Category: 149910-98-5

Application of 149910-98-5,Some common heterocyclic compound, 149910-98-5, name is 7-Bromoisochroman, molecular formula is C9H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4.1. General procedure for the CDC reaction of benzylic ethers with carbonyl compounds To a solution of 1 or 4 (0.25mmol, 1equiv), 2 (1.25 mmol, 5 equiv) and CuBr2 (0.05 mmol, 0.2 equiv) was added Na2S2O8 (0.75 mmol, 3 equiv). Then the mixture was stirred at 80C until the starting material disappeared monitored by TLC. After that, the above mixture was directly purified by flash chromatography (ethyl acetate/petroleum ether as eluent) to give the desired product 3 or 5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Bromoisochroman, its application will become more common.

Reference:
Article; Pan, Xinhui; Hu, Qingwen; Chen, Wenfang; Liu, Xigong; Sun, Bin; Huang, Zhouli; Zeng, Ziyu; Wang, Liguo; Zhao, Dan; Ji, Mei; Liu, Lei; Lou, Hongxiang; Tetrahedron; vol. 70; 21; (2014); p. 3447 – 3451;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 149910-98-5, name is 7-Bromoisochroman, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149910-98-5, Formula: C9H9BrO

Into a 500-mL round-bottom flask, was placed 7-bromoisochroman (8.48 g, 40.0 mmol, 1.0 equiv) in dioxane (200 mL)/water (20 mL). Pd(dppf)Cl2 (5.8 g, 8.0 mmol, 0.2 equiv) and CS2CO3 (26.1 g, 80.0 mmol, 2.0 equiv) (BPin)2 (2.5 eq) were added to the solution. The resulting solution was stirred for 16 hr at 90 degrees C, after which it was concentrated and purified with SiCk-gel column chromatography. This resulted in 4.6 g (44.2%) of 2-(isochroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromoisochroman, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS INFLAMMASOME RESEARCH, INC.; GLICK, Gary; ROUSH, William; VENKATRAMAN, Shankar; SHEN, Dong-Ming; GHOSH, Shomir; SEIDEL, Hans Martin; FRANCHI, Luigi; WINKLER, David Guenther; OPIPARI, Anthony William Jr.; KATZ, Jason; (468 pag.)WO2020/10140; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 149910-98-5, name is 7-Bromoisochroman, A new synthetic method of this compound is introduced below., Computed Properties of C9H9BrO

General procedure: Toa solution of the substituted isochroman (7.46 mmol) derivatives inacetonitrile (15 ml), CuBr2(8.95 mmol)was added under nitrogenatmosphere. The solution was refluxed for about 2hr and then cooled to roomtemperature. The reaction mixture was added water, extracted with ethyl acetate.The combined organic extracts were washed with brine and dried with anhydrousNa2SO4,filtered and concentrated and then purified by silicagel column chromatographyto afford the product 1in 68% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Shinde, Anand H.; Archith; Malipatel, Srilaxmi; Sharada, Duddu S.; Tetrahedron Letters; vol. 55; 50; (2014); p. 6821 – 6826;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 149910-98-5,Some common heterocyclic compound, 149910-98-5, name is 7-Bromoisochroman, molecular formula is C9H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4.1. General procedure for the CDC reaction of benzylic ethers with carbonyl compounds To a solution of 1 or 4 (0.25mmol, 1equiv), 2 (1.25 mmol, 5 equiv) and CuBr2 (0.05 mmol, 0.2 equiv) was added Na2S2O8 (0.75 mmol, 3 equiv). Then the mixture was stirred at 80C until the starting material disappeared monitored by TLC. After that, the above mixture was directly purified by flash chromatography (ethyl acetate/petroleum ether as eluent) to give the desired product 3 or 5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Bromoisochroman, its application will become more common.

Reference:
Article; Pan, Xinhui; Hu, Qingwen; Chen, Wenfang; Liu, Xigong; Sun, Bin; Huang, Zhouli; Zeng, Ziyu; Wang, Liguo; Zhao, Dan; Ji, Mei; Liu, Lei; Lou, Hongxiang; Tetrahedron; vol. 70; 21; (2014); p. 3447 – 3451;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 149910-98-5, name is 7-Bromoisochroman, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149910-98-5, Recommanded Product: 7-Bromoisochroman

Into a 500-mL round-bottom flask, was placed 7-bromoisochroman (8.48 g, 40.0 mmol, 1.0 equiv) in dioxane (200 mL)/water (20 mL). Pd(dppf)Cl2 (5.8 g, 8.0 mmol, 0.2 equiv) and CS2CO3 (26.1 g, 80.0 mmol, 2.0 equiv) (BPin)2 (2.5 eq) were added to the solution. The resulting solution was stirred for 16 hr at 90 degrees C, after which it was concentrated and purified with SiCk-gel column chromatography. This resulted in 4.6 g (44.2%) of 2-(isochroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromoisochroman, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS INFLAMMASOME RESEARCH, INC.; GLICK, Gary; ROUSH, William; VENKATRAMAN, Shankar; SHEN, Dong-Ming; GHOSH, Shomir; SEIDEL, Hans Martin; FRANCHI, Luigi; WINKLER, David Guenther; OPIPARI, Anthony William Jr.; KATZ, Jason; (468 pag.)WO2020/10140; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 149910-98-5, name is 7-Bromoisochroman, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 149910-98-5

General procedure: To a solution of the substituted isochroman derivatives (0.5 mmol) in MeCN (1 mL), CuBr2(0.6 mmol, 134 mg) was added under nitrogen atomosphere. The solution wasrefluxed for about 1h and then cooled to room temperature. The reaction mixturewas added water, extracted with EtOAc (2 ¡Á 10 ml). The combined organicextracts were washed with brine, dried (Na2SO4), filteredand concentrated and then purified by silicagel chromatography.

The synthetic route of 7-Bromoisochroman has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Mei-Yan; Kong, Shan-Shan; Zhang, Ling-Qiong; Zhao, Ming; Duan, Jin-Ao; Ou-Yang, Zhen; Wang, Min; Tetrahedron Letters; vol. 54; 30; (2013); p. 3962 – 3964;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 149910-98-5, A common heterocyclic compound, 149910-98-5, name is 7-Bromoisochroman, molecular formula is C9H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a round-bottom flask is added in 5- bromine different chroman (1.0mmol), acetonitrile (2 ml), trimethyl silicon base nitrine (3.0mmol), in 80 C in the heating module 1-2 minutes, then adding CuBr 2 (2.0mmol), then after sealing the system 80 C heating reaction under 3 hours, the reaction using the ethyl acetate extraction, concentration by the simple column chromatography (eluting agent using petroleum ether (60-90 C) and ethyl acetate mixed solvent) to get product 5-bromo-2 – (2-hydroxy ethyl) benzonitrile, the yield is 60%.

The synthetic route of 149910-98-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hangzhou Normal University; Wang, Min; Tao, Lianzhi; Zhang, Min; Yang, Pengfei; (39 pag.)CN105330565; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary