Category: 138526-69-9

Reference of 138526-69-9,Some common heterocyclic compound, 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, molecular formula is C6H2BrF3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

-(3,4-Difluoro-5-morpholinophenyl)-N-(4-(3-methyl-leta-1,2,4-triazol-1- yl)phenyl)pyrimidin-2-amine Part I: 4-(5-Bromo-2,3-difluorophenyl)morpholine[0375] A mixture of 5-bromo-1,2,3-trifluorobenzene (2.5 g, 11.8 mmol), morpholine (1.0 rnL, 11.8 mmol), K2CO3 (1.6 g, 11.8 mmol) and DMSO (2 mL) in a sealed tube was heated up to 90C for 2.5 h. The reaction mixture was cooled to room temperature and diluted with water. The resulting colorless precipitate was filtered, washed with water, and dried in vacuo to afford 4-(5-bromo-2,3-difluorophenyl)morpholine in 76% yield. 1H NMR (CDCl3, 400 MHz) delta 6.91-6.87 (m, 1H), 6.75-6.72 (m, 1H), 3.80-3.78 (m, 4H), 3.04-3.02 (m, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3,4,5-trifluorobenzene, its application will become more common.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/32861; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 138526-69-9, A common heterocyclic compound, 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, molecular formula is C6H2BrF3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 100 g of this 2-iodo-7-propyl-9,10-dihydrophenanthrene in 300 mL of THF was added 3.3 g of tetrakis(triphenylphosphine)palladium (0) and the mixture was stirred at room temperature. This mixture was then reacted with a Grignard reagent prepared from 79 g of 3,4,5-trifluorobromobenzene and 9.1 g of magnesium. Following stirring for 2 hours at room temperature, the mixture was allowed to cool to room temperature, water was added, the product was extracted into toluene, and the organic layer was washed sequentially with water and a saturated aqueous solution of sodium chloride before being dried over anhydrous sodium sulfate. The crude product obtained by removal of the solvent by evaporation was purified by silica gel columnchromatography (hexane) and then recrystallized 3 times from ethanol to yield 45 g of white crystals of 2-propyl-7-(3,4,5-trifluorophenyl)-9,10-dihydrophenanthrene. Measurement of the phase transition temperature revealed a transition from the crystalline phase to an isotropic liquid phase at 68C under rising temperature conditions. NMR: delta = 0.99 (t, J=7Hz, 3H), delta = 1.65 (m, 2H), delta = 2.52 (t, J=7Hz, 2H), delta = 2.88 (s, 4H), delta = 6.9 to 7.6 (m, 8H), MS: m/e = 352 (M+)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DAINIPPON INK AND CHEMICALS, INC.; EP1201632; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, molecular formula is C6H2BrF3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Bromo-3,4,5-trifluorobenzene

General procedure: To a mixture of 1,3,5-triazine(0.5 mmol), aryl halide (0.5 mmol), DMEDA (0.45 mmol)and K2CO3 (1 mmol) in MeCN (3 mmol) was added CuI (0.15mmol). The resulting mixture was stirred at reflux. After completionof the reaction, the reaction mixture was cooled to r.t.,concd NH3 (4 mL) and sat. NaCl (10 mL) were added, and theorganic phase was then extracted with EtOAc (3 × 15 mL). Theorganic phase was dried over anhyd Na2SO4. The crude residuewas obtained after evaporation of the solvent in vacuum, andthe residue was purified by flash chromatography with petroleumand EtOAc as the eluent to give the pure product. N2-(4-Methoxyphenyl)-N4,N4-dimethyl-6-phenyl-1,3,5-triazine-2,4-diamine (3a):

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 138526-69-9, its application will become more common.

Reference:
Article; Li, Jin Jing; Wu, Kong; Zhou, Wei; Wang, Hong; Cui, Dong-Mei; Zhang, Chen; Synlett; vol. 27; 13; (2016); p. 1993 – 1996;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 138526-69-9

The format reagent is kept at a reaction temperature of 5 C.3,4,5-trifluorobromobenzene 28.476 g (0.14 mol) was previously dissolved in 70 mL of THF to prepare a 3,4,5-trifluorobromobenzene solution.Trimethyl borate (64.4 g, 0.28 mol) was previously dissolved in THF (50 mL) to form a trimethyl borate solution.In a 1000 mL dry three-necked flask equipped with a thermometer and a constant pressure dropping funnel,Add 3.8 g (0.16 mol) of magnesium, THF (30 mL),Under the protection of N2, 1 mL of 1,2-dibromoethane and 5 mL of the above-mentioned 3,4,5-trifluorobromobenzene solution were added dropwise, and the reaction was initiated at 5 to 10 C, and a large amount of bubble temperature rose rapidly. Slowly turned grayish black,And controlling the temperature to drop the remaining 3,4,5-trifluorobromobenzene solution of the above configuration at 10 C, the solution slowly turns black gray, after the addition is completed,The reaction was incubated at 5 C for 2 h (ie, the format reagent was kept at a reaction temperature of 5 C).Then the reaction solution is cooled to about -30~-27 C.The above-prepared trimethyl borate solution was slowly added dropwise dropwise.After the completion of the dropwise addition, the reaction was continued at -30 C for 2 h.After the reaction was completed, dilute hydrochloric acid (135 mL of 12% dilute hydrochloric acid) was added dropwise at room temperature, and the mixture was stirred at room temperature for 4 h.Ester extraction (50 mL × 3), the organic phase is combined, dried over anhydrous sodium sulfate, and the organic phase is distilled off under reduced pressure, and the residue is distilled.Add 20 mL of dichloromethane, stir for 5 min, filter with a white solid, wash with a small amount of dichloromethane, and dry to give a white powder3,4,5-trifluorobenzeneboronic acid 14.78 g, yield 60%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhejiang University of Technology; Li Zhenhua; Zhang Xuchao; Tan Zhiyong; (11 pag.)CN109942433; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 138526-69-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a 3000 L reactor, 201.6 kg of KOH was added,Pumped 253.2 kg of 3,4,5-trifluorobromobenzene and 1500 L of methanol,Close the reaction kettle, stirring up to 60 ,After 6 hours of reaction,Raw materials have been basically complete.The material into the crystallization pot with nitrogen into the pot,Stirring and cooling to -5 C,Insulation 5h filter,To give 2,3-difluoro-5-bromoanisole,Yield 92.0%Content of 99.2%. The methanol recovery in the filtrate can be reused.

The synthetic route of 1-Bromo-3,4,5-trifluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang Linjiang Chemical Industry Co., Ltd.; Yi, Miao; Yin, Xin; Chen, Huanjun; Wang, Qijin; Xu, Xin; (8 pag.)CN106478377; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H2BrF3

To a solution of (ls,3s)-3-(4-fluorophenyl)cyclobutanol (0.13 g, 0.782 mmol, 1 equiv) and 5-bromo-l,2,3-trifluorobenzene (0.198 g, 0.939 mmol, 1.2 equiv) in DMF (8 mL) was added 60% NaH (0.038 g, 0.939 mmol, 1.2 equiv). After 1 h, the reaction was diluted with EtOAc and washed with saturated aqueous sodium bicarbonate and brine. The organic layer was dried (NaiSOr) and concentrated in vacuo. The crude product was purified by silica gel flash chromatography (0-30% EtO Ac/hexane) to provide 5-bromo-l,2-difluoro-3-((3-(4- fluorophenyl)cyclobutoxy)benzene (0.17 g, 61%) as a colorless oil. NMR (500 MHz, CDCb) d 7.26 – 7.20 (m, 2H), 7.07 – 7.01 (m, 2H), 6.98 (ddd, J= 9.3, 6.1, 2.3 Hz, 1H), 6.83 (dt, J= 6.3, 2.2 Hz, 1H), 4.69 (quin, J= 7.2 Hz, 1H), 3.24 – 3.11 (m, 1H), 3.04 – 2.92 (m, 2H), 2.40 – 2.29 (m, 2H).

The synthetic route of 138526-69-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; GILLIS, Eric P.; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M.; (367 pag.)WO2019/244066; (2019); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1-Bromo-3,4,5-trifluorobenzene

5-Bromo-1,2,3-trifluorobenzene (19.855 g, 94.110 mmol) was added slowly dropwise to a chilled (-85 to -80 C. (liquid nitrogen/acetone)) solution of n-butyllithium (9.10 mL, 2.38 M, 21.7 mmol combined with 45.5 mL, 1.57 M, 71.4 mmol; total: 93.1 mmol) in ether (200 mL) such that the temperature did not exceed -89 C. The temperature was allowed to increase to between -78 and -75 C. for 2.5 hours (dry ice bath) with formation of white precipitate. The reaction mixture was cooled to -85 C. A solution of dimethylphosphoramidous dichloride (6.791 g, 46.53 mmol) in ether (10 mL) was added very slowly dropwise such that the temperature did not exceed -80 C. Dry ice was added to the bath and the reaction mixture was allowed to stir overnight while warming to ambient temperature. 31P and 19F NMR spectra showed the product to be about 99.5% desired product. The reaction mixture was filtered and the volatiles were removed under reduced pressure. The residue was extracted with hexane, filtered, and the volatiles were removed under reduced pressure to give 5 as a pale yellow oil, 13.50 g, 86.04%. 1H NMR (500 MHz, CDCl3) delta 6.95 (dt, J=7.5, 6.4 Hz, 4H), 2.64 (d, J=9.7 Hz, 6H). BC NMR (101 MHz, CDCl3) delta 151.35 (dddd, J=254.1, 10.0, 8.2, 3.0 Hz), 140.00 (dtd, J=254.5, 15.5, 2.2 Hz), 134.44 (dq, J=21.9, 3.7 Hz), 115.41 (ddd, J=21.7, 15.1, 5.5 Hz), 41.47 (d, J=16.3 Hz). 31P NMR (202 MHz, CDCl3) delta 65.05. 19F NMR (376 MHz, CDCl3) delta -133.39–133.55 (m), -159.17 (ttd, J=20.3, 6.7, 3.4 Hz).

The synthetic route of 138526-69-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dow Global Technologies LLC; Klosin, Jerzy; Milbrandt, Kara A.; Boelter, Scott D.; Wilson, David R.; Rosen, Mari S.; Welsh, Dean M.; Margl, Peter M.; Koh, Kyoung Moo; Pearson, David M.; Huacuja, Rafael; (191 pag.)US2018/291048; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 138526-69-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Set the reflux reaction device, put the stirrer into the reaction flask, Adding 4-pentylbiphenylboronic acid, 1,2-difluoro-4-bromobenzene, catalyst Pd (Pph3) 4, sodium carbonate; Sealing the reaction system, replacing the air in the sealing system into nitrogen; Immediately add isopropanol and water, stir and slowly heat reflux to ensure that the system reacts under nitrogen. After 5 hours, the degree of reaction was measured with TLC.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3,4,5-trifluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shenzhen Chao Duowei Optoelectric Zi Co., Ltd.; Shenzhen Mokerui Optoelectric Zi Institute; Zhang Guoxian; Bao Rui; (19 pag.)CN106397288; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 138526-69-9,Some common heterocyclic compound, 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, molecular formula is C6H2BrF3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the styrene (3 mmol), the halogenated benzene (3 mmol), triethanolamine (3 mmol) and Pd(II) acetate (0.03 g) was stirred under argon at 100 C for 24 h. The reaction was cooled to 25 C, quenched by the addition of dil. aq. hydrochloric acid (2 N, 10 ml), and extracted with ether (3 × 100 ml). The organic phases were dried (Na2SO4), the solvents evaporated, and the crude product subjected to chromatography (silica gel, hexane/ethyl acetate mixtures).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3,4,5-trifluorobenzene, its application will become more common.

Reference:
Article; Albert, Sabrina; Horbach, Ralf; Deising, Holger B.; Siewert, Bianka; Csuk, Rene; Bioorganic and Medicinal Chemistry; vol. 19; 17; (2011); p. 5155 – 5166;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 138526-69-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Addition of iodine to a mixture of magnesium (264 mg, 11.0 mmol) and THF (5 mL)(5.0 mg) and 5-bromo-1,2,3-trifluorobenzene in THF (0.5 mL)(211 mg, 1 mmol) solution. The mixture is heated to 60 C,And 5-bromo-1,2,3-trifluorobenzene added dropwise in THF (4.5 mL)(1.9 g, 9 mmol) solution. The reaction is heated for two hours,The solution was cooled to room temperature and used directly in the next step.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3,4,5-trifluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER INC.; KUMPF, ROBERT ARNOLD; MCALPINE, INDRAWAN JAMES; MCTIGUE, MICHELE ANN; PATMAN, RYAN; RUI, EUGENE YUANJIN; TATLOCK, JOHN HOWARD; TRAN-DUBE, MICHELLE BICH; WYTHES, MARTIN JAMES; (445 pag.)TW2018/2074; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary