Category: 17100-65-1

Jung, Kwan-Young; Vanommeslaeghe, Kenno; Lanning, Maryanna E.; Yap, Jeremy L.; Gordon, Caryn; Wilder, Paul T.; MacKerell, Alexander D. Jr.; Fletcher, Steven published the artcile< Amphipathic α-Helix Mimetics Based on a 1,2-Diphenylacetylene Scaffold>, Name: Methyl 2-bromo-4-methoxybenzoate, the main research area is dipenylacetylene scaffold amphipathic alpha helix mimetic.

In order to mimic amphipathic α-helixes, a novel scaffold based on a 1,2-diphenylacetylene was designed. NMR and computational modeling confirmed that an intramol. hydrogen bond favors conformations of the 1,2-diphenylacetylene that allow for accurate mimicry of the i, i + 7 and i + 2, i + 5 side chains found on opposing faces of an α-helix.

Organic Letters published new progress about Amphipathicity. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Name: Methyl 2-bromo-4-methoxybenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gustafson, Jeffrey L.; Lim, Daniel; Miller, Scott J. published the artcile< Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination>, Application of C9H9BrO3, the main research area is dynamics kinetics resolution biaryl atropisomer peptide catalyzed asym bromination.

Despite the widespread use of axially chiral, or atropisomeric, biaryl ligands in modern synthesis and the occurrence of numerous natural products exhibiting axial chirality, few catalytic methods have emerged for the direct asym. preparation of this compound class. Here, the authors present a tripeptide-derived small-mol. catalyst for the dynamic kinetic resolution of racemic biaryl substrates. The reaction proceeds via an atropisomer-selective electrophilic aromatic substitution reaction using simple bromination reagents. The result is an enantioselective synthesis that delivers chiral nonracemic biaryl compounds with excellent optical purity and good isolated chem. yields (in most cases a >95:5 enantiomer ratio and isolated yields of 65 to 87%). A mechanistic model is advanced that accounts for the basis of selectivity observed

Science (Washington, DC, United States) published new progress about Atropisomers. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Application of C9H9BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fu, Liangbing; Xu, Mizhi; Yu, Jiyao; Gutekunst, Will R. published the artcile< Halide-Rebound Polymerization of Twisted Amides>, Reference of 17100-65-1, the main research area is halide rebound polymerization twisted amide.

The first living polymerization of twisted amides is reported, achieved using simple primary alkyl iodides as initiators. Polymerization occurs through a halide-rebound mechanism in which the nucleophilic twisted amide is quaternized and subsequently ring-opened by the iodide counterion. The covalent electrophilic polymerization generates polymers with living chain ends that are both isolable and stable to ambient conditions, enabling the synthesis of block polymers. This presents a new class of polymers for study that possess high glass transition temperatures and robust thermal stability.

Journal of the American Chemical Society published new progress about Chain extension polymerization. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Reference of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mousseau, James J.; Vallee, Frederic; Lorion, Melanie M.; Charette, Andre B. published the artcile< Umpolung Direct Arylation Reactions: Facile Process Requiring Only Catalytic Palladium and Substoichiometric Amount of Silver Salts>, Quality Control of 17100-65-1, the main research area is palladium catalyzed umpolung direct arylation aryl halide arene; biaryl preparation umpolung direct arylation palladium catalyst; aryl iodide bromide arene reactant palladium catalyzed direct arylation.

An umpolung direct arylation process is described. The reaction requires only a catalytic amount of Pd(OAc)2 and a substoichiometric amount of silver salts, without any external base or ligand to proceed. The directed oxidative insertion of the transition metal followed by the coupling into the C-H bond of an unactivated arene has surprisingly not yet been reported, despite the clear advantages in the ease of starting material synthesis. The reaction is regioselective with regards to the arene partner, and the role of the acetate and carbonate groups has been elucidated. This methodol. adds to the very few examples of benzene coupling without the inclusion of electron-withdrawing groups to increase acidity.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Quality Control of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jeffs, P. W.; Hansen, J. F.; Brine, G. A. published the artcile< Photochemical synthesis of 6,7-dihydro-5H-dibenz[c,e]azepine and 5,6,7,8-tetrahydrodibenz[c,e]azocine derivatives>, Synthetic Route of 17100-65-1, the main research area is dibenzoxepine; dibenzazepine; dibenzazocine; cyclization iododibenzylamine; photolysis iododibenzylamine; benzylamine iodo cyclization; iododibenzylamine cyclization; conformation dibenzazocine.

Photolysis of several substituted 2-iododibenzylamine hydrochlorides in aqueous solution provided convenient syntheses of the corresponding 6,7-dihydro-5H-dibenz[c,e]azepines in useful yields. Thus, irradiation of o-IC6H4CH2NHCH2Pb gave 57% dibenzazepine I. Irradiation of o-IC6H4CH2NHCH2C6H3(OMe)2-3.5 yielded only 2,4,6-(MeO)2CHOCH2)C6H2C6H4CH2OH-o together with a small amount of dibenzoxepine II. Photolysis of three N-(2-halogenobenzyl)-β-phenethylamine hydrochlorides provided convenient syntheses of the corresponding 5,6,7,8-tetrahydrodibenz[c,e]azocines. Thus, irradiation of O-IC6H4CH2NHCH2CH2Pb gave 33% dibenzazocine III. NMR examination of the dibenzazocines confirmed that they existed in a skewed biphenyl conformation, and that inversion of the system by rotation through the planar biphenyl was hindered.

Journal of Organic Chemistry published new progress about Cyclization. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Synthetic Route of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary