17696-11-6 Archives - Page 2 of 11 - Bromides-buliding-blocks

Shi, Shi’s team published research in Bioorganic Chemistry in 2022 | CAS: 17696-11-6

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Product Details of 17696-11-6

In 2022,Shi, Shi; Du, Yu; Huang, Lei; Cui, Jiaqi; Niu, Jing; Xu, Yungen; Zhu, Qihua published an article in Bioorganic Chemistry. The title of the article was 《Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy》.Product Details of 17696-11-6 The author mentioned the following in the article:

Although several Epidermal growth factor receptor (EGFR) inhibitors have been approved for the treatment of non-small-cell lung cancers (NSCLC), acquired drug resistance and side effects largely encumbered their application in clinic. The emerging technol. Proteolysis targeting chimera (PROTAC) could be an alternative strategy to overcome these problems. Here, we reported the discovery of Dacomitinib-based EGFR degraders. Promising compound I can effectively induce degradation of EGFRdel19 with DC50 value of 3.57 nM in HCC-827 cells, but not to other EGFR mutant, wild-type EGFR protein and the same family receptors (HER2 and HER4). Of note, I is the first EGFR-PROTAC to evaluate antitumor effect in vivo, and exhibited excellent antitumor efficacy (TGI = 90%) at a dose of 30 mg/kg without causing observable toxic effects. The preliminary mechanism study demonstrated that I can efficiently induce EGFR protein degradation through ubiquitin proteasome pathway and inhibit phosphorylation of downstream pathways in vitro and in vivo, which indicated that I exerted antitumor effect by degradation of EGFR protein in tumor tissue. Overall, our study provided further evidence to validate EGFR-PROTACs as a promising strategy for lung cancer therapy.8-Bromooctanoic acid(cas: 17696-11-6Product Details of 17696-11-6) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Cheng-Kun’s team published research in Organic Letters in 2022 | CAS: 17696-11-6

In 2022,Li, Cheng-Kun; Tao, Ze-Kun; Shoberu, Adedamola; Zhang, Wei; Zou, Jian-Ping published an article in Organic Letters. The title of the article was 《Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp3)-P Bond Formation》.Recommanded Product: 8-Bromooctanoic acid The author mentioned the following in the article:

A Cu(I)-catalyzed cross-coupling of alkyl- and P-centered radicals for C(sp3)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of P radicals from H-P(O) compounds In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Recommanded Product: 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ashush, Natali’s team published research in Organic Letters in 2020 | CAS: 17696-11-6

《Base- and Catalyst-Induced Orthogonal Site Selectivities in Acylation of Amphiphilic Diols》 was published in Organic Letters in 2020. These research results belong to Ashush, Natali; Fallek, Reut; Fallek, Amit; Dobrovetsky, Roman; Portnoy, Moshe. SDS of cas: 17696-11-6 The article mentions the following:

Seeking to selectively functionalize natural and synthetic amphiphiles, we explored acylation of model amphiphilic diols. The use of a nucleophilic catalyst enabled a remarkable shift of the site selectivity from the polar site, preferred in background noncatalyzed or base-promoted reactions, to the apolar site. This tendency was significantly enhanced for organocatalysts comprising an imidazole active site surrounded by long/branched tails. An explanation of these orthogonal modes of selectivity is supported by competitive experiments with monoalc. substrates. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Xin’s team published research in Bioorganic Chemistry in 2021 | CAS: 17696-11-6

Wang, Xin; Liu, Jun; Chen, Jinyao; Zhang, Ming; Tian, Chuan; Peng, Xiaoping; Li, Gang; Chang, Wenqiang; Lou, Hongxiang published their research in Bioorganic Chemistry in 2021. The article was titled 《Azole-triphenylphosphonium conjugates combat antifungal resistance and alleviate the development of drug-resistance》.HPLC of Formula: 17696-11-6 The article contains the following contents:

Azole antifungals are commonly used to treat fungal infections but have resulted in the occurrence of drug resistance. Therefore, developing azole derivatives (AZDs) that can both combat established drug-resistant fungal strains and evade drug resistance is of great importance. In this study, we synthesized a series of AZDs with a fluconazole (FLC) skeleton conjugated with a mitochondria-targeting triphenylphosphonium cation (TPP+). These AZDs displayed potent activity against both azole-sensitive and azole-resistant Candida strains without eliciting obvious resistance. Moreover, two representative AZDs, I and II, exerted synergistic antifungal activity with Hsp90 inhibitors against C. albicans strains resistant to the combination treatment of FLC and Hsp90 inhibitors. AZD 25, which had minimal cytotoxicity, was effective in preventing C. albicans biofilm formation. Mechanistic investigation revealed that AZD II inhibited the biosynthesis of the fungal membrane component ergosterol and interfered with mitochondrial function. Our findings provide an alternative approach to address fungal resistance problems. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pieters, Priscilla F.’s team published research in ACS Nano in 2022 | CAS: 17696-11-6

In 2022,Pieters, Priscilla F.; Laine, Antoine; Li, He; Lu, Yi-Hsien; Singh, Yashpal; Wang, Lin-Wang; Liu, Yi; Xu, Ting; Alivisatos, A. Paul; Salmeron, Miquel published an article in ACS Nano. The title of the article was 《Multiscale Characterization of the Influence of the Organic-Inorganic Interface on the Dielectric Breakdown of Nanocomposites》.SDS of cas: 17696-11-6 The author mentioned the following in the article:

Nanoscale engineered materials such as nanocomposites can display or be designed to enhance their material properties through control of the internal interfaces. Here, we unveil the nanoscale origin and important characteristics of the enhanced dielec. breakdown capabilities of gold nanoparticle/polymer nanocomposites. Our multiscale approach spans from the study of a single chem. designed organic/inorganic interface to micrometer-thick films. At the nanoscale, we relate the improved breakdown strength to the interfacial charge retention capability by combining scanning probe measurements and d. functional theory calculations At the meso- and macroscales, our findings highlight the relevance of the nanoparticle concentration and distribution in determining and enhancing the dielec. properties, as well as identifying this as a crucial limiting factor for the achievable sample size. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yeap, Guan-Yeow’s team published research in Liquid Crystals in 2018 | CAS: 17696-11-6

In 2018,Yeap, Guan-Yeow; Ooi, Yew-Hong published 《λ-Shaped liquid crystal trimers with dual terminal cholesteryl moieties: synthesis and concomitant of N*, SmA and cholesteric glassy phases》.Liquid Crystals published the findings.Application In Synthesis of 8-Bromooctanoic acid The information in the text is summarized as follows:

Two homologous series of λ-shaped chiral liquid crystal trimers composed of a laterally substituted benzylidene-aniline as the central core armed by two cholesteryl ester moieties via odd-even alkyl spacer are synthesized (I; X = halo, Me, OH; n = 4-10). All the compounds are mesogenic exhibiting both chiral nematic (N*) and SmA phases except for trimers bearing long spacers (n = 9-10). A pronounced odd-even effect is observed on the phase transition temperatures and clearing enthalpies when the spacer length is varied in which the even-parity members show higher value. The widening of N* phase upon elongation of the alkyl spacer can be interpreted as a result of the destabilization of SmA phase. Full recrystallization from the cholesteric phase upon cooling is not observed for all the compounds bearing long spacer, especially oxydecanoyl spacer. Instead, the anisotropic fluid vitrified to form the cholesteric glassy state characteristic of polymer at low temperature This finding is also evident from the polarizing optical microscope whereby non-crystalline texture which resembles the Grandjean texture with various reflection colors is observed upon cooling to low temperature The effect of the lateral substituents on the liquid-crystalline behavior is also discussed. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Application In Synthesis of 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ge, Weizhi’s team published research in Bioorganic Chemistry in 2019 | CAS: 17696-11-6

The author of 《Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia》 were Ge, Weizhi; Liu, Zhongquan; Sun, Yu; Wang, Tianpeng; Guo, Hongyu; Chen, Xinyi; Li, Shengzu; Wang, Mengmeng; Chen, Yue; Ding, Yahui; Zhang, Quan. And the article was published in Bioorganic Chemistry in 2019. Product Details of 17696-11-6 The author mentioned the following in the article:

A series of parthenolide-SAHA hybrids were synthesized and evaluated for their anti-AML activities against HL-60 and HL-60/ADR cell lines. The most active compound 26 exhibited high activity against HL-60/ADR cell line with IC50 value of 0.15 μM, which demonstrated 16.8-fold improvement compared to that of the parent compound PTL (IC50 = 2.52 μM). Moreover, it was six times more potent than the reference drug SAHA (IC50 = 0.90 μM) and fifty-one times more potent than ADR (IC50 = 7.72 μM). The preliminary mol. mechanism of 26 indicated that compound 26 could significantly induce apoptosis of HL-60/ADR cells. The effect of compound 26 was mainly through mitochondria pathway. Further investigation revealed that the protein level of HDAC1 and HDAC6 were reduced after the treatment of compound 26 with a dose-dependent manner. Compound 26 could significantly decrease ABCC1 expression, which increased the accumulation of intracellular drug for overcoming the drug resistance. On the base of these results, compound 26 might be considered as a promising candidate for further evaluation as a potential anti-AML drug. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6Product Details of 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Walker, Rebecca’s team published research in Liquid Crystals in 2022 | CAS: 17696-11-6

In 2022,Walker, Rebecca; Pociecha, Damian; Faidutti, Camilla; Perkovic, Eva; Storey, John M. D.; Gorecka, Ewa; Imrie, Corrie T. published an article in Liquid Crystals. The title of the article was 《Remarkable stabilisation of the intercalated smectic phases of nonsymmetric dimers by tert-butyl groups》.SDS of cas: 17696-11-6 The author mentioned the following in the article:

The synthesis and characterization of two groups of nonsym. dimers, the 1-(4-cyanobiphenyl-4′-yloxy)-ω-(4-alkylbenzylidene-4′-oxy)alkanes and the 1-(4-cyanobiphenyl-4′-yl)-ω-(4-alkylbenzylidene-4′-oxy)alkanes, are reported. The length and parity of the flexible spacer are varied. The tert-Bu homologues show higher m.ps. than the corresponding sec-Bu or Bu substituted dimers and suggesting that chain branching improves packing efficiency within the crystalline structure. The branched chain homologues have a stronger tendency to exhibit smectic phases than the n-butyl-substituted dimers and are exclusively smectic for longer spacers. A comparison of the nematic-isotropic transition temperatures (TNI) for the dimers and containing the different terminal chains is possible for one set of materials, and reveals a large reduction in TNI on passing from the Bu to sec-butyl-substituted, but a much smaller decrease on changing sec-Bu for tert-Bu. A different trend is observed for the smectic A-isotropic transition temperatures for which the tert-Bu substituted dimers and show a higher value than the corresponding sec-Bu homolog, and only marginally lower than that of the n-butyl-substituted dimers. This surprising behavior is interpreted in terms of the ability of the tert-Bu group to pack more efficiently into the intercalated smectic A phase as the spacer length increases. In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ou, E.’s team published research in Chemistry & Biodiversity in 2022 | CAS: 17696-11-6

In 2022,Ou, E.; Xu, Chao; Jia, Qi; Xu, Xiaojia; Chen, Zhenyu; Liu, Jiansong; Zhang, Hanyuan; Xu, Geng; Zhao, Yu published an article in Chemistry & Biodiversity. The title of the article was 《Synthesis and in Vivo Evaluation of Triphenylphosphonium Conjugated Trimetazidine with Enhanced Cardioprotection and Ability to Restore Mitochondrial Function》.Formula: C8H15BrO2 The author mentioned the following in the article:

Trimetazidine exhibits great therapeutic potential in cardiovascular diseases and mitochondria-mediated cardioprotection by trimetazidine has been widely reported. In this study, to enhance its cardioprotection, the triphenylphosphonium-based modification of trimetazidine was conducted to deliver it specifically to mitochondria. Fifteen triphenylphosphonium (TPP) conjugated trimetazidine analogs were designed and synthesized. Their protective effects were evaluated in vivo using a tert-Bu hydroperoxide (t-BHP) induced zebrafish injury model. Structure-activity relationship correlations revealed the best way to couple the TPP moiety to trimetazidine, and led to a new conjugate (18a) with enhanced therapeutic properties. Compared to trimetazidine, 18a effectively protects against heart injury in the zebrafish model at a much lower concentration Further study in t-BHP treated zebrafish and H9c2 cells demonstrated that 18a protects against cardiomyocyte death and damage by inhibiting excessive production of ROS, maintaining mitochondrial morphol., and preventing mitochondrial dysfunction. Consequently, 18a can be regarded as a potential therapeutic agent for cardioprotection. The results came from multiple reactions, including the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Formula: C8H15BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Iosub, Andrei V.’s team published research in Organic Letters in 2019 | CAS: 17696-11-6

The author of 《Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes》 were Iosub, Andrei V.; Moravcik, Stefan; Wallentin, Carl-Johan; Bergman, Joakim. And the article was published in Organic Letters in 2019. Product Details of 17696-11-6 The author mentioned the following in the article:

The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, di-Me dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overredn. to alcs. Moreover, this methodol. is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot use of the aldehyde products.8-Bromooctanoic acid(cas: 17696-11-6Product Details of 17696-11-6) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary