Category: 141215-32-9

Related Products of 141215-32-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141215-32-9 as follows.

First, the amine compound (10 g, 30.8 mmol) obtained in Step 2 was dissolved in dehydrated pyridine (300 ml) in a 1,000 ml three-necked flask under Ar gas, and N-thionylaniline(9.5 g, 66 mmol) and trimethylsilyl chloride (39.5 g, 363.5 mmol) were added. Thereafter, the internal temperature was raised to 80 C., and the mixture was stirred overnight.Then, the reaction solution was cooled to room temperature and poured into water (200 ml). Precipitated crystals were collected by filtration, and the solid was washed with THF / n-hexane to obtain 6 g of a solid (crystal).Thereafter, purification was carried out by silica gel chromatography (silica gel 300 g, developing solvent chlorobenzene / hexane = 10: 3) (yield 3 g, yield 27.6%)

According to the analysis of related databases, 141215-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Seiko Epson Corporation; Tetsuji, Fujita; Yamamoto, Hidetoshi; Hamade, Yuiga; (64 pag.)JP2018/111679; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 141215-32-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 141215-32-9 name is 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Dissolve 5,6-diamino-4,7-dibromobenzo [c] [1,2,5] thiadiazole (0.38g, 1.2mmol) in anhydrous chloroform (10mL) round bottom In a flask, the mixture was stirred with thionyl chloride (1.2 mL) at 0 C, then 8.0 mL of pyridine was added, and the reaction was carried out at room temperature for 20 hours. After the reaction, the mixture was cooled to room temperature and sucked onto ice water, and the precipitate was filtered and methanol was washed with water to obtain a core.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine, and friends who are interested can also refer to it.

Reference:
Patent; Beijing University Shenzhen Sheng Yuan; Meng Hong; Zhang Pengfei; He Yaowu; Qiu Fangcheng; (14 pag.)CN110872308; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 141215-32-9, A common heterocyclic compound, 141215-32-9, name is 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine, molecular formula is C6H4Br2N4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Gas in the flask with argon purged 200mL flask,Added1500mg heterocyclic compound according to Journal (Heterocycles), 1992, Vol. 33, No. 1, p.337-348 method described in the manufacture of 3 (1.54mmol), benzil 325mg (1.54mmol), acetic acid 25mL , the flask was immersed in an oil bath heated to 120 deg.] C, and reacted for 2 hours. Subsequently, the flask was cooled to room temperature (25 deg.] C), the reaction mixture was poured into 300mL of methanol. The solid was recovered by filtration, washed with methanol, and dried under vacuum to give 629mg of the title compound 32 (1.26mmol).

The synthetic route of 141215-32-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Chemical Co.,Ltd; Ken, Yoshimura; Kenichiro, Oya; (111 pag.)CN105601662; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary