Category: 135613-33-1

Ydhyam, Sridhar; Cha, Jin Kun published their research in Organic Letters on December 4 ,2015. The article was titled 《Construction of Seven-Membered Carbocycles via Cyclopropanols》.Synthetic Route of C11H13BrO2 The article contains the following contents:

A new method for seven-membered ring annulation has been devised by an intramol. cross-coupling of cyclopropanols and aryl/alkenyl halides. This cyclization reaction is broad in scope and provides easy access to not only fused but also bridged bicyclic compounds In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Synthetic Route of C11H13BrO2)

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Synthetic Route of C11H13BrO2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Battistuzzi, Gianfranco; Cacchi, Sandro; Fabrizi, Giancarlo; Bernini, Roberta published an article in Synlett. The title of the article was 《3-Arylpropanoate esters through the palladium-catalyzed reaction of aryl halides with acrolein diethyl acetal》.Category: bromides-buliding-blocks The author mentioned the following in the article:

The reaction of aryl halides with acrolein di-Et acetal in the presence of Pd(OAc)2, n-Bu3N, and n-Bu4NCl in DMF at 90° affords Et 3-arylpropanoates. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, nitrile, and nitro groups. Ortho-substituents do not hamper the reaction. 3-Arylpropanoate esters were isolated in good to excellent yields with many neutral, electron-rich and electron-poor aryl iodides and electron-poor aryl bromide. Neutral and electron-rich aryl bromides gave the desired ester in moderate yields. After reading the article, we found that the author used Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Category: bromides-buliding-blocks)

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C11H13BrO2On September 30, 1991 ,《Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2(TxA2)antagonists. Semicarbazone ω-chains》 was published in Journal of Medicinal Chemistry. The article was written by Misra, Raj N.; Brown, Baerbel R.; Han, Wen Ching; Harris, Don N.; Hedberg, Anders; Webb, Maria L.; Hall, Steven E.. The article contains the following contents:

A series of chiral interphenylene oxabicycloheptane semicarbazones I [n = 1, 2; X = CH2, OCH2, (CH2)2, (CH2)3] were prepared and evaluated for their in vitro thromboxane (TxA2) antagonist activity and in vivo duration of action. The potency of I was highly dependent on the substitution pattern of the interphenylene ring and decreased in the order ortho > meta > para. (S)-I [n = 1; X = (CH2)2 (II)] (SQ 35,091) was identified as a potent and long-acting TxA2 antagonist. In human platelet rich plasma II inhibited arachidonic acid (800 μM) and U-46,619 (10 μM) induced aggregation with T50 values of 3 and 12 nM, resp. In contrast, no inhibition of ADP (20 μM) induced aggregation was observed at >1000 μM. Receptor binding studies with [3H]-SQ 29,548 showed II was a competitive antagonist with a Kd value of 1.0 ± 0.1 nM in human platelet membranes. In vivo II (0.2 mg/kg po) showed extended protection (T50 = 16 h) from U-46,619 (2 mg/kg i.v.) induced death in mice. These compounds have for the 1st time demonstrated that a metabolically stable interphenylene α side chain can be introduced into a prostanoid-like series of TxA2 antagonists with the maintenance of potent antagonist activity. In the experimental materials used by the author, we found Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Synthetic Route of C11H13BrO2)

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Synthetic Route of C11H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C11H13BrO2On May 3, 1996 ,《Synthesis and Hydrogen Bonding Capabilities of Biphenyl-Based Amino Acids Designed To Nucleate β-Sheet Structure》 appeared in Journal of Organic Chemistry. The author of the article were Nesloney, Carey L.; Kelly, Jeffery W.. The article conveys some information:

The syntheses of 3′-(aminoethyl)-2-biphenylpropionic acid (I; R = OH, R1 = H) and 2-amino-3′-biphenylcarboxylic acid (II; R = OH, R1 = H) are described. I and II were designed to nucleate β-sheet structure in aqueous solution when incorporated into small, amphiphilic peptides in place of the backbone of the i + 1 and i + 2 residues of the β-turn. Amides I and II (R = NHCH2Ph, R1 = COCH2Ph) were synthesized and studied as model compounds to investigate hydrogen-bonding capabilities. The x-ray crystal structure of I (R = NHCH2Ph, R1 = COCH2Ph) indicates that a 13-membered intramol. hydrogen-bonded ring is formed, while the remaining amide proton and carbonyl are involved in intermol. hydrogen bonding. IR and variable-temperature NMR experiments indicate that, in solution (CH2Cl2), I (R = NHCH2Ph, R1 = COCH2Ph) exists as an equilibrium mixture of the 13- and the 15-membered intramolecularly hydrogen-bonded conformers with the 15-membered ring conformer being favored. Amide II (R = NHCH2Ph, R1 = COCH2Ph) was shown to exist in solution (CH2Cl2) as an equilibrium mixture of the 11-membered intramol. hydrogen-bonded ring and a nonbonded conformation. No contribution from the 9-membered hydrogen ring conformation was observed The x-ray crystal structure of II (R = NHCH2Ph, R1 = COCH2Ph) indicated the absence of intramol. hydrogen bonding in the solid state. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Formula: C11H13BrO2)

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Formula: C11H13BrO2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Chemical Communications (Cambridge, United Kingdom) included an article by Deng, Zhixin; Han, Sheng; Ke, Miaolin; Ning, Yingtang; Chen, Fen-Er. Safety of Ethyl 3-(2-bromophenyl)propanoate. The article was titled 《Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters》. The information in the text is summarized as follows:

Palladium-catalyzed linear-selective hydroesterification of vinyl arenes with alcs. enabled by diphosphine ligands derived from bis[2-(diphenylphosphino)ethyl]amides has been developed. A variety of 3-arylpropanoate esters were obtained in high yields and regioselectivity. The robustness of this methodol. was further demonstrated by the efficient gram-scale synthesis of the Et 3-phenylpropanoate as a precursor to hydrocinnamic acid. After reading the article, we found that the author used Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Safety of Ethyl 3-(2-bromophenyl)propanoate)

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Safety of Ethyl 3-(2-bromophenyl)propanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary