17696-11-6 Archives - Bromides-buliding-blocks

Liu, Pei’s team published research in Soft Matter in 2022 | CAS: 17696-11-6

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Electric Literature of C8H15BrO2

In 2022,Liu, Pei; Zhang, Sheng; Pei, Xiaomei; Song, Binglei; Jiang, Jianzhong; Cui, Zhenggang; Binks, Bernard P. published an article in Soft Matter. The title of the article was 《Recyclable and re-usable smart surfactant for stabilization of various multi-responsive emulsions alone or with nanoparticles》.Electric Literature of C8H15BrO2 The author mentioned the following in the article:

A novel multi-responsive surfactant (abbreviated as N+-8P8-N) was synthesized, in which one octyl trimethylamine group (quaternary ammonium) and one octyl dimethylamine group are connected to a benzene ring through ether bonds. This novel surfactant can stabilize conventional oil-in-water (O/W) emulsions alone, and O/W Pickering emulsions and novel oil-in-dispersion emulsions together with oppositely and similarly charged nanoparticles, resp. In all cases rapid demulsification can be achieved through either pH or CO2/N2 triggers, by which the surfactant is reversibly converted between a normal cationic surfactant form (N+-8P8-N) and a strongly hydrophilic and surface-inactive bola form (N+-8P8-NH+). Notably, the bola form N+-8P8-NH+ dissolves in the aqueous phase alone or together with nanoparticles after demulsification without contamination of the oil phase, and the aqueous phase can be recycled many times triggered by pH or CO2/N2 in accordance with the principle of green chem. This newly designed re-usable smart surfactant is significant for the development of various temporarily stable emulsions, which are extensively applied in emulsion polymerization, new material synthesis, heterogeneous catalysis and oil transportation.8-Bromooctanoic acid(cas: 17696-11-6Electric Literature of C8H15BrO2) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Marson, Domenico’s team published research in Small in 2019 | CAS: 17696-11-6

The author of 《Mixed Fluorinated/Hydrogenated Self-Assembled Monolayer-Protected Gold Nanoparticles: In Silico and In Vitro Behavior》 were Marson, Domenico; Guida, Filomena; Sologan, Maria; Boccardo, Silvia; Pengo, Paolo; Perissinotto, Fabio; Iacuzzi, Valentina; Pellizzoni, Elena; Polizzi, Stefano; Casalis, Loredana; Pasquato, Lucia; Pacor, Sabrina; Tossi, Alessandro; Posocco, Paola. And the article was published in Small in 2019. Formula: C8H15BrO2 The author mentioned the following in the article:

Gold nanoparticles (AuNPs) covered with mixtures of immiscible ligands present potentially anisotropic surfaces that can modulate their interactions at complex nano-bio interfaces. Mixed, self-assembled, monolayer (SAM)-protected AuNPs, prepared with incompatible hydrocarbon and fluorocarbon amphiphilic ligands, are used here to probe the mol. basis of surface phase separation and disclose the role of fluorinated ligands on the interaction with lipid model membranes and cells, by integrating in silico and exptl. approaches. These results indicate that the presence of fluorinated amphiphilic ligands enhances the membrane binding ability and cellular uptake of gold nanoparticles with respect to those coated only with hydrogenated amphiphilic ligands. For mixed monolayers, computational results suggest that ligand phase separation occurs on the gold surface, and the resulting anisotropy affects the number of contacts and adhesion energies with a membrane bilayer. This reflects in a diverse membrane interaction for NPs with different surface morphologies, as determined by surface plasmon resonance, as well as differential effects on cells, as observed by flow cytometry and confocal microscopy. Overall, limited changes in monolayer features can significantly affect NP surface interfacial properties, which, in turn, affect the interaction of SAM-AuNPs with cellular membranes and subsequent effects on cells. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Formula: C8H15BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Changhao’s team published research in ACS Omega in 2022 | CAS: 17696-11-6

In 2022,Li, Changhao; He, Qiaobian; Xu, Yuwen; Lou, Hongxiang; Fan, Peihong published an article in ACS Omega. The title of the article was 《Synthesis of 3-O-Acetyl-11-keto-β-boswellic Acid (AKBA)-Derived Amides and Their Mitochondria-Targeted Antitumor Activities》.HPLC of Formula: 17696-11-6 The author mentioned the following in the article:

In this study, the authors synthesized a series of amide and mitochondria-targeted derivatives with 3-O-acetyl-11-keto-β-boswellic acid (AKBA) as the parent structure and an ethylenediamine moiety as the link chain. Compound I, a mitochondrial-targeting potential derivative, showed significantly stronger antitumor activity than that of AKBA, and it could induce vacuolization of A549 cells and stimulate the production of reactive oxygen species (ROS) in a time- and concentration-dependent manner. The antioxidant N-acetylcysteine (NAC) could inhibit the ROS level but could not suppress vacuolization and cell death induced by I. Further studies demonstrated that I caused abnormal opening of mitochondrial permeability transition pore (MPTP) and a decrease of mitochondrial membrane potential; addnl., it caused cell cycle arrest in G0/G1 but did not induce apoptosis. I represents a compound with improved antiproliferative effects for cancer therapy working through new mechanisms. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Xiu-Ying’s team published research in Synthesis in 2021 | CAS: 17696-11-6

Xie, Xiu-Ying; Jiang, Wei-Tao; Xiao, Bin published their research in Synthesis in 2021. The article was titled 《Alkyl Carbagermatrane Enabled Synthesis of Seven-Membered Carbocycle-Fused Aromatics through Catellani Strategy》.Related Products of 17696-11-6 The article contains the following contents:

Synthesis of seven-membered carbocycle-fused aromatics was realized by Catellani reaction using terminally brominated alkyl carbagermatranes through intermol. cyclization manner. Various functional groups were well tolerated and this transformation was also expanded to the synthesis of carbocycles of other size. The utility of the above method was demonstrated by modification of natural product derivatives and synthesis of bioactive mols. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Related Products of 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kuodis, Zenonas’s team published research in Molecules in 2020 | CAS: 17696-11-6

Application In Synthesis of 8-Bromooctanoic acidIn 2020 ,《Reflection absorption infrared spectroscopy characterization of SAM formation from 8-mercapto-N-(phenethyl)octanamide thiols with Phe ring and amide groups》 was published in Molecules. The article was written by Kuodis, Zenonas; Matulaitiene, Ieva; Spandyreva, Marija; Labanauskas, Linas; Stoncius, Sigitas; Lorka, Olegas Eicher; Sadzeviciene, Rita; Niaura, Gediminas. The article contains the following contents:

Multifunctional amide-containing self-assembled monolayers (SAMs) provide prospects for the construction of interfaces with required physicochem. properties and distinctive stability. In this study, we report the synthesis of amide-containing thiols with terminal phenylalanine (Phe) ring functionality (HS(CH2)7CONH(CH2)2C6H5) and the characterization of the formation of SAMs from these thiols on gold by reflection absorption IR spectroscopy (RAIRS). For reliable assignments of vibrational bands, ring deuterated analogs were synthesized and studied as well. Adsorption time induced changes in Amide-II band frequency and relative intensity of Amide-II/Amide-I bands revealed two-state sigmoidal form dependence with a transition inflection points at 2.2 ± 0.5 and 4.7 ± 0.5 min, resp. The transition from initial (disordered) to final (hydrogen-bonded, ordered) structure resulted in increased Amide-II frequency from 1548 to 1557 cm-1, which is diagnostic for a strongly hydrogen-bonded amide network in trans conformation. However, the lateral interactions between the alkyl chains were found to be somewhat reduced when compared with well-ordered alkane thiol monolayers.8-Bromooctanoic acid(cas: 17696-11-6Application In Synthesis of 8-Bromooctanoic acid) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cortes, Ivan’s team published research in Food Chemistry in 2020 | CAS: 17696-11-6

《Synthesis and evaluation of aromatic methoxime derivatives against five postharvest phytopathogenic fungi of fruits. Main structure-activity relationships》 was written by Cortes, Ivan; di Liberto, Melina G.; Kaufman, Teodoro S.; Derita, Marcos G.; Bracca, Andrea B. J.. Safety of 8-Bromooctanoic acid And the article was included in Food Chemistry in 2020. The article conveys some information:

The antifungal activity of a library of twenty-four aromatic methoximes was examined against five representative postharvest phytopathogenic fungi. The panel included Penicillium digitatum, Penicillium italicum, Rhizopus stolonifer, Botrytis cinerea and Monilinia fructicola, all of which cause relevant economic losses worldwide as a result of affecting harvested fruits. The min. inhibitory concentrations and min. fungicidal concentrations of each compound were defined and the main structure-activity relationships were determined Although other congeners were more potent, drug likeliness considerations pointed to the methoxime derived from 2,4-dihydroxypropiophenone as the compound with the most suitable profile. The morphol. of the colonies of the fungal strains treated with the methoxime was examined microscopically and the compound was also tested in freshly harvested peaches and oranges, exhibiting promising control profiles in both fruits, similar to those of the com. agents Imazalil and Carbendazim. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6Safety of 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Almeida, Marcio M.’s team published research in Langmuir in 2019 | CAS: 17696-11-6

In 2019,Langmuir included an article by Almeida, Marcio M.; Perez, Katia R.; Faig, Allison; Uhrich, Kathryn E.; Riske, Karin A.. SDS of cas: 17696-11-6. The article was titled 《Location of the Positive Charges in Cationic Amphiphiles Modulates Their Mechanism of Action against Model Membranes》. The information in the text is summarized as follows:

Synthetic cationic amphiphiles (CAms) with physicochem. properties similar to antimicrobial peptides are promising mols. in the search for alternative antibiotics to which pathogens cannot easily develop resistance. Here, we investigate two types of CAms based on tartaric acid and containing two hydrophobic chains (of 7 or 11 carbons) and two pos. charges, located either at the end of the acyl chains (bola-like, B7 and B11) or at the tartaric acid backbone (gemini-like, G7 and G11). The interaction of the CAms with biomimetic membrane models (anionic and neutral liposomes) was studied with zeta potential and dynamic light scattering measurements, isothermal titration calorimetry, and a fluorescent-based leakage assay. We show that the type of mol. determines the mechanism of action of the CAms. Gemini-like mols. (G7 and G11) interact mainly via electrostatics (exothermic process) and reside in the external vesicle leaflet, altering substantially the vesicle surface potential but not causing significant membrane lysis. On the other hand, the interaction of bola-like CAms (B7 and B11) is endothermic and thus entropy-driven, and these mols. reach both membrane leaflets and cause substantial membrane permeabilization, likely after clustering of anionic lipids. The lytic ability is clearly higher against anionic membranes as compared with neutral membranes. Within each class of mol., longer alkyl chains (i.e., B11 and G11) exhibit higher affinity and lytic ability. Overall, the mol. B11 exhibits a high potential as antimicrobial agent, since it has a high membrane affinity and causes substantial membrane permeabilization. The results came from multiple reactions, including the reaction of 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Panettieri, Silvio’s team published research in ACS Omega in 2019 | CAS: 17696-11-6

In 2019,ACS Omega included an article by Panettieri, Silvio; Silverman, Julian R.; Nifosi, Riccardo; Signore, Giovanni; Bizzarri, Ranieri; John, George. Synthetic Route of C8H15BrO2. The article was titled 《Unique Photophysical Behavior of Coumarin-Based Viscosity Probes during Molecular Self-Assembly》. The information in the text is summarized as follows:

Intermol. interactions impact self-assembly phenomena with a variety of biochem., phys., and mech. consequences. Nevertheless, underlying mechanisms leading to a controlled stereo- and chemo-specific aggregation at the mol. level often remain elusive due to the intrinsically dynamic nature of these processes. This work describes two, 3-styryl coumarin mol. rotors capable of probing subtle intermol. interactions controlling self-assembly of a small mol. organogelator. Complementing the gel characterization using CD and at. force microscopy, thorough spectroscopic assessments on these sensors were conducted to prove their high chem. and spatial affinity toward the three-dimensional supramol. network. Results were also supported by mol. dynamics simulations to provide addnl. critical insights into gelator dynamic self-assembly mechanisms. These sensors could potentially serve as templates to study a variety of soft-supramol. architectures and ways in which they assemble. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6Synthetic Route of C8H15BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Walker, Rebecca’s team published research in ChemPhysChem in 2021 | CAS: 17696-11-6

Application In Synthesis of 8-Bromooctanoic acidIn 2021 ,《Twist-Bend Nematic Glasses: The Synthesis and Characterisation of Pyrene-based Nonsymmetric Dimers》 appeared in ChemPhysChem. The author of the article were Walker, Rebecca; Majewska, Magdalena; Pociecha, Damian; Makal, Anna; Storey, John MD; Gorecka, Ewa; Imrie, Corrie T.. The article conveys some information:

A selection of pyrene-based liquid crystal dimers I [n = 5, 6, 8, etc.] , II [n = 5, 6, 11, etc.] and III were prepared, containing either methylene-ether or diether linked spacers of varying length and parity. All the diether linked materials, II, exhibited conventional nematic and smectic A phases, with the exception of II [n = 11] which was exclusively nematic. The methylene-ether linked dimer, I with an even-membered spacer (n=5) was solely nematogenic, but odd-members (n=6, 8, 10) exhibited both nematic and twist-bend nematic phases. Replacement of the cyanobiphenyl fragment by cyanoterphenyl giving III, gave elevated melting and nematic-isotropic transition temperatures, and SmA and SmCA phases were observed on cooling the nematic phase. Intermol. face-to-face associations of the pyrene moieties drove glass formation, and all these materials had a glass transition temperature at or above room temperature The stability of the glassy twist-bend nematic phase allowed for its study using AFM, and the helical pitch length, PTB, was measured as 6.3 and 6.7 nm for I [n = 6, 8] , resp. These values were comparable to the shortest pitch of a twist-bend nematic phase measured to date. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6Application In Synthesis of 8-Bromooctanoic acid)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hou, Rui’s team published research in Biomaterials Science in 2020 | CAS: 17696-11-6

《In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy》 was published in Biomaterials Science in 2020. These research results belong to Hou, Rui; Liang, Xiaolong; Li, Xiaoda; Zhang, Xu; Ma, Xiaotu; Wang, Fan. Application of 17696-11-6 The article mentions the following:

Sonodynamic therapy (SDT) is a prospective therapy for many tumors by activation of sonosensitizers to produce reactive oxygen species (ROS) by ultrasound (US). However, limited generation of ROS and low drug delivery efficiency of sonosensitizers to the tumor tissue still hinder the application of SDT. Herein, an amphiphilic rose bengal (ARB) conjugate was designed to fabricate rose bengal microbubbles (RB-MBs) with high drug-loading contents (~6.8%) and excellent contrast enhancement capability for US imaging, well suited for detecting tumor location and size. More importantly, RB-MBs could be successfully converted into RB-NPs by local US exposure, resulting in ~7.5 times higher drug accumulation at the tumor tissue through the sonoporation effect as compared to RB-NPs and RB-MBs without US sonication. Meanwhile, using RB as the MB shell facilitated US energy transfer by the US mediated collapse of MBs through either a sonoluminescence or pyrolysis process; thus, the ROS generation efficiency could be greatly enhanced, resulting in a significantly higher tumor inhibition rate for the RB-MBs + US (~76.5%) in the HT-29 tumor model as compared to conventional MBs + US and RB-NPs + US (~23.8% and ~49.2%), resp. All these results suggested that this novel sonosensitizer delivery system of RB-MBs combined with US is a powerful strategy for remarkably enhancing SDT therapeutic efficacy with minimal side effects, showing great potential in cancer theranostics. In the experiment, the researchers used many compounds, for example, 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary