Category: 19190-91-1

Some common heterocyclic compound, 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, molecular formula is C12H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 19190-91-1

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19190-91-1, its application will become more common.

Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, A new synthetic method of this compound is introduced below., COA of Formula: C12H8Br2

The preparation method of the raw material A (4,5-dibromoacenaphthene) is as follows: In a 1000 mL two-necked flask, 18.72 g (60 mmOl) of 4,5-dibromofluorene and 500 mL of acetic anhydride were added, stirred and heated to 110 C, and a solution of chromium trioxide in acetic anhydride (46.4 g of three) was slowly added dropwise over about two hours. The chromium oxide is dissolved in 300 mL of acetic anhydride). After the completion of the dropwise addition, the temperature was raised to 160 C and the reaction was continued for 30 minutes. After the reaction was completed, the reaction solution was poured into a beaker containing 1000 g of crushed ice, and stirred to dissipate heat, and then 20 mL of concentrated hydrochloric acid was slowly added dropwise, and the mixture was decompressed. After filtration, a yellow solid was obtained, then the residue was recrystallized from acetic acid, and filtered, and then filtered to give a dark brown solid 5.21 g, yield: 25·54%.

The synthetic route of 19190-91-1 has been constantly updated, and we look forward to future research findings.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19190-91-1, HPLC of Formula: C12H8Br2

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

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Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, molecular formula is C12H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C12H8Br2

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19190-91-1, its application will become more common.

Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 19190-91-1,Some common heterocyclic compound, 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, molecular formula is C12H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dibromo-1,2-dihydroacenaphthylene, its application will become more common.

Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 19190-91-1, A common heterocyclic compound, 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, molecular formula is C12H8Br2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

The synthetic route of 19190-91-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, A new synthetic method of this compound is introduced below., COA of Formula: C12H8Br2

An integrated flow microreactor system consisting of four T-shaped micromixers (M1,M2, M3 and M4), four microtube reactors (R1, R2, R3 and R4), and five microtube units [P1(inner diameter = 1000 m, length l = 100 cm), P2 (= 1000 m, l = 50 cm), P3 (= 1000m, l = 100 cm), P4 (= 1000 m, l = 50 cm), P5 (= 1000 m, l = 100 cm)] was used. Thewhole flow microreactor system was dipped in a water bass (24 ). A solution of 5,6-dibromoacenaphthene (0.10 M) in THF (flowrate = 6.00 mL min-1) and a solution of BuLi (0.50 M) in hexane (flow rate = 1.20 mL min-1) were introduced to M1 (= 250 m). The resulting solution was passed through R1 (phi= 500 mum, l = 3.5 cm) and was mixed with a solution of benzophenone (0.20 M) in THF (flow rate = 3.00 mL min-1) in M2 (phi= 500 mum). The resulting solution was passed through R2 (phi= 1000 mum, l = 200 cm) and was introduced to M3 (phi= 500 mum) where the solution was mixed with a solution of BuLi (0.50 M) in hexane (flow rate = 1.44 mLmin-1). The resulting solution was passed through R3 (phi= 1000 mum, l = 200 cm) and was introduced to M4 (phi= 500 mum) where the solution was mixed with a solution of 4,4′-difluorobenzophenone (0.20 M) in THF (flow rate = 3.60 mL min-1). The resulting solution was passed through R4 (phi= 1000 mum, l = 200 cm). After a steady state was reached, the product solution was collected for 130 s and was stirred for 4 h at 22 C under argon. Then the mixture was treated with BuLi (1.59 M) in hexane (6.8 mL) to consume excess ketones at -78 C. The resultant solution was further stirred for 2 h, and was treated with water.

The synthetic route of 19190-91-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Suzuki, Takanori; Uchimura, Yasuto; Nagasawa, Fumika; Takeda, Takashi; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Murakoshi, Kei; Fukushima, Takanori; Nagaki, Aiichiro; Yoshida, Jun-Ichi; Chemistry Letters; vol. 43; 1; (2014); p. 86 – 88;,
Bromide – Wikipedia,
bromide – Wiktionary