Miura, Shotaro published the artcileRapid and efficient synthesis of a novel cholinergic muscarinic M1 receptor positive allosteric modulator using flash chemistry, Product Details of C7H7BrFN, the publication is Organic & Biomolecular Chemistry (2019), 17(35), 8166-8174, database is CAplus and MEDLINE.
Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative as a key intermediate of a novel cholinergic muscarinic M1 pos. allosteric modulator I bearing an isoindolin-1-one ring system as a pharmacophore was achieved using flow microreactors through selective I/Li exchange of 1-bromo-2-iodobenzene derivative with BuLi and subsequent formylation at -40° of the highly reactive 2-bromophenyllithium intermediate using DMF, which was difficult to achieve by a conventional batch process due to the conversion of the highly reactive 2-bromophenyllithium intermediate into benzyne even at -78°. Late-stage cyclization gave the isoindolin-1-one ring system, through reductive amination of 2-bromobenzaldehyde derivative followed by palladium-catalyzed carbonylation with carbon monoxide and intramol. cyclization, efficiently afforded I for its further research and development.
Organic & Biomolecular Chemistry published new progress about 1540204-53-2. 1540204-53-2 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Amine,Benzene, name is 4-Bromo-2-fluoro-3-methylaniline, and the molecular formula is C7H7BrFN, Product Details of C7H7BrFN.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary