14-Sep-21 News New learning discoveries about 185122-74-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 185122-74-1, its application will become more common.

Some common heterocyclic compound, 185122-74-1, name is 5-Bromo-2,3-dihydro-1H-inden-1-amine, molecular formula is C9H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 5-Bromo-2,3-dihydro-1H-inden-1-amine

To a suspension of 5-bromo-2,3 -dihydro- lH-inden-1 -amine (2.2 g, 10.4 mmol) and NaHC03 (2.6 g, 31.2 mmol) in MeCN (100 mL) was added Boc20 (3.4 mL, 15.6 mmol) at 0 C. The reaction was stirred at rt overnight, then concentrated in vacuo. The residue was dissolved in EtOAc (100 mL). The resulted solution was washed with H20 (50 mL x 2), dried over anhydrous a2S04, filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) =20/1) to give the title compound as a white solid (3.3 g, 100%). MS (ESI, pos. ion) m/z: 257 [M + H – 56]+; NMR (400 MHz, i/6-DMSO) delta (ppm): 1.48 (s, 9H), 1.72-1.85 (m, 1H), 2.49-2.62 (m, 1H), 2.77-2.88 (m, 1H), 2.89-2.98 (m, 1H), 4.67-4.77 (br, 1H), 5.07-5.17 (m, 1H), 7.18 (d, J= 8.0 Hz, 1H), 7.32 (d, J= 8.0 Hz, 1H), 7.36 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 185122-74-1, its application will become more common.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; WANG, Ruyong; WANG, Liang; WO2014/89324; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

3-Sep-2021 News Introduction of a new synthetic route about 185122-74-1

The synthetic route of 5-Bromo-2,3-dihydro-1H-inden-1-amine has been constantly updated, and we look forward to future research findings.

Reference of 185122-74-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 185122-74-1, name is 5-Bromo-2,3-dihydro-1H-inden-1-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2.7 g of 5-bromoindan-1-ylamine were dissolved in 30 ml of dichloromethane. 2.2 g of pyridine were added to this solution followed by the addition of 1.4 g of propionic anhydride while cooling with ice. After returning the reaction solution to room temperature and stirring overnight, the reaction solution was poured into ice water and extracted with chloroform. The organic layer was washed with water and saturated brine followed by drying with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the resulting residue was purified by silica gel column chromatography (developing solvent: ethyl acetate/n- hexane = 1/1 (volume ratio)) to obtain 2.4 g of the target compound. Yield: 70% 1H-NMR (CDCl3, deltappm): 1.20(t,3H), 1.73-1.85(m,1H), 2.25(q,2H), 2.55-2.65(m,1H), 2.80-3.00(m,2H), 5.41-5.59(m,2H), 7.14(d,1H) 7.33(d,1H), 7.3 8(s,1H)

The synthetic route of 5-Bromo-2,3-dihydro-1H-inden-1-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Soda Co., Ltd.; EP2186804; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Simple exploration of C9H10BrN

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2,3-dihydro-1H-inden-1-amine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 185122-74-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 185122-74-1, name is 5-Bromo-2,3-dihydro-1H-inden-1-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

5-bromo-2,3-dihydro-lH-inden-l -amine (2.2 g, 10.4 mmol) andSodium bicarbonate (2.6 g, 31.2 mmol)Suspended in acetonitrile (100 mL)The mixture was cooled to 0 C,To this was added Boc anhydride (3.4 mL, 15.6 mmol).The reaction mixture was stirred at room temperature overnight and concentrated under reduced pressure.The residue was taken up in ethyl acetate (100 mL) and the resulting solution was washed with water (50 mL x 2), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure.The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 20/1)The title compound was obtained as a white solid (3.3 g, 100%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2,3-dihydro-1H-inden-1-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Ruyong; Wang Liang; (112 pag.)CN104016979; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Introduction of a new synthetic route about 5-Bromo-2,3-dihydro-1H-inden-1-amine

According to the analysis of related databases, 185122-74-1, the application of this compound in the production field has become more and more popular.

Synthetic Route of 185122-74-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 185122-74-1 as follows.

At 0 0C and under protective atmosphere, a solution of 2-propanesulfonyl chloride (1 1.87 mL, 121 mmol) in DCM (121 mL) was added gradually to a solution of 5-bromo-2,3- dihydro-7/-/-inden-1 -amine (12.8 g, 60.4 mmol) and 1 ,8-diazabicyclo[5.4.0]undec-7-ene (4.83 mL, 32.1 mmol) in dichloromethane (300 mL). The reaction was stirred at rt overnight. The reaction mixture was washed with 1 N KHSO4 (1x) and sat NaHCOs (2x) before being dried on IS^SO4 and solvent evaporated in vacuo to afford a green oil. Purification by column chromatography (25% EtOAc in hept) afforded the title compound as a white solid (6.0 g, 18.9 mmol, 31 %). MS (ESI) : m/z [M – H]”317.0.

According to the analysis of related databases, 185122-74-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; N.V. ORGANON; WO2009/147167; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of 185122-74-1

According to the analysis of related databases, 185122-74-1, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 185122-74-1 as follows. Computed Properties of C9H10BrN

At 0 0C and under protective atmosphere, a solution of 2-Propanesulfonyl chloride (1 1.87 ml_, 121 mmol) in DCM (121 ml.) was added gradually to a solution of 5-bromo-2,3- dihydro-1 H-inden-1 -amine (12.8 g, 60.4 mmol) and 1 ,8-Diazabicyclo[5.4.0]undec-7-ene (4.83 ml_, 32.1 mmol) in Dichloromethane (300 ml_). The reaction was stirred at rt overnight. The reaction mixture was washed with 1 N KHSO4 (1x) and sat NaHCObeta (2x) before being dried on Na2SO4 and solvent evaporated in vacuo to afford a green oil. Purification by column chromatography (25% EtOAc in heptane) afforded the title compound as a white solid.(6.0 g, 31 %). MS (ESI) : m/z [M – H]” 317.0

According to the analysis of related databases, 185122-74-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; N.V. Organon; GILLEN, Kevin James; GILLESPIE, Jonathan; JAMIESON, Craig; MACLEAN, John Kinnaird Ferguson; MOIR, Elizabeth Margaret; RANKOVIC, Zoran; WO2010/115952; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

New learning discoveries about 185122-74-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 185122-74-1, its application will become more common.

Some common heterocyclic compound, 185122-74-1, name is 5-Bromo-2,3-dihydro-1H-inden-1-amine, molecular formula is C9H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Bromo-2,3-dihydro-1H-inden-1-amine

To a suspension of 5-bromo-2,3 -dihydro- lH-inden-1 -amine (2.2 g, 10.4 mmol) and NaHC03 (2.6 g, 31.2 mmol) in MeCN (100 mL) was added Boc20 (3.4 mL, 15.6 mmol) at 0 C. The reaction was stirred at rt overnight, then concentrated in vacuo. The residue was dissolved in EtOAc (100 mL). The resulted solution was washed with H20 (50 mL x 2), dried over anhydrous a2S04, filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) =20/1) to give the title compound as a white solid (3.3 g, 100%). MS (ESI, pos. ion) m/z: 257 [M + H – 56]+; NMR (400 MHz, i/6-DMSO) delta (ppm): 1.48 (s, 9H), 1.72-1.85 (m, 1H), 2.49-2.62 (m, 1H), 2.77-2.88 (m, 1H), 2.89-2.98 (m, 1H), 4.67-4.77 (br, 1H), 5.07-5.17 (m, 1H), 7.18 (d, J= 8.0 Hz, 1H), 7.32 (d, J= 8.0 Hz, 1H), 7.36 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 185122-74-1, its application will become more common.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; WANG, Ruyong; WANG, Liang; WO2014/89324; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Share a compound : 5-Bromo-2,3-dihydro-1H-inden-1-amine

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-2,3-dihydro-1H-inden-1-amine, and friends who are interested can also refer to it.

Related Products of 185122-74-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 185122-74-1 name is 5-Bromo-2,3-dihydro-1H-inden-1-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound C (2.5 g, 10.5 MMOL) was dissolved in MEOH (40 mL) and reacted with SNCI2-2H2O (4. 7 g, 20.8 MMOL) at rt overnight. The solvent was removed and NAOH (aq, 1 N, 50 mL) was added. The reaction mixture was extracted into EtOAc (50 mL). The organic layer was extracted with HCI (1 N, 50 mL x 2) and the aquoues layer was basified with solid NaOH until the pH was about 11. The mixture was extracted with EtOAc (50 mL x 3). The organic layers were combined and dried over NA2SO4 and then concentrated to give the corresponding amine. The amine was dissolved in CH2CI2 (50 mL) and cooled TO-78 C. TFAA (1.47 g, 6.9 MMOL) was added followed by slow addition of Et3N (1.05 g, 10.4 MMOL). The reaction mixture was slowly warmed up to rt and stirred for 3 h. H20 (50 mL) was used to wash the reaction mixture. The organic layer was washed with brine, then dried over NA2SO4, and concentrated to dryness. The crude product was purified via sgc (25% EtOAc/hexanes) to give 3.1 g (96%) of compound D.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-2,3-dihydro-1H-inden-1-amine, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING CORPORATION; WO2004/48322; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

A new synthetic route of 185122-74-1

The synthetic route of 185122-74-1 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 185122-74-1, name is 5-Bromo-2,3-dihydro-1H-inden-1-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-2,3-dihydro-1H-inden-1-amine

[B]1-(2,2,2-Trifluoro-acetylamino)-cyclopropanecarboxylic acid ((rac)-5-bromo-indan-1-yl)-amide 1-(2,2,2-Trifluoroacetamido)cyclopropanecarboxylic acid (390 mg, 1.98 mmol) and HATU (753 mg, 1.98 mmol) were dissolved in DMF (12 ml), then Et3N (601 mg, 828 mul, 5.94 mmol) was added and the reaction mixture was stirred for 30 minutes. Subsequently, (rac)-5-bromo-indan-1-ylamine (0.42 g, 1.98 mmol), dissolved in DMF (3 ml), was added and the mixture stirred at RT for 15 h. It was then poured into H2O (50 ml) and extracted with CH2Cl2 (2*25 ml). The organic layers were dried over MgSO4, filtered and concentrated in vacuo to give a crude product (0.876 g) which was purified by flash chromatography (silica gel, 20 g, 0% to 5% MeOH in CH2Cl2) to give the title compound (0.64 g, 83%) as light brown oil. MS: 389.0 (M-H-, 1Br).

The synthetic route of 185122-74-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Aebi, Johannes; Binggeli, Alfred; Hertel, Cornelia; Konkar, Anish Ashok; Kuehne, Holger; Kuhn, Bernd; Maerki, Hans P.; Wang, Haiyan; US2013/18055; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary