Application of 1786-36-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1786-36-3 as follows.
To a 4 mL vial, N-phenyl-N-(4-piperidyl)propanamide (25.6 mg, 0.11 mmol), K2CO3 (30 mg, 0.22 mmol), KI (9.4 mg, 0.06 mmol) were added with a magnetic stir bar. Acetonitrile (5 ml) was charged to the flask and then (2-bromo-l-fluoroethyl) benzene (37.1 mg, 0.18 mmol) was added. The reaction was allowed to stir at 115 C for 2 days. A sample aliquot was taken from the reaction, diluted with DCM in a microtube, and washed with half-saturated aq. Na2CCb. The organic layer was separated and analyzed by LCMS to confirm reaction completion. The reaction was concentrated under reduced pressure, and the crude material was dissolved in a minimal amount of DCM and dry loaded on celite. The celite/crude material was loaded onto a 10 g column which was connected to a l2 g Cl8 column and purified by reverse phase chromatography (12 g C18; 0-95% MeOH/water) to give S13 as a clear yellow oil (10 mg, 25%). 0.68; LC/MS tR = 1.42 min (Characterization Method A); m/z = 354.85 (M + H); NMR (300 MHz, CD2CI3) d = 7.46 – 7.27 (m, 8 H), 7.12 – 7.04 (m, 2 H), 5.69 – 5.44 (m, 1 H), 4.69 (tt, J = 4.0, 12.2 Hz, 1 H), 3.12 – 2.97 (m, 2 H), 2.87 (ddd, J = 9.3, 14.4, 17.2 Hz, 1 H), 2.64 – 2.43 (m, 1 H), 2.39 – 2.20 (m, 2 H), 1.93 (q, J = 7.4 Hz, 2 H), 1.86 – 1.74 (m, 2 H), 1.58 – 1.37 (m, 2 H), 1.02 (t, J = 7.5 Hz, 3 H).
According to the analysis of related databases, 1786-36-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MARQUETTE UNIVERSITY; DOCKENDORFF, Christopher; ROSAS, Ricardo, Jr.; (0 pag.)WO2020/6563; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary