Category: 141474-37-5

Some common heterocyclic compound, 141474-37-5, name is 2,4-Dibromo-6-fluoroaniline, molecular formula is C6H4Br2FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 141474-37-5

5.38g (20.0 mmol) of 2,4-dibromo-6-fluoro-phenylamine, 5.36 g (44.0 mmol) of phenylboronic acid, 1.15 g (1.0 mmol) of Pd(PPh3)4, and 8.29 g (60.0 mmol) of K2CO3 were dissolved in 80 mL of a mixed solution THF/H2O (2:1) to obtain a solution, which was then stirred at about 70C for about 5 hours. The reaction solution was cooled to room temperature, followed by three times of extraction with 60 mL of water and 60 mL of diethylether. The organic phase was collected, and was dried using magnesium sulfate to evaporate the solvent. The residue was separated and purified using silica gel column chromatography to obtain 4.11 g of Intermediate I-29 (Yield: 78 %) This compound was identified using LC-MS and NMR. C18H14FN : M+ 263.1 1H NMR (CD2Cl2, 400MHz) delta (ppm) 7.62-7.57 (t, 1H), 7.56-7.54 (m, 1H), 7.51-7.47 (m, 4H), 7.44-7.37 (m, 3H), 7.31-7.30 (m, 1H), 7.29-7.26 (m, 1H), 7.23-7.22 (m, 1H), 3.94 (s, 2H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 141474-37-5, its application will become more common.

Reference:
Patent; Samsung Mobile Display Co., Ltd.; EP2447250; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 141474-37-5, name is 2,4-Dibromo-6-fluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2,4-Dibromo-6-fluoroaniline

General procedure: A mixture of 2-iodoaniline (0.20 mmol), phenyl isothiocyanate (0.22 mmol), DABCO (0.40 mmol, 2.0 equiv) and polystyrene-immobilized phenanthroline-Cu(I) catalyst 4 (20 mg, containing Cu 0.005 mmol) and toluene (1.0 mL) was stirred at 60 C for 8 h. After completion of the reaction as indicated by TLC, the mixture was cooled to room temperature and Et2O (5.0 mL) was added and the mixture stirred for 10 min to ensure product removal from catalyst. As supported catalyst 4 was precipitated to the bottom of the flask, the organic layer was decanted and the residue was washed with Et2O (2×5.0 mL). The combined organic layers were concentrated, and then the residue was purified by flash chromatography on silica gel to provide the corresponding pure product 7a in 95% yield.

The synthetic route of 141474-37-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Jin; Li, Pinhua; Wang, Lei; Tetrahedron; vol. 67; 31; (2011); p. 5543 – 5549;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141474-37-5, name is 2,4-Dibromo-6-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2,4-Dibromo-6-fluoroaniline

2,4-dibromo-6-fluoro-phenylamine 2.69 g (10.0 mmol), phenylboronic acid 2.68 g (22.0 mmol), Pd(PPh3)4 (Tetrakis(triphenylphosphine)palladium(0)) 0.58 g ( 0.5 mmol) and K2CO3 6.21 g (45.0 mmol) were dissolved in 40 mL of a THF (tetrahydrofuran)/H20 (2/1) mixed solution, and stirred at 80C for 5 hours. After cooling the reaction solution to room temperature, it was extracted 3 times with 40 mL of water and 40 mL of diethyl ether. The organic layer obtained therefrom was dried over magnesium sulfate, and the residue obtained by evaporating the solvent was separated and purified through silica gel column chromatography to obtain intermediate I-2 (2.26 g, 86% yield).

According to the analysis of related databases, 141474-37-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samsung Display Co., Ltd.; Kim Su-yeon; Hwang Seok-hwan; Kim Yeong-guk; Jeong Hye-jin; Im Jin-o; Han Sang-hyeon; Jeong Eun-jae; Park Jun-ha; Lee Eun-yeong; Lee Jong-hyeok; (74 pag.)KR102105076; (2020); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 141474-37-5,Some common heterocyclic compound, 141474-37-5, name is 2,4-Dibromo-6-fluoroaniline, molecular formula is C6H4Br2FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 1L round bottom flask, 2,4-dibromo-6-fluoroaniline 30 g (111.56 mmol), phenylboronic acid-d5 31.2 g (245.44 mmol), potassium carbonate (K2CO3) 61.9 g (446.27 mmol), tetrakis Triphenylphosphine palladium (Pd(PPh3)4) 2.6 g (2.20 mmol), water 120 mL, toluene 300 mL and tetrahydrofuran 300 mL was added and refluxed for 24 hours. When the reaction was completed, the resultant product was layer-separated to remove the aqueous layer, the organic layer was separated and concentrated under reduced pressure, and then the solid obtained by separation by column chromatography using hexane and dichloromethane as a development solvent was dried, yielding 24.2 g. 79.4% of a white solid was obtained.

The synthetic route of 141474-37-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SFC Ltd.; Lee Sang-hae; Sim So-yeong; Ryu Se-jin; (30 pag.)KR102121582; (2020); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 141474-37-5, name is 2,4-Dibromo-6-fluoroaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 141474-37-5, Recommanded Product: 2,4-Dibromo-6-fluoroaniline

compound 2,4-dibromo-6-fluroaniline (2,4-dibromo-6-fluoroaniline) 40 g (149 mmol),phenylboronic Acid (Phenylboronic acid) 39.9 g (327 mmol),Tetrakis (triphenylphosphine) palladium (0), 8.59 g (7.44 mmol),K2CO3 82 g (595 mmol), Toluene (Toluene) 600 mL, H2O 150 mL Put the nitrogen was replaced. 24 hours of reaction at 100 degree and Distilled water and dichloromethane (MC), and extracted using NaCl. With a rotary evaporator after the organic layer was dried over anhydrous MgSO4After removal of the solvent hexane (Hexane): dichloromethane (MC) = 20: 1 using a column chromatography (columnPurification by chromatography) to obtain 32.9 g of the desired compound 2-3 (85%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dibromo-6-fluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hee Sung Material Co., Ltd; Kim, Ji Hee; Jang, So Hyun; Kim, Yeong Woo; Kim, Hyun Dong; Uhm, Song Jin; Lee, Ju Dong; (50 pag.)KR2016/1508; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary