Category: 1347736-74-6

Related Products of 1347736-74-6,Some common heterocyclic compound, 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, molecular formula is C6HBr2FN2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) a thiadiazole compound of the B-1 (4,7- dibromo-5-fluoro-benzo [c] [1,2,5]; 4,7-dibromo-5-fluorobenzo [c] [1,2,5] thiadiazole) (3.00 g, 9. 6 mmol), A-1Of the compound (3.84 g, 9.58 mmol),Pd2 (dba) 3 (0.174 g, 0.19 mmol), Then triphenylphosphine (triphenylphosphine) (0.202 g, 0.77 mmol) was dissolved in 100 mL of toluene was stirred for 48 hours at 80 .After the reaction, After lowered to normal temperature, into a 2M hydrochloric acid (HCl) and stirred for 1 hour.After the reaction was washed with dichloromethane (dichloromethane) and the solvent removed under reduced pressure. The resulting solid with chloroform (chloroform) to silica column purificationThe compounds of the orange A-2 (1.67 g, yield: 41%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, its application will become more common.

Reference:
Patent; LG Chem Co.Ltd.; Lim, Bo-Gyu; Bang, Ji-Won; Lee, Jae-Chol; Lee, Ji-Young; Kim, Jin-Seok; Cho, Geun; (37 pag.)KR2015/142609; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1347736-74-6,Some common heterocyclic compound, 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, molecular formula is C6HBr2FN2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A dried flask was charged with 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole (3.0 g, 9.6 mmol), compound 5(3.83 g, 9.58 mmol), Pd2dba3 (0.174 g, 0.19 mml), PPh3 (0.202 g,0.77 mmol) and 100ml of toluene. The reaction mixturewas heatedto 80 C for 48 h. Upon cooling, 30 mL of 2 M HCl was added andthen stirred for 1 h. After extract with dichloromethane, the solventwas removed by vacuum evaporation, and then recrystallized withchloroform/methanol and filtered. The solid was washed withcopious methanol, and dried under vacuum for 24 h. Compound 6was a red solid.Yield: 40.9% (1.67 g). 1H NMR (CDCl3, 500 MHz, [ppm]): delta 9.904(s, 1H), 8.066 (d, 1H, J 4 Hz), 7.764 (m, 2H), 7.458 (d, 1H, J 4 Hz),7.392 (d, 1H, J 4 Hz); APCI: m/z 425.0, calcd 423.88.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, its application will become more common.

Reference:
Article; Lim, Bogyu; Sun, Huabin; Noh, Yong-Young; Dyes and Pigments; vol. 146; (2017); p. 520 – 528;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks

To 150 ml of ethanol was added 4,7-dibromo-5-fluoro-2,1,3-benzothiadiazole (4,7-dibromo-5-fluoro-2,1,3- Benzothiadiazole (5 g, 0.016 mol) was dissolved, and sodium borohydride (12.1 g, 0.32 mol) was added at 0 C And stirred at room temperature for 20 hours. After evaporating the solution, 160 ml of water were added and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate and the residue was purified by silica column chromatography (hexane / ethyl acetate (25: 1)) to give 3,6-dibromo-4-fluoro

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LG CHEM, LTD.; KIM, JIN-SEOK; LEE, JAE-CHOL; LEE, HANG-KEON; LIM, BO-GYU; (33 pag.)KR2017/50088; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1347736-74-6

2.1.1 3,6-Dibromo-4-fluoro-1,2-phenylenediamine (1) 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole (5 g, 0.016 mol) was dissolved in ethanol (150 ml), then sodium borohydride (12.1 g, 0.32 mol) was added portion wise at 0 C, and the reactants were stirred for 20 h at room temperature. After evaporation of the solvent, 160 ml water was added, and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The residue was purified by column chromatography on silica gel using hexane/ethyl acetate (25:1) as eluent to afford 3,6-dibromo-4-fluoro-1,2-phenylenediamine (3.5 g) as a pale solid in 78% yield. 1H NMR (CDCl3, 500 MHz) delta(ppm): 6.81(d,1H,J = 8 Hz), 3.63(s,4H). 13C NMR(500 MHz, CDCl3): delta(ppm), 154.16, 152.25, 135.75, 135.73, 128.73, 128.71, 109.44, 109.35, 108.83, 108.62, 96.78, 96.58. mp: 94 C. Anal. Calcd for (C6H5Br2FN2) (%):C25.38, H 1.78, N 9.87. Found (%):C 24.29, H 1.83, N 10.14.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1347736-74-6.

Reference:
Article; Wu, Haimei; Qu, Bo; Tian, Di; Cong, Zhiyuan; Gao, Bowen; Liu, Jianqun; An, Zhongwei; Gao, Chao; Xiao, Lixin; Chen, Zhijian; Gong, Qihuang; Wei, Wei; Reactive and functional polymers; vol. 73; 11; (2013); p. 1432 – 1438;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1347736-74-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

the 4,6-dibromo-5-fluorobenzo [c] [1, 2, 5] thiadiazole (2.00g, 6 . 41 mmol) and ethanol (50 ml) is added to the three-hole and round-bottom flask cooled to 0 C. In slowly adding Na[BH4] (4.6g, 0 . 12 mol) later, the reaction mixture is stirred at room temperature overnight. After removing the volatile substance, the 100 distilled water added to the reaction mixture, then the mixture is extracted with ethyl ether, salt water cleaning, and the anhydrous Na2SO4dry. Removing volatile substances from the extract to obtain a light brown powder A (1.20g, 66%).

The synthetic route of 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SABIC Global Technology Company; Ibrahim Lafia, S·M·; Tate, C. Haug; Gillian, M · Bristol Senanayake; Amit, K · Jiefudiya; Ahmed, I. Abdul Rahman; (26 pag.)CN105531280; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1347736-74-6, Computed Properties of C6HBr2FN2S

To a solution of 3-hexylthiophene (1) (5 g, 29.0 mmol) in anhydrous 40 mL of THF was added n-BuLi (1.6 M in hexane) (21.8 mL, 34.8 mmol) over 30 min at -40 C under argon atmosphere. After stirring for 1 h at room temperature, the reaction mixture was treated with dropwise addition of tributyltin chloride (9.9 mL, 36.3 mmol) at -40 C, followed by stirring at RT overnight. The mixture was poured into saturated NaHCO3 solution and the organic phase was extracted with diethyl ether and washed with water. The organic phase was dried over MgSO4 and solvent was removed under reduced pressure. Tributyl-(4-hexyl-2-thienyl)stannane (2) as yellow liquid was acquired and used in the next step without further purification. The solution of compound 5 (3.0 g, 9.7 mmol) and compound 2 (9.7 g, 29.0 mmol) in anhydrous 10 mL of THF was treated with Pd(PPh3)2Cl2 (5 mg, 0.05 mmol). After stirring for overnight at 100 C under argon atmosphere, the reaction mixture was concentrated under reduced pressure and purified by flash column chromatography to give compound 6, 0.9 g (19%). 1H NMR (300 MHz, CDCl3): delta (ppm) 8.1 (s, 1H), 8.0 (s, 1H), 7.75 (d, 1H, J = 12.9 Hz), 7.16 (s, 1H), 7.10 (s, 1H), 2.71 (t, 2H, J = 7.00 Hz), 2.68 (t, 2H, J = 7.00 Hz), 1.60-1.78 (m, 4H), 1.51-1.21 (m, 12H), 0.93 (t, 6H, J = 7.00 Hz), 0.91 (t, 3H, J = 7.1 Hz); 13C NMR (75 MHz, CDCl3): delta (ppm) 160.4, 157.0, 153.3 (d, 3JC-F = 10.4 Hz), 149.6, 144.4, 143.4, 137.5, 132.3 (d, 5JC-F = 5.7 Hz), 131.4 (d, 4JC-F = 8.1 Hz), 125.6 (d, 3JC-F = 10.4 Hz), 125.6 (d, 1JC-F = 255.4 Hz), 122.9 (d, 4JC-F = 7.0 Hz), 116.5 (d, 2JC-F = 33.6 Hz), 111.0 (d, 2JC-F = 17.3 Hz), 31.8, 30.6, 30.5, 30.4, 29.1, 28.3, 26.8, 22.7, 17.3, 14.2, 13.7.1. HRMS (m/z, EI+) calcd for C26H31FN2S3 486.1633 found 486.1635.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jeong, Ina; Chae, Sangmin; Yi, Ahra; Kim, Juae; Chun, Ho Hwan; Cho, Jung Hyeong; Kim, Hyo Jung; Suh, Hongsuk; Polymer; vol. 109; (2017); p. 115 – 125;,
Bromide – Wikipedia,
bromide – Wiktionary