Category: 17696-11-6

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17696-11-6, is researched, Molecular C8H15BrO2, about The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells, the main research direction is fluorescent HDAC inhibitor preparation tumor imaging; HDAC; NIR; Probe; Tumor imaging.Recommanded Product: 17696-11-6.

Histone deacetylases (HDACs) have been found to be biomarkers of cancers and the corresponding inhibitors have attracted much attention these years. Herein we reported a near-IR fluorescent HDAC inhibitor based on vorinostat (SAHA) and a NIR fluorophore. This newly designed inhibitor showed similar inhibitory activity to SAHA against three HDAC isoforms (HDAC1, 3, 6). The western blot assay showed significant difference in compared with the neg. group. When used as probe for further kinematic imaging, Probe 1 showed enhanced retention in tumor cells and the potential of HDAC inhibitors in drug delivery was firstly brought out. The cytotoxicity assay showed Probe 1 had some anti-proliferation activities with corresponding IC50 values of 9.20 ± 0.96μM on Hela cells and 5.91 ± 0.57μM on MDA-MB-231 cells. These results indicated that Probe 1 could be used as a potential NIR fluorescent in the study of HDAC inhibitors and lead compound for the development of visible drugs.

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Bromide – Wikipedia,
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Formula: C8H15BrO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control. Author is Linnebank, Pim R.; Ferreira, Stephan Falcao; Kluwer, Alexander M.; Reek, Joost N. H..

Herein, the redesign of a supramol. Rh-bisphosphite hydroformylation catalyst containing a neutral carboxylate receptor (DIM pocket) with a larger distance between the phosphite metal binding moieties and the DIM pocket was reported. For the first time regioselective hydroformylation of internal CH3(CH2)nCH:CH(CH2)7C(O)OH (n = 3, 5, 7), CH3CH:CH(CH2)nC(O)OH (n = 6, 7) and terminal CH2:CH(CH2)nC(O)OH (n = 2, 3, 4, etc.) alkenes containing a remote carboxylate directing group is demonstrated. For carboxylate substrates that possess an internal double bond at the Δ-9 position, regioselectivity was observed As such, the catalyst was used to hydroformylate natural monounsaturated fatty acids (MUFAs) in a regioselective fashion, forming of an excess of the 10-formyl product (10-formyl/9-formyl product ratio of 2.51), which is the first report of a regioselective hydroformylation reaction of such substrates.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, Non-P.H.S., Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage, Author is Nguyen, Suong T.; McLoughlin, Elizabeth A.; Cox, James H.; Fors, Brett P.; Knowles, Robert R., which mentions a compound: 17696-11-6, SMILESS is O=C(O)CCCCCCCBr, Molecular C8H15BrO2, SDS of cas: 17696-11-6.

The accumulation of persistent plastic waste in the environment is widely recognized as an ecol. crisis. New chem. technologies are necessary both to recycle existing plastic waste streams into high-value chem. feedstocks and to develop next-generation materials that are degradable by design. Here, we report a catalytic methodol. for the depolymerization of a com. phenoxy resin and high mol. weight hydroxylated polyolefin derivatives upon visible light irradiation near ambient temperature Proton-coupled electron transfer (PCET) activation of hydroxyl groups periodically spaced along the polymer backbone furnishes reactive alkoxy radicals that promote chain fragmentation through C-C bond β-scission. The depolymerization produces well-defined and isolable product mixtures that are readily diversified to polycondensation monomers. In addition to controlling depolymerization, the hydroxyl group modulates the thermomech. properties of these polyolefin derivatives, yielding materials with diverse properties. These results demonstrate a new approach to polymer recycling based on light-driven C-C bond cleavage that has the potential to establish new links within a circular polymer economy and influence the development of new degradable-by-design polyolefin materials.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Nayak, Rashmi Ashwathama; Bhat, Sachin A.; Shanker, G.; Rao, D. S. Shankar; Yelamaggad, C. V. published an article about the compound: 8-Bromooctanoic acid( cas:17696-11-6,SMILESS:O=C(O)CCCCCCCBr ).SDS of cas: 17696-11-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17696-11-6) through the article.

Herein the authors report on the synthesis and characterization of four new series of optically active, nonsym. dimers in which cholesterol is covalently linked to a Schiff base core through an ω-oxyalkanoyl spacer. While the Schiff base core is substituted with n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy tails, three even-parity spacers, namely, 4-oxybutanoyl, 6-oxyhexanoyl, 8-oxyoctanoyl, and an odd-parity spacer, namely, 5-oxypentanoyl, were used to join the two cores. The length and parity of the spacer and the length of the terminal tail play a vital role in deciding the phase sequences of the dimers. In general, the dimers possessing an even-parity spacer display enantiotropic LC phases such as chiral nematic (N*), twist grain boundary (TGB), smectic A (SmA), chiral smectic C (SmC*) and twist grain boundary phase with SmC* slabs (TGBC*). Some of these dimers display TGBC* over a wide temperature range. The dimers with an odd-parity (5-oxypentanoyl) spacer display, unlike their even-membered counterparts, blue phases (BPIII/II/I); besides, they stabilize N* and/or unknown smectic (SmX) phases. The CD measurements were carried out as a function of temperature on the planar texture formed by three even-membered dimers and an odd-membered dimer. The occurrence of a strong neg. CD band in the N* phase of the even-membered dimers suggests a left-handed screw sense of the macroscopic helical structure, and the scenario is opposite in the case of an odd-membered dimer.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy.Formula: C8H15BrO2.

Sonodynamic therapy (SDT) is a prospective therapy for many tumors by activation of sonosensitizers to produce reactive oxygen species (ROS) by ultrasound (US). However, limited generation of ROS and low drug delivery efficiency of sonosensitizers to the tumor tissue still hinder the application of SDT. Herein, an amphiphilic rose bengal (ARB) conjugate was designed to fabricate rose bengal microbubbles (RB-MBs) with high drug-loading contents (~6.8%) and excellent contrast enhancement capability for US imaging, well suited for detecting tumor location and size. More importantly, RB-MBs could be successfully converted into RB-NPs by local US exposure, resulting in ~7.5 times higher drug accumulation at the tumor tissue through the sonoporation effect as compared to RB-NPs and RB-MBs without US sonication. Meanwhile, using RB as the MB shell facilitated US energy transfer by the US mediated collapse of MBs through either a sonoluminescence or pyrolysis process; thus, the ROS generation efficiency could be greatly enhanced, resulting in a significantly higher tumor inhibition rate for the RB-MBs + US (~76.5%) in the HT-29 tumor model as compared to conventional MBs + US and RB-NPs + US (~23.8% and ~49.2%), resp. All these results suggested that this novel sonosensitizer delivery system of RB-MBs combined with US is a powerful strategy for remarkably enhancing SDT therapeutic efficacy with minimal side effects, showing great potential in cancer theranostics.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromooctanoic acid( cas:17696-11-6 ) is researched.Related Products of 17696-11-6.Fisher, Louise M.; Kim, Eliana E.; Moskalev, Nicolai V.; Gribble, Gordon W. published the article 《Asymmetric syntheses of potential anti-malarial drugs designed from Fieser’s 2-hydroxy-3-(2-methyloctyl)naphthalene-1,4-dione》 about this compound( cas:17696-11-6 ) in ARKIVOC (Gainesville, FL, United States). Keywords: naphthalene dione preparation antimalarial activity. Let’s learn more about this compound (cas:17696-11-6).

Asym. syntheses of the potential anti-malarial drugs (S)-2-(8-fluoro-2-methyloctyl)-3- hydroxynaphthalene-1,4-dione, (S)-2-hydroxy-3-(8-trifluoromethyl-2-methyloctyl)-3-hydroxynaphthalene-1,4-dione, and (S)-2-hydroxy-3-(2-methyloctyl)naphthalene-1,4-dione, which are patterned after Fieser’s ”10576”, known to be active against the mosquito borne parasite Plasmodium falciparum were described.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Base- and Catalyst-Induced Orthogonal Site Selectivities in Acylation of Amphiphilic Diols, published in 2020-05-15, which mentions a compound: 17696-11-6, Name is 8-Bromooctanoic acid, Molecular C8H15BrO2, SDS of cas: 17696-11-6.

Seeking to selectively functionalize natural and synthetic amphiphiles, we explored acylation of model amphiphilic diols. The use of a nucleophilic catalyst enabled a remarkable shift of the site selectivity from the polar site, preferred in background noncatalyzed or base-promoted reactions, to the apolar site. This tendency was significantly enhanced for organocatalysts comprising an imidazole active site surrounded by long/branched tails. An explanation of these orthogonal modes of selectivity is supported by competitive experiments with monoalc. substrates.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C8H15BrO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Location of the Positive Charges in Cationic Amphiphiles Modulates Their Mechanism of Action against Model Membranes. Author is Almeida, Marcio M.; Perez, Katia R.; Faig, Allison; Uhrich, Kathryn E.; Riske, Karin A..

Synthetic cationic amphiphiles (CAms) with physicochem. properties similar to antimicrobial peptides are promising mols. in the search for alternative antibiotics to which pathogens cannot easily develop resistance. Here, we investigate two types of CAms based on tartaric acid and containing two hydrophobic chains (of 7 or 11 carbons) and two pos. charges, located either at the end of the acyl chains (bola-like, B7 and B11) or at the tartaric acid backbone (gemini-like, G7 and G11). The interaction of the CAms with biomimetic membrane models (anionic and neutral liposomes) was studied with zeta potential and dynamic light scattering measurements, isothermal titration calorimetry, and a fluorescent-based leakage assay. We show that the type of mol. determines the mechanism of action of the CAms. Gemini-like mols. (G7 and G11) interact mainly via electrostatics (exothermic process) and reside in the external vesicle leaflet, altering substantially the vesicle surface potential but not causing significant membrane lysis. On the other hand, the interaction of bola-like CAms (B7 and B11) is endothermic and thus entropy-driven, and these mols. reach both membrane leaflets and cause substantial membrane permeabilization, likely after clustering of anionic lipids. The lytic ability is clearly higher against anionic membranes as compared with neutral membranes. Within each class of mol., longer alkyl chains (i.e., B11 and G11) exhibit higher affinity and lytic ability. Overall, the mol. B11 exhibits a high potential as antimicrobial agent, since it has a high membrane affinity and causes substantial membrane permeabilization.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Evidence for lactone formation during infrared multiple photon dissociation spectroscopy of bromoalkanoate doped salt clusters, published in 2020, which mentions a compound: 17696-11-6, Name is 8-Bromooctanoic acid, Molecular C8H15BrO2, Safety of 8-Bromooctanoic acid.

Reaction mechanisms of organic mols. in a salt environment are of fundamental interest and are potentially relevant for atm. chem., in particular sea-salt aerosols. Here, the authors found evidence for lactone formation upon IR multiple photon dissociation (IRMPD) of noncovalent bromoalkanoate complexes as well as bromoalkanoate embedded in sodium iodide clusters. The mechanism of lactone formation from bromoalkanoates of different chain lengths was studied in the gas phase with and without salt environment by a combination of IRMPD and quantum chem. calculations IRMPD spectra are recorded in the 833-3846 cm-1 range by irradiating the clusters with tunable laser systems while they are stored in the cell of a Fourier transform ICR (FT-ICR) mass spectrometer. The measurements of the binary complex Br(CH2)mCOOH·Br(CH2)mCOO- for m = 4 indicate valerolactone formation without salt environment while lactone formation is hindered for longer chain lengths. When embedded in sodium iodide clusters, butyrolactone formation from 4-bromobutyrate seems to take place already during formation of the doped clusters in the electrospray process, evidenced by the IR signature of the lactone. In contrast, IRMPD spectra of sodium iodide clusters containing 5-bromovalerate contain signatures for both valerate as well as valerolactone. In both cases, however, a neutral fragment corresponding to the mass of valerolactone is eliminated, indicating that ring formation can be activated by IR light in the salt cluster. Quantum chem. calculations show that already complexation with one sodium ion significantly increases the barrier for lactone formation for all chain lengths. IRMPD of sodium iodide clusters doped with neutral bromoalkanoic acid mols. proceeds by elimination of HI or desorption of the intact acid mol. from the cluster.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C8H15BrO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Unique Photophysical Behavior of Coumarin-Based Viscosity Probes during Molecular Self-Assembly. Author is Panettieri, Silvio; Silverman, Julian R.; Nifosi, Riccardo; Signore, Giovanni; Bizzarri, Ranieri; John, George.

Intermol. interactions impact self-assembly phenomena with a variety of biochem., phys., and mech. consequences. Nevertheless, underlying mechanisms leading to a controlled stereo- and chemo-specific aggregation at the mol. level often remain elusive due to the intrinsically dynamic nature of these processes. This work describes two, 3-styryl coumarin mol. rotors capable of probing subtle intermol. interactions controlling self-assembly of a small mol. organogelator. Complementing the gel characterization using CD and at. force microscopy, thorough spectroscopic assessments on these sensors were conducted to prove their high chem. and spatial affinity toward the three-dimensional supramol. network. Results were also supported by mol. dynamics simulations to provide addnl. critical insights into gelator dynamic self-assembly mechanisms. These sensors could potentially serve as templates to study a variety of soft-supramol. architectures and ways in which they assemble.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary