Adding a certain compound to certain chemical reactions, such as: 167858-56-2, name is 1-Bromo-2-fluoro-4-propylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 167858-56-2, SDS of cas: 167858-56-2
71 g (276 mmol) of the boron compound 3, 67 g (690 mmol) of potassium acetate and 5 g (7 mmol) of PdCl2-dppf are added to a solution of 50 g (230 mmol) of the bromide 2 in 590 ml of dioxane, and the mixture is warmed at 100 C. for 17 h. Water is added to the cooled batch, which is extracted with MTB ether. The organic phase is dried over sodium sulfate and evaporated. The residue is filtered through silica gel (n-heptane). The residue 4 obtained is employed in the subsequent step without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-fluoro-4-propylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Merck Patent GmbH; US2008/132716; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary