Category: 14660-52-7

Jankowska, Agnieszka; Satala, Grzegorz; Latacz, Gniewomir; Partyka, Anna; Lubelska, Annamaria; Pociecha, Krzysztof; Swierczek, Artur; Wilczynska, Natalia; Mordyl, Barbara; Bojarski, Andrzej J.; Wyska, Elzbieta; Chlon-Rzepa, Grazyna published an article in 2021. The article was titled 《Design and Synthesis of Novel Aminoalkanamides Targeting Neurodegeneration and Symptoms of Alzheimer′s Disease》, and you may find the article in Current Medicinal Chemistry.Safety of Ethyl 5-bromovalerate The information in the text is summarized as follows:

There is currently no drug that slows the process of neurodegeneration or alleviates the cognitive and depressive symptoms in patients with Alzheimer′s disease. Due to the increasing number of Alzheimer′s patients, there is an urgent need to develop novel drugs with neuroprotective, procognitive, and antidepressant properties. The aim of this study was to design, synthesize, and evaluate novel aminoalkanamides with serotonin 5-HT1A/5-HT7 receptor affinity and phosphodiesterase (PDE) inhibitory activity as a new approach to combat neurodegeneration and symptoms of Alzheimer′s disease. The newly designed compounds were synthesized using classical methods of organic chem. and tested in vitro for their receptor affinity, functional profile, enzyme inhibition, and ADME properties. The neuroprotective effect against H2O2-induced increase of reactive oxygen species level was tested in SH-SY5Y cells. The novel object recognition and forced swimming tests were used to evaluate the procognitive and antidepressant activity, resp. Synthesized aminoalkanamides were characterized as potent 5-HT1A receptor antagonists with addnl. 5-HT7 receptor antagonistic properties and PDE4B inhibitory activity. Selected compound 15 showed neuroprotective, procognitive, and antidepressant properties. In addition, compound 15 revealed suitable ADME properties expressed as good membrane permeability and high metabolic stability. This study revealed a new class of compounds that may be useful in the search for an effective drug in the alleviation of neurodegeneration and symptoms of Alzheimer′s disease. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Safety of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Safety of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Medicinal Chemistry Research included an article by Lopez-Munoz, Marisol; Gomez-Pena, Jessica Johanna; Rios-Vasquez, Luz Amalia; Ocampo-Cardona, Rogelio; Jones, Marjorie A.; Haynes, Craig S.; Wallace, Craig; Robledo, Sara M.. SDS of cas: 14660-52-7. The article was titled 《Novel fluorinated quaternary ammonium salts and their in vitro activity as trypanocidal agents》. The information in the text is summarized as follows:

As the impact of aromatic rings and fluorine substituents in com. drugs is attributed to their electronic distribution and structure rigidity that determine metabolic stability and toxicity, 30 quaternary ammonium salts (QAS) of the form [X-CH2N(CH3)2(CH2)nCH = C(Ar2)]+I- (where X=H, Cl or I, n = 2 or 3, and Ar = m-C6H4CF3, p-C6H4CF3, m-C6H4F, p-C6H4F or C6H5) were tested as potential trypanocidal agents and assessed their cytotoxicity on U-937 cells. CF3-substituted QASs exhibited LC50 values in the range of 0.5 to 6.4 μg/mL and trypanocidal EC50 values between 0.6 and 7.0 μg/mL, while the LC50 values for F-substituted analogs are between 7.0 and 207 μg/mL and EC50 values range from 3.8 to 40.9 μg/mL. As a general trend, the more effective are those bearing an N-iodomethyl moiety or having a longer tether, and para-substituted ones. Few drugs therapies are in use for Chagas disease, so this study becomes a promising contribution. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7SDS of cas: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.SDS of cas: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Xu; Huang, Congcong; Yuan, Xiang-Ai; Yu, Shouyun published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Diastereoselective and Stereodivergent Synthesis of 2-Cinnamylpyrrolines Enabled by Photoredox-Catalyzed Iminoalkenylation of Alkenes》.HPLC of Formula: 14660-52-7 The article contains the following contents:

A photoredox-catalyzed iminoalkenylation of γ-alkenyl O-acyl oximes has been developed. Readily available alkenylboronic acids serve as alkenylation reagents, leading to densely functionalized pyrrolines. Both (E)- and (Z)-cinnamylpyrrolines are accessible depending on the reaction solvent. In dichloromethane, (E)-cinnamylpyrrolines are produced through a photoredox-mediated single-electron-transfer process. In THF, (Z)-cinnamylpyrrolines are generated by photocatalytic contra-thermodn. E-to-Z isomerization of (E)-cinnamylpyrrolines though an energy-transfer pathway. Two stereocenters are established with complete diastereoselectivity and only one diastereomer is isolated. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7HPLC of Formula: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.HPLC of Formula: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chrysochos, Nicolas; Ahmadi, Mohsen; Trentin, Ivan; Lokov, Maert; Tshepelevitsh, Sofja; Ullmann, G. Matthias; Leito, Ivo; Schulzke, Carola published an article in 2021. The article was titled 《Aiding a Better Understanding of Molybdopterin: Syntheses, Structures, and pKa Value Determinations of Varied Pterin-Derived Organic Scaffolds Including Oxygen, Sulfur and Phosphorus Bearing Substituents》, and you may find the article in Journal of Molecular Structure.Recommanded Product: Ethyl 5-bromovalerate The information in the text is summarized as follows:

Multistep synthetic procedures were established for the preparation of a set of four compounds serving as models for aspects of molybdopterin (mpt), a unique ligand system in the active sites of molybdenum and tungsten dependent oxidoreductases. The synthesized compounds were investigated with various anal. techniques including single crystal X-ray structural determination and the measurement of the specific pKa values of all four compounds in the non-aqueous solvent acetonitrile, which range from 11.09 to 11.82. The obtained physico-chem. data supported by theor. anal. indicate that even functional groups quite far away from the cofactor sites which are reactive can have an impact on characteristics which are important for the reactivity. The data were used to identify the likely protonation sites on the model compounds and thereby allow for a better understanding of molybdopterin′s potential active role in transformations in the active sites of oxidoreductases in relation to specific functional groups of mpt with respect to protonation events and tautomerization. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Powell, Chelsea E.; Hatcher, John M.; Jiang, Jie; Vatsan, Prasanna S.; Che, Jianwei; Gray, Nathanael S. published an article in ACS Medicinal Chemistry Letters. The title of the article was 《Selective Macrocyclic Inhibitors of DYRK1A/B》.Related Products of 14660-52-7 The author mentioned the following in the article:

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target of interest due to the roles it plays in both neurol. diseases and cancer. We present the development of the first macrocyclic inhibitors of DYRK1A. Initial lead inhibitor JH-XIV-68-3 (3) displayed selectivity for DYRK1A and close family member DYRK1B in biochem. and cellular assays, and demonstrated antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines. However, we noted that it suffered from rapid aldehyde oxidase (AO)-mediated metabolism To overcome this liability, we generated a derivative (JH-XVII-10 (10)), where fluorine was introduced to block the 2-position of the azaindole and render the mol. resistant to AO activity. We showed that 10 maintains remarkable potency and selectivity in biochem. and cellular assays as well as antitumor efficacy in HNSCC cell lines and improved metabolic stability. Therefore, 10 represents a promising new scaffold for developing DYRK1A-targeting chem. probes and therapeutics.Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of Ethyl 5-bromovalerateIn 2020 ,《Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC)》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhang, Hao; Zhao, Hong-Yi; Xi, Xiao-Xiao; Liu, Yan-Jie; Xin, Minhang; Mao, Shuai; Zhang, Jun-Jie; Lu, A-Xin; Zhang, San-Qi. The article conveys some information:

Herein, the discovery of small mol. EGFR degraders based on the proteolysis targeting chimera (PROTAC) strategy was reported. In the present study, 13 EGFR degraders containing pyrido[3,4-d]pyrimidine moiety I [X = CH2C(O)NHCH2CH2C(O), CH2CH2CH2CH2C(O), CH2CH2CH2CH2CH2C(O), etc.], II [C = CH2C(O)NHCH2CH2C(O), CH2CH2CH2CH2CH2CH2CH2C(O)] and III [X = CH2CH2CH2CH2C(O), CH2CH2OCH2CH2OCH2CH2, CH2CH2CH2CH2CH2CH2C(O), etc.] were designed and synthesized. Promising PROTACs I [X = CH2CH2CH2CH2CH2CH2CH2C(O)] and III [X = CH2CH2CH2CH2CH2CH2C(O)] induced degradation of EGFR in HCC827 cells with the DC50 values of 45.2 and 34.8 nM, resp. Cellular protein-controlling machinery ubiquitin proteasome system (UPS) was involved in the degradation process. Furthermore, the degraders I [X = CH2CH2CH2CH2CH2CH2CH2C(O)] and III [X = CH2CH2CH2CH2CH2CH2C(O)] could significantly induce the apoptosis of HCC827 cells and arrest the cells in G1 phase. These findings demonstrated that compounds I [X = CH2CH2CH2CH2CH2CH2CH2C(O)] and III [X = CH2CH2CH2CH2CH2CH2C(O)] could serve as effective EGFRdel19-targeting degraders in HCC827 cells. v. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Reference of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2020 ,《Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhang, Xuan; Thummuri, Dinesh; Liu, Xingui; Hu, Wanyi; Zhang, Peiyi; Khan, Sajid; Yuan, Yaxia; Zhou, Daohong; Zheng, Guangrong. The article conveys some information:

Anti-apoptotic protein BCL-XL plays a key role in tumorigenesis and cancer chemotherapy resistance, rendering it an attractive target for cancer treatment. However, BCL-XL inhibitors such as ABT-263 cannot be safely used in the clinic because platelets solely depend on BCL-XL to maintain their viability. To reduce the on-target platelet toxicity associated with the inhibition of BCL-XL, we designed and synthesized PROTAC BCL-XL degraders that recruit CRBN or VHL E3 ligase because both of these enzymes are poorly expressed in human platelets compared to various cancer cell lines. We confirmed that platelet-toxic BCL-XL/2 dual inhibitor ABT-263 can be converted into platelet-sparing CRBN/VHL-based BCL-XL specific degraders. A number of BCL-XL degraders are more potent in killing cancer cells than their parent compound ABT-263. Specifically, XZ739, a CRBN-dependent BCL-XL degrader, is 20-fold more potent than ABT-263 against MOLT-4 T-ALL cells and has >100-fold selectivity for MOLT-4 cells over human platelets. Our findings further demonstrated the utility of PROTAC technol. to achieve tissue selectivity through recruiting differentially expressed E3 ligases. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 14660-52-7In 2020 ,《Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yao, Dahong; Li, Chenyang; Jiang, Jin; Huang, Jian; Wang, Jinhui; He, Zhendan; Zhang, Jin. The article conveys some information:

The dysfunction of histone deacetylase (HDACs) is closely related to tumorigenesis and development, which has been emerged as an attractive drug design target for cancer therapy. In the present study, a series of novel HDAC inhibitors using a substituted quinazoline as the capping group and attaching 3,5-dimethylbenyl as a potential metabolic site protector have been designed and synthesized. Compounds I and II demonstrated potent HDAC inhibitory activities and anti-proliferative effects against MDA-MB-231 cells. In addition, I and II both could significantly increase the acetylation level of intracellular proteins, especially in α-Tubulin and HSP90. Compounds I and II displayed a slight different anti-tumor mechanism, I mainly induced apoptosis while II induced obviously ER-Stress. Furthermore, I and II both induced autophagy and migration inhibition. In pharmacokinetics assay, I showed a significant improvement of pharmacokinetic profile for oral administration. Addnl., I presented more potent anti-proliferation and anti-migration activity than SAHA in zebrafish MDA-MB-231 cell line-derived xenograft model. Together, these results demonstrate that I is a novel oral HDAC inhibitor with a potential capacity of treating breast cancer. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C7H13BrO2In 2021 ,《Hydrazone exchange: a viable route for the solid-tethered synthesis of [2]rotaxanes》 was published in New Journal of Chemistry. The article was written by Da Silva Rodrigues, Rafael; Luis, Ena T.; Marshall, David L.; McMurtrie, John C.; Mullen, Kathleen M.. The article contains the following contents:

Building on the success of other dynamic covalent synthetic methods, hydrazone exchange as a strategy to improve the formation of rotaxanes in solution and on solid surfaces were presented. Solution-state analogs containing naphthalenediimide (NDI) or bipyridinium motifs and 1,5-dinaphtho[38]crown-10 were initially prepared to establish ideal conditions for maintaining thermal equilibrium throughout the exchange reaction. Solid-state rotaxanes were synthesized on hydrazide-functionalised TentaGel polymer resins and analyzed with HR MAS 1H NMR spectroscopy. Surface rotaxane functionalisation of 80% was achieved for the NDI rotaxane, which was significantly higher than previously reported with either dynamic covalent or traditional irreversible synthetic strategies.Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A Tumor-Microenvironment-Responsive Lanthanide-Cyanine FRET Sensor for NIR-II Luminescence-Lifetime In Situ Imaging of Hepatocellular Carcinoma》 was written by Zhao, Mengyao; Li, Benhao; Wu, Yifan; He, Haisheng; Zhu, Xinyan; Zhang, Hongxin; Dou, Chaoran; Feng, Lishuai; Fan, Yong; Zhang, Fan. Category: bromides-buliding-blocks And the article was included in Advanced Materials (Weinheim, Germany) in 2020. The article conveys some information:

Deep tissue imaging in the second near-IR (NIR-II) window holds great promise for widespread fundamental research. However, inhomogeneous signal attenuation due to tissue absorption and scattering hampers its application for accurate in vivo biosensing. Here, lifetime-based in situ hepatocellular carcinoma (HCC) detection in NIR-II region is presented using a tumor-microenvironment (peroxynitrite, ONOO-)-responsive lanthanide-cyanine Foerster resonance energy transfer (FRET) nanosensor. A specially designed ONOO–responsive NIR-II dye, MY-1057, was synthesized as the FRET acceptor. Robust lifetime sensing is independent of tissue penetration depth. Tumor lesions are accurately distinguished from normal tissue due to the recovery lifetime. Magnetic resonance imaging and liver dissection results illustrate the reliability of lifetime-based detection in single and multiple HCC models. Moreover, the ONOO- amount can be calculated according to the standard curve. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary