Category: 15155-41-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 15155-41-6, name is 4,7-Dibromo-2,1,3-benzothiadiazole, A new synthetic method of this compound is introduced below., Safety of 4,7-Dibromo-2,1,3-benzothiadiazole

After inserting the round bottom flask the compound 1-a (5.0 g), 90 mL ethanol, 30 mL THF and then the insert, respectively, are injected to NaBH4 (3.2 g). After that, if the amount of catalyst injected CoCl2-6H2O, there is changed to black solution and the reaction was performed for 3 hours. After ether to complete the reaction, 50 mL and through the H2O 50 mL, if the solvent, extract the product through ether and aqueous NaCl solution is created, a yellow solid, when the recrystallization through the MC and hexane, a yellow solid product 3, to give the 6-dibromobenzene-1,2-diamine (compound a-2). (Yield: 78%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Pusan National University Industry-Academic Cooperation Foundation; Hwang, Do Hun; Kim, Ji Hun; Kim, Hee Woon; Im, Jong Min; (52 pag.)KR101495152; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 15155-41-6,Some common heterocyclic compound, 15155-41-6, name is 4,7-Dibromo-2,1,3-benzothiadiazole, molecular formula is C6H2Br2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 500 ml three-necked flask equipped with a refluxing condenser, 10.0 g (FW: 293.96; 34 mmole) of 4,7-dibromobenzothiadiazole and 400 ml of ethanol as the solvent were placed. Under cooling with ice, 24.2 g (FW: 37.83; 640 mmole) of sodium borohydride was added, and the resultant mixture was sufficiently stirred for about 2 hours. When generation of a gas (hydrogen sulfide) was not observed any more, the temperature was adjusted at the room temperature, and the reaction mixture was left standing for one night (about 14 hours). Then, the solvent was completely removed under a reduced pressure, and about 400 ml of water was added to dissolve the residue. The resultant solution was left standing for one night, and the object product was recrystallized (7.17 g). The obtained product was treated by extraction with ethyl ether three times, washed with a saturated aqueous solution of sodium chloride, dried with anhydrous sodium sulfate and filtered. After diethyl ether was removed by distillation, 0.88 g of the object compound (3,6-dibromo-1,2-diaminobenzene) was obtained. The overall yield was 82%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-2,1,3-benzothiadiazole, its application will become more common.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1749823; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 15155-41-6, A common heterocyclic compound, 15155-41-6, name is 4,7-Dibromo-2,1,3-benzothiadiazole, molecular formula is C6H2Br2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In two 250mL flask, followed by adding ethanol 150ml, 2,5- dibromo benzothiadiazole (5. 88g, 20mmol), the flask was placed in an ice-water bath, sodium borohydride was slowly added repeatedly (1. 52g, 40mmol after), 0 C reaction lOmin, room temperature, the reaction 3h, the reaction was completed. After rotary evaporation to dryness in vacuo purified by column chromatography, petroleum ether: dichloromethane = 1: 1 to giveOff-white product 5. 05g (95% yield).

The synthetic route of 15155-41-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NanjingFriend Photoelectric Technology Co., Ltd; MENG, HONG; ZHANG, XIAOTAO; YUAN, XIAO; YAN, LIJIA; (10 pag.)CN103450226; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 15155-41-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15155-41-6, name is 4,7-Dibromo-2,1,3-benzothiadiazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The reaction carried out by taking the suspension of compound 1 (2g, 6.8 mmol) in 25 mL absolute ethanol kept at 0 C, sodium borohydride(0.3 g, 8 mmol) was added by pinch wise and stirred at normaltemperature ffor 1 h. A pinch off cobaltous chloride was added into themixture for the successful finishing of the reaction. Finally, the productwas transferred to crushed ice followed by stirring, the obtained whiteprecipitate was filtered off and washed with deionized water. The resultantwhite residue was dehydrated under vacuum. Compound (2),yield 85%, 1H NMR spectrum (500 MHz, CDCl3) & (ppm) 6.75 (d, 2H).

The synthetic route of 4,7-Dibromo-2,1,3-benzothiadiazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gopi, Vidya; Subbiahraj, Saravanan; Chemmanghattu, Karthika; Ramamurthy, Praveen C.; Dyes and Pigments; vol. 173; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 15155-41-6,Some common heterocyclic compound, 15155-41-6, name is 4,7-Dibromo-2,1,3-benzothiadiazole, molecular formula is C6H2Br2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1000mL 1–neck flask (one neck flask) in 4,7-di-bromo-benzo-1,2,3-thiadiazole (4,7-dibromo-1,2,3-benzothiadiazole) (25g, 85 mmol) , NaBH4 (16g, mmol) and the mixture was placed 500mL of ethanol was stirred at room temperature for 16 hours. When the reaction is complete, remove the solvents by rotary evaporation the drier and extracted with CHCl3. This oil is extractedThe base layer is washed with brine (brine) solution. Thereafter, the dried organic layer was again put on MgSO4 and the solvent removed by evaporation to give a dry objective compound C-1 (19g, 71.4 mmol, 84%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-2,1,3-benzothiadiazole, its application will become more common.

Reference:
Patent; Hee SungMaterial Co., Ltd; Lee, Gyung Uhn; Kim, Sin Tae; Kim, Yeong Woo; Uhm, Sung Jin; Lee, Ju Dong; (54 pag.)KR101612903; (2016); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 15155-41-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15155-41-6 as follows.

Synthesis of 3,6-dibromobenzene-1,2-diamine: Dibromobenzo[c][1,2,5]thiadiazole (2.29 g, 10 mmol) and sodiumborohydride (5.7 g, 150 mmol) were added to ethanol at 0 Cand stirred at room temperature for 36 h. The solution wasadded water and ethyl acetate then was separated by separatoryfunnel. The organic layer was dried over MgSO4 then concentrated under reduced pressure and purified by chromatographyon a silica column eluting with petroleum ether/ethyl acetate(5:1, v/v) to afford a yellow solid (1.9 g, 71 % yield). 1H NMR(400 MHz, CDCl3, ppm) delta-aromatic H, 6.86 (d, 2H), 3.92 (s,4H); 13C NMR (100 MHz, CDCl3, ppm): 133.73,123.27, 109.70.

According to the analysis of related databases, 15155-41-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sun, Xiaoxia; Lei, Xiaolong; Hu, Yu; Asian Journal of Chemistry; vol. 27; 7; (2015); p. 2427 – 2430;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 15155-41-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15155-41-6, name is 4,7-Dibromo-2,1,3-benzothiadiazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4,7-Dibromo-2,1,3-benzothiadiazole (12.204 g, 42.5 mmol) was added to a 500 ml three-neck round bottom flask, dissolved in 400 ml of absolute ethanol, passed through a nitrogen atmosphere, and cooled to 0 C. NaBH4 (15.69 g, 425 mmol) was added portionwise to the solution. After the addition of NaBH4, the reaction mixture was transferred to room temperature overnight. The reaction solution was poured into a beaker, and the solid precipitated in the bottle was completely dissolved by adding 50 ml of water. The large amount of ethanol in the bottle was removed, extracted with dichloromethane and water, and the combined organic phases were washed with water, dried over anhydrous magnesium sulfate and filtered.The filtrate was distilled under reduced pressure to give a pale yellow solid (7.583 g, 28.74 mmol, 67.6%).That is, 3,6-dibromo-1,2-phenylenediamine, the structural formula is:

The synthetic route of 4,7-Dibromo-2,1,3-benzothiadiazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangxi Normal University; Liang Aihui; Zhou Wenjing; Xie Qi; Zhang Jiayu; Liu Zhiqian; Hu Sifan; (26 pag.)CN110204561; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary