Category: 16426-64-5

Qian, Yimin; Marugan, Juan Jose; Fossum, Renae D.; Vogt, Andreas; Sebti, Said M.; Hamilton, Andrew D. published the artcile< Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors>, Safety of 2-Bromo-4-nitrobenzoic acid, the main research area is methionine CAAX peptidomimetic preparation potent inhibitor farnesyltransferase; structure activity relationship farnesyltransferase inhibitor methionine CAAX peptidomimetic.

The authors report here the design, synthesis and biol. characterization of a series of CAAX (C = cysteine, AA = aromatic amino acid, X = methionine) peptidomimetics as farnesyltransferase inhibitors. For example, peptidomimetics I (R = Ph, 2-thienyl, 1-naphthyl, 2-pyridyl, 3-pyridyl, 4-pyridyl) are extremely potent towards farnesyltransferase with IC50 values ranging from subnanomolar to low nanomolar concentrations They have a high selectivity for farnesyltransferase over the closely related geranylgeranyltransferase-I. Structure-activity relationship studies demonstrated that a properly positioned hydrophobic group significantly enhanced inhibition potency, reflecting an improved complementarity to the large hydrophobic pocket in the CAAX binding site.

Bioorganic & Medicinal Chemistry published new progress about Peptidomimetics. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Safety of 2-Bromo-4-nitrobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Trofymchuk, Serhii; Bugera, Maksym Ya.; Klipkov, Anton A.; Razhyk, Bohdan; Semenov, Sergey; Tarasenko, Karen; Starova, Viktoriia S.; Zaporozhets, Olga A.; Tananaiko, Oksana Yu.; Alekseenko, Anatoliy N.; Pustovit, Yurii; Kiriakov, Oleksandr; Gerus, Igor I.; Tolmachev, Andrei A.; Mykhailiuk, Pavel K. published the artcile< Deoxofluorination of (Hetero)aromatic Acids>, HPLC of Formula: 16426-64-5, the main research area is deoxofluorination cinnamic carboxylic acid sulfur tetrafluoride safety.

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines – valuable building blocks for medicinal chem. and agrochem. Of note, sulfur tetrafluoride (SF4) and hydrogen fluoride (HF) are toxic, therefore, safety and addnl. tech. training must be taken before working with them.

Journal of Organic Chemistry published new progress about Aliphatic amines Role: SPN (Synthetic Preparation), PREP (Preparation) (fluorinated). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, HPLC of Formula: 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Alty, Isaac G.; Abelt, Christopher J. published the artcile< Stereoelectronics of the Hydrogen-Bond-Induced Fluorescence Quenching of 3-Aminofluorenones with Alcohols>, Product Details of C7H4BrNO4, the main research area is stereoelectronics hydrogen bond induced fluorescence quenching aminofluorenone alc.

Two derivatives of 3-amino-9-fluorenone (1) bearing one (2) and two Me (3) groups flanking the carbonyl group are prepared Comparison of their photophys. properties show that all suffer efficient radiationless deactivation in the presence of alcs. Preferential solvation studies with mono alcs. reveal that a single H-bonding interaction quenches the excited states of 1 and 2, but not that of 3. In contrast, a single mol. of ethylene glycol quenches all three. These results are interpreted in a quenching mechanism similar to one proposed by Inoue et al., but where an out-of-plane H-bond with the carbonyl group gives rise to an emissive species, while an in-plane H-bond results in quenching.

Journal of Physical Chemistry A published new progress about Alcohols Role: NUU (Other Use, Unclassified), PEP (Physical, Engineering or Chemical Process), USES (Uses), PROC (Process). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Product Details of C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bubel, O. N.; Bezborodov, V. S.; Ptashnikov, Yu. L. published the artcile< Synthesis of mesomorphic derivatives of p-aminobenzoic acid>, Synthetic Route of 16426-64-5, the main research area is Schiff base aminobenzoate mesomorphic; liquid crystal aminobenzoate Schiff base.

4-HOC6H4CHO was etherified with RX (R = Me, EtCHMeCH2, m-C5H11, n-C10H21; X = Br, iodo) to give 85-90% 4-ROC6H4CHO, which condensed with 2,4-R1(H2N)C6H3CO2R2 (R1 = H, Cl, Br; R2 = H, EtCHMeCH2, n-C5H11) to give 11 mesomorphic 4-ROC6H4CH:NC6H3(CO2R2)R1-4,3 (I). I (R = R2 = EtCHMeCH2, R1 = H) exists as a mixture of the crystalline and isotropic phases; the other I also exists as smectic liquid-crystalline A or C phases or as nematic liquid crystals.

Zhurnal Organicheskoi Khimii published new progress about Liquid crystals. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Synthetic Route of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mayuranathan, P. S. published the artcile< Thermal decomposition of mercuric o- and m-nitrobenzoate and 4-nitrophthalate>, Reference of 16426-64-5, the main research area is .

(o-O2NC6H4CO2)2Hg (18 g.) heated at 180° until evolution of CO2 ceased (4 hrs.) gave 16% (o-O2NC6H4)2Hg (I), a crystalline solid insoluble in organic solvents. I (4 g.) heated 1 hr. with 20 cc. 2M K perbromide or periodide, the resulting oils freed from halogen, and crystallized gave 1 g. o-BrC6H4NO2, m. 39°, or o-IC6H4NO2, m. 49°, resp. (m-O2NC6H4CO2)2Hg (II) did not decompose but gave anhydro-2-hydroxymercuri-3-nitrobenzoic acid (III). Thus, 10 g. II heated 6 hrs. at 190° gave III, soluble in warm alkali. III (5 g.) similarly treated with K perbromide or periodide, the solution evaporated to remove excess halogen, acidified, and extracted with Et2O, the solution washed with thiosulfate, dried, and evaporated gave 1 g. 2,3-Br(O2N)C6H3CO2H, m. 185°, and 2,3-I(O2N)C6H3CO2H, m. 205°, resp. 4-Nitrophthalic acid (23 g.) in 16 g. Na2CO3 dissolved in 20 cc. H2O treated with 45 g. Hg(OAc2) in 150 cc. H2O containing 1 cc. AcOH gave Hg 4-nitrophthalate (IV). IV (20 g.) heated 6 hrs. at 190° gave anhydro-2-hydroxymercuri-4-nitrobenzoic acid (V), identical with the product obtained from p-O2NC6H4CO2H (VI). V brominated or iodinated as above gave 2-Br- and 2,4-I(O2N)C6H3CO2H. Hydrolysis of V gave VI.

Journal of the Chemical Society published new progress about 16426-64-5. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Reference of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary