Category: 14660-52-7

《Design, sustainable synthesis, characterization, antimicrobial evaluation and in silico ADMET prediction of new functionalized imidazolium based ionic liquids》 was written by Al Johani, Anas R.; Almutairi, Saud M.; El-Sayed, Wael S.; Sahu, Pramod K.; Sahu, Praveen K.; Messali, Mouslim. Related Products of 14660-52-7 And the article was included in Asian Journal of Chemistry in 2020. The article conveys some information:

A series of sixteen new ionic liquids (ILs) bearing imidazolium moiety I (R = 2-chlorobenzyl, 3-cyanopropyl, 4-acetoxybutyl, etc.; X = Cl, Br) were designed and synthesized under sustainable and green conditions which were confirmed by anal. and spectral techniques using 1H- & 13C-NMR, FT-IR, mass and elemental anal. A panel of clin. isolated strains was used for in vitro inhibitory antimicrobial activities screening of synthesized ionic liquids I. The results of antimicrobial assay showed that some of synthesized ionic liquids I showed moderate to good activity. Among these ILs, ionic liquids (bearing alkyl chain with a Ph group) I [R = (2-chlorophenyl)methyl, X = Cl; R = 2-phenoxyethyl, X = Br; R = 3-phenoxypropyl, X = Br] significantly inhibited cell growth of strains. In this regard, these ionic liquids I considered as promising antibacterial agents when compared with standard antibiotics. By encouraging in vitro antimicrobial screening, in silico ADMET evaluation has been performed and found excellent pharmacokinetic, bioavailability and toxicity profiles. Synthesized ionic liquids have found to be safe and non-toxic according to calculated in vivo computed LD50 values (2.49-2.80 mg/kg) for rat acute toxicity. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Novel phenethylimidazolium based ionic liquids: Design, microwave synthesis, in-silico, modeling and biological evaluation studies》 was written by Titi, Abderrahim; Almutairi, Saud M.; Alrefaei, Abdulwahed F.; Manoharadas, Salim; Alqurashy, Bakheet A.; Sahu, Pramod K.; Hammouti, Belkheir; Touzani, Rachid; Messali, Mouslim; Ali, Imran. Synthetic Route of C7H13BrO2 And the article was included in Journal of Molecular Liquids in 2020. The article conveys some information:

An eco-friendly preparation method for the novel bioactive imidazolium ionic liquids halides (ILs) was developed under microwave-assisted conditions. Synthesized ILs were characterized by spectroscopic techniques. Selected ILs were investigated for their antimicrobial activity against highly resistant Gram-pos. and Gram-neg. bacterial strains. Overall, 3-(2-chlorobenzyl)-1-phenethyl-1H-imidazol-3-iumchloride (4) showed high antimicrobial activity against the Staphylococcus aureus strain in the inhibition zone tests and displayed low MIC and MBC levels against almost all tested bacteria. Furthermore, the ILs were screened in vitro against human hepatocellular carcinoma (HepG-2), human breast adenocarcinoma (MCF-7), and human colon carcinoma (Caco-2) cell lines. The screening results showed excellent to moderate anticancer activity across the ILs. Among the synthesized ILs, Overall, 3-(2-chlorobenzyl)-1-phenethyl-1H-imidazol-3-ium chloride (4) and 1-phenethyl-3-(3-phenoxypropyl)-1H-imidazol-3-ium bromide (7) were found to exhibit the most promising ant proliferative effects and had the lowest IC50 values. The docking study suggested strong interaction of ILs with DNA with binding energy ranging from -4.9 to -4.1 kcal/mol. ILs 4 and 7 were most strongly bonded with -4.9 and -4.8 kcal/mol binding energy; confirming in vitro anticancer results. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Panagiotakis, Stylianos; Mavroidi, Barbara; Athanasopoulos, Alexandros; Charalambidis, Georgios; Coutsolelos, Athanassios G.; Paravatou-Petsotas, Maria; Pelecanou, Maria; Mavridis, Irene M.; Yannakopoulou, Konstantina published an article in Carbohydrate Polymers. The title of the article was 《Unsymmetrical, monocarboxyalkyl meso-arylporphyrins in the photokilling of breast cancer cells using permethyl-β-cyclodextrin as sequestrant and cell uptake modulator》.Computed Properties of C7H13BrO2 The author mentioned the following in the article:

In the search for photosensitizers with chem. handles to facilitate their integration into complex drug delivery nanosystems, new, unsym. substituted, water insoluble meso-tetraphenylporphyrin and meso-tetra(m-hydroxyphenyl)porphyrin derivatives bearing one carboxyalkyl side chain were synthesized. Permethyl-β-cyclodextrin (pMβCD) was their ideal monomerizing host and highly efficient shuttle to transfer them into water. New assembly modes of the extremely stable (Kbinding > 1012 M-2) 2:1 complexes were identified. The complexes are photostable and do not disassemble in FBS-containing cell culture media for 24 h. Incubation of breast cancer MCF-7 cells with the complexes results in intense intracellular fluorescence, strongly enhanced in the endoplasmic reticulum (ER), high photokilling efficiency (∼90%) and low dark toxicity. pMβCD stands out as a very capable mol. isolator of mono-carboxyalkyl-arylporphyrins that increases uptake and modulates their localization in the cells. The most efficient porphyrins are envisaged as suitable photosensitizers that can be linked to biocompatible drug carriers for photo- and chemo-therapy applications. In the experimental materials used by the author, we found Ethyl 5-bromovalerate(cas: 14660-52-7Computed Properties of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Computed Properties of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 14660-52-7In 2019 ,《Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Zhao, Yunjie; Cao, Yongkai; Chen, Huizhen; Zhuang, Fei; Wu, Chao; Yoon, Goo; Zhu, Weiwei; Su, Ying; Zheng, Suqing; Liu, Zhiguo; Cheon, Seung Hoon. The article conveys some information:

We describe herein the design, synthesis, and biol. evaluation of a series of novel protein tyrosine phosphatase 1B (PTP1B) inhibitor retrochalcones having an allyl chain at the C-5 position of their B ring. Biol. screening results showed that the majority of these compounds exhibited an inhibitory activity against PTP1B. Thus, preliminary structure-activity relationship (SAR) and quant. SAR analyses were conducted. Among the compounds, 23 was the most potent inhibitor, exhibiting the highest in vitro inhibitory activity against PTP1B with an IC50 of 0.57 μM. Moreover, it displayed a significant hepatoprotective property via activation of the IR pathway in type 2 diabetic db/db mice. In addition, the results of our docking study showed that 23, as a specific inhibitor of PTP1B, effectively transformed the WPD loop from “”close”” to “”open”” in the active site. These results may reveal suitable compounds for the development of PTP1B inhibitors. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Woojin; Yoon, Younggun; Lee, Yunjee; Oh, Hyeongyeol; Choi, Jieun; Shin, Sujin; Lee, Seongsoo; Lee, Hohjai; Lee, Yunho; Seo, Jiwon published an article in 2021. The article was titled 《Photosensitizer-peptoid conjugates for photoinactivation of Gram-negative bacteria: structure-activity relationship and mechanistic studies》, and you may find the article in Organic & Biomolecular Chemistry.Recommanded Product: Ethyl 5-bromovalerate The information in the text is summarized as follows:

Multitarget engagement is considered an effective strategy to overcome the threat of bacterial infection, and antimicrobials with multiple mechanisms of action have been successful as natural chem. weaponry. Here, we synthesized a library of photosensitizer-peptoid conjugates (PsPCs) as novel antimicrobial photodynamic therapy (aPDT) agents. The peptoids, linkers, and photosensitizers were varied, and their structure-antimicrobial activity relationships against Escherichia coli were evaluated; PsPC 9 was indicated to be the most promising photoresponsive antimicrobial agent among the synthesized PsPCs. Spectroscopic analyses indicated that 9 generated singlet oxygen upon absorption of visible light (420 nm) while maintaining the weakly helical conformation of the peptoid. Mechanistic studies suggested that damage to the bacterial membrane and cleavage of DNA upon light irradiation were the main causes of bactericidal activity, which was supported by flow cytometry and DNA gel electrophoresis experiments We demonstrated that the optimal combination of membrane-active peptoids and photosensitizers can generate an efficient aPDT agent that targets multiple sites of bacterial components and kills bacteria by membrane disruption and reactive oxygen species generation. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Organic Chemistry included an article by Zemtsov, Artem A.; Ashirbaev, Salavat S.; Levin, Vitalij V.; Kokorekin, Vladimir A.; Korlyukov, Alexander A.; Dilman, Alexander D.. Recommanded Product: Ethyl 5-bromovalerate. The article was titled 《Photoredox Reaction of 2-Mercaptothiazolinium Salts with Silyl Enol Ethers》. The information in the text is summarized as follows:

A method for the generation of free radicals from thiazolinium salts upon photocatalytic reduction is described. The thiazolinium salts are generated by treatment with Me triflate of 2-mercaptothiazolines, which can be readily obtained from alkyl bromides and tosylates via a nucleophilic substitution reaction or by hydrothiolation of alkenes. Silyl enol ethers were used to trap the radicals, furnishing ketones after successive single-electron oxidation and elimination of the silyl cation. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein》 was written by Wang, Mingliang; Lu, Jianfeng; Wang, Mi; Yang, Chao-Yie; Wang, Shaomeng. Application of 14660-52-7 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Src homol. 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target for human cancers and other human diseases. Herein, we report our discovery of potent small-mol. SHP2 degraders whose design is based upon the proteolysis-targeting chimera (PROTAC) concept. This work has led to the discovery of potent and effective SHP2 degraders, exemplified by SHP2-D26. SHP2-D26(I) achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, resp., and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines. This study demonstrates that induced SHP2 degradation is a very effective approach to inhibit the function of SHP2. Further optimization of these SHP2 degraders may lead to the development of a new class of therapies for cancers and other human diseases. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Application of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Hua; Liu, Li; Ning, Baoan; Sun, Zhiyong; Yao, Sun; Jiang, Yongqiang; Liu, Jianqing published an article in 2021. The article was titled 《Selection of an artificial paraquat-specific binding protein from a ribosome display library based on a lipocalin scaffold》, and you may find the article in Biotechnology and Applied Biochemistry.Product Details of 14660-52-7 The information in the text is summarized as follows:

In this study, an anticalin that could specifically bind paraquat (PQ), a quaternary nitrogen herbicide, as a new set of engineered receptor protein with antibody-like properties was generated to detect PQ concentration To this end, a native and random library was constructed and engineered to allow in vitro transcription and translation using an Escherichia coli lysate system. Meanwhile, a PQ derivative that carries an active aliphatic carboxylate group at the end of an aliphatic spacer arm was synthesized. Then, this compound was coupled covalently to the carrier protein bovine serum albumin/ovalbumin and amino-functionalized paramagnetic beads. Alternating selection in solution and immobilization in microtiter wells were used to pan mRNA-ribosome-antibody complexes. After several rounds of ribosome display, three variants were selected from a random library of the bilin-binding protein. The variants that could bind complex PQ with high affinity and exhibit IC50 values as low as 14.039 ± 0.970 ng/mL were identified. Moreover, the limits of detection reached 0.083 ± 0.011 ng/mL. Our data suggest that the generation of anticalins may provide a promising alternative to recombinant antibody fragments to create a stable receptor protein against hapten with bioanal. relevance.Ethyl 5-bromovalerate(cas: 14660-52-7Product Details of 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Product Details of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jankowska, Agnieszka; Satala, Grzegorz; Swierczek, Artur; Pociecha, Krzysztof; Partyka, Anna; Jastrzebska-Wiesek, Magdalena; Gluch-Lutwin, Monika; Bojarski, Andrzej J.; Wyska, Elzbieta; Chlon-Rzepa, Grazyna published an article in 2021. The article was titled 《A new class of 5-HT1A receptor antagonists with procognitive and antidepressant properties》, and you may find the article in Future Medicinal Chemistry.Quality Control of Ethyl 5-bromovalerate The information in the text is summarized as follows:

5-HT1A receptor antagonists constitute a potential group of drugs in the treatment of CNS diseases. The aim of this study was to search for new procognitive and antidepressant drugs among amide derivatives of aminoalkanoic acids with 5-HT1A receptor antagonistic properties. Thirty-three amides were designed and evaluated in silico for their drug-likeness. The synthesized compounds were tested in vitro for their 5-HT1A receptor affinity and functional profile. Moreover, their selectivity over 5-HT7, 5-HT1A and D2 receptors and ability to inhibit phosphodiesterases were evaluated. A selected 5-HT1A receptor antagonist 20 (Ki = 35 nM, Kb = 4.9 nM) showed procognitive and antidepressant activity in vivo. Novel 5-HT1A receptor antagonists were discovered and shown as potential psychotropic drugs. In addition to this study using Ethyl 5-bromovalerate, there are many other studies that have used Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide》 was written by Zhang, Fangqing; Wu, Zhenwei; Chen, Pan; Zhang, Jian; Wang, Tao; Zhou, Jinpei; Zhang, Huibin. Safety of Ethyl 5-bromovalerate And the article was included in Bioorganic & Medicinal Chemistry in 2020. The article conveys some information:

Synthesis of dihydroquinazolinone-lenalidomide/pomalidomide derivatives I [n=1,2,3,4,5,6], II [n=4,5,6] and III [X = CH2, CO; n=0,1,2,3] and biol. evaluation of PROTAC BRD4 degraders was discovered. Gratifyingly, several compounds showed excellent inhibitory activity against BRD4 and high anti-proliferative potency against human monocyte lymphoma cell line THP-1. Especially, compound III [X = CO; n=0] (BRD4 BD1, IC50 = 41.8 nM) achieved a submicromolar IC50 value of 0.81μM in inhibiting the growth of THP-1 cell line, and was 4 times more potent than compound IV. Moreover, the mechanism study established that III [X = CO; n=0] could effectively induced the degradation of BRD4 protein and suppression of c-Myc. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Safety of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Safety of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary