Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 138526-69-9
General procedure: 2-Amino-4-dimethylamino-6-phenyl-1,3,5-triazine (0.1076 g, 0.50 mmol) was added to the reaction vessel,P-methoxyiodobenzene (0.1170 g, 0.50 mmol), cuprous iodide (0.0285 g, 0.15 mmol), potassium carbonate(0.1380 g, 1.00 mmol), N, N’-dimethylethylenediamine (DMEDA, 0.0396 g, 0.45 mmol)Acetonitrile (3 mL) was added and the mixture was refluxed for 10 hours. After completion of the reaction, 4 mL of ammonia water was added and the mixture was stirred for 5 minutesSaturated aqueous NaCl (20 mL) was added and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, concentrated,(Eluent: petroleum ether: ethyl acetate = 5: 1, v: v) and an Rf value of 0.4-0.45 (TLCThe eluent was separated and the solvent was removed by distillation under reduced pressure, and dried to obtain 0.1222 g of the aimed compound (IIII-1)Yield 76.0% The same operation as in Example 10 was repeated except that p-iodoanisole was replacedTrifluorobromobenzene (0.1057 g, 0.50 mmol),To give the title compound (IIII-17) (0.1218 g, yield 70.6%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhejiang University of Technology; CUI, DONG MEI; LI, JIN JING; WU, KONG; ZHANG, CHEN; (15 pag.)CN105837525; (2016); A;,
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