Category: 16426-64-5

Zeng, Liang; Fu, Hua; Qiao, Renzhong; Jiang, Yuyang; Zhao, Yufen published the artcile< Efficient copper-catalyzed synthesis of N-(alkyl)anthranilic acids via an ortho-substituent effect of the carboxyl group of 2-halobenzoic acids at room temperature>, Related Products of 16426-64-5, the main research area is anthranilic acid alkyl preparation copper iodide BINOL; Ullmann reaction amine halobenzoic acid amination copper BINOL.

A method for the synthesis of the title compounds [i.e., 2-(aminoalkyl)benzoic acid derivatives, N-(alkyl)anthranilic acids] is reported here. The protocol uses inexpensive copper iodide/racemic 1,1′-binaphthyl-2,2′-diol (racemic-BINOL) as catalyst/ligand system, readily available 2-halobenzoic acids and aliphatic amines as starting materials. The coupling reactions were performed at room temperature, and various functionalities in the substrates were tolerated.

Advanced Synthesis & Catalysis published new progress about Alicyclic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Related Products of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Goldberg, Frederick W.; Kettle, Jason G.; Xiong, Jian; Lin, Daoguang published the artcile< General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor>, COA of Formula: C7H4BrNO4, the main research area is alkyl sulfoximine preparation; sulfide amination oxidation alkylation.

The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clin. candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesizing a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, com. available precursor is discussed.

Tetrahedron published new progress about Alkylation. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, COA of Formula: C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sindelar, Karel; Jilek, Jiri O.; Pomykacek, Josef; Sedivy, Zdenek; Protiva, Miroslav published the artcile< Neurotropic and psychotropic agents. Part CXVIII. Synthesis of 2-acetyl and 3-acetyl derivatives of 8-chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin; 2-acyl-7-substituted thioxanthenes>, COA of Formula: C7H4BrNO4, the main research area is dibenzothiepin methylpiperazino; neurotropic methylpiperazinodibenzothiepin; psychotropic methylpiperazinodibenzothiepin; bactericide methylpiperazinodibenzothiepin; thioxanthene acyl; phenylthiophenylacetic acid cyclization; piperazinodibenzothiepin.

Reaction of 2-chlorodibenzo[b,f]thiepin with AcCl and AlCl3 proceeded under simultaneous acetylation of the nucleus and HCl addition with contraction of the central ring to give the thioxanthene I (R = Cl). Substitution reaction of I (R = Cl) with 1-methylpiperazine gave I (R = 4-methylpiperazino) and the elimination product II (X = CH2) was oxidized by air to II (X = O), also obtained by cyclization of 2-(4-acetylphenylthio)-5-chlorobenzoic acid. Total synthesis of the dibenzothiepins III (R1 = 2-, 3-MeCO; R2 = 4-methylpiperazino) were carried out. They started from the isomeric 2-(4-chlorophenylthio)-5(or4)-nitrobenzoic acids, the first of which was transformed in 6 steps to 5-amino-2-(4-chlorophenylthio)phenylacetic acid, which was cyclized to 2-amino-8-chlorodibenzo[b,f]thiepin-10(11H)-one. The 4-nitro acid, produced in 3 steps the homologous nitro acid, cyclized to 8-chloro-3-nitrodibenzo[b,f]thiepin-10(11H)-one. The Ac groups was introduced in III (R1 = 2-, 3-NH2; R2 = HO) by reaction of the diazonium salts with AcH semicarbazone followed by hydrolysis. The 2-acetyl- and 3-acetyl-8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-ol yielded by treatment with HCl 2-acetyl- and 3-acetyl-8,10-dichloro-10,11-dihydrodibenzo[b,f]thiepin, isomeric with I (R = Cl). Substitution reactions with 1-methylpiperazine gave III (R1 = 2-, 3-MeCO, R2 = 4-methylpiperazino) together with products of elimination, i.e. 2-acetyl- and 3-acetyl-8-chlorodibenzo[b,f]thiepin I (R = 4-methylpiperazino) when administered i.v. to mice, had a high central depressant activity, III (R1 = 2-MeCO, R2 = 4-methylpiperazino) had only mild activity; both substances in the test on rats were practically devoid of cataleptic activity (LD50 and ED50 given).

Collection of Czechoslovak Chemical Communications published new progress about Cyclocondensation reaction, intramolecular. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, COA of Formula: C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hylsova, Michaela; Carbain, Benoit; Fanfrlik, Jindrich; Musilova, Lenka; Haldar, Susanta; Kopruluoglu, Cemal; Ajani, Haresh; Brahmkshatriya, Pathik S.; Jorda, Radek; Krystof, Vladimir; Hobza, Pavel; Echalier, Aude; Paruch, Kamil; Lepsik, Martin published the artcile< Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines>, COA of Formula: C7H4BrNO4, the main research area is pyrazolo pyrimidine derivative preparation CDK2 inhibitor structure solvent; ATP-competitive type I inhibitors; Cyclin-dependent kinase 2; Molecular dynamics; Protein-ligand binding; Pyrazolo[1,5-a]pyrimidine; Quantum mechanical scoring; Water thermodynamics; X-ray crystal structure.

We present comprehensive testing of solvent representation in quantum mechanics (QM)-based scoring of protein-ligand affinities. To this aim, we prepared 21 new inhibitors of cyclin-dependent kinase 2 (CDK2) with the pyrazolo[1,5-a]pyrimidine core, whose activities spanned three orders of magnitude. The crystal structure of a potent inhibitor bound to the active CDK2/cyclin A complex revealed that the biphenyl substituent at position 5 of the pyrazolo[1,5-a]pyrimidine scaffold was located in a previously unexplored pocket and that six water mols. resided in the active site. Using mol. dynamics, protein-ligand interactions and active-site water H-bond networks as well as thermodn. were probed. Thereafter, all the inhibitors were scored by the QM approach utilizing the COSMO implicit solvent model. Such a standard treatment failed to produce a correlation with the experiment (R2 = 0.49). However, the addition of the active-site waters resulted in significant improvement (R2 = 0.68). The activities of the compounds could thus be interpreted by taking into account their specific noncovalent interactions with CDK2 and the active-site waters. In summary, using a combination of several exptl. and theor. approaches we demonstrate that the inclusion of explicit solvent effects enhance QM/COSMO scoring to produce a reliable structure-activity relationship with phys. insights. More generally, this approach is envisioned to contribute to increased accuracy of the computational design of novel inhibitors.

European Journal of Medicinal Chemistry published new progress about Crystal structure. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, COA of Formula: C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Friedrich, Karlheinz; Oester, Hans published the artcile< The preparation of aromatic polyhydroxy compounds and polyhydroxycarboxylic acids. VII. Bromo derivatives of 4-hydroxybenzoic acid>, Recommanded Product: 2-Bromo-4-nitrobenzoic acid, the main research area is .

Various methods for the preparation of 2,4-Br(HO)C6H3CO2H (I) and 2,3,5,4-Br3(HO)C6HCO2H (II) were investigated. A general method was described for oxidation of aliphatic side chains in the o-position to Br in the aromatic ring. 2,4-Br(O2N)C6H3Me (4 g.) and 50 cc. dilute HNO3 (1 volume HNO3, d. 1.5, and 2.5 volumes H2O) heated 3-4 hrs. with 1 drop Hg in a sealed tube at 130°, the mixture cooled, filtered, the residue dissolved in dilute aqueous NaOH, the solution filtered, and acidified gave 3.5 g. 2,4-Br(O2N)C6H3CO2H (III), needles, m. 162-4° (H2O). 2,6,4-Br2(O2N)C6H2Me (4 g.) oxidized similarly during 4 hrs. at 135-40° gave 1.5 g. 2,6,4-Br2(O2N)C6H2CO2H (IV), m. 195-8°. III (4 g.) in 50 cc. MeOH hydrogenated over Raney Ni yielded 40% 2,4-Br(H2N)C6H3CO2H (V), m. 198-200° (H2O). V (5 g.) in dilute H2SO4 diazotized, heated to boiling until the N evolution ceased, cooled, concentrated, and filtered yielded 2.8 g. I, m. 206-8° (H2O), dark yellow with FeCl3. I (4 g.) in 40 cc. AcOH and a small amount of Fe powder treated at 10° with 7 g. Br in 30 cc. AcOH with stirring, the mixture kept overnight, and filtered gave 3.6 g. II, m. 222-5° (aqueous EtOH). I with the appropriate amount of Br gave 60% 2,5,4-Br2(HO)C6H2CO2H, m. 218-20°. III and IV with CH2N2-Et2O gave 80% Me ester (VI) of III, m. 152°, and Me ester of IV, m. 82-4°, resp. VI (8 g.) in 150 cc. 10% HCl treated at 60-70° with 8 g. powd. Fe, the mixture heated to 90°, filtered hot, treated with a small amount of concentrated HCl, filtered, the residue in dilute EtOH treated with a few cc. 2N NaOH, heated to boiling, filtered, and cooled gave 4 g. Me ester (VII) of V, needles, m. 85-6°. VII (3 g.) diazotized and refluxed gave 2 g. Me ester of I, violet with aqueous FeCl3. I (3 g.) treated with CH2N2-Et2O, the resulting oil saponified with excess 40% KOH, and acidified with dilute HCl gave 2,4-Br(MeO)C6H3CO2H, needles, m. 196-7°. The following compounds were prepared by standard procedures: acetate of I, m. 153-4°; N-Ac derivative of VII, m. 52-3°; 2,6,4-Br2(O2N)-C6H2CO2H (VIII), m. 195-8°; 4-NH2 analog of VIII, m. 233-4°; Me ester of VIII, m. 142-5°; 4-OH analog of VIII, m. 218-20°.

Chemische Berichte published new progress about Acids. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Recommanded Product: 2-Bromo-4-nitrobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pump, Eva; Poater, Albert; Zirngast, Michaela; Torvisco, Ana; Fischer, Roland; Cavallo, Luigi; Slugovc, Christian published the artcile< Impact of Electronic Modification of the Chelating Benzylidene Ligand in cis-Dichloro-Configured Second-Generation Olefin Metathesis Catalysts on Their Activity>, SDS of cas: 16426-64-5, the main research area is benzylidene ruthenium imidazolidene carbene chelating complex preparation catalyst polymerization; impact electronic modification chelating benzylidene ruthenium dichloro metathesis catalyst; configured olefin metathesis catalyst benzylidene ruthenium imidazolidene carbene complex; cis trans isomerization benzylidene ruthenium imidazolidene carbene dichloro complex; crystal mol structure benzylidene ruthenium imidazolidene carbene chelating complex.

A series of electronically modified second-generation cis-dichloro ruthenium ester chelating benzylidene complexes was prepared, characterized, and benchmarked in a typical ring-opening metathesis polymerization (ROMP) experiment The electronic tuning of the parent chelating benzylidene ligand (2-Et ester benzylidene) was achieved by substitution at the 4- and 5-positions with electron-withdrawing nitro or electron-donating methoxy groups. The effect of the electronic tuning on the cis-trans isomerization process was studied exptl. and theor. D. functional theory calculations clearly revealed the influence of electronic modification on the relative stability between the cis and trans isomers, which is decisive for the activity of the studied compounds as initiators in ROMP.

Organometallics published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, SDS of cas: 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stoicescu-Crivetz, L.; Mandasescu, L. published the artcile< The antituberculotic action of some hydrazide and hydrazone derivatives of the p-amino-o-halobenzoic acids>, Category: bromides-buliding-blocks, the main research area is .

The following derivatives of the p-amino-o-halobenzoic acids were prepared to test the hydrazides and hydrazones for their tuberculostatic activity. The Me ester (I) of 2,4-Cl(O2N)C6H3CO2H (II) (6 g.), obtained by slowly adding 8 mL. concentrated H2SO4 to a solution of 6 g. II in 160 mL. MeOH and heating 6-8 h., m. 78-80° (from dilute EtOH). The analogous Br (III), m. 84°, and the iodo, m. 88°, compounds were prepared in the same way. 2,4-Cl(H2N)C6H3CO2Me, obtained by reduction of I with SnCl2 and HCl, m. 104° (from H2O). The Br, m. 94°, and iodo, m. 120°, analogs were obtained similarly. The hydrazide (1.5 g.) of 2,4-Cl(H2N)C6H3CO2H, prepared by adding dropwise 3 g. N2H4.H2O to 3 g. I, m. 175° (from dilute EtOH). The Br analog was obtained by the same method from III. 4-Amino-2-chlorobenzoylhydrazones of the following aldehydes were prepared: o-HOC6H4CHO, m. 190°; BzH, m. 195°; m-HOC6H4CHO, m. 226°; p-Me2NC6H4CHO; p-AcNHC6H4CHO, m. 255°. 4-Amino-2-bromobenzoylhydrazones: o-HOC6H4CHO, m. 215°; m-HOC6H4CHO, m. 226°; p-Me2NC6H4CHO, m. 207°. The hydrazides and hydrazones had a very weak antituberculotic action.

Studii si Cercetari de Chimie published new progress about Catalysts. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thompson, H. E.; Swanson, Carl P.; Norman, A. G. published the artcile< New growth-regulating compounds. I. Summary of growth-inhibitory activities of some organic compounds as determined by three tests>, Product Details of C7H4BrNO4, the main research area is .

Growth-regulating substances were prepared and subjected to 3 tests. In each a common reference material, (2,4-dichlorophenoxy)acetic acid (I), was employed and the results of any test were expressed as a percentage of the inhibition produced concurrently by I. The primary test, Test A (Corn Germination Test), involved the determination of inhibition of elongation of the primary root of germinating corn. Corn grains were germinated at 27° in Petri dishes containing 20 mL. of an aqueous solution of the compound to be tested at a concentration of 10 p.p.m. After 4 days of growth the length of the primary root of each plant was measured. Inhibition of growth was determined by subtracting the average length of the primary roots of the treated seeds from that of the control seeds, expressed in percentage. In Test B (Kidney-Bean Single-Droplet Water Test) kidney beans were placed in pots containing 1 lb. soil. After 7-10 days each plant was treated with 0.02 mL. of an aqueous solution containing 200 p.p.m. (4 γ) of the compound to be tested and 0.5% of Carbowax 1500. Treatment was applied to the upper surface of one of the primary leaves at a point along the midrib approx. one-eighth in. from the point of attachment of the blade and petiole. On the 10th day after treatment the fresh weight of that portion of each plant above the second node was determined Controls untreated and also treated with I were included in each test. Test C (Kidney-Bean Single-Droplet Oil Test) was essentially the same as Test B but 0.01 mL. of solution was applied containing 5γ in oil of the compound to be tested. Tri-Bu phosphate, at a concentration of 0.2%, was used as a co-solvent for compounds not directly soluble or miscible with oil. The introduction of I could be accomplished only in this way. Close numerical agreement was not necessarily expected between the 3 tests. The degree of inhibition produced by I in Tests B and C at different times of the year was not wholly identical and was affected by rate of growth. Test A was the most reproducible and formed the primary basis for detection of inhibitory activity and was reliable in separating those compounds that possess a high inhibitory activity for most broad-leaved plants from those with little or no activity at the same concentration Satisfactory agreement was found between Tests A and B with discrepancies in the direction of a lower activity by Test B. Variation between replications was greatest in Test C but the results were satisfactory in separating active inhibitors from those with low activity. Compounds showing high activity are promising for use as herbicides. The compounds tested have been classified into groups according to activity and the results under 3 tests reported. The following, as Group I, are compounds possessing 80% or more of the activity of I in Test A: (2-bromo-4-chlorophenoxy)acetic acid; Bu (2,4,5-trichlorophenoxy) acetate; (2-chloro-4-bromophenoxy)acetic acid; NH4 4-chlorocinnamate; α(4-chlorophenoxy)acetamide; (3-chlorophenoxy)acetic acid; 4-isomer; α-(2,4-dichlorophenoxy)acetamide; 2-(2,4-dichlorophenoxyacetamido)-1-butanol; Na 4-(2,4-dichlorophenoxyacetamido)-2,5-dichlorobenzenesulfonate; 2-(2,4-dichlorophenoxyacetamido)-2-ethyl-1,3-propanediol; 2-(2,4-dichlorophenoxyacetamido)-2-(hydroxymethyl)-1,3-propanediol; 2-(2,4-dichlorophenoxyacetamido)-2-methyl-1,3-propanediol; 2-(2,4-dichlorophenoxyacetamido)-1-naphthalenesulfonic acid; 8-(2,4-dichlorophenoxyacetamido)-1-naphthalenesulfonic acid; 8-(2,4-dichlorophenoxyacetamido)-1-naphthol-3,6-disulfonic acid; (3,4-dichlorophenoxy)acetic acid; 2,5-isomer; (2,4-dichlorophenoxy)acetic anhydride; α-(2,4-dichlorophenoxy)-4-sulfoacetanilide; (2,4-dichlorophenoxy)acetohydroxamic acid; (2,4-dichlorophenoxy) acetyl chloride; (2,4-dichlorophenoxyacetyl)guanidine; N-(2,4-dichlorophenoxyacetyl)urea; α-(2,4-dichlorophenoxy)butyric acid; 2-diethylaminoethyl (2,4-dichlorophenoxy)acetate; 2-diethylaminoethyl (2,4,5-trichlorophenoxy)acetate; 2,2-dimethyl-1,3-dioxolan-4-ylmethyl (2-methyl-4-chlorophenoxy)acetate; 1,4-bis(2,4,5-trichlorophenoxyacetamido)benzene; 1,3-isomer; Et (2,4-dichlorophenoxy)-acetate; Et (2-methyl-4-chlorophenoxy) acetate; Et 2-(2-methyl-4-chlorophenoxy) heptanoate; 2-hydroxyethyl (2,4-dichlorophenoxy)acetate; (2-iodo-4-chlorophenoxy)acetic acid; (2-methyl-4-bromophenoxy)acetic acid; (2-methyl-4-chlorophenoxy)acetamide; N-methyl-α-(4-chlorophenoxy)acetamide; 4-(2-methyl-4-chlorophenoxyacetamido)benzenesulfonic acid; 2-(2-methyl-4-chlorophenoxyacetamido)-6,8-naphthalenedisulfonic acid; 2-(2-methyl-4-chlorophenoxyacetamido)-1-naphthalenesulfonic acid; 8-(2-methyl-4-chlorophenoxyacetamido)-1-naphthalenesulfonic acid; 7-(2-methyl-4-chlorophenoxyacetamido)-1-naphthol-3,6-disulfonic acid; (2-methyl-4-chlorophenoxy)acetic acid; (2-methyl-6-chlorophenoxy)acetic acid; (2-methyl4-chlorophenoxy)acetic anhydride; (2-methyl-4-chlorophenoxy)acetyl chloride; (2-methyl-4-fluorophenoxy)acetic acid; N-methyl-α-(2,4,5-trichlorophenoxy)acetamide; 2-nitro-2-methylpropyl (2,4-dichlorophenoxy)acetate; 2-nitro-2-methylpropyl (2-methyl-4-chlorophenoxy)acetate; Ph chloroacetate; Ph (2-methyl-4-chlorophenoxy)acetate; iso-Pr (2-methyl-4-chlorophenoxy)acetate; 2-(2,4,5-trichlorophenoxyacetamido)-2-(hydroxymethyl)-1,3-propanediol; α-(2,4,5-trichlorophenoxy)-N,N-bis(2-hydroxyethyl)acetamide; (2,4,5-trichlorophenoxy)acetic piperidide; α-(2,4,5-trichlorophenoxy)-3-chloroacetanilide; α-(2,4,5-trichlorophenoxy)-2,4-dimethylacetanilide; α-(2,4,5-trichlorophenoxy)-4-ethoxyacetanilide; α-(2,4,5-trichlorophenoxy)-4-methylacetanilide; α-(2,4,5-trichlorophenoxy)-2,4,6-trichloroacetanilide; [3-(trifluoromethyl)phenoxy] acetic acid; N-[tris(hydroxymethyl)methyl]-N-{2-hydroxy-3-[tris(hydroxymethyl)methylamino]-propyl}-α-(2,4-dichlorophenoxy)acetamide-HCl. The following, as Group II, are compounds possessing 50-79% of the activity of I in Test A: 2-aminoethanol bis-[(4-chlorophenoxy)acetate];(4-bromophenoxy)acetic acid; O-(2-carboxymethoxy-3-methyl-5-bromobenzoyl)glycolic acid; O-(2-carboxymethoxy-3-methyl-5-nitrobenzoyl)-glycolic acid; decyl dihydrogen orthophosphate; (2-chloro-4-tert-butylphenoxy)acetic acid; (2-chloro-4-iodophenoxy)acetic acid; 1-chloronaphthylacetic acid (mixture), ammonium salt; 2-(4-chlorophenoxyacetamido)-1-naphthalenesulfonic acid; 4-(4-chlorophenoxyacetamido)-1-naphthalenesulfonic acid; 8-(4-chlorophenoxyacetamido)-1-naphthalenesulfonic acid; 8-(4-chlorophenoxyacetamido)-1-naphthol-3,6-disulfonic acid; α-(4-chlorophenoxy)-N,N-bis(2-hydroxyethyl)acetamide; (4-chlorophenoxy)acetyl chloride; 2-(4-chlorophenoxyacetamido)-2-(hydroxymethyl)-1,3-propanediol; γ-(4-chlorophenoxy)-butyric acid; S-(4-chlorophenyl)thioglycolic acid; 2-butenyl (4-chlorophenoxy)acetate; (2,4-dibromophenoxy)acetic acid; α,β-dibromo-γ-phenylpropionyl chloride; 3,5-dichloro-2-bromobenzoic acid; (2,4-dichloro-5-bromophenoxy)acetic acid; (2,4-dichlorophenoxy)acetic piperidide; 4-(2,4-dichlorophenoxyacetamido)-1-naphthalenesulfonic acid; (2,4-dichlorophenoxy)acetonitrile; N’-(2,4-dichlorophenoxyacetyl)betaine hydrazide hydrochloride; α-(2,4-dichlorophenoxy)-N,N-diethylacetamide; α-(2,4-dichlorophenoxy-N-methylacetamide; NH4 γ-(2,4-dichlorophenoxy)butyrate; 2,4-dichlorophenylglycine; S-(2,5-dichlorophenyl)thioglycolyl chloride; 2,2-dimethyl-1,3-dioxolan-4-ylmethyl (4-chlorophenoxy)-acetate; β-(2,4-dimethylphenoxy)propionic acid; 3,5-dimethylpyrazole; Et 3-hydroxy-2-naphthoate; Et (2-methyl-4,6-dichlorophenoxy) acetate; 2-hydroxy-3-methyl-5-bromobenzoic acid; 2-hydroxy-3-methyl-5-iodobenzoic acid; 2-hydroxyethyl (4-chlorophenoxy)-acetate; N-2-hydroxyethyl-α-(2,4-dichlorophenoxy)acetamide; N-2-hydroxyethyl-α-(2-methyl-4-chlorophenoxy)-acetamide; 2-hydroxyethyl (2-methyl-4-chlorophenoxy)-acetate; 2-hydroxy-3-methylbenzoic acid; 2-hydroxy-5-nitrobenzoic acid; (2-methyl-4-bromo-6-carboxyphenoxy)acetic acid; α-(3-methyl-4-chlorophenoxy)acetamide; Me (4-chlorophenoxy)acetate; (2-methyl-5-chlorophenoxy)acetic acid; (3-methyl-4-chlorophenoxy)-acetic acid; α-(2-methyl-4-chlorophenoxy)-N,N-bis(2-hydroxyethyl)acetamide; (3-methyl-4-chlorophenoxy)-acetyl chloride; Me (2,4-dibromophenoxy)acetate; Me (2,4-dimethylphenoxy) acetate; (2-methylphenoxy)acetyl chloride; Ph (4-chlorophenoxy)acetate; Ph (2,4-dichlorophenoxy)acetate; α-(2-propyl-4-chlorophenoxy)acetamide; α-(2,4,5-trichlorophenoxy) acetanilide; (2,4,5-trichlorophenoxy)acetonitrile; N-(2,4,5-trichlorophenoxyacetyl) bis[tris(hydroxymethyl) methylaminomethyl] carbinol hydrochloride. The following, as Group III, are compounds possessing 30-49% of the activity of I in Test A: 4-aminoazobenzene; 2-(amylamino)ethyl diphenylacetate-HCl; (2-amyl-4-chlorophenoxy)acetic acid; isoamyl (2,4-dimethylphenoxy)acetate; 2-bromoethyl (4-chlorophenoxy)acetate; (2-bromophenyl)sulfamic acid; butylamine mercuric chloride; Bu (3-methylphenoxy)acetate; cacotheline; 1-(4-carboxyphenyl-3-(3-chlorophenyl)urea; chloroacetamide; 4-chlorobenzoyl chloride; (4-chlorophenoxy)acetonitrile; 1-(4-chlorophenoxy)-2,3-epoxypropane; (4-chlorophenyl)acetic acid; N-(4-chlorophenyl)glycine; S-(4-chlorophenyl)thioglycolyl chloride; N-butyl-S-(4-chlorophenyl)thioglycolamide; [2-(cyanomethyl)-4-chlorophenoxy] acetic acid; NH4 N,N-(cyclopentamethylene)dithiocarbamate; 3,5-dibromo-2-aminobenzoic acid; 2,5-dichloroaniline mercuric chloride salt; (2,4-dichloro-5-aminophenoxy)-acetic acid; 2,4-dichlorocinnamic acid; α-(2,4-dichloro-6-methylphenoxy) acetamide; (2,4-dichloro-5-nitrophenoxy)acetic acid; (2,4-dichlorophenoxy)-N,N-bis(2-hydroxyethyl)acetamide; S-(2,5-dichlorophenyl)thioglycolic acid; 1,1-bis(1-hydroxy-2,2,2-trichloroethyl)urea; 3,4-dimethylphenol; (2,4-dimethylphenoxy)acetic acid; 3,4-isomer; (2,4-dimethylphenoxy)acetyl chloride; S-(2,4-dinitrophenyl)thioglycolic acid; N,N-bis [tris(hydroxymethyl)methyl]ethylenediamine-di-HCl; Et [2-(chloromethyl)-4-chlorophenoxy]acetate; (2-ethyl-4-chlorophenoxy)acetic acid; Et S-(4-chlorophenyl)thioglycolate; 2-hydroxy-3-carboxy-5-chlorotoluene; 4-hydroxy-3,5-dibromobenzoic acid; 2-hydroxyethyl 2,4-dichlorophenyl ether; N4-(iodoacetyl)sulfanilamide; 2-methyl-2-butylaminopropyl 4-(hexyloxy)benzoate-HCl; (2-methyl-4-chloro-6-carboxyphenoxy)acetic acid; Me(2-chlorophenoxy)acetate; 1-(2-methyl-4-chlorophenoxy)-2,3-epoxypropane; Me (2,4-dichlorophenoxy)acetate; (2-methylphenoxy)acetic acid; 4-nitrobenzoyl chloride; octyl dihydrogen orthophosphate; 2-isopropylaminoethyl 2-butoxybenzoate-HCl; Pr (2-methyl-4-chlorophenoxy)acetate; iso-Pr phenylcarbamate; Ba 3-pyridinesulfonate; sulfamerazine; 2,3,5-tribromobenzoic acid; 2,3,5-trichlorobenzoic acid; (2,2,2-trichloro-1-hydroxyethyl)urea; (2,4,6-trichlorophenoxy)acetic acid; (2,4,5-trichlorophenoxy)-2-nitroacetanilide; 2,4,6-trichlorophenyl phenylcarbamate; S-(2,4,5-trichlorophenyl)thioglycolamide; 1-[3-(trifluoromethyl)phenoxy]-2,3-epoxypropane; NH4 2,3,5-triiodobenzoate; N-[tris(hydroxymethyl)methyl]-N-{2-hydroxy-3-[tris(hydroxymethyl)methylamino]propyl}-α-(4-chlorophenoxy)acetamide-HCl. The following, as Group IV-A, are compounds showing less than 29% of the activity of I in Test A and 50% or more of the activity of I in either Test B or Test C: α-amino-β-(2,4-dichlorophenoxy)propionamide; α-amino-β-(3-nitro-4-hydroxyphenyl)propionic acid nitrate salt; aminotetrazole; aniline; (benzylsulfonyl)acetic acid; 5-bromo-2-nitrobenzoic acid; 2-bromo-3-nitrobenzoic acid; NH4 2-bromo-3-nitrobenzoate; β-bromopropionic acid; 2-butylaminoethyl 4-butoxybenzoate-HCl; 2-isobutylaminoethyl 4-butoxybenzoate-HCl; 2-butylaminoethyl 4-ethoxybenzoate-HCl; 2-butylaminoethyl 4-methoxybenzoate-HCl; camphor oxime; N4-(carbo-2-chloroethoxy)sulfanilamide; (2-carbomethoxy-4-chlorophenoxy)acetic acid; (2-carboxy-4-chlorophenoxy)acetic acid; (2-carboxy-6-methylphenoxy)acetic acid; (2-carboxyphenoxy)acetic acid; [2-(carboxymethoxy)-3,5-dichlorobenzoyl]glycolic acid; chloroacetic acid; 2-chloroaniline; 3-chloroaniline; 4-chloroaniline; 4-chlorobenzyl mercaptan; 4-chlorobenzenesulfonyl chloride; 4-chlorobenzylisothiourea-HCl; 4-chloromandelic acid; (2-chloro-4-methylphenoxy)acetic acid; 2-chloro-3-nitrobenzoic acid; 2-chloro-5-nitrobenzoic acid; (2-chlorophenoxy)acetic acid; [2-(2-chlorophenyl)phenoxy]acetic acid; 4-chlorothiophenol; diazoaminobenzene; 2,4-dibromophenol; dichloroacetic acid; 2,4-dichloroaniline; 2,5-dichloroaniline; (2,4-dichlorobenzylsulfonyl)acetic acid; 2,4-dichlorobenzoic acid; 2,4-dichlorobenzylisothiourea-HCl; (2,4-dichloro-6-carboxyphenoxy)acetic acid; (2,6-dichloro-4-nitrophenoxy)acetic acid; 2,4-dichlorophenyl phenylcarbamate; (2,5-dichlorophenyl)sulfamic acid; 2,4-dihydroxypyrimidine; 2,4-dimethylphenol; (2,4-dinitrophenyl)acetic acid; N,N’-bis[tris(hydroxymethyl)methyl] hexamethylenediamine-di-HCl; 3-ethoxy-2-naphthoic acid; 2-ethylaminobutyl 4-ethoxybenzoate-HCl; Et carbamate; Et β-methyl-β-(4-chlorophenyl)glycidate; 3-ethyl-4-methylpyridine; Et (2-propyl-4-chlorophenoxy)acetate; (2-fluorophenoxy)acetic acid; 2-hydroxy-3-bromo-5-chlorobenzoic acid; 2-hydroxy-3-methyl-5-nitrobenzoic acid; N-(2-hydroxy-3-chloropropyl)-p-toluidine; 2-hydroxy-3,5-dinitrobenzoic acid; 4-iodobenzoic acid; 2-methoxyphenol; 4-methoxyphenol; 2-methyl-2-amylaminopropyl diphenylacetate-HCl; 2-methyl-5-chlorophenol; 2-methyl-6-chlorophenol; (2-methyl-4-chlorophenoxy)fumaric acid; Me 3-chlorophenylcarbamate; 2-methyl-4,6-dichlorophenol; 2-methyl-2-hexylaminopropyl 4-ethoxybenzoate-HCl; Me (2-methyl-6-chlorophenoxy)acetate; (4-methylphenoxy)acetic acid; Me phenylthiocarbamate; S-(2-methylphenyl)thioglycolic acid; 4-methyl-4-(trichloromethyl)-2,5-cyclohexadien-1-one O-carboxymethyloxime; 2-nitrobutyl phenylcarbamate; 1-phenyl-3-methyl-5-pyrazole; phthalic acid; α-pinene; 2-isopropylaminoethyl 4-butoxybenzoate-HCl; (2-propyl-4-chlorophenoxy)acetic acid; iso-Pr (2,4-dimethylphenoxy)acetate; iso-Pr (2-methyl-6-chlorophenoxy)acetate; 3-propyl-2-naphthoic acid; iso-Pr (2-propyl-4-chlorophenoxyacetate); trichloroacetamide; trichloroacetic acid; trichloroacetyl chloride; 2,4,5-trichlorobenzenesulfonamide; 3,4,5-trihydroxybenzoic acid; N-[tris(hydroxymethyl)methyl]-2,3-dibromopropylamine-HBr; salicylic acid. The following, as Group IV-B, are compounds insufficiently soluble in water for Test A to be performed but exhibiting 50% or more of the activity of I in either Test B or Test C: allyl (4-chlorophenoxy)acetate; allyl (2,4-dichlorophenoxy)acetate; 2-aminonaphthoic acid; amyl (2,4-dichlorophenoxy)acetate; isoamyl (2,4-dichlorophenoxy)acetate; amyl 1-naphthalenecarbamate; bis-(4-chlorophenyl)(trichloromethyl)methane; 1,1′-(bis-2-naphthol)phenylmethane; 2-bromo-3,5-dichlorobenzamide; 2-bromo-3,5-dichlorobenzanilide; 2,2′-dibromo-3,5-dichlorobenzanilide; 2,3′-dibromo-3,5-dichlorobenzanilide; 2,4′-dibromo-3,5-dichlorobenzanilide; 2-bromo-3,3′,5-trichlorobenzanilide; 2-bromo-2′,3,4′,5-tetrachlorobenzanilide; 2-bromo-3,5-dichloro-m-benzotoluidide; 2-bromo-3,5-dichlorobenzoyl chloride; 2-bromoethyl (2,4-dibromophenoxy) acetate; 2-bromoethyl (2,4-dichlorophenoxy) acetate; α-(4-bromophenoxy)acetamide; 1-(3-bromophenyl)-3-(2-chlorophenyl)urea; 1-(3-bromophenyl)-3-(3-chlorophenyl)urea; Bu (2,4-dichlorophenoxy)acetate; iso-Bu (2,4-dichlorophenoxy)acetate; 1-carbethoxy-3-(3-chlorophenyl)urea; 2-chloroethyl (4-chlorophenoxy)acetate; 2-chloroethyl (2,4-dibromophenoxy)acetate; 2-chloroethyl (2,4-dichlorophenoxy)acetate; 2-chloroethyl (2-methyl-4-chlorophenoxy)acetate; 2-chloroethyl 1-naphthalenecarbamate; 2-chloroethyl phenylcarbamate; α-(4-chlorophenoxy)-p-acetanisidide; α-(4-chlorophenoxy)-2-bromoacetanilide; α-(4-chlorophenoxy)-3-bromoacetanilide; α-(4-chlorophenoxy)-4-bromoacetanilide; α-(4-chlorophenoxy)-2-chloroacetanilide; α-(4-chlorophenoxy)-3-chloroacetanilide; α-(4-chlorophenoxy)-2,4-dimethylacetanilide; α-(4-chlorophenoxy)-4-ethoxyacetanilide; 1-(4-chlorophenoxyacetyl)-2-phenylhydrazine; α-(4-chlorophenoxy)-4-iodoacetanilide; α-(4-chlorophenoxy)-3-nitroacetanilide; α-(4-chlorophenoxy)-p-acetotoluidide; α-(4-chlorophenoxy)-N-p-xenylacetamide; γ-(4-chlorophenoxy)butyronitrile; 4-chlorophenyl (4-chlorophenoxy)acetate; 1-(4-chlorophenyl)-3-(2-chlorophenyl) urea; 4-chlorophenyl (2,4-dichlorophenoxy)acetate; 1-(3-chlorophenyl)-3,3-(cyclopentamethylene)urea; 1-(3-chlorophenyl-3-phenylurea; S-(4-chlorophenyl)-2-bromothioglycolanilide; S-(4-chlorophenyl)-3-bromothioglycolanilide; 4-chlorophenyl (2,4,5-trichlorophenoxy)acetate; 2,6-dibromobenzoquinone-4-chloroimide; 2,4-dichlorobenzylsulfonyl chloride; 1,3-bis(4-chlorophenoxyacetamido)benzene; 1,4-isomer; 4,4′-bis(4-chlorophenoxyacetamido)biphenyl; 2,4-bis(4-chlorophenoxyacetamido)toluene; α-(2,4-dichlorophenoxy)acetanilide; α-(2,4-dichlorophenoxy)-N-(2-aminoethyl)acetamide; α-(2,4-dichlorophenoxy)-p-acetanisidide; α-(2,4-dichlorophenoxy-2,5-dichloroacetanilide; α-(2,4-dichlorophenoxy)-2,4-dimethylacetanilide; 1-(2,4-dichlorophenoxyacetyl)-2-(2,4-dinitrophenyl)hydrazine; (2,4-dichlorophenoxy)acetic hydrazide; α-(2,4-dichlorophenoxy)aceto-2-naphthalide; α-(2,4-dichlorophenoxy)-p-acetotoluidide; α-(2,4-dichlorophenoxy)-N-o-xenylacetamide; 4-(2,4-dichlorophenoxyacetamido)azobenzene; (2,4-dichlorophenoxy)acetylaminoguanidine; (2,4-dichlorophenoxy)acetyl bromide; α-(2,4-dichlorophenoxy)-N-(hydroxy-tert-butyl)acetamide; S-(2,4-dichlorophenoxyacetyl)isothiourea; 1-(2,4-dichlorophenoxyacetyl)-2-methyl-2-thioisourea; γ-(2,4-dichlorophenoxy)butyric acid; γ,-(2,4-dichlorophenoxy)butyronitrile; 2,4-dichlorophenyl (4-chlorophenoxy)acetate; 2,4-dichlorophenyl (2,4-dichlorophenoxy)acetate; 1-(2,5-dichlorophenyl)-3-phenylurea; S-(2,5-dichlorophenyl)thioglycolamide; 4,4′-bis(2,4-dichlorophenoxyacetamido)biphenyl; 1,4-bis (2,4-dimethylphenoxyacetamido)benzene; 2,4-bis(2,4-dimethylphenoxyacetamido)toluene; 2,4-dichlorophenyl (2,4,5-trichlorophenoxy)acetate; 2,4-dichlorophenyl (4-chlorophenoxy)acetate; 2,3-dichloropropyl (2,4-dibromophenoxy)acetate; 2,3-dichloropropyl (2,4-dichlorophenoxy)acetate; 2-diethylaminoethyl 2,3,5-triiodobenzoate; 3,3′-dimethyl-4,4′-bis(4-chlorophenoxyacetamido)biphenyl; 3,3′-dimethyl-4,4′-bis(2-methylphenoxyacetamido)biphenyl; 1,3-bis(2-methylphenoxyacetamido)benzene; 1,4-isomer; 4,4′-bis(2-methylphenoxyacetamido)biphenyl; 4,4′-bis(2,4-dimethylphenoxyacetamido)biphenyl; 1-(4-ethoxyphenyl)-3-phenylurea; Et 2-bromo-3,5-dichlorobenzoate; Et (4-bromophenoxy)acetate; Et (4-chlorophenoxy)acetate; 2-ethylhexyl (2,4-dichlorophenoxy)acetate; methallyl (4-chlorophenoxy)acetate; 2-methoxy-4-methylphenyl 1-naphthalenecarbamate; Me 2-bromo-3-nitrobenzoate; 4-(2-methyl-4-chlorophenoxyacetamido)azobenzene; α-(2-methyl-6-chlorophenoxy)-2,5-dichloroacetanilide; 2-methyl-4-chlorophenyl (2,4-dichlorophenoxy)acetate; 1-methyl-2,4-bis(2,4-dichlorophenoxyacetamido)benzene; Me 4-nitrophenylcarbamate; Me (2,4,5-trichlorophenoxy)acetate; (2-hydroxy-1-naphthyl)-1-piperidylphenylmethane; 2-nitrobutyl (2,4,5-trichlorophenoxy)acetate; 4-nitro-N,N-dimethylaniline; octyl (2,4-dichlorophenoxy)acetate; pentachlorophenyl (2,4,5-trichlorophenoxy)acetate; 1-phenyl-3,3-cyclopentamethyleneurea; Ph phenylcarbamate; Ph (2,4,5-trichlorophenoxy)acetate; iso-Pr (2,4-dichlorophenoxy)acetate; 3-isopropoxy-2-naphthoic acid; 1,3-di-m-tolyl-urea; (2,4,5-tribromo-3,5-dimethylphenoxy)acetic acid; 2,4,6-tribromophenyl acetate; 2,4,5-trichlorobenzamide; trichloroethyl (2,4-dibromophenoxy)acetate; 2,2,2-trichloroethyl (2,4-dichlorophenoxy)acetate; 2,4,5-trichlorophenoxyacetic acid; 2-(2,4,5-trichlorophenoxyacetamido)anthraquinone; α-(2,4,5-trichlorophenoxy)-4-bromoacetanilide; α-(2,4,5-trichlorophenoxy)-4-methoxyacetanilide; (2,4,5-trichlorophenoxy)aceto-2-naphthalide; α-(2,4,6-trichlorophenoxy)-4-sulfoacetonaphthalide; α-(2,4,5-trichlorophenoxy)-m-acetotoluidide; (2,4,5-trichlorophenoxy)acetyl chloride; 1-(2,4,5-trichlorophenoxyacetyl)-2-(p-nitrophenyl)hydrazine; 2,4,6-trichlorophenyl (4-chlorophenoxy)acetate; 2,4,6-trichlorophenyl (2,4-dichlorophenoxy)acetate; 2,4,6-trichlorophenyl (2,4,5-trichlorophenoxy)acetate; N-[3-(trifluoromethyl)phenyl]-α-(4-chlorophenoxy)acetamide; N-[3-(trifluoromethyl)phenyl]-α-(2,4,5-trichlorophenoxy)acetamide; 2,3,5-triiodobenzoic acid; 2,3,5-triiodobenzoyl chloride; 1-[tris(hydroxymethyl)methylamino]-2,4-dinitrobenzene; N-(p-xenyl)-α-(2,4-dichlorophenoxy)acetamide. The following, as Group IV-C, were also examined by the three tests and showed relatively low activity as compared with I: 2-acetoxyethyl 1-naphthalenecarbamate; 2-acetoxyethyl phenylcarbamate; (2-acetyl-4-chlorophenoxy)acetic acid; (2-allyl-4-chlorophenoxy)acetic acid; allyl 1-naphthalenecarbamate; allyl phenylcarbamate; allyl 4-tolyl sulfone; 1-aminoanthraquinone; 2-isomer; 4-aminobenzyl tris(hydroxymethyl)methylamine-di-HCl; 2-amino-3,5-dichlorobenzoic acid; 2-aminoethylsulfuric acid; 8-amino-1-naphthol-3,6-disulfonic acid; 1-amino-2-naphthol-4-sulfonic acid; 4-aminophenol; (2-aminophenoxy)acetic acid; (4-aminophenyl)acetic acid; 2-aminopyridine; 2-aminothiazole; 2-amylaminoethyl 4-butoxybenzoate-HCl; isoamyl formate; amyl (2-methylphenoxy)acetate; isoamyl 1-naphthalenecarbamate; 4-tert-amylphenol; amyl phenylcarbamate; isoamyl phenylcarbamate; (4-arsonophenoxy)acetic acid; benzoic acid; 4-benzylaminophenol-HCl; benzyl Bu sulfone; allyl (benzylsulfonyl)acetate; Me (benzylsulfonyl)acetate; N-benzyl-N,N’-bis[tris(hydroxymethyl)methyl]-2-hydroxy-1,3-diaminopropane; benzyl Et sulfone; benzyl Me sulfone; benzyl 4-tolyl sulfone; benzyl[tris(hydroxymethyl)methyl]amine; 1,3-bis{ [tris(hydroxymethyl)methyl]amino}-2-propanol-HCl; 2-bromobenzamide; 2-bromobenzanilide; 2-bromo-2′,4′-dichlorobenzanilide; 2-bromobenzoic acid; 3-isomer; NH4 4-bromobenzoate; 4-bromobenzonitrile; (2-bromo-4-tert-butylphenoxy)acetic acid; 2-bromo-3,5-dichloro-N-butylbenzamide; 2-bromo-3,4′,5-trichlorobenzanilide; 2-bromoethylamine; 2-bromoethyl 4-ethoxythiolbenzoate; 2-bromoethyl (2-methyl-4-chlorophenoxy)acetate; 2-bromo-4-nitrobenzoic acid; 2-bromo-5-nitrobenzoic acid; NH4 2-bromo-5-nitrobenzoate; 3-bromo-4-nitrobenzoic acid; 3-bromo-5-nitrobenzoic acid; 4-bromophenol; (2-bromophenoxy)acetic acid; α-(4-bromophenoxy)-4-bromoacetanilide; α-(4-bromophenoxy)-4-chloroacetanilide; α-(4-bromophenoxy)-2,5-dichloroacetanilide; 3-bromophenylammonium fluoroborate; 4-bromophenylammonium fluoroborate; 1-(2-bromophenyl)-3-(2-chlorophenyl)urea; 1-(4-bromophenyl)-3-(3-chlorophenyl)urea; 1-(2-bromophenyl)-3-(3-chlorophenyl)urea; N-(4-bromophenyl)-3-(2-chlorophenyl)urea; NH4 (4-bromophenyl)dithiocarbamate; 4-bromophenyl 1-naphthalenecarbamate; (2-bromo-4-phenylphenoxy)acetic acid; 4-bromophenyl phenylcarbamate; 1-(2-bromophenyl)-3-phenylurea; 1-(3-bromophenyl)-3-phenylurea; 1-(4-bromophenyl)-3-phenylurea; 3-bromophenylsulfamic acid; N-(3-bromophenyl) α,α,α-trichloroacetamide; 2-butylaminoethyl 2-butoxybenzoate-HCl; 2-butylaminoethyl diphenylacetate-HCl; 2-butylaminoethyl 4-(heptyloxy)benzoate-HCl; 2-butylaminoethyl 4-propoxybenzoate-HCl; 2-butylaminoethyl 2-(thiobutoxy)benzoate; (2-sec-butyl-4-chlorophenoxy)acetic acid; Hg butyldithiocarbamate; Bu 1-naphthalenecarbamate; iso-Bu 1-naphthalenecarbamate; 4-tert-butylphenol; Bu phenylcarbamate; iso-Bu phenylcarbamate; tert-Bu phenylcarbamate; 1-butyl-3-phenylthiourea; N-butyl-α-(2,4,5-trichlorophenoxy)acetamide; 4-carbethoxy-6-methoxyquinoline; 1-carbethoxy-3-phenylurea; 1-carbobutoxyethyl 1-naphthalenecarbamate; 1-carboisopropoxyethyl 1-naphthalenecarbamate; O-(2-carboxymethoxybenzoyl)glycolic acid; O-(2-carboxymethoxy-3-methyl-5-chlorobenzoyl)glycolic acid; NH4 (carboxymethyl)dithiocarbamate; Na (4-carboxymethylphenyl)dithiocarbamate; 2-carboxy-6-methylphenyl phenylcarbamate; NH4 (4-carboxyphenyl)dithiocarbamate; 4-carboxyphenylglycine; o-carboxyphenyl 1-naphthalenecarbamate; 1-(4-carboxyphenyl)-3-(1-naphthyl)urea; 4-carboxyphenyl phenylcarbamate; S-(4-carboxyphenyl)thioglycolic acid; N4-(β-carboxypropionyl)sulfanilamide; pyrocatechol; chloroacetyl chloride; 4-chloroanisole; 2-chlorobenzaldehyde O-carboxymethyloxime; 2-chlorobenzaldehyde oxime; 4-chlorobenzamide; 4-chlorobenzenesulfonamide; 4-chlorobenzoic acid; bis(4-chlorobenzyl)disulfide; S-(4-chlorobenzyl)thioglycolic acid; bis(4-chlorobenzyl)sulfide; (4-chlorobenzylsulfonyl)acetic acid; 4-chlorocinnamic acid; highly chlorinated 1,5-dihydroxynaphthalene; 2-chloroethyl (2-propyl-4-chlorophenoxy)acetate; chlorohydroquinone; chlorohydroquinone-O,O-diacetic acid; 4-(chloromercuri)phenol; [4-(chloromercuri)phenoxy]acetic acid; [2-(chloromethyl)-4-chlorophenoxy]acetic acid; 2-chloro-4-methyl-6-methoxyquinoline; 2-chloro-4-methylquinoline; (7-chloro-1-naphthoxy)acetic acid; 1-chloronaphthylacetic acid mixture; 4-chlorophenetole; 1-(4-chlorophenoxyacetamido)naphthalene; 2-(4-chlorophenoxyacetamido)naphthalene; α-(4-chlorophenoxy)-2,5-dichloroacetanilide; α-(4-chlorophenoxy)-N,N-diethyl-acetamide; (4-chlorophenoxy)acetic piperidide; α-(4-chlorophenoxy)-2-nitroacetanilide; α-(4-chlorophenoxy)-2,4,6-trichloroacetanilide; (4-chlorophenoxy)(4-chlorophenyl)acetic acid; (4-chlorophenoxy)fumaric acid; 2-(4-chlorophenoxy)heptanoic acid; β-(4-chlorophenoxy)propionic acid; β-(4-chlorophenoxy)propionitrile; 4-chlorophenylammonium fluoroborate; 1-(2-chlorophenyl)-3-butylurea; 1-(3-chlorophenyl)-3-butylurea; 1-(2-chlorophenyl)-1-(4-carboxyphenyl)urea; N-(3-chlorophenyl)-α-chloroacetamide; 4-isomer; 1-(3-chlorophenyl)-3-(2-chlorophenyl) urea; 1-(4-chlorophenyl)-3-(3-chlorophenyl) urea; 3-(2-chlorophenyl)-1,1-cyclopentamethyleneurea; NH4 (4-chlorophenyl)dithiocarbamate; 2-chloro-1,4-phenylene bis(phenylcarbamate); N-(2-chlorophenyl)glycine; 1-(2-chlorophenyl)-3-(2-hydroxyethyl) urea; 3-chloro isomer; 3-chlorophenyl isocyanate; 1-(2-chlorophenyl)-3-(1-naphthyl) urea; 4-isomer; [2-(4-chlorophenyl)phenoxy]acetic acid; 1-(2-chlorophenyl)-3-phenylurea; 4-chloro isomer; 1-(2-chlorophenyl)-3-phenylthiourea; 3-isomer; 4-isomer; Na (3-chlorophenyl)sulfamate; (4-chlorophenyl)sulfamic acid; S-(2-chlorophenyl)thioglycolic acid; S-(4-chlorophenyl)thioglycolamide; S-(4-chlorophenyl)thioglycolanilide; S-(4-chlorophenyl)-4′-bromothioglycolanilide; S-(4-chlorophenyl)thioglycol-p-phenetidide; S-(4-chlorophenyl)thioglycol-m-toluidine; 1-(2-chlorophenyl)urea; 3-isomer; 1,3-bis(2-chlorophenyl)urea; 3-isomer; cinnamic acid; cinnamoyl chloride; o-cresol; m-isomer; p-isomer; 4-toloxyacetyl chloride; cyanoacetamide; (2-cyclohexyl-4-chlorophenoxy)acetic acid; (decyl-mercapto)acetic acid; (decylsulfonyl)acetic acid; bis(2-acetoxyethyl) sulfone; 2,6-diaminopyridine monohydrochloride; 2,6-dibromo-4-carboxyphenyl phenylcarbamate; α,β-dibromodihydrocinnamic acid; 4,6-dibromo-1,3-dihydroxybenzene; (2,6-dibromo-4-methylphenoxy)acetic acid; 2,4-dibromophenyl phenylcarbamate; α, β-dibromo-γ-phenylpropionamide; bis(2-butyroxyethyl) sulfone; 2,5-dichloro-4-aminobenzenesulfonic acid; 2,4-dichloroanisole; 2,6-dichlorobenzenoneindophenol sodium salt; 2,5-dichlorobenzenesulfonamide; 2,5-dichlorobenzenesulfonyl chloride; (2,4-dichlorobenzylmercapto)acetic acid; bis(2,4-dichlorobenzyl)disulfide; 2,4-dichlorobenzyl mercaptan; bis(2,4-dichlorobenzyl)sulfide; bis(2,4-dichlorobenzyl)sulfone; 5,7-dichloro-3-coumaranone; N,2,4-trichloroacetanilide; 2,6-dichloro-3-ethyl-4-methylpyridine; 2,4-dichloromandelic acid; 2,6-dichloro-4-methyl-5-ethylnicotinamide; (2,6-dichloro-4-methylphenoxy)acetic acid; (2,4-dichloro-6-methylphenoxy)acetyl chloride; (2,4-dichloro-1-naphthoxy)acetic acid; 2,4-dichlorophenetole; 2,4-dichlorophenol; 1-(2,4-dichlorophenoxyacetamido)anthraquinone; 2-(2,4-dichlorophenoxyacetamido)anthraquinone; (2,6-dichlorophenoxy)acetic acid; 3,5-isomer; α-(2,4-dichlorophenoxy)-4-bromoanilide; α-(2,4-dichlorophenoxy)-4-chloroacetanilide; α-(2,4-dichlorophenoxy)-p-acetophenetide; α-(2,4-dichlorophenoxy)-N-(2-hydroxyethyl)acetamide; 2,4-dichlorophenoxyaceto-1-naphthalide; α-(2,4-dichlorophenoxy)-2-nitroacetanilide; α-(2,4-dichlorophenoxy)-3-nitroacetanilide; 1-(2,4-dichlorophenoxyacetyl)-2-(p-nitrophenyl)hydrazine; α-(2,4-dichlorophenoxy)-N-2′-pyridylacetamide; α-(2,4-dichlorophenoxy)-2,4,6-trichloroacetanilide; 2-(2,4-dichlorophenoxyacetamido)-6,8-naphthalenedisulfonic acid; 1-(2,4-dichlorophenoxyacetyl)-1-phenylsemicarbazide; (2,4-dichlorophenoxy)(p-chlorophenyl)acetic acid; 1-(2,4-dichlorophenoxy)-2,3-epoxypropane; (2,4-dichlorophenoxy) fumaric acid; Addnl. information in printed abstract

Botanical Gazette (Chicago) published new progress about Hormones, plant Role: BIOL (Biological Study). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Product Details of C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shi, Yusheng; Zhang, Tiexin; Jiang, Xiao-Ming; Xu, Gang; He, Cheng; Duan, Chunying published the artcile< Synergistic photoredox and copper catalysis by diode-like coordination polymer with twisted and polar copper-dye conjugation>, HPLC of Formula: 16426-64-5, the main research area is copper catalysis diode coordination polymer polar dye conjugation.

Synergistic photoredox and copper catalysis confers new synthetic possibilities in the pharmaceutical field, but is seriously affected by the consumptive fluorescence quenching of Cu(II). By decorating bulky auxiliaries into a photoreductive triphenylamine-based ligand to twist the conjugation between the triphenylamine-based ligand and the polar Cu(II)-carboxylate node in the coordination polymer, we report a heterogeneous approach to directly confront this inherent problem. The twisted and polar Cu(II)-dye conjunction endows the coordination polymer with diode-like photoelectronic behaviors, which hampers the inter- and intramol. photoinduced electron transfer from the triphenylamine-moiety to the Cu(II) site and permits reversed-directional ground-state electronic conductivity, rectifying the productive loop circuit for synergising photoredox and copper catalysis in pharmaceutically valuable decarboxylative C(sp3)-heteroatom couplings. The well-retained Cu(II) sites during photoirradiation exhibit unique inner-spheric modulation effects, which endow the couplings with adaptability to different types of nucleophiles and radical precursors under concise reaction conditions, and distinguish the multi-olefinic moieties of biointeresting steride derivatives in their late-stage trifluoromethylation-chloration difunctionalisation.

Nature Communications published new progress about Absorption. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, HPLC of Formula: 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bolchi, Cristiano; Pallavicini, Marco; Rusconi, Chiara; Diomede, Luisa; Ferri, Nicola; Corsini, Alberto; Fumagalli, Laura; Pedretti, Alessandro; Vistoli, Giulio; Valoti, Ermanno published the artcile< Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency>, Safety of 2-Bromo-4-nitrobenzoic acid, the main research area is peptidomimetic inhibitor farnesyltransferase antiproliferative aorta smooth muscle atherosclerosis.

2-O-Tolyl or 2-o-anisyl substituted 4-hydroxy- and 4-carboxybenzamides of methionine, etherified and amidified with 2-hydroxymethyl- and 2-aminomethylpyridodioxane, resp., are described as inhibitors of Ras protein farnesyltransferase (FTase). Of the sixteen compounds, resulting from the substitution pattern of benzamide and the configuration of the two stereocenters, seven inhibited FTase activity with potencies in the nanomolar range. They were all 2-oxymethylpyridodioxane ethers and, among them, the four o-tolyl substituted stereoisomers also showed micromolar antiproliferative effect on human aortic smooth muscle cells interfering with Ras farnesylation. The docking anal. enlightened significant differences in enzyme interaction between oxymethylpyridodioxane and aminomethylpyridodioxane derivatives

Bioorganic & Medicinal Chemistry Letters published new progress about Antiatherosclerotics. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Safety of 2-Bromo-4-nitrobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary