Category: 166821-88-1

James, Tony D. published the artcileA saccharide ‘sponge’. Synthesis and properties of a dendritic boronic acid, Related Products of bromides-buliding-blocks, the publication is Chemical Communications (Cambridge) (1996), 705-6, database is CAplus.

Very low concentrations of D-galactose and D-fructose are bound to a dendrimer containing eight boronic acids and eight anthracene units; the binding events are sensitively monitored by changes in the fluorescence intensity.

Chemical Communications (Cambridge) published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

James, Tony D. published the artcileA diboronic acid ‘glucose cleft’ and a biscrown ether ‘metal sandwich’ are allosterically coupled, Name: 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, the publication is Journal of the Chemical Society, Chemical Communications (1995), 1483-5, database is CAplus.

Glucose is released from the diboronic acid ‘cleft’ I when a metal ‘sandwich’ is formed by two 15-crown-5 rings; the binding events are sensitively monitored by changes in the fluorescence intensity.

Journal of the Chemical Society, Chemical Communications published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Name: 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dhungana, Roshan K. published the artcileNi-Catalyzed Arylbenzylation of Alkenylarenes: Kinetic Studies Reveal Autocatalysis by ZnX₂, Category: bromides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2021), 60(42), 22977-22982, database is CAplus and MEDLINE.

We report a Ni-catalyzed regioselective arylbenzylation of alkenylarenes with benzyl halides and arylzinc reagents. The reaction furnishes differently substituted 1,1,3-triarylpropyl structures that are reminiscent of the cores of oligoresveratrol natural products. The reaction is also compatible for the coupling of internal alkenes, secondary benzyl halides and variously substituted arylzinc reagents. Kinetic studies reveal that the reaction proceeds with a rate-limiting single-electron-transfer process and is autocatalyzed by in-situ-generated ZnX₂. The reaction rate is amplified by a factor of three through autocatalysis upon addition of ZnX₂.

Angewandte Chemie, International Edition published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dhungana, Roshan K. published the artcileNi-catalyzed regioselective 1,2-dialkylation of alkenes enabled by the formation of two C(sp³)-C(sp³) bonds, Formula: C12H16BBrO2, the publication is Journal of the American Chemical Society (2020), 142(50), 20930-20936, database is CAplus and MEDLINE.

The authors disclosed a Ni-catalyzed vicinal difunctionalization of alkenes with benzyl halides and alkylzinc reagents, which produces products with two new alkyl-alkyl bonds. This alkene dialkylation is effective in combining secondary benzyl halides and secondary alkylzinc reagents with internal alkenes, which furnishes products with three contiguous all-carbon secondary stereocenters. The products can be readily elaborated to access complex tetraene, benzosuberene, and bicyclodecene cores. The reaction also features as the most efficient alkene difunctionalization process to date with catalyst loadings down to 500 ppm and the catalytic turnover number (TON) and turnover frequency (TOF) registering up to 2 x 10³ and 165 h^-1 at rt, resp.

Journal of the American Chemical Society published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Formula: C12H16BBrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

James, Tony D. published the artcileNovel saccharide-photoinduced electron transfer sensors based on the interaction of boronic acid and amine, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (1995), 117(35), 8982-7, database is CAplus.

Two boronic acid systems, monoboronic acid 3 and diboronic acid 8, were synthesized. When saccharides form cyclic boronate esters with these boronic acids, the Lewis acid-base interaction between the boronic acid moiety and tertiary amine is strengthened; when saccharides form cyclic boronate esters with boronic acids the acidity of the boronic acid is enhanced. The strength of this acid-base interaction modulates the photoinduced electron transfer (PET) from the amine to anthracene. Both of these compounds show increased fluorescence at pH 7.77 through suppression of the photoinduced electron transfer from nitrogen to anthracene on saccharide binding, a direct result of the stronger boron-nitrogen bond. Compound 3 shows the typical selectivity of monoboronic acids towards saccharides. Compound 8 which has a cleftlike structure is particularly selective and sensitive for glucose due to the formation of an intramol. 1:1 complex between the two boronic acids and the 1,2- and 4,6-hydroxyls of glucose. This is the first example in which ditopic recognition of monosaccharides is achieved in a PET sensor system.

Journal of the American Chemical Society published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Yan-En published the artcileSynthesis of fluorescent bisboronic acid sensors and their recognition of mono-/oligo-saccharides, COA of Formula: C12H16BBrO2, the publication is Chinese Chemical Letters (2017), 28(6), 1262-1267, database is CAplus.

Sensors capable of recognizing cell surface carbohydrates, such as sialyl Lewis X (sLe^x), are invaluable research tools and for the diagnosis and early detection of many forms of cancer. In this paper, we report the design and synthesis of a series of bisboronic acids 6(a-f) as fluorescent sensors towards mono-/oligosaccharides. Among them, compounds 6d and 6e showed strong binding affinities with glucose and fructose, while compound 6c, in which two anthracene-based boronic acid units were linked by a hexamethylene spacer, was able to recognize sLe^x selectivity and stained HEPG2 cells at 1 μmol/L.

Chinese Chemical Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C15H21BO2, COA of Formula: C12H16BBrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Yan’en published the artcileTriazole-linked fluorescent bisboronic acid capable of selective recognition of the Lewis Y antigen, Formula: C12H16BBrO2, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(9), 1983-1988, database is CAplus and MEDLINE.

Cell surface carbohydrates of the Lewis blood group antigens, Lewis X (Le^x), Lewis Y (Le^y), Lewis A (Le^a), and their sialylated derivatives, such as sialy Lewis X (sLe^x) and sialy Lewis A (sLe^a), play important roles in various recognition processes. These cell surface carbohydrates have also been associated with the development and progression of many types of cancers. Recently, we synthesized four anthracene-based fluorescent bisboronic acid sensors (compounds 2a-d) linked by ‘click’ chem. with tethers of different lengths to match the epitope of various Lewis group of sugars. Among the four compounds, 2a appears to have both high sensitivity and selectivity for Le^y among other carbohydrate antigens.

Bioorganic & Medicinal Chemistry Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C15H21BO2, Formula: C12H16BBrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kawanishi, T. published the artcileA Study of Boronic Acid Based Fluorescent Glucose Sensors, Product Details of C12H16BBrO2, the publication is Journal of Fluorescence (2004), 14(5), 499-512, database is CAplus and MEDLINE.

Boronic acid based anthracene dyes were designed, synthesized, and immobilized to solid phase, creating a continuous glucose sensor. Glucose sensitivities of dyes can decrease drastically after immobilization, therefore how to immobilize a dye to solid phase without changing the dye property is a key issue in developing the sensor. The glucose sensitivity of the simplest 1st generation sensor, which is based on an immobilized mono-phenylboronate/single-arm type, came short of the sensitivity requirement for practical use, because of the very moderate fluorescence intensity change over the physiol. glucose range. However, the 2nd generation, an immobilized bis-phenylboronate/double-arm type sensor, which contained two boronate groups in the dye moiety in expectation of a large intensity change, brought about considerable improvement on its glucose sensitivity. The authors tried to introduce functional groups onto an anthracene ring to improve the dyes’ fluorescence properties. Acetyl or carboxyl substitution on anthracene contributed to shift the fluorescence wavelength into the more visible range (red-shift) and a divergence of wavelength between an excitation peak and an emission peak. This improvement is advantageous to the design of an optical detection system. Furthermore, single arm immobilization to this carboxyl group, thus linking directly to the fluorophore led to a 3rd generation sensor, an immobilized bis-phenylboronate/single-arm type, that was twice as sensitive as that of the 2nd generation sensor, presumably due to increased mobility of the dye moiety. The results of the authors’ study advance closer toward a clin. useful continuous fluorescent glucose sensor.

Journal of Fluorescence published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Product Details of C12H16BBrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Deng, Mengyu published the artcileTricolor core/shell polymeric ratiometric nanosensors for intracellular glucose and oxygen dual sensing, Related Products of bromides-buliding-blocks, the publication is Sensors and Actuators, B: Chemical (2019), 437-444, database is CAplus.

Monitoring cell metabolism is crucial for understanding cell life activity and cytopathic mechanism. Glucose and oxygen are very important parameters for cell metabolism In this work, core/shell nanomaterials as novel tricolor ratiometric luminescence nanosensors were prepared for real-time monitoring of intracellular oxygen and glucose levels. The nanosensors were achieved by covalently embedding of red emitting oxygen probes and yellow emitting reference probes into the hydrophobic cores and covalently grafting blue emitting glucose probes onto hydrophilic shells. This system realized simultaneous detection of glucose and oxygen through two different luminescent signals without enzyme assistance, and the two kinds of detection signals didn′ t interfere with each other. The nanosensors could sensitively detect glucose in the range of 0.01 to 5.0 mM and simultaneously detect dissolved oxygen in the range of 0.05 to 39.3 mg/L, indicating the suitableness for intracellular glucose and oxygen monitoring. Because of the small sizes (< 60 nm), biocompatible core-shell structures, covalently imparted dye leaking-free construction of the nanosensors, these nanomaterials showed good cell permeability and low cytotoxicity. Cell imaging and intracellular sensing of the nanosensors were studied by confocal luminescence microscopy. Hela cells stained with the nanosensors showed an increase in blue emission when glucose was added and an increase in red emission when oxygen was reduced. While, the yellow emission from the reference probes was not affected by glucose or oxygen. This work is expected to lead to the design of intracellular glucose and oxygen sensors, and can be extended to other multiple sensors in biol. systems.

Sensors and Actuators, B: Chemical published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zuo, Minzan published the artcileMultiresponsive Supramolecular Theranostic Nanoplatform Based on Pillar[5]arene and Diphenylboronic Acid Derivatives for Integrated Glucose Sensing and Insulin Delivery, HPLC of Formula: 166821-88-1, the publication is Small (2018), 14(38), n/a, database is CAplus and MEDLINE.

A closed-loop “smart” insulin delivery system with the capability to mimic pancreatic cells will be highly desirable for diabetes treatment. This study reports a multiple stimuli-responsive insulin delivery platform based on an explicit supramol. strategy. Self-assembled from a well-designed amphiphilic host-guest complex formed by pillar[5]arene and a diphenylboronic acid derivative and loaded with insulin and glucose oxidase, the obtained insulin-GOx-loaded supramol. vesicles can selectively recognize glucose, accompanied by the structure disruption and efficient release of the entrapped insulin triggered by the high glucose concentration as well as the in situ generated H₂O₂ and acid microenvironment during the GOx-promoted specific oxidation of glucose into gluconic acid. Moreover, such a “smart” supramol. theranostic nanoplatform is able to function as both a glucose sensor and a controlled insulin delivery actuator. In vivo experiments further demonstrate that this smart supramol. nanocarrier shows fast response to hyperglycemic circumstances and can effectively regulate the glucose levels in a mouse model of type I diabetes.

Small published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H14IN, HPLC of Formula: 166821-88-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary