Category: 185345-46-4

On January 15, 2019, Dumas, Megan E.; Chen, Geng-Yuan; Kendrick, Nicole D.; Xu, George; Larsen, Scott A.; Jana, Somnath; Waterson, Alex G.; Bauer, Joshua A.; Hancock, William; Sulikowski, Gary A.; Ohi, Ryoma published an article.Name: 3-Bromo-5-fluoro-4-hydroxybenzaldehyde The title of the article was Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. And the article contained the following:

The mitotic spindle is a microtubule-based machine that segregates a replicated set of chromosomes during cell division. Many cancer drugs alter or disrupt the microtubules that form the mitotic spindle. Microtubule-dependent mol. motors that function during mitosis are logical alternative mitotic targets for drug development. Eg5 (Kinesin-5) and Kif15 (Kinesin-12), in particular, are an attractive pair of motor proteins, as they work in concert to drive centrosome separation and promote spindle bipolarity. Furthermore, we hypothesize that the clin. failure of Eg5 inhibitors may be (in part) due to compensation by Kif15. In order to test this idea, we screened a small library of kinase inhibitors and identified GW108X, an oxindole that inhibits Kif15 in vitro. We show that GW108X has a distinct mechanism of action compared with a com. available Kif15 inhibitor, Kif15-IN-1 and may serve as a lead with which to further develop Kif15 inhibitors as clin. relevant agents. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).Name: 3-Bromo-5-fluoro-4-hydroxybenzaldehyde

The Article related to kif15 eg5 oxindole kinesin inhibitors mitosis, eg5, kif15, kinesin, mitosis, oxindole, Pharmacology: Structure-Activity and other aspects.Name: 3-Bromo-5-fluoro-4-hydroxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 30, 2021, Zhang, Dasheng published a patent.HPLC of Formula: 185345-46-4 The title of the patent was Fluorescent dye, preparation method therefor and use thereof. And the patent contained the following:

A fluorescent dye I [wherein Ar = (un)substituted arylene or heteroarylene; Y = O or S; R1 = H or alkyl; R2 = halo, OH, or CN], a preparation method therefor and use thereof. For example, II was prepared in a multi-step synthesis. The fluorescent dye has the advantages of sensitivity and specificity to viscosity response, low background fluorescence and the like, and can also be used as a fluorescence activation lighting-type probe for fluorescence labeling, quantification or detection of proteins, enzymes or nucleic acids. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).HPLC of Formula: 185345-46-4

The Article related to fluorescent dye preparation fluorescence probe proteins enzyme nucleic acid, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.HPLC of Formula: 185345-46-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 15, 2021, there was a patent about enzymes.Reference of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde The title of the patent was Fluorescent dye, preparation method therefor and use thereof. And the patent contained the following:

A fluorescent dye I [wherein Ar = (un)substituted arylene or heteroarylene; Y = O or S; R1 = H or alkyl; R2 = halo, OH, or CN], a preparation method therefor and use thereof. For example, II was prepared in a multi-step synthesis. The fluorescent dye has the advantages of sensitivity and specificity to viscosity response, low background fluorescence and the like, and can also be used as a fluorescence activation lighting-type probe for fluorescence labeling, quantification or detection of proteins, enzymes or nucleic acids. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).Reference of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde

The Article related to fluorescent dye preparation fluorescence probe proteins enzyme nucleic acid, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 24, 2021, Yang, Yi; Chen, Xianjun; Xie, Xin; Su, Ni published a patent.Related Products of 185345-46-4 The title of the patent was New method for detecting and quantifying RNA. And the patent contained the following:

The invention relates to a nucleic acid mol., including a complex of an aptamer and a fluorophore small mol. The nucleic acid mol. is used for detecting intracellular or extracellular RNA, DNA or other target mols. The invention also provides a test kit including the aptamer. The aptamer of the invention can specifically bind a fluorophore small mol. and significantly increase its fluorescence intensity upon excitation with light of the appropriate wavelength. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).Related Products of 185345-46-4

The Article related to aptamer nucleic acid mol preparation detection rna dan, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Related Products of 185345-46-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 30, 2021, Yang, Yi; Chen, Xianjun; Xie, Xin; Su, Ni published a patent.Related Products of 185345-46-4 The title of the patent was New method for detecting and quantifying RNA. And the patent contained the following:

Provided in the present invention are an aptamer nucleic acid mol., a compound containing the aptamer and a fluorophore small mol., a method for detecting RNA, DNA, or another target mol. inside or outside of a cell by using the aptamer nucleic acid mol., and a kit containing the aptamer. The aptamer of the present invention can specifically bind to a fluorophore small mol. and significantly improves the fluorescence intensity under light excitation at suitable wavelength. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).Related Products of 185345-46-4

The Article related to aptamer nucleic acid mol preparation detection rna dan, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Related Products of 185345-46-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Jian-An; Chen, Cheng; Huang, Jian-Gang; Liu, Hong-Wei; Cao, Song; Ji, Ya-Fei published an article in 2014, the title of the article was Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions.Synthetic Route of 185345-46-4 And the article contains the following content:

A hindered para-hydroxyl group-directed remote benzylic C(sp3)-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcs. and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds The ligand- and additive-free Cu(OAc)2-catalyzed atm. oxidation-mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodol. is expected to be of significant value for both fundamental research and practical applications. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).Synthetic Route of 185345-46-4

The Article related to cresol alkylphenol hydroxybenzyl alc ether copper catalyzed benzylic oxyfunctionalization, hindered phenol oxidation air ethylene glycol ligand additive free, hydroxybenzaldehyde hydroxyphenone environmentally benign preparation and other aspects.Synthetic Route of 185345-46-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Jian-An; Chen, Cheng; Huang, Jian-Gang; Liu, Hong-Wei; Cao, Song; Ji, Ya-Fei published an article in 2014, the title of the article was Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions.Synthetic Route of 185345-46-4 And the article contains the following content:

A hindered para-hydroxyl group-directed remote benzylic C(sp3)-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcs. and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds The ligand- and additive-free Cu(OAc)2-catalyzed atm. oxidation-mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodol. is expected to be of significant value for both fundamental research and practical applications. The experimental process involved the reaction of 3-Bromo-5-fluoro-4-hydroxybenzaldehyde(cas: 185345-46-4).Synthetic Route of 185345-46-4

The Article related to cresol alkylphenol hydroxybenzyl alc ether copper catalyzed benzylic oxyfunctionalization, hindered phenol oxidation air ethylene glycol ligand additive free, hydroxybenzaldehyde hydroxyphenone environmentally benign preparation and other aspects.Synthetic Route of 185345-46-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary