Category: 14660-52-7

In 2022,Ado, Genyir; Noda, Naotaka; Vu, Hue T.; Perron, Amelie; Mahapatra, Amarjyoti D.; Arista, Karla Pineda; Yoshimura, Hideaki; Packwood, Daniel M.; Ishidate, Fumiyoshi; Sato, Shin-ichi; Ozawa, Takeaki; Uesugi, Motonari published an article in Chemical Science. The title of the article was 《Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells》.Related Products of 14660-52-7 The author mentioned the following in the article:

Phase-separated membraneless organelles or biomol. condensates play diverse functions in cells, however recapturing their characteristics using small organic mols. has been a challenge. In the present study, cell-lysate-based screening of 843 self-assembling small mols. led to the discovery of a simple organic mol., named huezole, that forms liquid droplets to selectively sequester tubulin. Remarkably, this small mol. enters cultured human cells and prevents cell mitosis by forming tubulin-concentrating condensates in cells. The present study demonstrates the feasibility of producing a synthetic condensate out of non-peptidic small mols. for exogenous control of cellular processes. The modular structure of huezole provides a framework for designing a class of organelle-emulating small mols. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Lo, Chang-Lun; Akula, Pavan Sudheer; Hong, Bor-Cherng; Lee, Gene-Hsiang; Chien, Su-Ying published an article in Organic Letters. The title of the article was 《Total Synthesis of Ulodione A via a Double-Alkylation and DABCO Promoted Ring-Expansion Rearrangement Sequence》.COA of Formula: C7H13BrO2 The author mentioned the following in the article:

First total synthesis of ulodione A has been achieved via the key-step reactions of DIPEA-promoted dialkylation of 1,3-cyclopentadione with a bromonitroolefin and DABCO promoted/catalytic semipinacol-like ring-expansion rearrangement, with regioselective transformation of the nitrocyclohexane intermediates to their cyclopentenone counterparts via a sequence of reactions in a one-pot operation. Structures of six products were unequivocally established by X-ray crystallog. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7COA of Formula: C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.COA of Formula: C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Chemoselective formal β-functionalization of substituted aliphatic amides enabled by a facile stereoselective oxidation event》 were Bauer, Adriano; Maulide, Nuno. And the article was published in Chemical Science in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

A facile and stereoselective dehydrogenation event enabling the functionalization of aliphatic amides, e.g., 1-(indolin-1-yl)-2-methylpropan-1-one at different positions in a one-pot fashion has been described. Derivatives of relevant pharmaceuticals were formally functionalized in the β-position in late-stage manner. A single-step synthesis of incrustoporine from a simple precursor further showcases the potential utility of this approach. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: Ethyl 5-bromovalerateIn 2021 ,《””TPG-lite””: A new, simplified “”designer”” surfactant for general use in synthesis under micellar catalysis conditions in recyclable water》 appeared in Tetrahedron. The author of the article were Thakore, Ruchita R.; Takale, Balaram S.; Hu, Yuting; Ramer, Selene; Kostal, Jakub; Gallou, Fabrice; Lipshutz, Bruce H.. The article conveys some information:

Using the oxidized, carboxylic acid-containing form of MPEG-750, esterification with racemic vitamin E affords a new surfactant (TPG-lite) that functions as an enabling, nanoreactor-forming amphiphile for use in many types of important reactions in synthesis. The presence of a single ester bond is suggestive of simplified treatment as a component of (eventual) reaction waste water, after recycling. Many types of reactions, including aminations, Suzuki-Miyaura, SNAr, and several others are compared directly with TPGS-750-M, leading to the conclusion that TPG-lite can function as an equivalent nanomicelle-forming surfactant in water. Prima facie evidence amassed via DLS and cryo-TEM analyses support these exptl. observations. In silico evaluations of the aquatic toxicity and carcinogenicity of TPG-lite indicate that it is safe to use. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic enantioselective synthesis of carbocyclic and heterocyclic spiranes via a decarboxylative aldol cyclization》 was published in Chemical Science in 2020. These research results belong to Inanaga, Kazato; Wollenburg, Marco; Bachman, Shoshana; Hafeman, Nicholas J.; Stoltz, Brian M.. Related Products of 14660-52-7 The article mentions the following:

The synthesis of a variety of enantioenriched 1,3-diketospiranes from the corresponding racemic allyl β-ketoesters via an interrupted asym. allylic alkylation is disclosed. Substrates possessing pendant aldehydes undergo decarboxylative enolate formation in the presence of a chiral Pd catalyst and subsequently participate in an enantio- and diastereoselective, intramol. aldol reaction to furnish spirocyclic β-hydroxy ketones which may be oxidized to the corresponding enantioenriched diketospiranes. Addnl., this chem. has been extended to α-allylcarboxy lactam substrates leading to a formal synthesis of the natural product (-)-isonitramine. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sole, Daniel; Amenta, Arianna; Campos, Cristina; Fernandez, Israel published their research in Dalton Transactions in 2021. The article was titled 《Iron-promoted dealkylative carbene aminocyclization of δ-arylamino-α-diazoesters》.Application of 14660-52-7 The article contains the following contents:

Herein, a novel methodol. to access N-aryl proline derivatives I (R = Ph, 2,4-dimethylphenyl, naphthalen-1-yl, etc.; R1 = Me, Et) using amino-tethered α-diazoesters RN(R2)(CH2)3C(=N2)C(O)OR1 [R2 = Me, Et, i-Pr, t-Bu, Bn] and cheap, readily available iron salts were reported. Mechanistically, the aminocyclization reaction involves the initial formation of an iron-carbene complex followed by a nucleophilic attack of the aniline nitrogen atom to give an ammonium ylide intermediate, which finally undergoes the iron-promoted dealkylation. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Application of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Catalysts included an article by Willot, Sebastien J.-P.; Tieves, Florian; Girhard, Marco; Urlacher, Vlada B.; Hollmann, Frank; de Gonzalo, Gonzalo. Quality Control of Ethyl 5-bromovalerate. The article was titled 《P450BM3-catalyzed oxidations employing dual functional small molecules》. The information in the text is summarized as follows:

A set of dual functional small mols. (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P 450 monooxygenase P450BM3 from Bacillus megaterium in H2O2-dependent oxidation reactions. These DFSMs enhance P450BM3 activity with hydrogen peroxide as an oxidant, converting these enzymes into formal peroxygenases. This system has been employed for the catalytic epoxidation of styrene and in the sulfoxidation of thioanisole. Various P450BM3 variants have been evaluated in terms of activity and selectivity of the peroxygenase reactions. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Functional Janus dendrimers containing carbazole with liquid crystalline, optical and electrochemical properties》 was written by Iguarbe, Veronica; Barbera, Joaquin; Serrano, Jose Luis. Computed Properties of C7H13BrO2 And the article was included in Liquid Crystals in 2020. The article conveys some information:

Novel liquid crystalline Janus dendrimers that combine a mesogenic block and an electroactive block have been synthesized. The mesogenic block is based on two third-generation Percec-type dendrons bearing six or eight terminal dodecyloxy alkyl chains, whereas the electroactive blocks are formed by one or two carbazole units. The liquid crystal behavior was investigated by polarized-light optical microscopy, differential scanning microscopy and X-ray diffraction. The Janus dendrimers with one electroactive unit exhibited cubic or columnar liquid crystal phases, whereas the Janus dendrimers with two electroactive units did not show liquid crystalline behavior. The UV-vis absorption and emission properties of the Janus dendrimers were investigated. The spectra suggested the existence of π-π stacking and the formation of aggregates in the solid state. Electrodeposition of the carbazole-containing dendrimers afforded semi-globular particles in which the number of electropolymerizable units and the flexible or rigid character of the linker have a decisive influence in the particle size. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Computed Properties of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Computed Properties of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ibrahim, Tarek S.; Malebari, Azizah M.; Mohamed, Mamdouh F. A. published an article in 2021. The article was titled 《Design, Synthesis, In Vitro Anticancer Evaluation and Molecular Modelling Studies of 3,4,5-Trimethoxyphenyl-Based Derivatives as Dual EGFR/HDAC Hybrid Inhibitors》, and you may find the article in Pharmaceuticals.Category: bromides-buliding-blocks The information in the text is summarized as follows:

Recently, combining histone deacetylase (HDAC) inhibitors with chemotherapeutic drugs or agents, in particular epidermal growth factor receptor (EGFR) inhibitors, is considered to be one of the most encouraging strategy to enhance the efficacy of the antineoplastic agents and decrease or avoid drug resistance. Therefore, in this work, based on introducing 3,4,5-trimethoxy Ph group as a part of the CAP moiety, in addition to incorporating 4-6 aliphatic carbons linker and using COOH or hydroxamic acid as ZBG, 12 novel EGFR/HDAC hybrid inhibitors 2a-c, 3a-c, 4a-c and 5a-c were designed, constructed, and evaluated for their anticancer activities against 4 cancer cell lines (HepG2, MCF-7, HCT116 and A549). Among all, hybrids with hydroxamic acid 4a-c and 5a, exhibited the highest inhibition against all cancer cell lines with IC50 ranging from 0.536 to 4.892 μM compared to Vorinostat (SAHA) with IC50 ranging from 2.43 to 3.63 μM and Gefitinib with IC50 ranging from 1.439 to 3.366 μM. Mechanistically, the most potent hybrids 4a-c and 5a were further tested for their EGFR and HDACs inhibitory activities. The findings disclosed that hybrid 4b displayed IC50 = 0.063 μM on the target EGFR enzyme which is slightly less potent than the standard Staurosporine (IC50 = 0.044 μM). Furthermore, hybrid 4b showed less HDAC inhibitory activity IC50 against HDAC1 (0.148), 2 (0.168), 4 (5.852), 6 (0.06) and 8 (2.257) than SAHA. In addition, the investigation of apoptotic action of the most potent hybrid 4b showed a significant increase in Bax level up to 3.75-folds, with down-regulation in Bcl2 to 0.42-fold, compared to the control. Furthermore, hybrid 4b displayed an increase in the levels of Caspases 3 and 8 by 5.1 and 3.15 folds, resp. Addnl., the cell cycle anal. of hybrid 4b revealed that it showed programmed cell death and cell cycle arrest at G1/S phase. Moreover, all these outcomes together with the mol. docking study recommended the rationalized target hybrids 4a-c and 5a, particularly 4b, may be considered to be promising lead candidates for discovery of novel anticancer agents via dual inhibition of both EGFR/HDAC enzymes. In addition to this study using Ethyl 5-bromovalerate, there are many other studies that have used Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Organic Letters included an article by Elek, Gabor Zoltan; Koppel, Kaur; Zubrytski, Dzmitry M.; Konrad, Nele; Jarving, Ivar; Lopp, Margus; Kananovich, Dzmitry G.. Computed Properties of C7H13BrO2. The article was titled 《Divergent access to histone deacetylase inhibitory cyclopeptides via a late-stage cyclopropane ring cleavage strategy. Short synthesis of chlamydocin》. The information in the text is summarized as follows:

A unified step-economical strategy for accessing histone deacetylase inhibitory peptides is proposed, based on the late-stage installation of multiple zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripotent cyclopropanol precursor. The efficacy of the proposed diversity-oriented approach has been validated by short stereoselective synthesis of natural product chlamydocin, containing a challenging-to-install fragment of (2S,9S)-2-amino-8-oxo-9,10-epoxydecanoic acid (Aoe) and a range of its analogs, derivatives of 2-amino-8-oxodecanoic and 2-aminosuberic acids. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Computed Properties of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Computed Properties of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary