17696-11-6 Archives - Page 3 of 11 - Bromides-buliding-blocks

Al-shargabi, Arwa’s team published research in Liquid Crystals in 2020 | CAS: 17696-11-6

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Safety of 8-Bromooctanoic acid

《Liquid crystal dimers containing Cholesteryl and Triazole-containing mesogenic units》 was written by Al-shargabi, Arwa; Yeap, Guan-Yeow; Mahmood, Wan Ahmad Kamil; Han, Chun-Chieh; Lin, Hong-Cheu; Ito, Masato M.. Safety of 8-Bromooctanoic acid And the article was included in Liquid Crystals in 2020. The article conveys some information:

New liquid crystals categorized as cholesteryl dimers have been successfully synthesized through the reaction between cholesteryl 4-(prop-2-ynyloxy)benzoate moieties with n-azido(cholesteryloxy-carbonyl)alkane. All the dimers display enantiotropic mesophases. While the odd-numbered dimers exhibit chiral nematic (N*), twisted grain boundary (TGB) and chiral smectic C (SmC*) phases, the even-numbered members from the same series show chiral smectic A and C. A detailed inspection on mesophase reveals that the chiral centers and the bent conformation of the odd-numbered members are essential for the induction of TGB phase. However, upon decreasing the temperature, the ratio of the transition temperatures (TSmC*-SmA*/TSmA*-I) is found to be 0.95, which indicate the second order transition according to the McMillan’s mol. theory. In addition, the X-ray diffraction study supports the presence of the smectic A phase on the even members rather than the N* by the appearance of the Bragg diffraction peaks at 190°. A comparison study with the other analogs in which the cholesterol entity is substituted by azobenzene or bipheny tails has been carried out to assess the relationship between the mol. structure and mesomorphic behavior.8-Bromooctanoic acid(cas: 17696-11-6Safety of 8-Bromooctanoic acid) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bian, Jinlei’s team published research in Bioorganic Chemistry in 2018 | CAS: 17696-11-6

《Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity》 was written by Bian, Jinlei; Ren, Jie; Li, Yongren; Wang, Jubo; Xu, Xi; Feng, Yifan; Tang, Hui; Wang, Yajing; Li, Zhiyu. Application of 17696-11-6This research focused onWogonin PROTAC CDK9 antitumor click chem; Antitumor; CDK9; Click Chemistry; PROTAC; Wogonin. The article conveys some information:

Wogonin is a natural product isolated from the Scutellaria baicalensis and has been proved to be a potent and selective inhibitor of CDK9. Using this scaffold, we designed and synthesized a series of proteolysis targeting chimeras (PROTACs) targeting CDK9 by recruiting ubiquitin E3 ligase cereblon (CRBN). For constructing diverse Wogonin-based PROTACs, a “”click chem.”” approach was employed for the synthesis of CDK9-targeting PROTACs. The results of western blotting assays showed that compounds containing triazole group in the linker could selectively downregulate the intracellular CDK9 level. Among these compounds, 11c could selectively degrade CDK9 in a concentration-dependent manner. In addition, the application of the proteasome inhibitor MG132 and CRBN siRNA silencing confirmed that 11c could promote the proteasome-dependent and CRBN-dependent degradation Consistent with the degradation of the CDK9 protein, 11c selectively inhibits proliferation of CDK9-overexpressed cancer cells. Thus, our Wogonin-based PROTAC would be an efficient probe that induces the degradation of CDK9. The results came from multiple reactions, including the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Shiyu’s team published research in Chinese Journal of Chemistry in 2021 | CAS: 17696-11-6

《Deoxyfluorination of Carboxylic, Sulfonic, Phosphinic Acids and Phosphine Oxides by Perfluoroalkyl Ether Carboxylic Acids Featuring CF2O Units》 was written by Zhao, Shiyu; Guo, Yong; Su, Zhaoben; Wu, Chengying; Chen, Wei; Chen, Qing-Yun. COA of Formula: C8H15BrO2 And the article was included in Chinese Journal of Chemistry in 2021. The article conveys some information:

The synthesis of acyl fluorides RCOF [R = Br(CH2)6CH2, Ph, 1-naphthyl, etc.], sulfonyl fluorides R1SO2F [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.] and phosphoric fluorides R2PO(F)R3 [R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R3 = Me, F, Ph, etc.] could be realized via carbonic difluoride (COF2) generated in situ from thermal degradation of the PFECA salt. The use of potassium salts of perfluoroalkyl ether carboxylic acids (PFECA) was reported featuring CF2O units as deoxyfluorination reagents, which were generated mainly as byproducts in the manufacture of hexafluoropropene oxide (HFPO). After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6COA of Formula: C8H15BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lin, Lucy’s team published research in Journal of Medicinal Chemistry in 2020 | CAS: 17696-11-6

《Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Lin, Lucy; Olson, Margaret E.; Sugane, Takashi; Turner, Lewis D.; Tararina, Margarita A.; Nielsen, Alexander L.; Kurbanov, Elbek K.; Pellett, Sabine; Johnson, Eric A.; Cohen, Seth M.; Allen, Karen N.; Janda, Kim D.. Reference of 8-Bromooctanoic acid The article mentions the following:

Botulinum neurotoxins have remarkable persistence (~weeks to months in cells), outlasting the small-mol. inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores-a zinc binding group and a Cys-reactive warhead-were designed to leverage both affinity and reactivity. A series of first-generation bifunctional inhibitors was achieved through structure-based inhibitor design. Through X-ray crystallog., engagement of both the catalytic Zn2+ and Cys165 was confirmed. A second-generation series improved on affinity by incorporating known reversible inhibitor pharmacophores; the mechanism was confirmed by exhaustive dialysis, mass spectrometry, and in vitro evaluation against the C165S mutant. Finally, a third-generation inhibitor was shown to have good cellular activity and low toxicity. In addition to our findings, an alternative method of modeling time-dependent inhibition that simplifies assay setup and allows comparison of inhibition models is discussed. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Reference of 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Veerapen, Natacha’s team published research in Bioconjugate Chemistry in 2018 | CAS: 17696-11-6

In 2018,Bioconjugate Chemistry included an article by Veerapen, Natacha; Kharkwal, Shalu Sharma; Jervis, Peter; Bhowruth, Veemal; Besra, Amareeta K.; North, Simon J.; Haslam, Stuart M.; Dell, Anne; Hobrath, Judith; Quaid, Padraic J.; Moynihan, Patrick J.; Cox, Liam R.; Kharkwal, Himanshu; Zauderer, Maurice; Besra, Gurdyal S.; Porcelli, Steven A.. HPLC of Formula: 17696-11-6. The article was titled 《Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation》. The information in the text is summarized as follows:

Activation of invariant natural killer T lymphocytes (iNKT cells) by α-galactosylceramide (α-GC) elicits a range of pro-inflammatory or anti-inflammatory immune responses. We report the synthesis and characterization of a series of α-GC analogs with acyl chains of varying length and a terminal benzophenone. These bound efficiently to the glycolipid antigen presenting protein CD1d, and upon photoactivation formed stable CD1d-glycolipid covalent conjugates. Conjugates of benzophenone α-GCs with soluble or cell-bound CD1d proteins retained potent iNKT cell activating properties, with biol. effects that were modulated by acyl chain length and the resulting affinities of conjugates for iNKT cell antigen receptors. Anal. by mass spectrometry identified a unique covalent attachment site for the glycolipid ligands in the hydrophobic ligand binding pocket of CD1d. The creation of covalent conjugates of CD1d with α-GC provides a new tool for probing the biol. of glycolipid antigen presentation, as well as opportunities for developing effective immunotherapeutics. In the experiment, the researchers used many compounds, for example, 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Izraylit, Victor’s team published research in European Polymer Journal in 2020 | CAS: 17696-11-6

《Alkynyl-functionalized chain-extended PCL for coupling to biological molecules》 was published in European Polymer Journal in 2020. These research results belong to Izraylit, Victor; Hommes-Schattmann, Paul J.; Neffe, Axel T.; Gould, Oliver E. C.; Lendlein, Andreas. Computed Properties of C8H15BrO2 The article mentions the following:

Chem. functionalization of poly(ε-caprolactone) (PCL) enables a mol. integration of addnl. function. Here, the authors report an approach to incorporate reactive alkynyl side-groups by synthesizing a chain-extended PCL, where the reactive site is introduced through the covalently functionalizable chain extender 3-(prop-2-yn-1-yloxy)propane-1,2-diol (YPD). Chain-extended PCL with Mw of 101 to 385 kg·mol-1 were successfully synthesized in a one-pot reaction from PCL-diols with various molar masses, L-lysine Et ester diisocyanate (LDI) or trimethyl(hexamethylene)diisocyanate (TMDI), and YPD, in which the d. of functionalizable groups and spacing between them can be controlled by the composition of the polymer. The employed diisocyanate compounds and YPD possess an asym. structure and form a non-crystallizable segment leaving the PCL crystallites to dominate the material′s mech. properties. The mixed glass transition temperature Tg = -60 to -46° of the PCL/polyurethane amorphous phase maintains the synthesized materials in a highly elastic state at ambient and physiol. conditions. Reaction conditions for covalent attachment in copper(I)-catalyzed azide-alkyne-cycloaddition reactions (CuAAC) in solution were optimized in a series of model reactions between the alkyne moieties of the chain-extended PCL and benzyl azide, reaching conversions over 95% of the alkyne moieties and with yields of up to 94% for the purified functionalized PCL. This methodol. was applied for reaction with the azide-functionalized cell adhesion peptide GRGDS. The required modification of the peptide provides selectivity in the coupling reactions. The obtained results suggest that YPD could potentially be employed as versatile mol. unit for the creation of a variety of functionalizable polyesters as well as polyurethanes and polycarbonates offering efficient and selective click-reactions. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Computed Properties of C8H15BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nurieva, E. V.’s team published research in Russian Chemical Bulletin in 2018 | CAS: 17696-11-6

《Synthesis of steroid analogs of tubuloclustin, their cytotoxicity and effect on microtubules of A549 carcinoma cells》 was written by Nurieva, E. V.; Zefirov, N. A.; Mamaeva, A. V.; Wobith, B.; Kuznetsov, S. A.; Zefirova, O. N.. Reference of 8-Bromooctanoic acidThis research focused ontubuloclustin methoxyestradiol analog preparation antitumor microtubule lung carcinoma. The article conveys some information:

Synthesis of analogs of tubuloclustin (N-(7-adamant-2-yloxy-7-oxoheptanoyl)-N-deacetylcolchicine ) with the colchicine fragment replaced with 2-methoxyestradiol scaffold attached via phenolic hydroxy group was described. Esters 3a-c exhibit moderate cytotoxicity (EC50 = 5-6 μmol L-1) and exert a weak effect on the microtubule network in A549 human lung carcinoma cells similar to the clustering effect of tubuloclustin and its derivatives Conjugates 6a-c and 7a-c with the phenolic ester bond are low stable and compounds 7a-c are inactive to the microtubules of A549 cells, while compounds 6a-c cause an unusual effect of curling of the microtubules. In the experimental materials used by the author, we found 8-Bromooctanoic acid(cas: 17696-11-6Reference of 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lin, Rui-Lian’s team published research in Journal of Organic Chemistry in 2020 | CAS: 17696-11-6

Recommanded Product: 17696-11-6In 2020 ,《Symmetrical-Tetramethyl-Cucurbit[6]uril-Driven Movement of Cucurbit[7]uril Gives Rise to Heterowheel [4]Pseudorotaxanes》 was published in Journal of Organic Chemistry. The article was written by Lin, Rui-Lian; Li, Ran; Shi, Hao; Zhang, Kun; Meng, Di; Sun, Wen-Qi; Chen, Kai; Liu, Jing-Xin. The article contains the following contents:

Two novel heterowheel [4]pseudorotaxanes consisting of cucurbit[7]uril (Q[7]) and sym.-tetramethyl-cucurbit[6]uril (TMeQ[6]) were constructed via the multirecognition mechanism, in which Q[7] can rotate freely around the horizontal axis, while TMeQ[6] cannot. In the construction process, due to strong repulsive forces between carbonyl portals of two neighboring wheels, the dethreading and movement of the wheels along the axle was observed The dissociation of the [4]pseudorotaxanes was also discussed. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Recommanded Product: 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Bo’s team published research in ACS Applied Materials & Interfaces in 2018 | CAS: 17696-11-6

《Driving Quick and Large Amplitude Contraction of Viologen-Incorporated Poly-L-Lysine-Based Hydrogel by Reduction》 was written by Wang, Bo; Tahara, Hironobu; Sagara, Takamasa. Related Products of 17696-11-6This research focused onviologen functionalized polylysine hydrogel reduction induced contraction; actuation; contraction and re-expansion; hydrogel; redox; viologen. The article conveys some information:

A glutaraldehyde-crosslinked poly-L-lysine-based hydrogel with pendant viologens was synthesized with various [viologen unit]/[Lys unit] ratios. The hydrogel with the ratio of 25% had (i) a water content of 95.8%, (ii) unbound viologen unit was absent, and (iii) lyophilized gel showing porous structure was rewettable. The hydrogel in contact with a gold, glassy carbon, pyrolytic graphite, or ITO electrode was electroactive, showing voltammetric responses involving diffusion process. Occurrence of electron transfer between viologen sites was verified by ESR measurements. The electroreflectance spectrum indicated significant dimerization of one-electron-reduced forms, viologen radical cations. Reduction of the hydrogel by dithionite showed a 93% volume decrease, being near to the water content, at 100 s and finally 97% contraction at 380 s. The initial rate of contraction was 0.02 s-1, and the swelling weight ratio was > 17. The contraction rate was much faster than that observed when adding of redox-inactive salts in the outer medium. Recovery by reoxidation was relatively sluggish even when O2-saturated water was used. The quick and large-amplitude contraction with removal of water from the gel body should be the consequence of permeability of reductant, interchain π-stacking of one-electron-reduced forms (viologen monoradical monocation), desolvation of viologen upon reduction, electron hopping between viologen units and its acceleration with contraction, and effective osmotic pressure difference. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Related Products of 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Ying’s team published research in Bioorganic & Medicinal Chemistry in 2020 | CAS: 17696-11-6

《The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells》 was written by Huang, Ying; Ru, Hong-bo; Bao, Bin; Yu, Jia-hui; Li, Jia; Zang, Yi; Lu, Wei. SDS of cas: 17696-11-6 And the article was included in Bioorganic & Medicinal Chemistry in 2020. The article conveys some information:

Histone deacetylases (HDACs) have been found to be biomarkers of cancers and the corresponding inhibitors have attracted much attention these years. Herein we reported a near-IR fluorescent HDAC inhibitor based on vorinostat (SAHA) and a NIR fluorophore. This newly designed inhibitor showed similar inhibitory activity to SAHA against three HDAC isoforms (HDAC1, 3, 6). The western blot assay showed significant difference in compared with the neg. group. When used as probe for further kinematic imaging, Probe 1 showed enhanced retention in tumor cells and the potential of HDAC inhibitors in drug delivery was firstly brought out. The cytotoxicity assay showed Probe 1 had some anti-proliferation activities with corresponding IC50 values of 9.20 ± 0.96μM on Hela cells and 5.91 ± 0.57μM on MDA-MB-231 cells. These results indicated that Probe 1 could be used as a potential NIR fluorescent in the study of HDAC inhibitors and lead compound for the development of visible drugs. In addition to this study using 8-Bromooctanoic acid, there are many other studies that have used 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary