Category: 135999-16-5

Borrajo-Calleja, Gustavo M.; Bizet, Vincent; Mazet, Clement published the artcile< Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans>, Application of C7H7BrO2, the main research area is tetrahydrofurobenzofuran preparation enantioselective intermol carboetherification palladium catalyst; carboetherification in situ generated chiral bisphosphine mono oxide ligand.

A novel enantioselective Pd-catalyzed intermol. carboetherification of dihydrofurans is reported. The in situ generation of chiral bis-phosphine mono-oxide ligands is crucial, and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.

Journal of the American Chemical Society published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation) (furobenzofurans). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Application of C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thomas, A. W. published the artcile< Product subclass 1: diaryl ethers>, Electric Literature of 135999-16-5, the main research area is review diaryl ether preparation organic synthesis.

A review of methods to prepare diaryl ethers.

Science of Synthesis published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Electric Literature of 135999-16-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Maddirala, Amarendar Reddy; Klein, Roger; Pinkner, Jerome S.; Kalas, Vasilios; Hultgren, Scott J.; Janetka, James W. published the artcile< Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design>, Related Products of 135999-16-5, the main research area is galactoside biphenyl preparation FmlH lectin antagonist UPEC urinary infection; galactosaminoside biphenyl preparation FmlH lectin antagonist UPEC urinary infection.

The F9/Yde/Fml pilus, tipped with the FmlH adhesin, has been shown to provide uropathogenic Escherichia coli (UPEC) a fitness advantage in urinary tract infections (UTIs). Here, the authors used X-ray structure guided design to optimize our previously described ortho-biphenyl Gal and GalNAc FmlH antagonists by replacing the carboxylate with a sulfonamide. Other groups which can accept H-bonds were also tolerated. The authors pursued further modifications to the biphenyl aglycon resulting in significantly improved activity. Two of the most potent compounds (IC50 = 0.051 μM) and (IC50 = 0.034 μM), exhibited excellent metabolic stability in mouse plasma and liver microsomes but showed only limited oral bioavailability (<1%) in rats. Another compound also showed a good pharmacokinetic (PK) profile in mice after IP dosing with compound exposure above the IC50 for 6 h. These new FmlH antagonists represent new antivirulence drugs for UTIs. Journal of Medicinal Chemistry published new progress about Drug design. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Related Products of 135999-16-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hazra, Gurupada; Mishra, Gitanjali; Dandela, Rambabu; Thirupathi, Barla published the artcile< A Method to Access Highly Functionalized Dibenzobicyclo[3.2.1]octadienones: Application to the Construction of the 6/6/5/6/6 Carbon Skeleton of Rubialatin A>, Recommanded Product: 2-Bromo-3-methoxyphenol, the main research area is keto indandione aryne insertion diastereoselective; dibenzobicyclo octadienone stereoselective preparation.

The dibenzobicyclo[3.2.1]octadienone scaffold, which has been found in naphthocyclinones, engelharquinones, rubialatin A, etc., has been synthesized under mild transition metal-free conditions by aryne insertion reaction with 2-keto-1,3-indandiones. The application of this methodol. has been demonstrated for the synthesis of the 6/6/5/6/6 scaffold of rubialatin A. 1H NMR exptl. studies confirm that the reaction proceeds through the formation of benzocyclobutane followed by a 7-member carbocycle ring.

Journal of Organic Chemistry published new progress about Alkynes, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Recommanded Product: 2-Bromo-3-methoxyphenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zuo, Zhijun; Wang, Jing; Liu, Jingjing; Wang, Yaoyu; Luan, Xinjun published the artcile< Palladium-Catalyzed [2+2+1] Spiroannulation via Alkyne-Directed Remote C-H Arylation and Subsequent Arene Dearomatization>, Formula: C7H7BrO2, the main research area is alkynyl iodobenzene bromophenol palladium catalyst tandem regioselective spiroannulation; C−H activation; aryl halides; cross-coupling; dearomatization; palladacycles.

A highly chemoselective Pd0-catalyzed alkyne-directed cross-coupling of aryl iodides with bromophenols, which was subsequently followed by phenol dearomatization was reported to furnish a very attractive [2+2+1] spiroannulated products. Notably, possible homo-coupling of aryl iodides was not observed at all. Mechanistic studies indicated that a five-membered aryl/vinyl palladacycle most likely accounts for promoting the key step of biaryl cross-coupling.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Formula: C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Viana, Hugo; Carreiro, Elisabete P.; Goth, Albertino; Bacalhau, Patricia; Caldeira, Ana Teresa; Martins, Maria do Rosario; Burke, Anthony Joseph published the artcile< Sequential alcohol oxidation/putative homo Claisen-Tishchenko-type reaction to give esters: a key process in accessing novel biologically active lactone macrocycles>, SDS of cas: 135999-16-5, the main research area is diether ester preparation acetylcholinesterase butyrylcholinesterase inhibitor; aryloxyethyl alc tandem PCC oxidation Claisen Tishchenko esterification; lactone macrocycle preparation; borylated diether ester regioselective preparation Suzuki Miyaura coupling.

Application of a sequential pyridinium chlorochromate (PCC) alc. oxidation/putative Cr-catalyzed Claisen-Tishchenko reaction of primary alcs. to provide diether-esters, e.g., I was reported. The reaction could be conducted with 1 equiv of PCC and 1 equiv of BF3·OEt2. Indications based on literature precedent were that the reaction might proceed via a sequential alc. oxidation to the aldehyde followed by a putative Cr or boron catalyzed Claisen-Tishchenko-type reaction. Using this efficient methodol., a family of novel diether-esters was synthesized in very good yields; some of these mols. were subsequently tested against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). In addition, a new synthetic strategy for the synthesis of lactone macrocycles with potential biol. activity was also disclosed. This methodol. included the regioselective borylation of the ester substrate and a subsequent Suzuki-Miyaura coupling to obtain the desired lactone macrocycle.

RSC Advances published new progress about Borylation. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, SDS of cas: 135999-16-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pearce-Higgins, Robert; Hogenhout, Larissa N.; Docherty, Philip J.; Whalley, David M.; Chuentragool, Padon; Lee, Najung; Lam, Nelson Y. S.; McGuire, Thomas M.; Valette, Damien; Phipps, Robert J. published the artcile< An Enantioselective Suzuki-Miyaura Coupling To Form Axially Chiral Biphenols>, COA of Formula: C7H7BrO2, the main research area is arylbromide phenylboronate ester palladium sSPhos catalyst Suzuki Miyaura coupling; arylphenol enantioselective preparation.

The use of enantiopure, sulfonated SPhos (sSPhos), an existing ligand that has until now been used only in racemic form and that derived its chirality from an atropisomeric axis that was introduced through sulfonation. The attractive noncovalent interactions involving the ligand sulfonate group was responsible for the high levels of asym. induction that we obtain in the 2,2′-biphenol products of Suzuki-Miyaura coupling, and a highly practical resolution of sSPhos via diastereomeric salt recrystallization was developed.

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, COA of Formula: C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cui, Chun-Xiao; Zhang, Jie; Qiu, Zaozao; Xie, Zuowei published the artcile< Palladium-catalyzed intramolecular dehydrogenative coupling of BH and OH: synthesis of carborane-fused benzoxaboroles>, Safety of 2-Bromo-3-methoxyphenol, the main research area is carborane fused benz.

Palladium acetate-catalyzed intramol. BH-OH coupling and cyclization of 2-hydroxyphenyl-substituted carboranes afforded carborane-fused benzoxaboroles I (2a-t; R1 = H, Me; R2 = H, halo, Me, OMe, Ph, tBu, benzo) and II (3a-p). A Pd-catalyzed intramol. dehydrogenative coupling of BH and OH for the construction of cage B-O bonds has been developed, leading to a new class of 1,3- and 1,4-o-carboranobenzoxaborole derivatives This represents a new route to C,B-carborane-fused heterocycles.

Dalton Transactions published new progress about Carboranes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Safety of 2-Bromo-3-methoxyphenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shintani, Ryo; Otomo, Haruka; Ota, Kensuke; Hayashi, Tamio published the artcile< Palladium-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic Dibenzosiloles via Enantioselective C-H Bond Functionalization>, HPLC of Formula: 135999-16-5, the main research area is palladium catalyzed asym carbon hydrogen bond activation silylaryl triflate; dibenzosilole silicon stereogenic preparation; crystal structure dibenzosilole silicon stereogenic; mol structure dibenzosilole silicon stereogenic.

A Pd-catalyzed asym. synthesis of Si-stereogenic dibenzosiloles, e.g., 4-methoxy-5-tert-butyl-5-phenyl-5H-dibenzosilole, is developed through enantioselective C-H bond functionalization of prochiral 2-(arylsilyl)aryl triflates. High chemo- and enantioselectivities are achieved by employing a Josiphos-type ligand under mild conditions.

Journal of the American Chemical Society published new progress about Bidentate ligands Role: CAT (Catalyst Use), USES (Uses). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, HPLC of Formula: 135999-16-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pave, Gregoire; Leger, Jean-Michel; Jarry, Christian; Viaud-Massuard, Marie-Claude; Guillaumet, Gerald published the artcile< Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy>, COA of Formula: C7H7BrO2, the main research area is asym synthesis spirocyclic aminochroman derivative cyano phenyl oxazolopiperidine substitution; crystal structure absolute configuration aminochroman derivative benzopyran piperidine.

Enantiomerically pure (3’R)- and (3’S)-3′,4′-dihydrospiro[piperidine-2,3′(2’H)-benzopyran]s I (R = H) and II (R = H) were successfully synthesized according to the CN(R,S) methodol. with the aim of serving as a pattern for the generation of related spirocyclic compounds Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine III. One of them was selected and used for the preparation of amines I (R = OMe) and II (R = OMe) starting from III and IV, resp. The enantiomeric purity of all final aminochroman derivatives was determined by capillary electrophoresis using β-cyclodextrin as the chiral selector.

Journal of Organic Chemistry published new progress about Absolute configuration. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, COA of Formula: C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary