Category: 18392-81-9

Related Products of 18392-81-9,Some common heterocyclic compound, 18392-81-9, name is 5,6-Dibromobenzo[c][1,2,5]thiadiazole, molecular formula is C6H2Br2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of N,N?-1,3-bis(2,6-diisopropylphenyl)imidazolium chloride [51] (0.45 g, 1.06 mmol) and Pd(OAc)2 (0.13 g, 0.59 mmol) in toluene (4mL), a suspension of NaOt-Bu (0.16g, 1.66mmol) in dry toluene (3mL) was added under inert conditions. The solution was heated at 88C for 30min. This mixture was cooled to room temperature and added to a pressure tube containing 2 [41] (2.00g, 6.8mmol) in toluene (70mL). To this mixture, tert-butylamine (1.5mL, 14.27mmol) was added followed by NaO-tBu (1.60g, 16.65mmol). The pressure tube was sealed and heated for 16hat 130C. After cooling, the reaction mixture was filtered through Celite. The filtrate was collected and evaporated to yield 3 as a light brown solid (1.941g, crude yield). The crude product was engaged in the following reaction with no further purification. 1H NMR (CDCl3, 300MHz): delta 7.14 (s, 2H, ArH), 3.40 (br, 2H, NH), 1.41 (s, 18H, CH3).

The synthetic route of 18392-81-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tapu, Daniela; Buckner, Ossie J.; Boudreaux, Chance M.; Norvell, Bradley; Vasiliu, Monica; Dixon, David A.; McMillen, Colin D.; Journal of Organometallic Chemistry; vol. 823; (2016); p. 40 – 49;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 18392-81-9,Some common heterocyclic compound, 18392-81-9, name is 5,6-Dibromobenzo[c][1,2,5]thiadiazole, molecular formula is C6H2Br2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1. 1 mmol of 5,6-dibromobenzothiadiazole,2 mmol of triphenylamine-4-boronic acid pinacol ester, 0.05 mmol of tetrakis(triphenylphosphine)palladium, 0.1 mmol of tetrabutylammonium bromide, 6 mmol of sodium hydroxide and 10 ml of toluene, reacted at 120 C for 48 h, with water Extract with dichloromethane and combine the organic layers.After drying, the organic solvent is removed, and purified by using a mixed solvent of dichloromethane and petroleum ether as a solvent column chromatography.4,4′-(Benzo[c][1,2,5]thiadiazole-5,6-diyl)bis(N,N-diphenylaniline) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dibromobenzo[c][1,2,5]thiadiazole, its application will become more common.

Reference:
Patent; Heilongjiang University; Han Chunmiao; Zhao Bingjie; Xu Hui; (30 pag.)CN110028506; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 18392-81-9,Some common heterocyclic compound, 18392-81-9, name is 5,6-Dibromobenzo[c][1,2,5]thiadiazole, molecular formula is C6H2Br2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of N,N?-1,3-bis(2,6-diisopropylphenyl)imidazolium chloride [51] (0.45 g, 1.06 mmol) and Pd(OAc)2 (0.13 g, 0.59 mmol) in toluene (4mL), a suspension of NaOt-Bu (0.16g, 1.66mmol) in dry toluene (3mL) was added under inert conditions. The solution was heated at 88C for 30min. This mixture was cooled to room temperature and added to a pressure tube containing 2 [41] (2.00g, 6.8mmol) in toluene (70mL). To this mixture, tert-butylamine (1.5mL, 14.27mmol) was added followed by NaO-tBu (1.60g, 16.65mmol). The pressure tube was sealed and heated for 16hat 130C. After cooling, the reaction mixture was filtered through Celite. The filtrate was collected and evaporated to yield 3 as a light brown solid (1.941g, crude yield). The crude product was engaged in the following reaction with no further purification. 1H NMR (CDCl3, 300MHz): delta 7.14 (s, 2H, ArH), 3.40 (br, 2H, NH), 1.41 (s, 18H, CH3).

The synthetic route of 18392-81-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tapu, Daniela; Buckner, Ossie J.; Boudreaux, Chance M.; Norvell, Bradley; Vasiliu, Monica; Dixon, David A.; McMillen, Colin D.; Journal of Organometallic Chemistry; vol. 823; (2016); p. 40 – 49;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 18392-81-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18392-81-9, name is 5,6-Dibromobenzo[c][1,2,5]thiadiazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Take 100mL reaction tube,5,6-dibromobenzothiadiazole (2.94 g, 10 mmol) was added,2-dodecylthiophene (2.77 g, 11 mmol),Potassium carbonate (1.66 g, 12 mmol),Trimethylacetic acid (306 mg, 3 mmol),5% of the catalyst palladium acetate,Nitrogen vacuum drum,30 mL of anhydrous N, N-dimethylacetamide was injected with a syringe,Stir at room temperature for 1 minute to make it fully dissolved,110 C for 4 hours.After completion of the reaction, the mixture was extracted with ethyl acetate,Add more saturated salt water layer is more obvious.Dried over anhydrous sodium sulfate,The solvent was removed under reduced pressure to give the crude product,Column chromatography,Petroleum ether / dichloromethane (8: 1).To give the product 1a (2.79 g, 60%),Light yellow oily liquid.

The synthetic route of 5,6-Dibromobenzo[c][1,2,5]thiadiazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing University of Posts and Telecommunications; Fu, Nina; Huang, Wei; Shi, Xin; Zhao, Baomin; Liu, Shuli; Wang, Lianhui; (15 pag.)CN106008558; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18392-81-9, name is 5,6-Dibromobenzo[c][1,2,5]thiadiazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H2Br2N2S

Take 1.4g (4.76mmol) of 4,7-dibromobenzothiadiazole in a 250mL round-bottom flask, add a mixed solvent of 16mL of tetrahydrofuran and 160mL of absolute ethanol, and add 3.244g at 0 C under a nitrogen atmosphere. 85mmol) sodium borohydride, continue to stir for 10min, then stir at room temperature for 3h, remove the organic solvent, add deionized water, extract the organic phase with anhydrous ether, wash with saturated sodium chloride solution and dry with anhydrous magnesium sulfate, again Remove the solvent to obtain 4,5-dibromo-1,2-phenylenediamine as a light yellow solid powder with a yield of 80%;

According to the analysis of related databases, 18392-81-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanxi University; Li Juan; Wu Zhenzhen; (8 pag.)CN111057011; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary