Category: 14425-64-0

Improved Flavodoxin Inhibitors with Potential Therapeutic Effects against Helicobacter pylori Infection was written by Galano, Juan J.;Alias, Miriam;Perez, Reyes;Velazquez-Campoy, Adrian;Hoffman, Paul S.;Sancho, Javier. And the article was included in Journal of Medicinal Chemistry in 2013.Application of 14425-64-0 This article mentions the following:

A variety of electron-deficient chromenes and styrenes and nitrobenzooxadiazolyl thioethers and other compounds were tested (and in some cases prepared) as selective inhibitors of flavodoxin in Helicobacter pylori for potential use in the treatment of gastric ulcer and prevention of stomach cancer with fewer side effects and reduced susceptibilities to drug resistance; their inhibition of flavodoxin and of Helicobacter pylori and their cytotoxicities were determined For example, (E)-ArCH:CHNO₂ (Ar = 2-F-5-F₃CC₆H₃, 4-Cl-2,6-F₂C₆H₂) inhibited H. pylori with IC₅₀ values of 0.53 μM and therapeutic indexes of 38 and 15, resp. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Cross-Coupling of Functionalized Alkyl Halides and Tosylates with Secondary and Tertiary Alkyl Grignard Reagents was written by Ren, Peng;Stern, Lucas-Alexandre;Hu, Xile. And the article was included in Angewandte Chemie, International Edition in 2012.HPLC of Formula: 14425-64-0 This article mentions the following:

A highly efficient method for the cross-coupling of non-activated and functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents has been developed. The copper-based method is remarkably practical and general. The wide scope, and especially the tolerance to a large number of important yet sensitive functional groups, make this method attractive for the streamlined synthesis of functional mols. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0HPLC of Formula: 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.HPLC of Formula: 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Reductive Conjugate Addition of Primary Alkyl Bromides to Enones To Form Silyl Enol Ethers was written by Huihui, Kierra M. M.;Shrestha, Ruja;Weix, Daniel J.. And the article was included in Organic Letters in 2017.Safety of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Conjugate addition of organometallic reagents to enones to form silyl enol ether products is a versatile method to difunctionalize activated olefins, but the organometallic reagents required can be limiting. The reductive cross-electrophile coupling of unhindered primary alkyl bromides with enones and chlorosilanes to form silyl enol ether products is catalyzed by a nickel-complexed ortho-brominated terpyridine ligand. The conditions are compatible with a variety of cyclic/acyclic enones and functional groups. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Safety of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and anticancer activity of chromone-based analogs of lavendustin A was written by Nam, Dong Hyuk;Lee, Ki Yong;Moon, Chang Sang;Lee, Yong Sup. And the article was included in European Journal of Medicinal Chemistry in 2010.Application of 14425-64-0 This article mentions the following:

Lavendustin A and hormothamnione were reported to exhibit cytotoxic effects on tumor cell lines. In the present studies, a series of chromone-based lavendustin analogs were synthesized as a simplified hybrid of hormothamnione and lavendustin A by the reductive-amination of formyl-chromone with various amines followed by aminoalkylation. Most compounds synthesized showed significantly improved potencies compared to the standard compound lavendustin A against most of cancer cell lines tested indicating that the removal of styryl group enhanced cancer cell growth inhibitory activities. Compound I and II showed the most potent inhibitory activities with GI₅₀ values in the range of 6.01-9.92 μg/mL on A-549 and HCT-15 cells. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formation of C(sp²)-boronate esters by borylative cyclization of alkynes using BCl₃ was written by Warner, Andrew J.;Lawson, James R.;Fasano, Valerio;Ingleson, Michael J.. And the article was included in Angewandte Chemie, International Edition in 2015.Computed Properties of C9H11BrO This article mentions the following:

Arylpropargyl compounds R¹C₆H₄YCH₂CCR² undergo cyclization in a reaction with BCl₃ and pinacol, yielding cyclic alkenylboronates I (2, R¹ = H, Me, MeO, Cl; Y = CH₂, NTs, O; R² = Ph, ClC₆H₄, C₆F₅, 3-CF₃C₆H₄, 4-NCC₆H₄, MeC₆H₄, Br, Me, 1-naphthyl, PhCH:CH, 4-NO₂C₆H₄, 4-EtO₂CC₆H₄). Diynes R³CCCH₂YCH₂CCR³ gave boronates II (R³ = Ph, 10a,b; Y = CH₂, NTs) or III (11, R³ = H, Y = CH₂). BCl₃ is an inexpensive electrophile which induces the borylative cyclization of a wide range of substituted alkynes to regioselectively form polycycles containing synthetically versatile C(sp²)-boronate esters. It proceeds rapidly, with good yields and is compatible with a range of functional groups and substitution patterns. Intermol. 1,2-carboboration of alkynes Ar¹CCMe is also achieved using BCl₃ and arene Ar²H to generate trisubstituted vinyl boronate esters Ar¹Ar²C:CMe(Bpin) (12, Ar¹ = Ph, Ar² = 5-methyl-2-thienyl). In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Total Synthesis of Dictyodendrins B and E was written by Liang, Jingjing;Hu, Weimin;Tao, Pengyu;Jia, Yanxing. And the article was included in Journal of Organic Chemistry in 2013.Computed Properties of C9H11BrO This article mentions the following:

The concise synthesis of the novel telomerase inhibitors dictyodendrins B and E, I and II, resp., was completed in only 9 and 11 steps (longest linear sequence). The highly convergent strategy employed a palladium-catalyzed Larock indole synthesis and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C-H activation reaction as key steps. The present synthesis exhibits respectable levels of atom-, redox-, and step-economy. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Inhibition of tyrosine phenol-lyase by tyrosine homologues was written by Do, Quang;Nguyen, Giang T.;Phillips, Robert S.. And the article was included in Amino Acids in 2016.Formula: C9H11BrO This article mentions the following:

The authors designed, synthesized, and evaluated tyrosine homologs and their O-Me derivatives as potential inhibitors for tyrosine phenol-lyase (TPL; EC 4.1.99.2). Recently, the authors reported that homologs of tryptophan were potent inhibitors of tryptophan indole-lyase (tryptophanase; TIL, EC 4.1.99.1), with K_i values in the low micromolar range. As the structure and mechanism for TPL is very similar to that of TIL, the authors postulated that tyrosine homologs could also be potent inhibitors of TPL. However, the authors found that homotyrosine, bishomotyrosine, and their corresponding O-Me derivatives were competitive inhibitors of TPL, which exhibited K_i values in the range of 0.8-1.5 mM. Thus, these compounds were not potent inhibitors, but instead bound with affinities similar to common amino acids, such as phenylalanine or methionine. Pre-steady-state kinetic data were very similar for all compounds tested and demonstrated the formation of an equilibrating mixture of aldimine and quinonoid intermediates upon binding. Interestingly, the authors also observed a blue-shift for the absorbance peak of external aldimine complexes of all tyrosine homologs, suggesting possible strain at the active site due to accommodating the elongated side-chains. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Formula: C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Equivalent Loading of Directed Arenes in Pd(II)-Catalyzed Oxidative Cross-Coupling of Aryl C-H Bonds at Room Temperature was written by Mei, Chong;Zhao, Mengdi;Lu, Wenjun. And the article was included in Journal of Organic Chemistry in 2021.Category: bromides-buliding-blocks This article mentions the following:

Here, in a palladium/oxidant/acid catalytic system at room temperature, one arene could highly selectively couple with the other one to afford the target unsym. biaryls just by controlling the directing groups and the substituted groups on their Ph rings was reported. The utility of this one-one cross-coupling was also demonstrated by synthesis of a few bioactive mols. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Category: bromides-buliding-blocks).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Construction of Chiral 2-Substituted Octahydroindoles from Cyclic Ketones and Nitroolefins Bearing only One α-Substituent was written by Han, Yong;Zheng, Bo;Peng, Yungui. And the article was included in Advanced Synthesis & Catalysis in 2015.Computed Properties of C9H11BrO This article mentions the following:

A dual catalytic system was developed following the screening of a series of chiral primary amine catalysts and chiral phosphoric acid catalysts for the Michael addition of cyclic ketones to nitroolefins bearing only one α-substituent. The resulting γ-nitro ketones, which contain a substituent on the carbon connected to the nitro group, were formed in excellent yields (>80%) with high levels of stereoselectivity (up to 94:6 dr and 98% ee) when the reaction was performed in benzene at 0° with 10 mol% of the optimal amine/phosphoric acid combination (1:1) as a catalyst. Subsequent reduction of the nitro group followed by intramol. reductive amination afforded optically active cis-octahydroindole analogs bearing a non-functional substituent at their 2-position. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Radical trifunctionalization of hexenenitrile via remote cyano migration was written by Chang, Chenyang;Zhang, Huihui;Wu, Xinxin;Zhu, Chen. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Category: bromides-buliding-blocks This article mentions the following:

A novel radical-mediated trifunctionalization of hexenenitriles via the strategy of remote functional group migration is disclosed. A portfolio of functionalized hexenenitriles are employed as substrates. After difunctionalization of the unactivated alkenyl part via remote cyano migration, the in situ formed radical intermediate is captured by an azido radical, thus enabling the trifunctionalization. The reaction features mild conditions and broad functional group compatibility, leading to valuable products bearing multiple useful groups. This protocol further extends the scope of remote functional group migration. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Category: bromides-buliding-blocks).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary