Category: 18648-66-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, A new synthetic method of this compound is introduced below., HPLC of Formula: C20H15Br

P-aminobenzeneboronic acid hydrochloride was added1000ml three-necked flask, add 800ml tetrahydrofuran, then add 2mol / L potassium carbonate solution 168ml, magnetic stirring and argon, oil bath heated to 70 , adding 0.1g tetraphenylphenylphosphine palladium, reflux reaction 24h, The reaction product was spin-dried and the product was spin-dried to dry the powder and dried in vacuo at 60 C for 24 h to give the white intermediate TriP-NH2 in 86% yield.

The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sun Yat-sen University; Zhang, Yi; Liu, Yiwu; Xu, Jiarui; Wu, Xinhui; Shi, Jie; Liu, Siwei; Chi, Zhenguo; (20 pag.)CN104341311; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18648-66-3, Safety of 2-(4-Bromophenyl)-1,1-diphenylethylene

theTriphenylethylene bromide (3.35g,10.0mmol) dissolved in 20ml of tetrahydrofuran,cool down to -78 C, slowly drop wise added 2.5M n-butyllithium solution(4.0ml,10.0ml). After the addition was complete for 2 h, N, N-dimethylformamide(1.46g,20.0ml)was added, naturally heated to room temperature and kept thereaction for 24 h. The reaction was terminated, extraction was carried out withwater,after organic phase was dried over anhydrous sodium sulfate and dried invacuo on a rotary evaporator to give the crude product. The product waspurified by silica gel column chromatography; the eluent was a mixed solvent ofdichloromethane and n-hexane with volume ratio of 3:1. Pure product as a whitesolid, 3.3 g (yield 81%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Bromophenyl)-1,1-diphenylethylene, and friends who are interested can also refer to it.

Reference:
Patent; Sun Yat-sen University; Ma, ChunPing; Chi, ZhenGuo; Zhou, Xie; Zhang, Yi; Liu, SiWei; Xu, JiaRui; (14 pag.)CN103804318; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary