Category: 16523-02-7

Weng, Wei published the artcileSynthesis and electrochemical property of sulfone-functionalized imidazolium ionic liquid electrolytes, Safety of 2-Bromoethyl Methyl Sulfone, the publication is Electrochimica Acta (2013), 392-396, database is CAplus.

Sulfone-functionalized imidazolium ionic liquids were synthesized from direct nucleophilic substitution for the 1st time. Detailed NMR anal. of the products revealed the competition pathways of classic S_N2 substitution and E2 elimination in the synthesis reaction. Impurities from E2 elimination can easily be overlooked during the conventional method of ionic liquid preparation via S_N2 substitution. Initial electrochem. examination of the synthesized ionic liquids shows good compatibility with Li_1.1(Ni_1/3Co_1/3Mn_1/3)_0.9O₂ cathode material.

Electrochimica Acta published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C6H20Cl2N4, Safety of 2-Bromoethyl Methyl Sulfone.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bendale, Pravin published the artcileSecond Generation Tetrahydroquinoline-Based Protein Farnesyltransferase Inhibitors as Antimalarials, Product Details of C3H7BrO2S, the publication is Journal of Medicinal Chemistry (2007), 50(19), 4585-4605, database is CAplus and MEDLINE.

Substituted tetrahydroquinolines (THQs) have been previously identified as inhibitors of mammalian protein farnesyltransferase (PFT). Previously it was shown that blocking PFT in the malaria parasite led to cell death and that THQ-based inhibitors are the most potent among several structural classes of PFT inhibitors (PFTIs). THQ-based PFTIs, e.g., I, were synthesized and several compounds were discovered that inhibit the malarial enzyme in the sub- to low-nanomolar range and that block the growth of the parasite (P. falciparum) in the low-nanomolar range. This body of structure-activity data can be rationalized in most cases by consideration of the X-ray structure of one of the THQs bound to mammalian PFT together with a homol. structural model of the malarial enzyme. The results of this study provide the basis for selection of antimalarial PFTIs for further evaluation in preclin. drug discovery assays.

Journal of Medicinal Chemistry published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, Product Details of C3H7BrO2S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Akagi, Katsuhiko published the artcileRelative reactivities of organic halides in displacement reactions. V. Effect of substituent on the reactivity of ω-substituted primary alkyl halides in the reaction with sodium thiosulfate, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (1956), 4034-7, database is CAplus.

Br(CH₂)₃SEt, b₅ 54-6°, n_D²⁰ 1.5113 (obtained from Br(CH₂)₃Br and NaSEt in poor yield) oxidized with 30% H₂O₂ in AcOH yielded 66% Br(CH₂)₃SO₂Et (XIX), b₄ 140°. Similarly was prepared Br(CH₂)₂SO₂Et (XX), b_3.5 126-8°. The rate constants for the reaction with Na₂S₂O₃ in 50% EtOH were determined by the method of Crowell and Hammett (C.A. 43, 1632h) for the following compounds (k × 10³ 1./mole/sec. at the temperatures indicated in parentheses, and heat and entropy of activation in kcal./mole and e.u., resp., given): EtBr, 0.298 ± 0.003 (12.3°), 1.07 ± 0.01 (24.9°), 3.33 ± 0.03 (37.3°), 16.2, -15.7; PrBr, 0.175 ± 0.001 (12.3°), 0.631 ± 0.004 (24.9°), 1.94 ± 0.02 (37.3°), 16.2, -16.9; BuBr, 0.132 ± 0.001 (12.3°) 0.465 ± 0.003 (24.9°), 1.47 ± 0.01 (37.3°), 16.1, -17.5; Br(CH₂)₂OEt (b₇₆₀ 125°), 0.344 ± 0.002 (37.3°), 1.16 ± 0.02 (49.8°), 3.44 ± 0.02 (62.5°), 18.3, -13.7°; Br(CH₂)₃OEt, 0.407 ± 0.003 (24.9°), 1.36 ± 0.01 (37.3°), 4.04 ± 0.02 (49.8°), 17.0, -15.0; (BrCH₂)₄OEt, 0.726 ± 0.007 (24.9°), 2.35 ± 0.02 (37.3°), 6.74 ± 0.06 (49.8°), 16.5, -15.6; Br(CH₂)₂Cl, 0.107 ± 0.002 (24.9°), 0.376 ± 0.003 (37.3°), 1.26 ± 0.01 (49.8°), 18.3, -13.5°; Cl(CH₂)₃Br, 0.405 ± 0.002 (24.9°), 1.35 ± 0.01 (37.3°), 4.26 ± 0.01 (49.8°), 17.4, -13.6; Br(CH₂)₄Cl, (b₁₁₀ 103-4°), 0.197 ± 0.002 (12.3°), 0.734 ± 0.002 (24.9°), 2.33 ± 0.01 (37.3°), 16.6, -15.0; XX, 0.722 ± 0.011 (24.9°), 2.60 ± 0.05 (37.3°), 8.08 ± 0.18 (49.8°), 19.2, -9.2; Br(CH₂)₃SO₂Et (b₄ 140°), 3.58 ± 0.11 (24.9°), 12.3 ± 0.3 (37.3°), 33.3 ± 0.1 (49.8°), 17.2, -12.3°; Ph(CH₂)₃Br, 0.890 ± 0.006 (37.3°), 3.24 ± 0.03 (49.8°), 8.47 ± 0.01 (62.5°), 17.9, -13.0; Ph(CH₂)₃Br, 0.417 ± 0.002 (24.9°), 1.53 ± 0.02 (37.3°), 4.65 ± 0.03 (49.8°), 17.9, -12.0; Ph(CH₂)₄Br, 1.36 ± 0.02 (37.3°), 4.34 ± 0.02 (49.8°), 12.8 ± 0.1 (62.5°), 17.8, -12.4; CH₂:CHCH₂Cl, 0.932 ± 0.01 (12.2°), 2.51 ± 0.04 (24.6°), 7.33 ± 0.03 (37.4°), 13.8, -21.7°; trans-CHCl:CHCH₂Cl (b₇₆₀ 111°, n_D²⁰ 1.4751), 1.60 ± 0.08 (12.2°), 4.94 ± 0.05 (24.6°), 13.7 ± 0.1 (37.4°), 14.5, -18.3; cis-CHCl:CHCH₂Cl (b₇₆₀ 104°, n_D²⁰ 1.4687), 2.59 ± 0.03 (12.2°), 7.42 ± 0.07 (24.6°), 21.6 ± 0.5 (37.4°), 14.4, -17.7; ClCH:CHCO₂Et, 1.71 ± 0.07 (12.3°), 5.36 ± 0.21 (24.9°), 18.0 ± 0.6 (37.3°), 15.8, -13.7.

Journal of the American Chemical Society published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Adam, Rosa published the artcileSelf-Assembly of Catalytically Active Supramolecular Coordination Compounds within Metal-Organic Frameworks, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (2019), 141(26), 10350-10360, database is CAplus and MEDLINE.

Supramol. coordination compounds (SCCs) represent the power of coordination chem. methodologies to self-assemble discrete architectures with targeted properties. SCCs are generally synthesized in solution, with isolated fully coordinated metal atoms as structural nodes, thus severely limited as metal-based catalysts. Metal-organic frameworks (MOFs) show unique features to act as chem. nanoreactors for the in situ synthesis and stabilization of otherwise not accessible functional species. Here, authors present the self-assembly of Pd^II SCCs within the confined space of a pre-formed MOF (SCCs@MOF) and its post-assembly metalation to give a Pd^II-Au^III supramol. assembly, crystallog. underpinned. These SCCs@MOFs catalyze the coupling of boronic acids and/or alkynes, representative multi-site metal-catalyzed reactions in which traditional SCCs tend to decompose, and retain their structural integrity as a consequence of the synergetic hybridization between SCCs and MOFs. These results open new avenues in both the synthesis of novel SCCs and their use in heterogeneous metal-based supramol. catalysis.

Journal of the American Chemical Society published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Labanauskas, Linas published the artcileSynthesis of 1-substituted 4-[4-(1H-indol-3-yl)butyl]piperazines, Safety of 2-Bromoethyl Methyl Sulfone, the publication is ARKIVOC (Gainesville, FL, United States) (2013), 363-376, 14 pp., database is CAplus.

A convenient synthetic route for preparation of various 4-[4-(1H-indol-3-yl)butyl]piperazines bearing heterocyclic and aliphatic substituents in position 1 has been developed. During this work, some synthetic possibilities of the common precursor, 4-[4-(1H-indol-3-yl)butyl]piperazine, were studied and evaluated.

ARKIVOC (Gainesville, FL, United States) published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, Safety of 2-Bromoethyl Methyl Sulfone.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Rui published the artcileDesign, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment, Safety of 2-Bromoethyl Methyl Sulfone, the publication is European Journal of Medicinal Chemistry (2021), 113004, database is CAplus and MEDLINE.

In this study, a series of novel tetrahydroisoquinoline I [R¹ = CHO, CH₂CH₂SO₂Me, CH₂CO₂Me, etc.; configuration = S, Rac, R], II [R² = Bn, Et; R³ = CO₂Me, CHO, etc.; configuration = S, Rac] and III [R⁴ = Et, Me; R⁵ = 5-phenyl-1H-indolyl, 5-methoxy-1H-indolyl, etc.; configuration = S, Rac] were developed based on the crystal structure of PDE4D in complex with I [R¹ = CHO, configuration = S]. Anti-inflammatory effects of these compounds were evaluated and III [R⁴ = Me, R⁵ = 7-chloro-1H-indolyl, configuration = S] with high safety, permeability and selectivity, exhibited significant inhibitory potency against the enzymic activity of PDE4D and the TNF-α release from the LPS-stimulated RAW 264.7 and hPBMCs. Moreover, an in-vivo study demonstrated that a topical administration of III [R⁴ = Me, R⁵ = 7-chloro-1H-indolyl, configuration = S] achieved more significant efficacy than calcipotriol to improve the features of psoriasis-like skin inflammation. Overall, this study provided a basis for further development of tetrahydroisoquinoline-based PDE4 inhibitors against psoriasis.

European Journal of Medicinal Chemistry published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C8H16N2O, Safety of 2-Bromoethyl Methyl Sulfone.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Szabo, Gyorgy published the artcileMultiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABA_A Receptor Negative Allosteric Modulators, Name: 2-Bromoethyl Methyl Sulfone, the publication is Journal of Medicinal Chemistry (2022), 65(11), 7876-7895, database is CAplus and MEDLINE.

The discovery and characterization of novel naphthyridine derivatives with selective α5-GABA_AR neg. allosteric modulator (NAM) activity are disclosed. Utilizing a scaffold-hopping strategy, fused [6 + 6] bicyclic scaffolds were designed and synthesized. Among these, 1,6-naphthyridinones were identified as potent and selective α5-GABA_AR NAMs with metabolic stability, cardiac safety, and beneficial intellectual property (IP) issues. Relocation of the oxo acceptor function and subsequent modulation of the physicochem. properties resulted in novel 1,6-naphthyridines with improved profile, combining good potency, selectivity, ADME, and safety properties. Besides this, compound 20 (I), having the most balanced profile, provided in vivo proof of concept (POC) for the new scaffold in two animal models of cognitive impairment associated with schizophrenia (CIAS).

Journal of Medicinal Chemistry published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C8H11NO, Name: 2-Bromoethyl Methyl Sulfone.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary