Category: 1435-54-7

Related Products of 1435-54-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1435-54-7 name is 1,3-Dibromo-2-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 1,3-dibromo-2-fluorobenzene (1 equiv) in DMF/EtrN (1 : 1) is added Pdi PPh ; ): (3 mol %) and 4-ethynyl-3-fluorobenzonitrile (2 equiv), and the mixture is stirred for 5 minutes. Sodium ascorbate (6 mol % in DMF) and CuS04 (1 mol % in DMF) are then added, and the reaction is stirred at 80 C for 4 hours. The reaction is diluted with EtOAc and washed with saturated NH4C1 solution and brine. The organic layer is dried over anhydrous Na?.SQ4, filtered, and concentrated under reduced pressure. The crude residue is purified by column chromatography on silica gel to provide 4,4′-((2-fluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(3-fluorobenzonitrile) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dibromo-2-fluorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.; WANG, Binghe; BOYKIN, David, W.; CHOUDHARY, Manjusha, Roy; KUMAR, Arvind; YU, Bingchen; ZHU, Mengyuan; (498 pag.)WO2019/241566; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 1435-54-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-54-7, name is 1,3-Dibromo-2-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 2: 2-(3,5-dibromo-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane To a solution of 1,3-dibromo-2-fluorobenzene (1.43 g, 5.63 mmol) in n-heptane (100 mL) was added Pin2B2 (953 mg, 3.75 mmol), cycloocta-1,5-diene iridium salt (63 mg, 0.094 mmol) and 2,6-diisopropyl-N-(pyridin-2-ylmethylene)aniline (37 mg, 0.14 mmol). The mixture was refluxed for 4 h under N2, cooled to rt, quenched with water, extracted with EA (3*50 mL). The combined organic layer was washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography eluted with PE: EA=80:1 to give 2-(3,5-dibromo-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.046 g, yield 49%) as solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-2-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; Akama, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen; US2013/131016; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1435-54-7, These common heterocyclic compound, 1435-54-7, name is 1,3-Dibromo-2-fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-isopropylphenol 0.1 mol,Dissolved in 100 mL of anhydrous tetrahydrofuran,Stirring, accurately weighing 0.4 moles of sodium hydride in batches added to the reaction flask,Do not be too fast to prevent too much bubble generated, plus the solution after the yellow,Then add 1,3-dibromo-2-fluorobenzene 0.11mol, also added in batches, room temperature reaction overnight. The resulting reaction product was filtered,Remove the solid material, the filtrate spin dry, add methylene chloride dissolved,Column column with petroleum ether: ethyl acetate = 1: 5 (volume ratio)To give 1,3-dibromo-2- (2-isopropylphenoxy) benzene (Intermediate A-1) (0.05 mol, y = 50%).

The synthetic route of 1435-54-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Cui, Dunzhu; Gao, Chunji; Wang, Hui; Ma, Xiaoyu; Li, Ming; Li, Wenju; (54 pag.)CN106187963; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1435-54-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1435-54-7, name is 1,3-Dibromo-2-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 4. SYNTHESIS OF L-B MOIETIES [0503] Scheme 4-1 : In Step 1 the appropriately substituted dibromo species is coupled with an appropriate boronic acid as known in the art to form a mixture of biaryl and triaryl products from which the desired biaryl compound is isolated. In Step 2 the appropriately substituted biaryl species is converted to the Grignard reagent with activated magnesium. In Step 3 the appropriately substituted aldehyde is treated with the previously prepared Grignard reagent to form an alcohol. In Step 4 the appropriately substituted alcohol is converted to a bromide as known in the art with carbon tetrabromide and triphenyl phosphine. In Step 5 the appropriately substituted bromide is converted to the Grignard reagent with activated magnesium.

The chemical industry reduces the impact on the environment during synthesis 1,3-Dibromo-2-fluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (317 pag.)WO2017/35413; (2017); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1435-54-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-54-7, name is 1,3-Dibromo-2-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A stirred solution of 1,3-dibromo-2-fluorobenzene (15.95 g, 62.82 mmol, 1.0 equiv.) in anhydrous THF (100 mL) is cooled to -78 C. n-Butyllithium (1.6 N, 47.1 mL, 75.36 mmol, 1.2 equiv.) is added dropwise and the resulting mixture is stirred for 30 min at -78 C. D-2b (10.00 g, 62.82 mmol, 1.0 equiv.) dissolved in THF (40 mL) is slowly added. After complete conversion, saturated aqueous ammonium chloride is added. The aqueous layer is extracted with EtOAc, the organic layers are combined, dried over Na 2SO 4 and concentrated under reduced pressure. The crude product is purified by chromatography on silica gel (gradient elution: 10% to 20% ethyl acetate in petroleum ether) yielding the desired product D-3b.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-2-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Boehringer Ingelheim International GmbH; RAMHARTER, Juergen; KOFINK, Christiane; STADTMUELLER, Heinz; WUNBERG, Tobias; HOFMANN, Marco Hans; BAUM, Anke; GMACHL, Michael; RUDOLPH, Dorothea Ingrid; SAVARESE, Fabio; OSTERMEIER, Markus; FRANK, Markus; GILLE, Annika; GOEPPER, Stefan; SANTAGOSTINO, Marco; WIPPICH, Julian; (175 pag.)US2019/194192; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary