Category: 1435-52-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, A new synthetic method of this compound is introduced below., Quality Control of 1,4-Dibromo-2-fluorobenzene

150ml three-necked flask, add 0.01 mol of 2,5-dibromofluorobenzene, 0.012 mol M1, 0.02 mol sodium carbonate and 10 ml ethylene glycol dimethyl ether, It was purged with nitrogen, heated to 190 ¡ã C, and stirred for 48 hours. Then cooled to room temperature and poured into a beaker.Add 50 ml of toluene and 50 ml of water and stir for 20 minutes. Filtration, the filtrate is steamed, passed through a silica gel column, Obtaining white intermediate 1a, The purity was 98.60percent, and the yield was 80.5percent.

The synthetic route of 1435-52-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Ye Zhonghua; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (57 pag.)CN109575057; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-52-5, SDS of cas: 1435-52-5

General procedure: 6.11 1,4-Di(2-thienyl)-2-fluorobenzene (7k): Starting with 6 (100 mg, 0.39 mmol), Cs2CO3 (190 mg, 0.50 mmol), Pd(PPh3)4 (3 molpercent), 2-thienylboronic acid (49 mg, 0.39 mmol) and 1,4-dioxane (4 mL), 7k was isolated as a colorless solid (51 mg, 50percent). Mp 94-96 ¡ãC. 1H NMR (300 MHz, CDCl3): delta = 7.00-7.06 (m, 2H, ArH), 7.22-7.34 (m, 5H, ArH), 7.41-7.43 (m, 1H, ArH), 7.52-7.57 (m, 1H, ArH). 13C NMR (75.46 MHz, CDCl3): delta = 113.4 (d, J = 24.5 Hz, CH), 121.1 (d, J = 13.5 Hz, C), 121.8 (d, J = 3.1 Hz, CH), 123.8 (CH), 125.6 (CH), 125.8 (d, J = 4.5 Hz, CH), 126.3 (d, J = 7.1 Hz, CH), 127.8 (CH), 128.3 (CH), 129.0 (d, J = 4.2 Hz, CH), 134.9 (d, J = 9.4 Hz, C), 136.9 (d, J = 3.87 Hz, C), 142.6 (d, J = 2.9 Hz, C), 159.2 (d, JCF = 250.2 Hz, CF). 19F NMR (282.4 MHz, CDCl3): delta = -107.4 (CF). IR (ATR, cm-1): , 3074 (w), 2961 (w), 2854 (w), 1799 (w), 1606 (w), 1553 (w), 1483 (m), 1419 (m), 1354 (w), 1289 (w), 1259 (m), 1207 (w), 1135 (w), 1058 (m), 1015 (m), 945 (w), 866 (m), 805 (s), 692 (s), 630 (m), 579 (w), 550 (m), 528 (m). GC-MS (EI, 70 eV): m/z (percent) = 260 (100) [M+], 215 (12). HRMS (EI) calcd. for C14H9FS2 [M]+: 260.01242; found 260.01269.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1435-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 6.12 1,4-Di(3′-chlorophenyl)-4-fluorobenzene (7l): Starting with 6 (200 mg, 0.79 mmol), Cs2CO3 (385 mg, 1.81 mmol), Pd(PPh3)4 (3 molpercent), 3-chlorophenylboronic acid (246 mg, 1.58 mmol) and 1,4-dioxane (4 mL), 7l was isolated as a colorless solid (201 mg, 80percent). Mp 102-103 ¡ãC. 1H NMR (300 MHz, CDCl3): delta = 7.25-7.33 (m, 5H, ArH), 7.34-7.35 (m, 1H, ArH). 7.37-7.43 (m, 3H, ArH), 7.49-7.52 (m, 2H, ArH). 13C NMR (75 MHz, CDCl3): delta = 114.8 (d, J = 25.7 Hz, CH), 123.0 (d, J = 4.0 Hz, CH), 125.1 (CH), 127.1 (2CH), 128.0 (d, J = 9.4 Hz, 2CH), 129.0 (d, J = 4.0 Hz, CH), 130.0 (d, J = 33.7 Hz, 2CH), 131.0 (d, J = 4.0 Hz, CH), 134.4 (C), 134.9 (C), 137.0 (C), 141.1 (C), 141.4 (C), 141.5 (C), 159.9 (d, JCF = 248.8 Hz, CF). 19F NMR (282 MHz, CDCl3): delta = -114.6 (CF). IR (ATR, cm-1): , 2923 (w), 2851 (w), 1619 (m), 1562 (m), 1463 (m), 1386 (s), 1288 (m), 1248 (m), 1186 (m), 1130 (m), 1079 (m), 1022 (m), 967 (m), 915 (m), 876 (m), 824 (m), 773 (s), 756 (s), 686 (s), 636 (m), 552 (m), 515 (m), 468 (m), 419 (m) cm-1. GC-MS (EI, 70 eV): m/z (percent) = 292 (100) [M]+, 277 (34), 249 (23), 233 (12). HRMS (EI) calcd. for C18H11Cl2F [M]+: 316.02164; found 316.021941; calcd. for C18H11Cl37ClF [M]+: 318.01869; found 318.01898.

The synthetic route of 1,4-Dibromo-2-fluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1435-52-5 as follows. name: 1,4-Dibromo-2-fluorobenzene

To a stirred solution of 1,4-dibromo-2-fluorobenzene (100 g, 395.2 mmol) in ethylene glycol(510 mL), NMP (50 mL) was added at rt under N2 atmosphere. Then tBuOK (155.2 g,1383.0 mmol) was added slowly over 10 mm at 10 C. The reaction mixture was heated at100 C for 12 h. The completion of the reaction was monitored by TLC. The reaction mixture was cooled to rt and diluted with water (200 mL) and stirred for 15 mm at rt. The resulting solid was filtered and washed with ethylene glycol (2 x 30 mL). Water (2200 mL) was added to the filtrate, the solution was cooled to 15 C and stirred for I h. The resulting precipitate was filtered and washed with water (2 x 100 mL), pet ether (2 x 100 mL) and dried. It was further dried with the addition of toluene and its evalportaion (3 x 200 mL). It was then use in the next step without further purification. Yield: 77.5% (90 g, pale brown solid). 1H NMR (400 MHz, CDCI3): 6 7.41 (d, J = 8.4 Hz, I H), 7.06 (d, J = 2.0 Hz, I H), 7.02 (dd, J = 8.4, 2.4 Hz, IH), 4.14 (t, J = 4.4 Hz, 2H), 4.03-4.00 (m, 2H), 2.36 (t, J = 6.4 Hz,IH).

According to the analysis of related databases, 1435-52-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-52-5, Recommanded Product: 1,4-Dibromo-2-fluorobenzene

50 ml three-necked flask, adding 0.01 mol of 2,5-dibromofluorobenzene, 0.012 mol of M20.02 mol of sodium carbonate and 10 ml of ethylene glycol dimethyl ether were purged with nitrogen, heated to 190 ¡ã C, and stirred for 48 hours.It was then cooled to room temperature, poured into a beaker, and stirred for 50 minutes by adding 50 ml of toluene and 50 ml of water.Filtration and evaporation of the filtrate over silica gel column afforded white intermediate 3a, purity 98.10percent, yield 77.5percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Ye Zhonghua; Li Chong; Zhang Zhaochao; Zhang Xiaoqing; (74 pag.)CN109575056; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1435-52-5, A common heterocyclic compound, 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, molecular formula is C6H3Br2F, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 6.3 1,4-Di(4′-ethoxyphenyl)-2-fluorobenzene (7c): Starting with 6 (100 mg, 0.39 mmol), Cs2CO3 (190 mg, 0.50 mmol), Pd(PPh3)4 (3 molpercent), 4-ethoxyphenylboronic acid (64 mg, 0.39 mmol) and 1,4-dioxane (4 mL), 7c was isolated as a colorless solid (86 mg, 65percent). Mp 96-98 ¡ãC. 1H NMR (300 MHz, CDCl3): delta = 1.39 (t, J = 7.2 Hz, 6H, CH3), 3.99 (q, J = 6.89 Hz, 4H, OCH2), 6.85-6.91 (m, 4H, CH), 7.21-7.28 (m, 3H, CH), 7.36-7.50 (m, 4H, CH). 13C NMR (75 MHz, CDCl3): delta = 14.9 (2CH3), 63.6 (2OCH2), 106.8 (d, J = 22.0 Hz, C), 114.5 (d, J = 16.5 Hz, CH), 114.7 (CH), 115.0 (CH), 123.4 (d, J = 3.8 Hz, CH), 127.7 (CH), 128.0 (CH), 131.3 (C), 133.6 (CH), 133.9 (C), 144.1 (C), 159.2 (d, 1JCF = 247.0 Hz, C). 19F NMR (282 MHz, CDCl3): delta = -114.92. IR (ATR, cm-1): , 2935 (w), 2838 (w), 1897 (w), 1597 (m), 1474 (s), 1243 (s), 1180 (m), 1027 (s), 805 (s), 751 (m), 692 (m), 412 (w). GC-MS (EI, 70 eV): m/z (percent) = 336 (100) [M]+, 307 (22), 280 (32), 279 (15), 251 (14). HRMS (EI) calcd. for C22H21FO2 [M]+: 336.15201; found 336.15196.

The synthetic route of 1435-52-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 1435-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1,4-dibromo-2-fluorobenzene (6.86 g, 27 mmol), ethanediol (35 mL), N-methylpyrrolidone (35 mL) and potassium tert-butoxide (11.2 g, 95 mmol) was stirred at 100 C overnight under N2. After the mixture was cooled to room temperature, water (15 mL) was added slowly within 30 min. Then the mixture was filtered, and the filter cake was washed by ethanediol. To the filtrate was added water and the mixture was stirred for 30 min. The resulting solution was then cooled to 15 C, and let stay for 1 h. The precipitate was filtered, washed by water, and dried to give the title compound (4.70 g, 59 %). 1H NMR (CDCl3): delta 7.40 (1H, d, J = 8.4 Hz), 7.05 (1H, d, J = 2.4 Hz), 7.02-6.70 (1H, m), 4.14 (2H, t, J = 4.4 Hz), 4.02-3.98 (2H, m), 2.13 (1H, t, J = 6.4 Hz)

The synthetic route of 1,4-Dibromo-2-fluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Li, Yuliang; WANG, Huting; ZHU, Yan; WANG, Zhe; ZHANG, Hui; ZHAO, Ruiyu; HUANG, Yuanyuan; WANG, He; PENG, Yong; LUO, Hong; XIAO, Dengming; CAO, Shousong; HAN, Yongxin; EP2862571; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1435-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 1,4-dibromo-2-fluorobenzene (Combi-Blocks, 1000 g, 3938 mmol) in ethylene glycol (5100 mL), NMP (500 mL) was added at rt under nitrogen atmosphere. Then potassium tert-butoxide (1547 g, 1378 mmol) was added in portion over 45 min at 5 C and the resulting mixture was heated to 90 C for 16 h. Completion of the reaction was monitored by HPLC. The reaction mixture was cooled to rt and diluted with water (2000 mL) and stirred for 15 min at rt. The resultant solid was filtered and washed with ethylene glycol (300 mL x 2). To the filtrate, water (16000 mL) was added. The mixture was cooled to 10 C and stirred 1 h at the same temperature to get solid. The solid was filtered and washed with water (1000 mL x 2), pet ether (3 X 1000 mL) and dried. This solid was mixed with toluene and toluene was evaporated. This process was repeated 3 times (3 X 500 mL) to give the title compound. Yield: 78% (910 g, White solid). 1H NMR (400 MHz, CDCl3): delta 7.41 (d, J = 8.0 Hz, 1H), 7.06-7.00 (m, 2H), 4.14 (t, J = 4.0 Hz, 2H), 4.01 (q, J = 3.6 Hz, 2H). LCMS: (Method A) 296.0 (M+H), Rt. 3.97 min, 98.16% (Max). HPLC: (Method A) Rt. 3.67 min, 99.53% (Max), 99.38% (220nm).

The synthetic route of 1,4-Dibromo-2-fluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; KOEK, Johannes Nicolaas; (64 pag.)WO2017/144635; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

A common compound: 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 1435-52-5

General procedure: 6.9 1,3-Di(4′-fluorphenyl)-5-fluorobenzene (7i): Starting with 6 (100 mg, 0.37 mmol), Cs2CO3 (263 mg, 0.81 mmol), Pd(PPh3)4 (3 molpercent), 4-fluoromethylphenylboronic acid (109 mg, 0.78 mmol) and 1,4-dioxane (4 mL), 7i was isolated as a colorless solid (54 mg, 48percent). Mp 145-149 ¡ãC. 1H NMR (300 MHz, CDCl3): delta = 7.03-7.09 (m, 2H, ArH), 7.24-7.29 (m, 1H, ArH), 7.32-7.36 (m, 4H, ArH), 7.41-7.50 (m, 4H, ArH). 13C NMR (75 MHz, CDCl3): delta = 114.5 (dd, J = 24.2, 3.8 Hz, CH), 115.5 (d, J = 21.5 Hz, CH), 115.9 (d, J = 21.4 Hz, CH), 122.8 (t, J = 3.2 Hz, CH), 128.2 (CH), 128.8 (CH), 129.2 (CH), 130.5 (d, J = 3.34 Hz, CH), 130.7 (dd, J = 8.2, 3.3 Hz, CH), 130.9 (d, J = 3.3 Hz, CH), 131.3 (CH), 133.7 (d, J = 1.1 Hz, C), 134.2 (d, J = 4.9 Hz, C), 137.8 (d, J = 1.7 Hz, C), 141.1 (d, J = 8.3 Hz, C), 159.9 (d, JCF = 248.2 Hz, CF), 162.5 (d, JCF = 247.6 Hz, CF), 168.8, (d, JCF = 247.7 Hz, CF). 19F NMR (282 MHz, CDCl3): delta = -114.2.5, -117.3, -117.6 (CF). IR (ATR, cm-1): , 3041 (w), 2953 (w), 2917 (w), 2849 (w), 1907 (w), 1602 (w), 1595 (w), 1524 (w), 1480 (m), 1429 (w), 1387 (w), 1298 (w), 1224 (m), 1163 (m), 1094 (w), 1006 (w), 967 (w), 892 (m), 833 (m), 809 (s), 751 (w), 709 (w), 690 (w), 613 (w), 577 (m), 546 (w). MS (EI, 70 eV); m/z (percent) = 284 (100) [M]+. HRMS (EI) calcd. for C18H11F3 [M]+: 284.08074; found 284.10827.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1435-52-5, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary