17696-11-6 Archives - Page 6 of 11 - Bromides-buliding-blocks

Fisher, Louise M.’s team published research in ARKIVOC (Gainesville, FL, United States) in 2020 | CAS: 17696-11-6

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application In Synthesis of 8-Bromooctanoic acid

《Asymmetric syntheses of potential anti-malarial drugs designed from Fieser’s 2-hydroxy-3-(2-methyloctyl)naphthalene-1,4-dione》 was written by Fisher, Louise M.; Kim, Eliana E.; Moskalev, Nicolai V.; Gribble, Gordon W.. Application In Synthesis of 8-Bromooctanoic acid And the article was included in ARKIVOC (Gainesville, FL, United States) in 2020. The article conveys some information:

Asym. syntheses of the potential anti-malarial drugs (S)-2-(8-fluoro-2-methyloctyl)-3- hydroxynaphthalene-1,4-dione, (S)-2-hydroxy-3-(8-trifluoromethyl-2-methyloctyl)-3-hydroxynaphthalene-1,4-dione, and (S)-2-hydroxy-3-(2-methyloctyl)naphthalene-1,4-dione, which are patterned after Fieser’s ”10576”, known to be active against the mosquito borne parasite Plasmodium falciparum were described. In addition to this study using 8-Bromooctanoic acid, there are many other studies that have used 8-Bromooctanoic acid(cas: 17696-11-6Application In Synthesis of 8-Bromooctanoic acid) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bersenkowitsch, Nina K.’s team published research in Physical Chemistry Chemical Physics in 2020 | CAS: 17696-11-6

《Evidence for lactone formation during infrared multiple photon dissociation spectroscopy of bromoalkanoate doped salt clusters》 was written by Bersenkowitsch, Nina K.; Oncak, Milan; Heller, Jakob; Pascher, Tobias F.; van der Linde, Christian; Beyer, Martin K.. Category: bromides-buliding-blocks And the article was included in Physical Chemistry Chemical Physics in 2020. The article conveys some information:

Reaction mechanisms of organic mols. in a salt environment are of fundamental interest and are potentially relevant for atm. chem., in particular sea-salt aerosols. Here, the authors found evidence for lactone formation upon IR multiple photon dissociation (IRMPD) of noncovalent bromoalkanoate complexes as well as bromoalkanoate embedded in sodium iodide clusters. The mechanism of lactone formation from bromoalkanoates of different chain lengths was studied in the gas phase with and without salt environment by a combination of IRMPD and quantum chem. calculations IRMPD spectra are recorded in the 833-3846 cm-1 range by irradiating the clusters with tunable laser systems while they are stored in the cell of a Fourier transform ICR (FT-ICR) mass spectrometer. The measurements of the binary complex Br(CH2)mCOOH·Br(CH2)mCOO- for m = 4 indicate valerolactone formation without salt environment while lactone formation is hindered for longer chain lengths. When embedded in sodium iodide clusters, butyrolactone formation from 4-bromobutyrate seems to take place already during formation of the doped clusters in the electrospray process, evidenced by the IR signature of the lactone. In contrast, IRMPD spectra of sodium iodide clusters containing 5-bromovalerate contain signatures for both valerate as well as valerolactone. In both cases, however, a neutral fragment corresponding to the mass of valerolactone is eliminated, indicating that ring formation can be activated by IR light in the salt cluster. Quantum chem. calculations show that already complexation with one sodium ion significantly increases the barrier for lactone formation for all chain lengths. IRMPD of sodium iodide clusters doped with neutral bromoalkanoic acid mols. proceeds by elimination of HI or desorption of the intact acid mol. from the cluster. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6Category: bromides-buliding-blocks)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Besten, Willem den’s team published research in Journal of the American Chemical Society in 2021 | CAS: 17696-11-6

Application of 17696-11-6In 2021 ,《Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein》 appeared in Journal of the American Chemical Society. The author of the article were Besten, Willem den; Verma, Kshitij; Yamazoe, Sayumi; Blaquiere, Nicole; Phung, Wilson; Izrael-Tomasevic, Anita; Mulvihill, Melinda M.; Helgason, Elizabeth; Prakash, Sumit; Goncharov, Tatiana; Vucic, Domagoj; Dueber, Erin; Fairbrother, Wayne J.; Wertz, Ingrid; Yu, Kebing; Staben, Steven T.. The article conveys some information:

We hypothesized that the proximity-driven ubiquitylation of E3-interacting small mols. could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small mols. was modified to append a nucleophilic primary amine. This modification transforms XIAP binders into inducers of XIAP degradation The degradation of XIAP is E1- and proteasome-dependent, dependent on the ligase function of XIAP, and is rescued by subtle modifications of the small mol. that would obviate ubiquitylation. We demonstrate in vitro ubiquitylation of the small mol. that is dependent on its interaction with XIAP. Taken together, these results demonstrate the designed ubiquitylation of an engineered small mol. and a novel approach for the degradation of E3 ubiquitin ligases. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chu-Farseeva, Yu-yi’s team published research in European Journal of Medicinal Chemistry in 2018 | CAS: 17696-11-6

Synthetic Route of C8H15BrO2In 2018 ,《Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat》 appeared in European Journal of Medicinal Chemistry. The author of the article were Chu-Farseeva, Yu-yi; Mustafa, Nurulhuda; Poulsen, Anders; Tan, Eng Chong; Yen, Jeffrey J. Y.; Chng, Wee Joo; Dymock, Brian W.. The article conveys some information:

Specifically blocking more than one oncogenic pathway simultaneously in a cancer cell with a combination of different drugs is the mainstay of the majority of cancer treatments. Being able to do this via two targeted pathways without inducing side effects through a general mechanism, such as chemotherapy, could bring benefit to patients. In this work we describe a new dual inhibitor of the JAK-STAT and HDAC pathways through designing and developing two types of mol. based on the JAK2 selective inhibitor XL019 and the pan-HDAC inhibitor, vorinostat. Both series of compounds had examples with low nanomolar JAK2 and HDAC1/6 inhibition. In some cases good HDAC1 selectivity was achieved while retaining HDAC6 activity. The observed potency is explained through mol. docking studies of all three enzymes. One example, 69c had 16-25 fold selectivity against the three other JAK-family proteins JAK1, JAK3 and TYK2. A number of compounds had sub-micromolar potencies against a panel of 4 solid tumor cell lines and 4 hematol. cell lines with the most potent compound, 45h, having a cellular IC50 of 70 nM against the multiple myeloma cell line KMS-12-BM. Evidence of both JAK and HDAC pathway inhibition is presented in Hela cells showing that both pathways are modulated. Evidence of apoptosis with two compounds in 4 sold tumor cell lines is also presented. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Synthetic Route of C8H15BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yu, Shaoze’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 17696-11-6

In 2022,Yu, Shaoze; Shen, Guosong; He, Faqian; Yang, Xiaoyu published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Asymmetric synthesis of planar-chiral macrocycles via organocatalyzed enantioselective macrocyclization》.Application of 17696-11-6 The author mentioned the following in the article:

A novel enantioselective macrocyclization method was developed for the asym. synthesis of planar-chiral macrocycles I [R1 = Br, C≡Ccyclopropyl, C≡CPh, etc.; R2 = Me, Et; R3 = Piv, C(O)CMe2Et; n = 0, 1, 2, 3, 4] through chiral phosphoric acid-catalyzed intramol. addition of the hydroxy group with the allenamide moiety. A series of planar-chiral macrocycles bearing various ring sizes (18-member to 22-member) and various functional groups were generated with good to high enantioselectivities. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Lixin’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2019 | CAS: 17696-11-6

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Liu, Lixin; Dong, Jianyu; Yan, Yani; Yin, Shuang-Feng; Han, Li-Biao; Zhou, Yongbo. Recommanded Product: 8-Bromooctanoic acid. The article was titled 《Photoredox-catalyzed decarboxylative alkylation/cyclization of alkynylphosphine oxides: a metal- and oxidant-free method for accessing benzo[b]phosphole oxides》. The information in the text is summarized as follows:

By photoredox-catalysis, alkylation/aryl C-H cyclization of readily available alkynylphosphine oxides towards benzo[b]phospholes has been realized under metal- and oxidant-free conditions at room temperature This reaction readily incorporates various functionalized alkyl groups into the benzo[b]phosphole skeletons, representing a mild and versatile tool for the preparation of valuable phosphole compounds The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Recommanded Product: 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Bingying’s team published research in Analytical Chemistry (Washington, DC, United States) in 2018 | CAS: 17696-11-6

In 2018,Xu, Bingying; Zhou, Haibo; Mei, Qingsong; Tang, Wei; Sun, Yilun; Gao, Mengping; Zhang, Cuilan; Deng, Shengsong; Zhang, Yong published 《Real-Time Visualization of Cysteine Metabolism in Living Cells with Ratiometric Fluorescence Probes》.Analytical Chemistry (Washington, DC, United States) published the findings.Name: 8-Bromooctanoic acid The information in the text is summarized as follows:

Sulfite from cysteine metabolism in living cells plays a crucial role in improving the water solubility of metabolic xenobiotics for their easier excretion in urine or bile. However, an imbalance of sulfite in vivo would lead to oxidative stress or age-related diseases, and an effective strategy for real-time imaging of cysteine metabolism in living cells is still lacking due to its low metabolite concentration and rapid reaction kinetics. Herein, a cyanine moiety based ratiometric fluorescence probe (I) was developed for highly selective and sensitive detection of sulfite in aqueous solution and living cells. The free probe exhibited an orange emission color, and the fluorescence color would gradually change to blue once sulfite anions selectively reacted with the unsaturated carbon double bonds in the probe mol. This ratiometric fluorescence manner endowed the probe excellent sensitivity with a detection limit of 0.78 nM, which was then explored to image the kinetic process of sulfite release in hepatic BRL cells after incubating with an excess amount of cysteine. This strategy opens new opportunities for revealing thiol-containing species metabolism and even quant. tracking their distributions in live cells or organelles. In the experimental materials used by the author, we found 8-Bromooctanoic acid(cas: 17696-11-6Name: 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Das, Soumen’s team published research in Journal of Labelled Compounds and Radiopharmaceuticals in 2018 | CAS: 17696-11-6

Electric Literature of C8H15BrO2In 2018 ,《Synthesis and biodistribution studies of 99mTc labeled fatty acid derivatives prepared via “”Click approach”” for potential use in cardiac imaging》 was published in Journal of Labelled Compounds and Radiopharmaceuticals. The article was written by Das, Soumen; Mathur, Anupam; Sakhare, Navin; Mallia, Madhava B.; Sarma, Haladhar Dev; Sachdev, Satbir Singh; Dash, Ashutosh. The article contains the following contents:

123I-Iodophenylpentadecanoic acid (IPPA) is a metabolic agent used in nuclear medicine for diagnosis of myocardial defects. Efforts are underway worldwide to develop a 99mTc substitute of the above radiopharmaceutical for the aforementioned application. Herein, we report synthesis and biodistribution studies of 99mTc labeled fatty acids (8, 11, and 15 carbons) obtained via “”click chem.”” for its potential use in myocardial imaging. ω-Bromo fatty acids (8C/11C/15C) were synthetically modified at bromo terminal to introduce a heterocyclic triazole with glycine sidearm in a five step procedure. Modified fatty acids were subsequently radiolabeled with preformed [99mTc(CO)3]+ synthon to yield the desired fatty acid complexes which were evaluated in Swiss mice. All the radiolabeled complexes were obtained with radiochem. purities >80%, as characterized by HPLC. Biodistribution studies of all three complexes in Swiss mice showed myocardial uptake of ∼6-9% ID/g at 2 min post-injection, close to*I-IPPA (∼9% ID/g). Complexes exhibited significant retention in the myocardium up to 30 min (∼1% ID/g) but were lower to the standard agent (∼7% ID/g). Similar uptake of activity in myocardium for the newly synthesized complexes in comparison to 125I-IPPA along with favorable in vivo pharmacokinetics merits potential for the present “”click”” design of complexes for myocardial imaging. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Electric Literature of C8H15BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Acosta-Martinez, Delvis R.’s team published research in Colloids and Surfaces, B: Biointerfaces in 2020 | CAS: 17696-11-6

Quality Control of 8-Bromooctanoic acidIn 2020 ,《Bis-quaternary ammonium gemini surfactants for gene therapy: Effects of the spacer hydrophobicity on the DNA complexation and biological activity》 was published in Colloids and Surfaces, B: Biointerfaces. The article was written by Acosta-Martinez, Delvis R.; Rodriguez-Velazquez, Eustolia; Araiza-Verduzco, Fernanda; Taboada, Pablo; Prieto, Gerardo; Rivero, Ignacio A.; Pina-Luis, Georgina; Alatorre-Meda, Manuel. The article contains the following contents:

Gemini surfactants (GS) have been highlighted as attractive gene carriers for a few years now; however, key aspects of the role of the GS chem. structure on the DNA-GS complexation and subsequent biol. activity remain to be determined Aiming to elucidate the effects of the GS spacer hydrophobicity, this work was focused on the biophys. characterization of the self-assembly, DNA complexation, cytocompatibility, and DNA transfection of a series of bis-quaternary ammonium GS with fixed side alkyl chains of 14 carbons and varying head-to-head alkyl chain spacers of 4, 6, and 14 carbons (referred to as GS4, GS6, and GS14, resp.). The characterization was carried out by a battery of exptl. techniques including UV-vis and fluorescence spectroscopies, ζ potential, dynamic light scattering (DLS), isothermal titration calorimetry (ITC), and flow cytometry, among others. Overall, the spectroscopic results showed that the self-assembly of the GS was favored with the spacer hydrophobicity since lower values of critical micelle concentration (CMC) were observed for samples with longer spacer chains. On the other hand, the ITC results revealed that the DNA-GS complexation was driven by an initial electrostatic attraction between DNA and GS monomers/micelles followed by complementary hydrophobic interactions which strengthen the DNA-GS binding, the latter being more pronounced for GS with longer spacers. Finally, the biol. tests demonstrated that while GS with moderate hydrophobicity (GS4 and GS6) yielded outstanding levels of cytocompatibility and DNA transfection over a range of concentrations, the most hydrophobic sample (GS14) proved to be cytotoxic upon administration to cultured HeLa cells (p < 0.05). In our opinion, the fundamental information here presented might be pivotal not only for understanding the DNA-GS complexation mechanism, but also for developing efficient GS-based carriers for gene therapy. In the experiment, the researchers used many compounds, for example, 8-Bromooctanoic acid(cas: 17696-11-6Quality Control of 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Uchinomiya, Shohei’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 17696-11-6

《Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells》 was written by Uchinomiya, Shohei; Matsunaga, Naoya; Kamoda, Koichiro; Kawagoe, Ryosuke; Tsuruta, Akito; Ohdo, Shigehiro; Ojida, Akio. Application In Synthesis of 8-Bromooctanoic acid And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, the authors report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6Application In Synthesis of 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary