Category: 17696-11-6

Name: 8-Bromooctanoic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Mixed Fluorinated/Hydrogenated Self-Assembled Monolayer-Protected Gold Nanoparticles: In Silico and In Vitro Behavior. Author is Marson, Domenico; Guida, Filomena; Sologan, Maria; Boccardo, Silvia; Pengo, Paolo; Perissinotto, Fabio; Iacuzzi, Valentina; Pellizzoni, Elena; Polizzi, Stefano; Casalis, Loredana; Pasquato, Lucia; Pacor, Sabrina; Tossi, Alessandro; Posocco, Paola.

Gold nanoparticles (AuNPs) covered with mixtures of immiscible ligands present potentially anisotropic surfaces that can modulate their interactions at complex nano-bio interfaces. Mixed, self-assembled, monolayer (SAM)-protected AuNPs, prepared with incompatible hydrocarbon and fluorocarbon amphiphilic ligands, are used here to probe the mol. basis of surface phase separation and disclose the role of fluorinated ligands on the interaction with lipid model membranes and cells, by integrating in silico and exptl. approaches. These results indicate that the presence of fluorinated amphiphilic ligands enhances the membrane binding ability and cellular uptake of gold nanoparticles with respect to those coated only with hydrogenated amphiphilic ligands. For mixed monolayers, computational results suggest that ligand phase separation occurs on the gold surface, and the resulting anisotropy affects the number of contacts and adhesion energies with a membrane bilayer. This reflects in a diverse membrane interaction for NPs with different surface morphologies, as determined by surface plasmon resonance, as well as differential effects on cells, as observed by flow cytometry and confocal microscopy. Overall, limited changes in monolayer features can significantly affect NP surface interfacial properties, which, in turn, affect the interaction of SAM-AuNPs with cellular membranes and subsequent effects on cells.

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Application In Synthesis of 8-Bromooctanoic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates. Author is Baalmann, Mathis; Neises, Laura; Bitsch, Sebastian; Schneider, Hendrik; Deweid, Lukas; Werther, Philipp; Ilkenhans, Nadja; Wolfring, Martin; Ziegler, Michael J.; Wilhelm, Jonas; Kolmar, Harald; Wombacher, Richard.

Bioorthogonal chem. holds great potential to generate difficult-to-access protein-protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation chem., use of undesirable catalysts, or often do not result in quant. product formation. Here the authors present a highly efficient technol. for protein functionalization with commonly used bioorthogonal motifs for Diels-Alder cycloaddition with inverse electron demand (DAinv). With the aim of precisely generating branched protein chimeras, the authors systematically assessed the reactivity, stability and side product formation of various bioorthogonal chemistries directly at the protein level. The authors demonstrate the efficiency and versatility of the authors′ conjugation platform using different functional proteins and the therapeutic antibody trastuzumab. This technol. enables fast and routine access to tailored and hitherto inaccessible protein chimeras useful for a variety of scientific disciplines. The authors expect the authors′ work to substantially enhance antibody applications such as immunodetection and protein toxin-based targeted cancer therapies.

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Bromide – Wikipedia,
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Safety of 8-Bromooctanoic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Symmetrical-Tetramethyl-Cucurbit[6]uril-Driven Movement of Cucurbit[7]uril Gives Rise to Heterowheel [4]Pseudorotaxanes. Author is Lin, Rui-Lian; Li, Ran; Shi, Hao; Zhang, Kun; Meng, Di; Sun, Wen-Qi; Chen, Kai; Liu, Jing-Xin.

Two novel heterowheel [4]pseudorotaxanes consisting of cucurbit[7]uril (Q[7]) and sym.-tetramethyl-cucurbit[6]uril (TMeQ[6]) were constructed via the multirecognition mechanism, in which Q[7] can rotate freely around the horizontal axis, while TMeQ[6] cannot. In the construction process, due to strong repulsive forces between carbonyl portals of two neighboring wheels, the dethreading and movement of the wheels along the axle was observed The dissociation of the [4]pseudorotaxanes was also discussed.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called Nickel-Catalyzed Inter- and Intramolecular Aryl Thioether Metathesis by Reversible Arylation, Author is Delcaillau, Tristan; Bismuto, Alessandro; Lian, Zhong; Morandi, Bill, which mentions a compound: 17696-11-6, SMILESS is O=C(O)CCCCCCCBr, Molecular C8H15BrO2, Recommanded Product: 17696-11-6.

A nickel-catalyzed aryl thioether metathesis was developed to access high-value thioethers. 1,2-Bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional-group-tolerant reaction. Furthermore, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis that does not involve alkene bonds. In-depth organometallic studies support a reversible Ni0/NiII pathway to product formation. Overall, this work not only provides a more sustainable alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information that are highly relevant to the further development and application of unusual single-bond metathesis reactions.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Bromooctanoic acid(SMILESS: O=C(O)CCCCCCCBr,cas:17696-11-6) is researched.Recommanded Product: 3,4,5-Trichloropyridine. The article 《Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:17696-11-6).

In this study, a class of novel HDACs inhibitors I (R = H, 4-CH3OC6H4; R1 = H, C6H5, 4-CH3OC6H4, 4-OHC6H4; R2 = H, OH; X = (CH2)n, n = 1, 3, 4, 5, 6, 7), II•HCl (R3 = N(CH3)2, 4-methylpiperazin-1-yl, morpholin-4-yl, piperidin-1-yl, pyrrolidin-1-yl; Y = (CH2)n, n = 5, 6, 7; Z = (CH2)n, n = 2, 3) was designed and synthesized based on the structure of flavones and isoflavones, followed by biol. evaluation. To be specific, a lead compound II•HCl [R3 = N(CH3)2; Y = (CH2)5; Z = (CH2)2 (III)] was discovered with strong anti-proliferative effects on a variety of solid tumor cells, especially for breast cancer cells with resistance to SAHA. Studies demonstrated that III could significantly inhibit the activity of HDAC 1,2,3 (class I) and 6 (class IIB), leading to a dose-dependent accumulation of acetylated histones and α-Tubulin, cell cycle arrest (G1/S phase) and apoptosis in breast cancer cells. Furthermore, the lead compound III could also antagonize the activation of STAT3 induced by HDACs inhibition in some breast cancer cells, which further reduced the level of pro-survive proteins in tumor cells and enhanced anti-tumor activity regulated by STAT3 signaling in vivo. Overall, findings demonstrated that the novel compound III might be a HDACs inhibitor candidate, which could be used as promising chemotherapeutic agent for breast cancer.

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Bromide – Wikipedia,
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Application In Synthesis of 8-Bromooctanoic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Streamlined One-Pot Synthesis of Nitro Fatty Acids. Author is Hassan, Mohamed; Krieg, Sara-Cathrin; Ndefo Nde, Cedric; Roos, Jessica; Maier, Thorsten J.; El Rady, Eman A.; Raslan, Mohamed A.; Sadek, Kamal U.; Manolikakes, Georg.

A novel method for the synthesis of nitro fatty acids (NFAs), an intriguing class of endogenously occurring lipid mediators, is reported. This one-pot procedure enables the controlled and stereoselective construction of nitro fatty acids from a simple set of common building blocks in a highly facile manner. Thereby, this methodol. offers a streamlined, highly modular access to naturally occurring nitro fatty acids as well as non-natural NFA derivatives

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Uchinomiya, Shohei; Matsunaga, Naoya; Kamoda, Koichiro; Kawagoe, Ryosuke; Tsuruta, Akito; Ohdo, Shigehiro; Ojida, Akio published an article about the compound: 8-Bromooctanoic acid( cas:17696-11-6,SMILESS:O=C(O)CCCCCCCBr ).Computed Properties of C8H15BrO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17696-11-6) through the article.

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, the authors report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Schaeker-Huebner, Linda; Warstat, Robin; Ahlert, Heinz; Mishra, Pankaj; Kraft, Fabian B.; Schliehe-Diecks, Julian; Schoeler, Andrea; Borkhardt, Arndt; Breit, Bernhard; Bhatia, Sanil; Huegle, Martin; Guenther, Stefan; Hansen, Finn K. researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).COA of Formula: C8H15BrO2.They published the article 《4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads》 about this compound( cas:17696-11-6 ) in Journal of Medicinal Chemistry. Keywords: antileukemia drug HDAC BET dual inhibitors BRD4 apoptosis anticancer. We’ll tell you more about this compound (cas:17696-11-6).

Multitarget drugs are an emerging alternative to combination therapies. In three iterative cycles of design, synthesis, and biol. evaluation, we developed a novel type of potent hybrid inhibitors of bromodomain, and extra-terminal (BET) proteins and histone deacetylases (HDACs) based on the BET inhibitor XD14 and well-established HDAC inhibitors. The most promising new hybrids, 49 and 61, displayed submicromolar inhibitory activity against HDAC1-3 and 6, and BRD4(1), and possess potent antileukemia activity. 49 induced apoptosis more effectively than the combination of ricolinostat and birabresib (1:1). The most balanced dual inhibitor, 61, induced significantly more apoptosis than the related control compounds 62 (no BRD4(1) affinity) and 63 (no HDAC inhibition) as well as the 1:1 combination of both. Addnl., 61 (I) was well tolerated in an in vivo zebrafish toxicity model. Overall, our data suggest an advantage of dual HDAC/BET inhibitors over the combination of two single targeted compounds

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Name: 8-Bromooctanoic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Alkyl Carbagermatrane Enabled Synthesis of Seven-Membered Carbocycle-Fused Aromatics through Catellani Strategy. Author is Xie, Xiu-Ying; Jiang, Wei-Tao; Xiao, Bin.

Synthesis of seven-membered carbocycle-fused aromatics was realized by Catellani reaction using terminally brominated alkyl carbagermatranes through intermol. cyclization manner. Various functional groups were well tolerated and this transformation was also expanded to the synthesis of carbocycles of other size. The utility of the above method was demonstrated by modification of natural product derivatives and synthesis of bioactive mols.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus.Computed Properties of C8H15BrO2.

All cells require sustained intracellular energy flux, which is driven by redox chem. at the subcellular level. NAD+, its phosphorylated variant NAD(P)+, and its reduced forms NAD(P)/NAD(P)H are all redox cofactors with key roles in energy metabolism and are substrates for several NAD-consuming enzymes (e.g. poly(ADP-ribose) polymerases, sirtuins, and others). The nicotinamide salvage pathway, constituted by NMN adenylyltransferase (NMNAT) and nicotinamide phosphoribosyltransferase (NAMPT), mainly replenishes NAD+ in eukaryotes. However, unlike NMNAT1, NAMPT is not known to be a nuclear protein, prompting the question of how the nuclear NAD+ pool is maintained and how it is replenished upon NAD+ consumption. In the present work, using human and murine cells; immunoprecipitation, pulldown, and surface plasmon resonance assays; and immunofluorescence, small-angle X-ray scattering, and MS-based analyses, we report that GAPDH and NAMPT form a stable complex that is essential for nuclear translocation of NAMPT. This translocation furnishes NMN to replenish NAD+ to compensate for the activation of NAD-consuming enzymes by stressful stimuli induced by exposure to H2O2 or S-nitrosoglutathione and DNAdamage inducers. These results indicate that by forming a complex with GAPDH, NAMPT can translocate to the nucleus and thereby sustain the stress-induced NMN/NAD salvage pathway.

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