Category: 1435-53-6

Related Products of 1435-53-6,Some common heterocyclic compound, 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, molecular formula is C6H3Br2F, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 8.10 1-(2′,5′-Dimethoxyphenyl)-3-(2′,5′-dimethoxyphenyl)-4-fluorobenzene (11j): Starting with 10 (100 mg, 0.39 mmol), Cs2CO3 (253 mg, 0.78 mmol), Pd(PPh3)4 (3 mol%), 2,5-dimethoxyphenylboronic acid (158 mg, 0.85 mmol) and 1,4-dioxane (4 mL), 11j was isolated as a colorless solid (91 mg, 65%). Mp 149-150 C. 1H NMR (300 MHz, CDCl3): delta = 3.68 (s, 3H, CH3), 3.69 (s, 3H, OCH3), 3.71 (s, 6H, OCH3), 6.70-6.80 (m, 6H, ArH), 7.04-7.10 (m, 1H, ArH), 7.40-7.45 (m, 2H, ArH). 13C NMR (75 MHz, CDCl3): delta = 55.8 (2OCH3), 56.3 (OCH3), 56.4 (OCH3), 112.4 (CH), 112.6 (CH), 113.2 (CH), 114.2 (CH), 115.1 (d, J = 22.6 Hz, CH), 116.7 (CH), 117.1 (CH), 125.6 (d, J = 16.4 Hz, C), 126.0 (C), 130.3 (d, J = 7.6 Hz, CH), 130.5 (C), 132.8 (d, J = 4.0 Hz, CH), 134.0 (d, J = 3.5 Hz, C), 150.7 (C), 151.3 (C), 153.5 (C), 153.8 (C), 159.3 (d, JCF = 249.0 Hz, CF). 19F NMR (282 MHz, CDCl3): delta = -116.3 (CF). IR (ATR, cm-1): , 3021 (w), 2948 (w), 2832 (w), 1582 (w), 1486 (s), 1463 (m), 1407 (m), 1381 (m), 1295 (m), 1264 (m), 1220 (s), 1174 (s), 1113 (m), 1049 (s), 1023 (s), 915 (w), 855 (m), 803 (m), 755 (w), 706 (s), 5651 (w), 568 (w), 507 (w), 468 (w) cm-1. MS (EI, 70 eV): m/z (%) = 368 (100) [M]+, 339 (12), 338 (57), 169 (12). HRMS (ESI) calcd. for C22H22O4F [M + H]+: 369.14966; found 369.14871.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4-Dibromo-1-fluorobenzene, its application will become more common.

Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tamas; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 1435-53-6,Some common heterocyclic compound, 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, molecular formula is C6H3Br2F, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Mix 4g (23.1 mmol) of intermediate B, 6.4 g (25.4 mmol) of 2,4-bromo-1-fluorobenzene (2,4-Bromo-2-Fluorobenzene), 11.3 g (34.6 mmol) cesium carbonate and 80 ml DMF, and placed under nitrogen, followed by heating at 150CStir for 12h. After the reaction was completed, the mixture was allowed to cool to room temperature. The solution was extracted with 250 ml of ethyl acetate and 300 ml of water. organicThe layer was dried using anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to obtainWhite solid product (7.8 g, 19.2 mmol, yield: 83.1%).

The synthetic route of 1435-53-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiguang Technology Co., Ltd.; Yan Fengwen; (56 pag.)CN107739382; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1435-53-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

a. o . g . mmo , – romo- – uorobezene, 8.20 g (39.4 mmol) 1- phenylbenzimidazol-2-amine and 25.1 g (11.8 mmol) potassium phosphate tribasic in 200 ml DMA are stirred at 110 C for 4 h under nitrogen. The reaction mixture is poured on water. The water phase is extracted with dichloromethane. The organic phase is washed with 3 times water and dried with magnesium sulfate. The solvent is distilled of. The product is decocted in diethyl ether. (0820) Yield 5.30 g (36 %). 1H NMR (400 MHz, CDCl3): ^ = 8.01 (d, 1H), 7.81-7.86 (m, 3H), 7.63-7.7.67 (m, 3H), 7.57-5.59 (m, 1H), 7.46-7.51 (m, 2H), 7.36-7.44 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis 2,4-Dibromo-1-fluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; KAWAMURA, Masahiro; NAGASHIMA, Hideaki; (320 pag.)WO2017/56053; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1435-53-6, A common heterocyclic compound, 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, molecular formula is C6H3Br2F, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 8.1 1,3-Diphenyl-4-fluorobenzene (11a): Starting with 10 (100 mg, 0.39 mmol), Cs2CO3 (253 mg, 0.78 mmol), Pd(PPh3)4 (3 mol%), phenylboronic acid (94 mg, 0.78 mmol) and 1,4-dioxane (4 mL), 11a was isolated as a colorless oil (54 mg, 55%). 1H NMR (300 MHz, CDCl3): delta = 7.09-7.16 (m, 1H, ArH), 7.23-7.32 (m, 2H, ArH), 7.33-7.45 (m, 5H, ArH), 7.47-7.63 (m, 5H, ArH). 13C NMR (75 MHz, CDCl3): delta = 116.3 (d, J = 23.6 Hz, CH), 127.1 (2CH), 127.6 (d, J = 8.02 Hz, CH), 128.6 (2CH), 128.9 (2CH), 129.1 (CH), 129.6 (CH), 130.9 (CH), 132.5 (C), 135.8 (C), 137.7 (d, J = 3.57 Hz, C), 140.2 (C), 159.4, (d, JCF = 249.0 Hz, CF). 19F NMR (282 MHz, CDCl3): delta = -120.67 (CF). IR (ATR, cm-1): , 3029 (w), 2956 (w), 2927 (w), 2857 (w), 1948 (w), 1883 (w), 1806 (w), 1723 (m), 1600 (w), 1539 (w), 1478 (s), 1392 (w), 1332 (w), 1257 (m), 1183 (w), 1121 (m), 1073 (m), 1000 (w), 945 (w), 892 (m), 823 (s), 759 (s), 721 (m), 693 (s), 631 (s), 584 (s), 539 (m). MS (EI, 70 eV); m/z (%) = 248 (100) [M]+. HRMS (EI) calcd. for C18H13OF [M]+: 248.09958; found 248.89357.

The synthetic route of 1435-53-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tamas; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3Br2F

General procedure: To a mixture of 1,3-dibromo-5-fluorobenzene (1.39 g, 5.51 mM), 2-tri-n-butylstannylpyridine(5.00 g, 13.6 mM), bis(triphenylphosphine)palladium dichloride (1.00 g, 1.43 mM),and lithium chloride (0.37 g, 8.84 mM) in an oven dried Schlenk tube, distilled toluene(40 mL) was added. The mixture was degassed via the freeze-pump-thaw method until nogas bubbles were observed and refluxed at 110 C under nitrogen for 48 h. After coolingthe reaction mixture to room temperature, an aqueous solution of potassium fluoride(40 mL) was added and the insoluble black residue was filtered and washed with toluene.The toluene was removed under reduced pressure. Dichloromethane (100 mL) and aqueoussodium bicarbonate (100 mL) were added to the remaining residue. The organic phase wasseparated, washed with sodium bicarbonate (2 ¡Á 100 mL), then dried over anhydroussodium sulfate and evaporated to obtain a yellow residue. This residue was then purifiedover silica with a mixture of 90% hexane: 10% diethyl ether, whose mole fraction was measuredto 50% hexane: 50% diethyl ether to obtain a pale yellow solid (0.8078 g, 58%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Papo, Tshephiso R.; Jaganyi, Deogratius; Journal of Coordination Chemistry; vol. 68; 5; (2015); p. 794 – 807;,
Bromide – Wikipedia,
bromide – Wiktionary

1435-53-6, The chemical industry reduces the impact on the environment during synthesis 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, I believe this compound will play a more active role in future production and life.

The 1L in three-mouth bottle, by adding benzo [d] imidazole (11.8g, 0 . 1mol), 2, 4-dibromide fluoride bonzene (51g, 0.2mol), Cs 2 CO 3 (65g, 0.2mol), N, N-dimethyl acetamide (DMA, 350g), N 2 protection, warming to reflux, thermal insulation reaction 48h, to room temperature, the reaction solution slowly into 1.4L deionized water, stirring 30 min, filtered, 400mLX2 deionized water washing, the crude product by silica gel column chromatography, eluting agent is petroleum ether: ethyl acetate = 2:1, to obtain the target compound 1-(2, 4-dibromo) phenyl-benzo [d] imidazole (compound 1a) 25.7g, yield 73%,

The chemical industry reduces the impact on the environment during synthesis 2,4-Dibromo-1-fluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; The energy-Mason Co.; Sheng, Lei; Shi, Yu; Zhang, Xinxin; Gao, Ziliang; Zhang, Xueheng; Guo, Haiyan; (31 pag.)CN104109532; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

1435-53-6, A common compound: 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Example 195N-(4-(3-methyl-lH-1,2,4-triazol-1-yl)phenyl)-4-(2-(methylsulfonyl)-5- morpholinophenyl)pyrimidin-2-aminePart I: 4-(3-bromo-4-(methylsulfonyl)phenyl)morpholine[0353] A mixture of 2,4-dibromo-1-fluorobenzene (1.0 g, 4.0 mmol), NaSMe (0.33 g, 4.8 mmol), triethylamine (0.52 rnL, 4.0 mmol) and dimethylacetamide (3 mL) in a sealed tube was heated up to 100C for 12 hr. The reaction mixture was cooled, diluted with EtOAc and washed with brine. The organic layer was separated, dried (MgSO4) and concentrated to give a crude residue which was purified by chromatography on silica gel (EtOAc/hexanes) to afford (2,4-dibromophenyl)(methyl)sulfane.[0354] 4-(3-bromo-4-(methylsulfonyl)phenyl)morpholine was obtained by following procedure O utilizing morpholine and 2,4-dibromo-1-(methylsulfonyl)benzene which was prepared from (2,4-dibromophenyl) (methyl) sulfane following the protocol as described forExample 43.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dibromo-1-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/32861; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary