Category: 18648-66-3

Adding a certain compound to certain chemical reactions, such as: 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18648-66-3, COA of Formula: C20H15Br

General procedure: A mixture of 1-bromo-4-(2,2-diphenylvinyl)benzene (1) (2.0 g, 5.97 mmol) and phenylboronic acid (873 mg, 7.16 mmol) was dissolved in toluene (15 mL) under argon atmosphere. Aqueous solution of K2CO3 (2 mL, 2 M), tricaprylylmethylammoniumchloride (Aliquat336) (3 drops) and Pd(PPh3)4 (10 mg) was added to the mixture. The reaction mixture was heated at 90C for 6 h. After being cooled to room temperature, distilled water (5 mL) was added and extracted with dichloromethane (310 mL). Organic layer was dried over anhydrous Na2SO4. The solvent was removed under reduced pressure, the residue was purified using column chromatography (silica gel, ethyl acetate/petroleum ether 5:95) afforded 2 (240 mg, 85%) as a white solid. Mp 97-98C; IR (KBr,cm-1): 3015, 1601, 1493; 1H NMR (300 MHz, CDCl3): delta 7.53 (d, 2H, J=7.5 Hz), 7.42-7.20 (m, 15H), 7.08 (d, 2H, J=7.5 Hz), 6.99 (s, 1H); 13C NMR (75 MHz, CDCl3): delta 143.2, 142.5, 140.4, 140.3, 139.1, 136.3, 130.0, 129.9, 128.7, 128.6, 128.1, 127.6, 127.5, 127.45, 127.4, 126.7, 126.4; LCMS (EI): m/z 333 (MH+, 100%); Anal. Calcd for C26H20: C,93.94; H, 6.06. Found: C, 93.88; H, 6.09.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Bromophenyl)-1,1-diphenylethylene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jana, Debabrata; Boxi, Shatabdi; Ghorai, Binay K.; Dyes and Pigments; vol. 99; 3; (2013); p. 740 – 747;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-(4-Bromophenyl)-1,1-diphenylethylene

To a reaction vessel purged with nitrogen, 8.11 g of 2- (4-bromophenyl) -1,1-diphenylethylene, 4.24 g of 1,2,3,3a, 4,8b-hexahydrocyclopenta [b] indole, 56 mL of xylene was added, and 0.127 g of triphenylphosphine, 5.43 g of potassium t-butoxide, and 0.27 g of palladium acetate were added, followed by degassing under reduced pressure. The reaction was carried out for 10 hours while stirring at 125 C. Cool to 50 C, add 9.4 g of activated clay,After stirring for 1 hour, suction filtration was performed, 100 mL of water was added, and the mixture was stirred to extract an organic layer. The organic layer was washed with water, separated, dried over sodium sulfate, and concentrated under reduced pressure to obtain an oily crude product. The crude product was purified by column chromatography (carrier: silica gel, eluent: hexane / toluene = 10/1 (volume ratio)) to obtain a yellow solid (9.98 g). 2 g of the obtained yellow solid was brominated according to a conventional method to obtain 2.35 g of a bromo compound represented by the following formula (10).

The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hodogaya Chemical Industry Co., Ltd.; Okaji, Makoto; (40 pag.)JP2020/15898; (2020); A;,
Bromide – Wikipedia,
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Related Products of 18648-66-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, This compound has unique chemical properties. The synthetic route is as follows.

Into a 500 ml three-necked flask equipped with a condenser, 0.16 g (6.6 mmole) of magnesium, a small piece of iodine and 10 ml of THF were placed under a stream of argon. After the resultant mixture was stirred at the room temperature for 30 minutes, a solution prepared by dissolving 1 g (3 mmole) of 1-(4-bromophenyl)-2,2-diphenylethylene into 10 ml of THF was added dropwise. After the addition was completed, the resultant mixture was stirred at 60C for 1 hours, and a Grignard reagent was prepared. Into a 500 ml three-necked flask equipped with a condenser, 0.45 g (1 mmole) of 2,6/2,7-di-t-butyl-9,10-dibromoanthracene, 0.04 g (5% by mole) of dichlorobis(triphenylphosphine)palladium, 0.1 ml (1M; 0.1 mmole) of a toluene solution of diisobutylaluminum hydride and 10 ml of THF were placed under a stream of argon. After the Grignard reagent prepared above was added dropwise to the obtained solution at the room temperature, the resultant mixture was heated under stirring for one night. After the reaction was completed, the reaction solution was cooled with ice water. The formed crystals were separated by filtration and washed with 50 ml of methanol and 50 ml of acetone successively, and 0.4 g of a yellow powder was obtained. The obtained yellow powder was identified to be Compound (A2) by the measurements in accordance with NMR, IR and FD-MS (the yield: 50%).

The chemical industry reduces the impact on the environment during synthesis 2-(4-Bromophenyl)-1,1-diphenylethylene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1440959; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 18648-66-3, The chemical industry reduces the impact on the environment during synthesis 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, I believe this compound will play a more active role in future production and life.

A flask was charged with a mixture of 3-(4-vinylphenyl)-9-ethylcarbazole (1, 0.3 g, 1.01 mmol), 2-(4-bromophenyl)-1,1-diphenylethylene (triPE, 0.28 g, 0.84 mmol), palladium acetate(Pd(OAc)2, 2.3 mg, 0.01 mmol), P(o-tolyl)3 (15 mg, 0.05 mmol),dimethylformamide (8 mL) and trimethylamine (3 mL). The flaskwas degassed and purged with argon. The reaction mixture washeated at 90 C for 4 h under argon atmosphere. Then, it wasfiltered, and was purified by column chromatography using hexane/ethyl acetate (50/1) as an eluent. The target product wasrecrystallized from the eluent mixture of solvents. The yield ofyellow crystals was 43% (0.2 g). Mp 219-220 C. MS (APCI, 20V),m/z(%): 553 ([MH], 100). 1H NMR (400 MHz, CDCl3, d, ppm): 1.49(t, J 7.2 Hz, 3H, CH3), 4.40 (q, J 7.2 Hz, 2H, NCH2), 7.01 (s, 1H, CH),7.07 (d, J 8.4 Hz, 2H, Ar), 7.13 (d, J 6.3 Hz, 2H, Ar), 7.27e7.53 (m,16H, Ar, 2CH), 7.62 (d, J 8.3 Hz, 2H, Ar), 7.73e7.78 (m, 3H, Ar), 8.20(d, J 8.4 Hz, 1H, Ar), 8.34 (s, 1H, Ar). 13C NMR (100 MHz, CDCl3, d,ppm): 13.9 (CH3), 37.7 (CH2), 108.6, 108.7, 118.7, 119.0, 120.5, 123.1,123.5,125.0,125.9,126.1,127.0,127.4,127.5,127.6,127.8,127.9,128.2,128.8, 129.9, 130.4, 131.7, 135.5, 135.9, 136.8, 139.5, 140.4, 141.4,142.6, 143.4. IR. nmax in cm1 (KBr): (CeH Ar) 3048, 3021; (CeH)2970, 2929; (C]C Ar) 1597, 1456, 1443; (CeN) 1233; (trans, CH]CH) 978; (CeH, Ar) 801, 761, 701. Elemental analysis. Calcd. forC42H33N (%): C 91.43, H 6.03, N 2.54. Found (%): C 91.36, H 6.09, N2.64.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Bromophenyl)-1,1-diphenylethylene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tomkeviciene; Sutaite; Volyniuk; Kostiv; Simkus; Mimaite; Grazulevicius; Dyes and Pigments; vol. 140; (2017); p. 363 – 374;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-(4-Bromophenyl)-1,1-diphenylethylene

For 500 ml three-necked flask was added (2-(4-bromophenyl)ethene-1,1-diyl)dibenzene (10.1g, 30mmol) and 4-aminophenylboronic acid hydrochloride (6.07g, 35mmol). Add 200 ml tetrahydrofuran, stirring to form a uniform clear solution. Add 90 ml K2CO3 solution (2M). Under Ar gas protection, raise temperature to 80 C, rapidly add 0.02g Pd(PPh3)4. Stirring reflux reaction 24h. Cooling to room temperature, separating takes organically phase, the aqueous phase is CH2Cl2Extraction two times, the combined organic phase, adding anhydrous MgSO4Drying. Pumping the filtrate, mixes the silica gel decompression turns on lathe does solvent, in order to CH2Cl2/Normal hexane as eluent for column chromatography, collecting ultraviolet ray, turns on lathe does solvent under reduced pressure, vacuum drying, be pale yellow green powder 9.61g, yield 92%.

The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sun Yat-sen University; Zhang, Yi; Zhou, Zhuxin; Xu, Jiarui; Liu, Siwei; Chi, Zhenguo; (13 pag.)CN106565617; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 18648-66-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Into a 500 ml three-necked flask equipped with a condenser, 0.16 g (6.6 mmole) of magnesium, a small piece of iodine and 10 ml of tetrahydrofuran (THF) were placed under a stream of argon. After the resultant mixture was stirred at the room temperature for 30 minutes, a solution prepared by dissolving 1 g (3 mmole) of 1-(4-bromophenyl)-2,2-diphenylethylene into 10 ml of THF was added dropwise. After the addition was completed, the resultant mixture was stirred at 60C for 1 hours, and a Grignard reagent was prepared. Into a 500 ml flask equipped with a condenser, 0.6 g (1 mmole) of 9,10-dibromo-2,6-di(2-ethylhexyloxy)anthracene, 0.04 g (5% by mole) of dichlorobis(triphenylphosphine)palladium, 0.1 ml (1 M; 0.1 mmole) of a toluene solution of diisobutylaluminum hydride and 10 ml of THF were placed under a stream of argon. After the Grignard reagent prepared above was added dropwise to the obtained solution at the room temperature, the resultant mixture was heated under stirring for one night. After the reaction was completed, the reaction solution was cooled with ice water. The formed crystals were separated by filtration and washed with 50 ml of methanol and 50 ml of acetone successively, and 0.56 g of a yellow powder was obtained. The obtained yellow powder was identified to be Compound (A1) by the measurements in accordance with NMR, IR and the filed desorption mass spectroscopy (FD-MS) (the yield: 60%).

The synthetic route of 2-(4-Bromophenyl)-1,1-diphenylethylene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1440959; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, molecular formula is C20H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C20H15Br

(1) Synthesis of 2-(2-biphenylyl)-9,10-bis(4-(2,2-diphenylvinyl)phenyl)-9,10-dihydroxy-9,10-dihydro anthracene; [Compound (B1-0)]; Under an atmospheric argon gas flow, 4-(2,2-diphenylvinyl)-1-bromobenzene in an amount of 9.8 g (29 mmol, 3 eq) was dissolved into a mixed solvent of anhydrous toluene in an amount of 45 milliliter and anhydrous THF in an amount of 45 milliliter, followed by cooling down to the temperature of – 20 C by means of dry ice / methanol bath. Adding hexane solution of n-butyllithium in an amount of 19 milliliter (1.59 mol/litter, 30 mmol; 1.04 eq), the resultant solution was stirred at the temperature of -20 C for 1 hour. Into the resultant solution, 2-(2-biphenylyl)-9,10-anthraquinone [Compound (A)] in an amount of 3.5 g (9.7 mmol) was added and after stirring at the room temperature for 2 hours, it was stood alone for a night. The resultant reaction mixture was deactivated with the use of saturated ammonium chloride aqueous solution in an amount of 50 milliliter, and the resultant solid was separated. The solid was washed use of the mixed solvent of hexane : dichloromethane = 1:1 (capacity ratio) and as a result, 5.0 g of white solid compound was obtained (yield: 59 %). The white solid was identified as the Compound (B1-0) in accordance with 1H-NMR. The measurement results of 1 H-NMR are shown as the following: 1H-NMR (CDCl3, TMS) delta 2.17 (1H, s), 2.66 (1H, s), 6.21 (2H, d, J=8Hz), 6.51 (2H, d, J=8Hz), 6.55 (4H, s), 6.80 (2H, d, J=4Hz), 7.0-7.4 (3H, m), 7.6-7.7 (3H, m)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 18648-66-3, its application will become more common.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1695952; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, A new synthetic method of this compound is introduced below., Quality Control of 2-(4-Bromophenyl)-1,1-diphenylethylene

Under the atmosphere of argon, 4-(2,2-diphenylvinyl)bromobenzene (10 g, 30 mmole, 3 eq) was dissolved into a mixed solvent composed of anhydrous toluene (45 ml) and anhydrous THF (45 ml), and the resultant solution was cooled to -20C in a dry ice/methanol bath. To the cooled solution, a hexane solution of n-butyllithium (1.59 mmole/liter, 20 ml, 32 mmole, 1.06 eq) was added, and the obtained solution was stirred at -20C for 1 hour. To the resultant solution, 2-(2-phenyl-2-)propylanthraquinone (3.5 g, 11 mmole) was added, and the obtained mixture was stirred at the room temperature for 3 hours and then left standing for one night. To the resultant reaction mixture, a saturated aqueous solution of ammonium chloride (50 ml) was added. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride and dried with magnesium sulfate. After the solvent was removed by distillation, the product was purified in accordance with the column chromatography (silica gel; hexane+50% dichloromethane, dichloromethane and finally dichloromethane+3% methanol), and a light yellow amorphous solid was obtained (5.7 g; the yield: 67%).

The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1440959; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 18648-66-3,Some common heterocyclic compound, 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, molecular formula is C20H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)trimethylstannan (0.81 g 2.66 mmol), 1-bromo-4-(2,2-diphenylvinyl)benzene (a compound of the Chemical Formula 2r) (1.7 g, 3.2 mmol), and Pd(PPh3)4 (0.15 g, 0.13 mmol) were dissolved in toluene (40 ml), and then refluxed under nitrogen atmosphere for 8 hours. Subsequently, an organic layer was extracted with methylene chloride and water and distilled, and column chromatography was performed (eluent-MC:Hx=1:4) to synthesize a compound of the Chemical Formula 4r.1H NMR (CDCl3): [ppm]=4.68 (s, 2H), 4.72 (s, 2H), 6.71 (s, 1H), 6.96 (s, 1H), 7.08 (s, 1H), 7.18 (m, 4H), 7.40 (m, 2H), 7.48 (m, 6H), 7.56 (d, 3JHH=8.8 Hz, 2H).

The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dongjin Semichem Co., Ltd.; US2011/94588; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 18648-66-3

General procedure: A flask was charged with a mixture of 3-(4-vinylphenyl)-9-ethylcarbazole (1, 0.3 g, 1.01 mmol), 2-(4-bromophenyl)-1,1-diphenylethylene (triPE, 0.28 g, 0.84 mmol), palladium acetate(Pd(OAc)2, 2.3 mg, 0.01 mmol), P(o-tolyl)3 (15 mg, 0.05 mmol),dimethylformamide (8 mL) and trimethylamine (3 mL). The flaskwas degassed and purged with argon. The reaction mixture washeated at 90 C for 4 h under argon atmosphere. Then, it wasfiltered, and was purified by column chromatography using hexane/ethyl acetate (50/1) as an eluent. The target product wasrecrystallized from the eluent mixture of solvents. The yield ofyellow crystals was 43% (0.2 g).

The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tomkeviciene; Sutaite; Volyniuk; Kostiv; Simkus; Mimaite; Grazulevicius; Dyes and Pigments; vol. 140; (2017); p. 363 – 374;,
Bromide – Wikipedia,
bromide – Wiktionary