Category: 1450711-53-1

Yang, Peng published the artcileEnantioselective Dearomative [3 + 2] Umpolung Annulation of N-Heteroarenes with Alkynes, HPLC of Formula: 1450711-53-1, the publication is Journal of the American Chemical Society (2022), 144(3), 1087-1093, database is CAplus and MEDLINE.

Enantioselective [3 + 2] annulation of N-heteroarenes such as 2-(2-bromophenyl)quinoline with alkynes R¹CCR² [R¹ = Me, Ph, benzyloxymethyl, (thiophen-2-ylmethoxy)methyl, etc.; R² = Me, Ph, benzyloxymethyl, (thiophen-2-ylmethoxy)methyl, etc.] has been developed via a cobalt-catalyzed dearomative umpolung strategy in the presence of chiral ligand e.g., [(2R,3R)-3-(diphenylphosphanyl)butan-2-yl]diphenylphosphane and reducing reagent. A variety of electron-deficient N-heteroarenes e.g., 2-(2-bromophenyl)quinoline and internal or terminal alkynes are employed in this reaction, showing a broad substrate scope and good functionality tolerance. Annulation of electron-rich indoles I (R = H, 5-Cl) with alkynes is also developed. This protocol provides a straightforward access to a variety of N-spiroheterocyclic mols. such as II and in excellent enantioselectivities (76 examples, up to 99% ee).

Journal of the American Chemical Society published new progress about 1450711-53-1. 1450711-53-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (2-Bromo-5-methylphenyl)boronic acid, and the molecular formula is C8H15ClN2, HPLC of Formula: 1450711-53-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Durka, Krzysztof published the artcileThe Influence of Boronate Groups on the Selectivity of the Br-Li Exchange in Model Dibromoaryl Boronates, Product Details of C7H8BBrO2, the publication is European Journal of Organic Chemistry (2013), 2013(15), 3023-3032, database is CAplus.

The selectivity of the Br/Li exchange reaction of 6-butyl-2-(2,5-dibromophenyl)-1,3,6,2-dioxazaborocane (2,5-Br₂C₆H₃B(OCH₂CH₂)₂NBu) and the analogous anionic derivatives, 2,5-Br₂C₆H₃B(OiPr)₃Li and 2,5-Br₂C₆H₃BF₃K, was studied using BuLi as the lithiating reagent. In the case of the former compound there was a slight preference for lithiation at the 5-position. For 2,5-Br₂C₆H₃B(OiPr)₃Li, the lithiation occurred exclusively at C5, but for 2,5-Br₂C₆H₃BF₃K, 2-lithiation was preferred. Calculations performed for the lithiation of ortho- and meta-brominated Ph boronates revealed that ortho-lithiated aryl boronates are thermodynamically more stable, but that the Br/Li exchange is generally dictated by kinetics, which accounts for the variation of selectivity depending on the type of boronate group. The successful generation of the 2,5-dilithiophenyl boronate species 2,5-Li₂C₆H₃B(OCH₂CH₂)₂NBu by a double Br/Li interconversion is reported. The Br/Li exchange in the related 6-butyl-2-[3-(2,5-dibromothienyl)]-1,3,6,2-dioxazaborocane, 2,5-Br₂-3-ThB(OCH₂CH₂)₂NBu, occurred preferentially at the 5-position, but the product was readily transformed into the more stable 2-lithiated isomer. The use of 2 equiv of BuLi resulted in the efficient formation of the dilithiated species, 2,5-Li₂-3-ThB(OCH₂CH₂)₂NBu. The obtained lithiated aryl boronates were converted into functionalized arylboronic acids by treatment with selected electrophiles.

European Journal of Organic Chemistry published new progress about 1450711-53-1. 1450711-53-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (2-Bromo-5-methylphenyl)boronic acid, and the molecular formula is C7H8BBrO2, Product Details of C7H8BBrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary