providing insights into the structural properties required for activity. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Application In Synthesis of Methyl 3-bromo-5-hydroxybenzoate).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of Methyl 3-bromo-5-hydroxybenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-Catalyzed Regioselective Synthesis of 1-Hydroxycarbazoles Under Aerobic Conditions was written by Youn, So Won;Kim, Young Ho;Jo, Yoon Hyung. And the article was included in Advanced Synthesis & Catalysis in 2019.Recommanded Product: 192810-12-1 This article mentions the following:

A palladium-catalyzed aerobic C-H amidation of N-Ts-2-amino-3′-hydroxylbiaryls was developed to afford a diverse range of 1-hydroxycarbazoles with high regioselectivity and efficiency. This protocol benefits from operational simplicity, robustness, and sustainability using ambient air as the sole terminal oxidant. Further elaboration of the products obtained from this process provides facile access to various carbazole alkaloids including carbazolequinones and biscarbazoles. A mechanism involving dual directing group-assisted regioselective C-H activation at the more sterically hindered C2′-position of 2-amino-3′-hydroxylbiaryls is proposed. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Recommanded Product: 192810-12-1).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 192810-12-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mechanically axially chiral catenanes and noncanonical mechanically axially chiral rotaxanes was written by Maynard, John R. J.;Gallagher, Peter;Lozano, David;Butler, Patrick;Goldup, Stephen M.. And the article was included in Nature Chemistry in 2022.Computed Properties of C8H7BrO3 This article mentions the following:

The symmetry properties of these mols. and in doing so identify a straightforward route to access them from simple chiral building blocks was re-examined This anal. also led us to identify an analogous but previously unremarked upon rotaxane stereogenic unit, which also yielded to our co-conformational auxiliary approach. With methods to access mech. axially chiral mols. in hand, their properties and applications can now be explored. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Computed Properties of C8H7BrO3).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C8H7BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM was written by Park, Kaapjoo;Lee, Byoung Moon;Hyun, Kwan Hoon;Han, Taedong;Lee, Dong Hoon;Choi, Hyun Ho. And the article was included in ACS Medicinal Chemistry Letters in 2015.Related Products of 192810-12-1 This article mentions the following:

Novel acetylenyl-containing benzamide derivatives were synthesized and screened using an in vitro assay measuring increases in glucokinase activity stimulated by 10 mM glucose concentration and glucose uptake in rat hepatocytes. Lead optimization of an acetylenyl benzamide series led to the discovery of several active compounds via in vitro enzyme assays (EC₅₀ < 40 nM) and in vivo OGTT assays (AUC reduction > 40% at 50 mg/kg). Of the active compounds tested, 3-(3-amino-phenylethynyl)-5-(2-methoxy-1-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide I was identified as a potent glucokinase activator exhibiting an EC₅₀ of 27 nM and eliciting a 2.16-fold increase in glucose uptake. Compound I caused a glucose AUC reduction of 47.4% (30 mg/kg) in an OGTT study in C57BL/6J mice compared to 22.6% for sitagliptin (30 mg/kg). Single treatment of compound I in C57BL/6J mice elicited basal glucose lowering activity without any significant evidence for hypoglycemia risk. Compound I was therefore selected as a candidate for further preclin. development for the treatment of type 2 diabetes. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Related Products of 192810-12-1).

Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 192810-12-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary