Category: 13633-25-5

Reference of 13633-25-5,Some common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, molecular formula is C10H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of iminodiacetic acid hydrochloride (2 mmol) in MeOH (10 mL) were added NEt3 (6 mmol) and the corresponding bromide derivative (2 mmol). The mixture was stirred overnight at room temperature. The crude product was purified by preparative HPLC.

The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Charton, Julie; Gauriot, Marion; Totobenazara, Jane; Hennuyer, Nathalie; Dumont, Julie; Bosc, Damien; Marechal, Xavier; Elbakali, Jamal; Herledan, Adrien; Wen, Xiaoan; Ronco, Cyril; Gras-Masse, Helene; Heninot, Antoine; Pottiez, Virginie; Landry, Valerie; Staels, Bart; Liang, Wenguang G.; Leroux, Florence; Tang, Wei-Jen; Deprez, Benoit; Deprez-Poulain, Rebecca; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 547 – 567;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 13633-25-5, A common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, molecular formula is C10H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: General Procedure 3: An oven-dried 12.0 ml_ Schlenk tube containing a stirring bar was charged with the compound of formula (Ilia) (20 mol%, 16.8 mg, 0.06 mmol), L2 (10 mol%, 8.1 mg, 0.03 mmol), alkyl bromide (0.30 mmol, if solid), CF3C02Na (1.0 eq, 40.8 mg, 0.3 mmol). The schlenk tube was transferred to a nitrogen-filled glove-box where the Ni(acac)2 (10 mol%, 7.7 mg, 0.03 mmol), Na2C03 (1.0 eq, 32.0 mg, 0.30 mmol), alkyl bromide of formula R?-Br (0.30 mmol, if liquid) and anhydrous THF (0.075 M, 4ml_) were added. Then, the mixture was stirred for 1 minute and taken out of the glovebox. The Schlenk tube was placed approximately ~3 cm away from two 32 W CFL and it was rigorously stirred for 36- 96 h. After completion of the reaction, the crude material concentrated under reduced pressure. The desired product was directly purified by flash column chromatography in silica gel with pentane/EtOAc.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; FUNDACIO INSTITUT CATALA D’INVESTIGACIO QUIMICA (ICIQ); INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA); MARTIN ROMO, Ruben; SHEN, Yangyang; GU, Yiting; (56 pag.)WO2019/96832; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13633-25-5, name is 1-Bromo-4-phenylbutane, A new synthetic method of this compound is introduced below., name: 1-Bromo-4-phenylbutane

Under nitrogen protection, p-methyliodobenzene (0.1 mmol), sodium metabisulfite (0.2 mmol, 2.0 equiv.), Tin powder (0.3 mmol, 3.0 equiv.), 1,1′-bis (diphenylphosphino) Ferrocene palladium dichloride (0.01 mmol, 10 mol%), 1,1′-bis (diphenylphosphine) ferrocene (0.02 mmol, 20 mol%), dipotassium hydrogen phosphate trihydrate (0.2 mmol, 2.0 equiv .), Tetrabutylammonium bromide (0.15 mmol, 1.5 equiv.) Was added to the reaction tube containing the magneton, and after nitrogen evacuation three times, bromophenylbutane (0.3 mmol, 3.0 equiv.) Was added, and DMSO ( 1.0mL), the reaction system was heated to 100 C for 10 hours, and the reaction was completed by spot detection. After the aryl iodide was completely converted, the reaction system was cooled to room temperature, diluted with water and added with ethyl acetate (10mL * 3) for extraction. Anhydrous sulfuric acid Sodium was dried, filtered, concentrated, and separated by column chromatography to obtain the purified target product 3ad (72%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; East China Normal University; Jiang Xuefeng; Meng Yingying; Wang Ming; (40 pag.)CN110563619; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 13633-25-5, These common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-bromophenol (8.6 g, 49.9 mmol), 4-phenylbutyl bromide (11.2 g, 52.6 mmol) and potassium carbonate (13.7 g, (40 ml) was added under stirring with N, N-dimethylformamide (40 ml). The reaction was heated to reflux and refluxed at reflux conditions The reaction was carried out for 2 hours. The reaction solution was cooled to room temperature, water (160 ml) was added, and the mixture was extracted with ether (100 ml x 2) to combine the organic phases. The organic phase was washed successively with 0.5 M sodium hydroxide solution (110 ml) and water (110 ml), dried over anhydrous sodium sulfate and filtered to remove The filtrate was concentrated under reduced pressure and the concentrate was purified by silica gel chromatography to give 11.3 g of the title compound in 74.3% yield.

The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Haibu Pharmaceutical Technology Co., Ltd.; Di Wei; Sun Fengqing; (17 pag.)CN107253903; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13633-25-5, name is 1-Bromo-4-phenylbutane, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 13633-25-5

To a stirred solution of tert-Butylprop-2-yn-1-ylcarbamate (300 mg, 1.93 mmol, 1 eq.) in dry DMF (1.93 mL) under nitrogen at 0C, was added NaH (93 mg, 60% in oil, 2.32 mmol, 1.2 eq.) in small portions. After stirring for 15min, (4-bromobutyl)benzene (410 muL, 2.34 mmol, 1.2 eq.) was added dropwise followed by KI(32 mg, 0.19 mmol, 0.1 eq.) and the reaction was warmed up to room temperature for 15 h.After completion of the reaction, water and brine were added and the aqueous layer wasextracted with Et2O (three times). Then, the combined organic layers were dried over MgSO4,filtered and concentrated under vacuum. The crude residue was purified by flash columnchromatography on silica gel (cyclohexane/DCM: 50/50) to afford 1h (446 mg, 1.54 mmol, 80%)as a colorless oil. 1H NMR (300 MHz, CDCl3): delta 7.31-7.24 (m, 2H), 7.21-7.14 (m, 3H), 4.01 (br. s,2H), 3.33 (t, J = 6.6 Hz, 2H), 2.64 (t, J = 7.1 Hz, 2H), 2.16 (t, J = 2.4 Hz, 1H), 1.67-1.56 (m, 4H),1.45 (s, 9H); 13C NMR (100 MHz, CDCl3): delta 155.2 (br. s), 142.4 (br. s), 128.5 (2C), 128.4 (2C),125.8, 80.2, 80.0 (br. s), 71.4 (br. s), 46.4, 36.4 and 36.0 (br. S, rot.), 35.6, 28.6 (br. s), 28.5 (3C),27.6 (br. s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13633-25-5.

Reference:
Article; Guissart, Celine; Dolbois, Aymeric; Tresse, Cedric; Saint-Auret, Sarah; Evano, Gwilherm; Blanchard, Nicolas; Synlett; vol. 27; 18; (2016); p. 2575 – 2580;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 13633-25-5, These common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The reaction mixture of 28 (0.50 g, 1.5 mmol) and (4-bromobutyl)benzene (36) (0.34 ml, 2.0 mmol) in dry 1,4-dioxane (16 ml) was stirred for 4 days to afford the title compound as a white solid in 90% yield (0.66 g). mp: 224-225 C; 1H-NMR (400 MHz, DMSO-d6): delta = 7.19-7.39 (m, 15H), 6.76 (s, 1H), 5.20 (brs, 1H), 3.80 (m, 1H), 3.31-3.40 (m, 3H), 3.18 (m, 3H), 2.95 (m, 1H), 2.60 (m, 2H), 2.25 (brs, 1H), 1.55-1.91 (m, 8H); 13C-NMR (100 MHz, DMSO-d6): delta = 172.3, 143.0, 141.4, 128.3, 127.8, 127.7, 127.1, 127.0, 126.0, 80.7, 68.6, 66.3, 62.6, 59.3, 52.6, 34.4, 27.7, 20.8, 17.6; HRMS calcd. for C31H36N1O3 [M]+: 470.2695; found: m/z = 470.2691; HPLC (Method A): tR (min) = 9.15 (96%).

The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yamashita, Yasunobu; Tanaka, Ken-ichiro; Yamakawa; Asano; Kanda, Yuki; Takafuji; Kawahara, Masahiro; Takenaga, Mitsuko; Fukunishi, Yoshifumi; Mizushima; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3339 – 3346;,
Bromide – Wikipedia,
bromide – Wiktionary