Category: 1647-23-0

These common heterocyclic compound, 1647-23-0, name is 1-Bromo-3,3-dimethylbutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1647-23-0

Example 42 9-(3,3-Dimethylbutyl)-7-methoxy-l,2,3,9-tetrahydro-4H-carbazol-4-one; 7-methoxy-l,2,3,9-tetrahydro-4H-carbazol-4-one from Example 41 Step B in 1 mL anhydrous DMF were added 27.2 mg l-bromo-3,3-dimethylbutane and 53.8 mg cesium carbonate. The reaction mixture was heated at 45C for 1 hour and at 35C for 3 days. After cooling to room temperature, the reaction mixture was diluted with 1: 1 dioxane and water and purified on RP-EtaPLC using 60-100% MeCN gradient in water with 0.1% TFA. The title compound was obtained as a colorless solid following lyophilization. LC-MS: 3.66 min. (m/Z = 300.2, 322.1).

The synthetic route of 1-Bromo-3,3-dimethylbutane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2006/44232; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1647-23-0, name is 1-Bromo-3,3-dimethylbutane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C6H13Br

General procedure: The solution of dihydroxyacetophenone (1, 1.0equiv), anhydrous potassium carbonate (2.0equiv) and corresponding alkyl bromides (2, 1.1equiv) in acetonitrile was stirred at 70-80C for 4-5h. After evaporation of acetonitrile, the reaction mixture was diluted with dichloromethane and washed with water three times. The organic layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography to give 3. 6.1.1.5 1-(2-(3,3-Dimethylbutoxy)-6-hydroxyphenyl)ethanone (3e) Yield 38%; light yellow liquid; Rf 0.52 (0.5:9.5 EA: HX); IR (KBr) 3233, 2919, 2852, 1611 cm-1; 1H NMR (CDCl3) delta 13.28 (s, 1H), 7.33 (t, J = 8.4 Hz, 1H), 6.55 (dd, J = 0.8, 8.4 Hz, 1H), 6.38 (d, J = 8.2 Hz, 1H), 4.13 (t, J = 7.4 Hz, 2H), 2.68 (2, 3H), 1.89 (t, J = 7.4 Hz, 2H), 0.98 (s, 9H).

The synthetic route of 1647-23-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Venkateswararao, Eeda; Sharma, Vinay K.; Yun, Jieun; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3386 – 3392;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 1647-23-0, The chemical industry reduces the impact on the environment during synthesis 1647-23-0, name is 1-Bromo-3,3-dimethylbutane, I believe this compound will play a more active role in future production and life.

6-t-butyll-8-H-pteridinone (50 mg, 0.21 mmol, from preparative example 3) in 1 mL DMF was added 60 mg potasium carbonate and 1.5equiv. of 1-bromo-3,3-dimethylbutane. The reaction mixture was stirred at rt for 4 hours. The solid was filtered. The filtrate was concentrated. The residue was purified by column chromotagraphy (silica gel, 4:1 hexanes:ethyl acetate) to give 51 mg desired product. LC-MS [M+1]=319.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3,3-dimethylbutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhu, Song; US2005/250779; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1647-23-0 as follows. Computed Properties of C6H13Br

To a mixture of 2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4,6-bis(trifluoromethyl)- 2H-pyrazolo[3,4-d]pyrimidin-3-amine (100 mg, 0.21 mmol, 1 equiv), l-bromo-3,3- dimethylbutane (69.3 mg, 0.42 mmol, 2 equiv) in CH3CN (3.0 mL) was added potassium iodide (KI; 34.9 mg, 0.21 mmol, 1 equiv) and K3P04 (89.2 mg, 0.42 mmol, 2 equiv). The dark mixture was heated at 60 C for 5 h. The cooled mixture was diluted with EtOAc and washed with 0 (10 mL). The organic phase was concentrated in vacuo to give a residue, which was purified by preparative TLC to give the title compound (23 mg, 19.6%) as a yellow solid: ]H NMR (300 MHz, CDC13) delta 7.84 (s, 2H), 5.20 (br s, 1H), 2.91 – 2.84 (m, 2H), 1.46 – 1.41 (m, 2H), 0.77 (s, 9H); ESIMS m/z 568 [(M+H)]+.

According to the analysis of related databases, 1647-23-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DOW AGROSCIENCES LLC; POBANZ, Mark A.; DENT, William Hunter; BENKO, Zoltan L.; ERICKSON, W. Randal; GENG, Chaoxian; WATSON, Gerald B.; SPARKS, Thomas C.; PATNY, Akshay; WO2014/126580; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 1647-23-0, name is 1-Bromo-3,3-dimethylbutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1647-23-0

The first step, weighed indole acetic acid (1.05g),Added to DMF (5 mL) and stirred to dissolve,Cooling to 0 ~ 5 C stirring;60% sodium hydride (0.72 g) was added,Stirring for 10min,3,3-dimethyl-1-bromobutane(1.5 g) was added,0 ~ 5 C reaction 0.5h,Slowly rose to room temperature reaction 2h;Add ethyl acetate (40mL), water (40mL); rapid mixing, 2min drop 6N hydrochloric acid solution 10mL,Stirring for 5 min; the phases were separated and the aqueous phase was extracted with ethyl acetate (20 mL). The phases were separated and the ethyl acetate phases were combined. Saturated brine(30 mL) for 5 min,The ethyl acetate phase was removed at 50 C under reduced pressure to give the crude product of the first step2- [1- (2-tert-butylethyl) -1H-indol-3-yl] acetic acid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1647-23-0.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Chen Qing; Chen Minghua; Ba Mingyu; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107151223; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

1647-23-0, A common compound: 1647-23-0, name is 1-Bromo-3,3-dimethylbutane, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

In an oven-dried flask, a suspension of magnesium turnings (1.82 g, 75 mmol) in THF (40 mL) is treated with molecular iodine (254 mg, 1 mmol). To this mixture is added twenty drops of a solution of 3,3-dimethylbutyl bromide (7.14 mL, 50 mmol) in THF (10 mL) via a fitted separatory funnel. The resulting mixture is heated to reflux, followed by addition of the remaining 3,3-dimethylbutyl bromide solution. The reaction mixture is allowed to reflux for 1h, cooled to rt, and used as is (1.0 M solution of 3,3-dimethylbutylmagnesium bromide in THF, 50 mmol)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3,3-dimethylbutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; EP1856090; (2009); B1;,
Bromide – Wikipedia,
bromide – Wiktionary