Category: 17696-11-6

Application In Synthesis of 8-Bromooctanoic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion. Author is Qiu, Xiaqiu; Li, Yuanqing; Yu, Bin; Ren, Jie; Huang, Huidan; Wang, Min; Ding, Hong; Li, Zhiyu; Wang, Jubo; Bian, Jinlei.

Cyclin-dependent kinase 9 (CDK9) is an increasingly important potential cancer treatment target. Nowadays, developing selective CDK9 inhibitors has been extremely challenging as its ATP-binding sites are similar with other CDKs. Here, we report that the CDK9 inhibitor BAY-1143572 is converted into a series of proteolysis targeting chimeras (PROTACs) which leads to several compounds inducing the degradation of CDK9 in acute myeloid leukemia cells at a low nanomolar concentration In addition, the most potent PROTAC mol. could inhibit cell growth more effectively than warhead alone, with little inhibition of other kinases. This enhanced antiproliferative activity is mediated by a slight increase in kinase inhibitory activity and an increase in the level of apoptosis induction. Moreover, the most potent PROTAC mol. could induce the degradation of CDK9 in vivo. Our work provides evidence that the most potent PROTAC mol. represents a lead for further development and that CDK9 degradation is a potential valuable therapeutic strategy in acute myeloid leukemia.

《Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(8-Bromooctanoic acid)Application In Synthesis of 8-Bromooctanoic acid.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 8-Bromooctanoic acid. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Interaction of Carboxyalkylated Cellulose Nanocrystals and Antibiotics.

Although antibiotics are beneficial for treating infections, their release into the environment has raised global concerns. In this work, the interactions of cellulose nanocrystal (CNC) derivatives with sulfamethoxazole (SMX), ciprofloxacin (CIP), and doxycycline (DOX) antibiotics were studied fundamentally. CNC was carboxyalkylated to bear different carbon chain lengths but similar neg. charges on its surface. The highest level of adsorption of DOX on the carboxypantadecanated CNC (i.e., carboxyalkylated CNC with more carbon spacer, PCNC) occurred at pH 6.0, which was due to the electrostatic and π interactions along with hydrogen bonding. The contact angle and quartz crystal microbalance (QCM) adsorption analyses revealed a faster interaction and adsorption of DOX than other antibiotics on PCNC. The results also depicted the diffusion of DOX into the porous structure of CNC derivatives, especially that of PCNC. Also, a more compact adsorbed layer of DOX was formed on PCNC than on other CNC derivatives Carboxyalkylation was observed to slightly reduce the surface area of CNC, while the antibiotic adsorption drastically increased the surface area of CNC due to their adsorption on the surface. XPS anal. revealed that carboxyalkylation significantly enhanced the C-C/C-H bond, while antibiotic adsorption on PCNC enhanced C-N/C-O and C-C/C-H bonds in antibiotic-loaded CNC samples. Overall, carboxyalkylated CNC was observed to have an outstanding affinity for capturing antibiotics, especially DOX, which could pave the way for the use of CNC in such applications that surface/antibiotic interactions were essential.

《Interaction of Carboxyalkylated Cellulose Nanocrystals and Antibiotics》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(8-Bromooctanoic acid)Name: 8-Bromooctanoic acid.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 8-Bromooctanoic acid. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Na2 Eosin Y Catalyzed Alkylation of Enol Acetates by Radical Decarboxylation of N-Hydroxyphthalimide Esters. Author is Nie, Yu; Wang, Zechao; Feng, Zengqiang; Dong, Bingbing; Bai, Yuyang; Leng, Yuting; Wu, Junliang.

A novel, efficient and transition-metal-free alkylation of enol acetates by radical decarboxylation of N-hydroxyphthalimide esters to synthesize α-alkylated ketones in existence of Na2-eosin Y at room temperature has been developed. This methodol. features operational simplicity, mild reaction conditions, widely functional group tolerance, affording a diverse array of α-alkylated ketones in moderate to good yields.

《Na2 Eosin Y Catalyzed Alkylation of Enol Acetates by Radical Decarboxylation of N-Hydroxyphthalimide Esters》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(8-Bromooctanoic acid)Name: 8-Bromooctanoic acid.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nayak, Rashmi Ashwathama; Bhat, Sachin A.; Rao, D. S. Shankar; Yelamaggad, C. V. researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).SDS of cas: 17696-11-6.They published the article 《Wide thermal range, exclusive occurrence of technically significant chiral nematic phase: synthesis and mesomorphism of cholesterol-based non-symmetric dimers》 about this compound( cas:17696-11-6 ) in Bulletin of Materials Science. Keywords: cholesterol salicylaldimine liquid crystal preparation mesomorphism; cholesteryl hydroxy benzylidene amino phenoxy ester preparation mesomorphism. We’ll tell you more about this compound (cas:17696-11-6).

Fifteen new non-sym. chiral dimers belonging to three different series have been synthesized and evaluated for their mesomorphic properties. They were formed by interlinking cholesterol with salicylaldimine (SAN) cores (with reverse imine groups) via an ω-oxyalkanoyloxy spacer. Within a series, the length of the terminal n-alkoxy tails had been varied for a fixed even-parity spacer. Three even-parity spacers such as 4-oxybutanoyloxy, 6-oxyhexanoyloxy and 8-oxyoctanoyloxy have been used to join two cores, whereas the terminal tails such as n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy chains have been attached to the SAN core. Microscopic and calorimetric exptl. results show that all the dimers behave identically exhibiting the chiral nematic (N*) phase solely, which was authenticated by powder X-ray diffraction studies carried out on some selected samples. In the vast majority of the cases,the phase was thermodynamically stable, and while cooling, it exists over a wide thermal range covering room temperature(RT)due to supercooling. Finding was notable given the fact that the N* phase possesses technol. significant optical properties. At RT, the N* phase displayed one of the iridescent colors characteristically caused by interference and diffraction of the reflected and scattered light. A comparative study reveals that the lengths of both the terminal chain and central spacer influence the clearing temperature of the dimers, and also the temperature range of the N* phase. The selective reflection measurements revealed that the pitch of the N* phase was either temperature sensitive or temperature insensitive. Temperature-dependent CD (CD) spectra were recorded for the planar texture of the N* phase formed by a dimer, as a representative case. The presence of an intense neg. CD band suggests the left-handed screw sense of the N* phase helix.

Different reactions of this compound(8-Bromooctanoic acid)SDS of cas: 17696-11-6 require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 8-Bromooctanoic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Deoxyfluorination of Carboxylic, Sulfonic, Phosphinic Acids and Phosphine Oxides by Perfluoroalkyl Ether Carboxylic Acids Featuring CF2O Units. Author is Zhao, Shiyu; Guo, Yong; Su, Zhaoben; Wu, Chengying; Chen, Wei; Chen, Qing-Yun.

The synthesis of acyl fluorides RCOF [R = Br(CH2)6CH2, Ph, 1-naphthyl, etc.], sulfonyl fluorides R1SO2F [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.] and phosphoric fluorides R2PO(F)R3 [R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R3 = Me, F, Ph, etc.] could be realized via carbonic difluoride (COF2) generated in situ from thermal degradation of the PFECA salt. The use of potassium salts of perfluoroalkyl ether carboxylic acids (PFECA) was reported featuring CF2O units as deoxyfluorination reagents, which were generated mainly as byproducts in the manufacture of hexafluoropropene oxide (HFPO).

Different reactions of this compound(8-Bromooctanoic acid)Name: 8-Bromooctanoic acid require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Ke; Bai, Bing; Liu, Yu-Hsuan; Lowary, Todd L. published the article 《Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii》. Keywords: antibacterial Mycobacterium kansasii antigen tridecasaccharide pathogen mycobacteria tuberculosis immunomodulator; BSA bovine serum albumin structure activity lipooligosaccharide tridecasaccharide bioconjugate; antigens; complex glycans; lipooligosaccharides; mycobacteria; total synthesis.They researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).Category: bromides-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17696-11-6) here.

The outer surfaces of mycobacteria, including the organism that causes tuberculosis, are decorated with an array of immunomodulatory glycans. Among these are lipooligosaccharides (LOSs), a class of mols. for which the function remains poorly understood. We describe the chem. synthesis of the glycan portion of a tridecasaccharide LOS from the opportunistic pathogen Mycobacterium kansasii. The target contains a number of unusual structural motifs that complicate its assembly and is the most complex mycobacterial LOS glycan to be synthesized to date when considering size and number of unique monosaccharides and glycosidic linkages. These studies not only provide a road-map for the preparation of addnl. members of this family of glycans, but also provides a valuable probe for use in structure-activity relationship investigations.

《Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(8-Bromooctanoic acid)Category: bromides-buliding-blocks.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromooctanoic acid( cas:17696-11-6 ) is researched.Synthetic Route of C8H15BrO2.Sanchez-Cadena, Lorena E.; Tersac, Gilles; Coqueret, Xavier; Gamino-Arroyo, Zeferino published the article 《Solvolysis of acrylate-urethane coatings cured by electron-beam and UV radiation》 about this compound( cas:17696-11-6 ) in Progress in Organic Coatings. Keywords: polyurethane acrylate cured electron beam UV radiation coating solvolysis. Let’s learn more about this compound (cas:17696-11-6).

Solvolysis was investigated for two different types of thermosetting polyacrylate-urethane resin coatings. One type of resin was cross-linked by ultra violet (UV) radiation and the other by electron beam (EB). The cured coatings were deposited on aluminum sheets. Solvolysis was carried out with diethylene glycol (DEG) catalyzed by KOH. The resins were characterized by FT-IR ATR spectroscopy prior to solvolysis. The kinetics of the solvolysis process were investigated, and the depolymerization products were studied by FT-IR ATR spectroscopy and size exclusion chromatog. The results show that total solvolysis is possible for both cured resins, albeit it is faster for resins cured by UV radiation.

The article 《Solvolysis of acrylate-urethane coatings cured by electron-beam and UV radiation》 also mentions many details about this compound(17696-11-6)Synthetic Route of C8H15BrO2, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Romanov, Semyon R.; Dolgova, Yana V.; Morozov, Maxim V.; Ivshin, Kamil A.; Semenov, Dmitriy A.; Bakhtiyarova, Yulia V.; Galkina, Irina V.; Kataeva, Olga N.; Galkin, Vladimir I. published the article 《New phosphonium salts based on 3-(diphenylphosphino)propanoic and ω-haloalkanoic acids》. Keywords: crystal structure mol phosphonium bromide diphenyl dicarboxy preparation.They researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).Reference of 8-Bromooctanoic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17696-11-6) here.

Quaternization of 3-(diphenylphosphino)propanoic acid with ω-haloalkanoic acids affords novel phosphonium salts containing two carboxy groups. The phosphonium salts were treated with 1 M alkali solution to obtain corresponding carboxylate phosphabetaines. The structure of the compounds was established by IR and NMR spectroscopy, elemental anal. and X-ray single crystal diffraction.

Different reactions of this compound(8-Bromooctanoic acid)Reference of 8-Bromooctanoic acid require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary