Category: 14660-52-7

Zhang, Cheng; Yue, Hu; Sun, Ping; Hua, Lei; Liang, Shuli; Ou, Yitao; Wu, Dan; Wu, Xinyi; Chen, Hao; Hao, Ying; Hu, Wenhui; Yang, Zhongjin published an article in 2021. The article was titled 《Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of Ethyl 5-bromovalerate The information in the text is summarized as follows:

NLRP3 inflammasome activation plays a critical role in inflammation and its related disorders. Herein we report a hit-to-lead effort resulting in the discovery of a novel and potent class of NLRP3 inflammasome inhibitors. Among these, the most potent lead 40 exhibited improved inhibitory potency and almost no toxicity. Further mechanistic study indicated that compound 40 inhibited the NLRP3 inflammasome activation via suppressing ROS production More importantly, treatment with 40 showed remarkable therapeutic effects on LPS-induced sepsis and DSS-induced colitis. This study encourages further development of more potent inhibitors based on this chem. scaffold and provides a chem. tool to identify its cellular binding target. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Angewandte Chemie, International Edition included an article by Sun, Haotian; Haque, Farihah M.; Zhang, Yi; Commisso, Alex; Mohamed, Mohamed Alaa; Tsianou, Marina; Cui, Honggang; Grayson, Scott M.; Cheng, Chong. Application In Synthesis of Ethyl 5-bromovalerate. The article was titled 《Linear-Dendritic Alternating Copolymers》. The information in the text is summarized as follows:

Herein, the design, synthesis, and characterization of an unprecedented copolymer consisting of alternating linear and dendritic segments is described. First, a 4th-generation Hawker-type dendron with two azide groups was synthesized, followed by a step-growth azide-alkyne “”click”” reaction between the 4th-generation diazido dendron and poly(ethylene glycol) diacetylene to create the target polymers. Unequal reactivity of the functional groups was observed in the step-growth polymerization The resulting copolymers, with alternating hydrophilic linear and hydrophobic dendritic segments, can spontaneously associate into a unique type of microphase-segregated nanorods in water. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Application In Synthesis of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application In Synthesis of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 14660-52-7In 2022 ,《Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues》 was published in Journal of Medicinal Chemistry. The article was written by Ahmed-Belkacem, Rostom; Hausdorff, Marcel; Delpal, Adrien; Sutto-Ortiz, Priscila; Colmant, Agathe M. G.; Touret, Franck; Ogando, Natacha S.; Snijder, Eric J.; Canard, Bruno; Coutard, Bruno; Vasseur, Jean-Jacques; Decroly, Etienne; Debart, Francoise. The article contains the following contents:

Enzymes involved in RNA capping of SARS-CoV-2 are essential for the stability of viral RNA, translation of mRNAs, and virus evasion from innate immunity, making them attractive targets for antiviral agents. In this work, we focused on the design and synthesis of nucleoside-derived inhibitors against the SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) that catalyzes the transfer of the Me group from the S-adenosyl-L-methionine (SAM) cofactor to the N7-guanosine cap. Seven compounds out of 39 SAM analogs showed remarkable double-digit nanomolar inhibitory activity against the N7-MTase nsp14. Mol. docking supported the structure-activity relationships of these inhibitors and a bisubstrate-based mechanism of action. The three most potent inhibitors significantly stabilized nsp14 (ΔTm ≈ 11°C), and the best inhibitor demonstrated high selectivity for nsp14 over human RNA N7-MTase. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain》 was written by Fiala, Tomas; Wang, Jihang; Dunn, Matthew; Sebej, Peter; Choi, Se Joon; Nwadibia, Ekeoma C.; Fialova, Eva; Martinez, Diana M.; Cheetham, Claire E.; Fogle, Keri J.; Palladino, Michael J.; Freyberg, Zachary; Sulzer, David; Sames, Dalibor. Quality Control of Ethyl 5-bromovalerateThis research focused onvoltage sensitive fluorescent dye brain. The article conveys some information:

Voltage sensitive fluorescent dyes (VSDs) are important tools for probing signal transduction in neurons and other excitable cells. The impact of these highly lipophilic sensors has, however, been limited due to the lack of cell-specific targeting methods in brain tissue or living animals. The authors address this key challenge by introducing a nongenetic mol. platform for cell- and mol.-specific targeting of synthetic VSDs in the brain. The authors employ a dextran polymer particle to overcome the inherent lipophilicity of VSDs by dynamic encapsulation and high-affinity ligands to target the construct to specific neuronal cells utilizing only native components of the neurotransmission machinery at physiol. expression levels. Dichloropane, a monoamine transporter ligand, enables targeting of dense dopaminergic axons in the mouse striatum and sparse noradrenergic axons in the mouse cortex in acute brain slices. PFQX in conjunction with ligand-directed acyl imidazole chem. enables covalent labeling of AMPA-type glutamate receptors in the same brain regions. Probe variants bearing either a classical electrochromic ANEP dye or state-of-the-art VoltageFluor-type dye respond to membrane potential changes in a similar manner to the parent dyes, as shown by whole-cell patch recording. The authors demonstrate the feasibility of optical voltage recording with the probes in brain tissue with one-photon and two-photon fluorescence microscopy and define the signal limits of optical voltage imaging with synthetic sensors under a low photon budget determined by the native expression levels of the target proteins. This work demonstrates the feasibility of a chem. targeting approach and expands the possibilities of cell-specific imaging and pharmacol. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Bioorganic & Medicinal Chemistry Letters included an article by Wang, Jian-Ta; Peng, Jin-Gang; Zhang, Ji-Quan; Wang, Zhong-Xiao; Zhang, Yi; Zhou, Xun-Rong; Miao, Jing; Tang, Lei. Related Products of 14660-52-7. The article was titled 《Novel berberine-based derivatives with potent hypoglycemic activity》. The information in the text is summarized as follows:

Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound I exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, resp. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Yun-Dong; Xu, Yan-Hong; Liu, Ji-Ping; Wang, Bin; Shi, Yong-Heng; Wang, Wei; Wang, Xiao-Ping; Sun, Meng; Xu, Xin-Ya; Bian, Xiao-Li published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《1,3-Benzodioxole-based fibrate derivatives as potential hypolipidemic and hepatoprotective agents》.Recommanded Product: Ethyl 5-bromovalerate The article contains the following contents:

A series of target compounds 1,3-benzodioxole-based fibrate derivatives were designed and synthesized. All the target compounds were preliminarily evaluated by hyperlipidemia mice induced by Triton WR-1339, in which compound I displayed a greater anti-hyperlipidemia activity than other compounds as well as pos. drug fenofibrate (FF). I showed a significant reduction of plasma lipids, such as triglycerides (TG), total cholesterol (TC) and low-d. lipoprotein cholesterin (LDL-C), in high fat diet (HFD) induced hyperlipidemic mice. In addition, hepatic transaminases (AST and ALT) were ameliorated after administration of I, in particular the AST, and the histopathol. examination showed that I improved the hepatic lipid accumulation. The expression of PPAR-α involved in lipids metabolism was up-regulated in the liver tissues of 12-treated group. Other significant activity such as antioxidant, and anti-inflammation was confirmed and reinforced the effects of I as a potential hypolipidemia and hepatoprotective agent.Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: Ethyl 5-bromovalerate) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and evaluation of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-one derivatives as vasorelaxing agents》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Singh, Sarita; Agarwal, Karishma; Iqbal, Hina; Yadav, Pankaj; Yadav, Deepika; Chanda, Debabrata; Tandon, Sudeep; Khan, Feroz; Gupta, Anil Kumar; Gupta, Atul. COA of Formula: C7H13BrO2 The article mentions the following:

A series of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-ones I [R = Me, (CH2)2NMe2, CH2C(O)N(Me)(n-Bu), etc.] was synthesized from scopoletin as vasorelaxing agents. The synthesized compounds were evaluated for vasorelaxation in endothelium intact rat main mesenteric artery (MMA). Scopoletin, and compounds I [R = Me, CH2C(O)N(Me)(n-Bu), (CH2)4C(O)N(Me)(n-Bu), CH2C(O)NH(n-pentyl), (CH2)3C(O)N(Me)(n-pentyl), (CH2)4C(O)NH(n-pentyl)] showed significant vasorelaxation in precontracted MMA within the range of EC50 value 1.58-5.02μM. These derivatives presented 29.40-70.89 fold increased sensitivity for exptl. tissue compared to scopoletin, the parent mol. Among others, compound I [R = Me] was found to be the most active compound which had EC50 1.58μM with 70.89 fold increased sensitivity. The mechanistic evaluation of compound I [R = Me] showed that it exerted vasorelaxation through Ca2+-activated K+ (BKca) channel and the effect was endothelium-independent. In the experimental materials used by the author, we found Ethyl 5-bromovalerate(cas: 14660-52-7COA of Formula: C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.COA of Formula: C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Erdogan, Merve; Kilic, Burcu; Sagkan, Rahsan Ilikci; Aksakal, Fatma; Ercetin, Tugba; Gulcan, Hayrettin O.; Dogruer, Deniz S. published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer’s disease》.Recommanded Product: 14660-52-7 The article contains the following contents:

In this study, four series of compounds I [R = N(Me)(Bn), N(CH2)2CH(Ph)(CH2)2, N(CH2)2N(Bn)(CH2)2, etc.; X = O, S], II [n = 2,3] and III with benzoxazolone and benzothiazolone cores were designed, synthesized and evaluated as multifunctional agents against Alzheimer’s disease (AD). Addnl., in order to shed light on the effect of the carbonyl groups of benzoxazolone/benzothiazolone, benzoxazole/benzothiazole-containing analogs were also synthesized and evaluated. Inhibition potency of all final compounds towards cholinesterase enzymes and their antioxidant activity were tested. Subsequently, the anti-inflammatory activity, cytotoxicity, apoptosis, and Aβ aggregation inhibition tests were also performed for selected compounds The results indicated that compounds II [R = N(CH2)2CH(Ph)(CH2)2, X = S, n = 3] and III [R = N(CH2)2CH(Ph)(CH2)2, X = S] were considered as promising multi-functional agents for further investigation against AD. The reversibility, kinetic and mol. docking studies were also performed for the compounds with the highest AChE III [R = N(CH2)2CH(Ph)(CH2)2, X = S] and BChE II [R = N(CH2)2CH(Ph)(CH2)2, X = S, n = 3] inhibitory activities.Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design, synthesis and biological evaluation of novel hybrids of N-aryl pyrrothine-base α-pyrone as bacterial RNA polymerase inhibitors》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Tan, Xiangduan; Huang, Mohan; Nian, Siyun; Peng, Yanfen; Qin, Jianli; Kong, Bo; Duan, Xiaoqun. Category: bromides-buliding-blocks The article mentions the following:

Antibiotic resistance in bacteria has been an emerging public health problem, thus discovery of novel and effective antibiotics is urgent. A series of novel hybrids of N-aryl pyrrothine-base α-pyrone hybrids was designed, synthesized and evaluated as bacterial RNA polymerase (RNAP) inhibitors. Among them, compound I exhibited potent antibacterial activity against antibiotic-resistant S. aureus with the min. inhibitory concentration (MIC) in the range of 1-4μg/mL. Moreover, compound I exhibited strong inhibitory activity against E. coli RNAP with an IC50 value of 16.06μM, and cytotoxicity in HepG2 cells with IC50 value of 7.04μM. The mol. docking study further suggested that compound I binds to the switch region of bacterial RNAP. In summary, compound I is a novel bacterial RNAP inhibitor, and a promising lead compound for further optimization. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Yun-Mei; Li, Yang; Liu, Rong-Fang; Xiao, Jie; Zhou, Bin-Ning; Zhang, Qi-Zhi; Song, Jian-Xin published their research in Journal of Asian Natural Products Research in 2021. The article was titled 《Synthesis, characterization and preliminary biological evaluation of chrysin amino acid derivatives that induce apoptosis and EGFR downregulation》.Product Details of 14660-52-7 The article contains the following contents:

Chrysin amino acid derivatives were synthesized to evaluate for their antiproliferative activities. Among them, N-(7-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)valeryl)-L-leucine () displayed the most remarkable inhibitory activities against MCF-7 cells with IC50 values of 16.6 microM. Preliminary mechanistic studies showed that could inhibit the colony formation and migration of MCF-7 cells. Flow cytometry anal. demonstrated that mediated cell apoptosis and the prolongation of cell cycle progression in G1/S-phase against MCF-7 cells. Besides, displayed the moderate inhibition against EGFR. Western blot assay suggested that significantly inhibited EGFR phosphorylation. Mol. docking showed that can bind the EGFR kinase well. In addition to this study using Ethyl 5-bromovalerate, there are many other studies that have used Ethyl 5-bromovalerate(cas: 14660-52-7Product Details of 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Product Details of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary