Category: 13273-53-5

Lian, Yajing et al. published their research in Tetrahedron in 2015 | CAS: 13273-53-5

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C3H4BrN3

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation was written by Lian, Yajing;Burford, Kristen;Londregan, Allyn T.. And the article was included in Tetrahedron in 2015.Computed Properties of C3H4BrN3 This article mentions the following:

A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like mols. containing heterocyclic diversity and in the study of the gem-dialkyl effect. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Computed Properties of C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Begtrup, Mikael et al. published their research in Acta Chemica Scandinavica (1947-1973) in 1966 | CAS: 13273-53-5

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 13273-53-5

Methylated 1,2,3-triazoles. II was written by Begtrup, Mikael;Pedersen, Christian. And the article was included in Acta Chemica Scandinavica (1947-1973) in 1966.Reference of 13273-53-5 This article mentions the following:

1-Methyl-5-methoxy-1,2,3-triazole (I) with MeI yielded 1,3-dimethyl-4-methoxy-1,2,3-triazolium iodide (II) which was also prepared from 1,3-dimethyl-1,2,3-triazol-4-one (III) with MeI or from 1,3-dimethyl-4-bromo-1,2,3-triazolium iodide (IV) with NaOMe. II heated or kept in CHCl3 at room temperature lost MeI to give III. The chloride analog (V) of IV with NaOH gave a compound believed to be the 5-Br derivative (VI) of III; it was also obtained by the bromination of III. 1-Methyl-4-bromo-1,2,3-triazole (417 mg.) and 2.5 cc. MeI heated 6 hrs. in a sealed tube, and the product stirred 2 hrs. in EtOH with excess AgCl gave 440 mg. V, m. 193鎺?(EtOH-Et2O). IV (98 mg.), 8.0 mg. Na, and 3.5 cc. MeOH heated 2 hrs. at 75鎺? treated with 70 mg. NaI, stirred 15 min., and filtered gave 3 mg. II; the mother liquors yielded 35 mg. III. V (70 mg.) and 0.17 cc. soln, of 220 mg. Na in 5 cc. EtOH heated 3 hrs. at 70鎺? neutralized with CO2, and worked up gave 63 mg. 1,3-dimethyl-4-ethoxy-1,2,3-triazolium chloride (VII), yellow, hygroscopic oil. III (30 mg.) refluxed 3 hrs. with 2 cc. EtI, and the product (74 mg.) stirred 1 hr. in EtOH with excess AgCl yielded 49 mg. yellowish, oily, hygroscopic VII. III (217 mg.) refluxed 3 hrs. with 2 cc. MeI gave 455 mg. yellow II, m. 111鎺?(MeOH-Et2O). II (19 mg.) in 0.5 cc. CDCl3 in an N.M.R. tube kept at room temperature showed after 4 days the spectrum of III; the solution evaporated gave 9 mg. III, m. 78-85鎺? VII in CHCl3 was unchanged, after 4 days at room temperature, but heated 1 hr. at 80鎺?gave III. I (50 mg.) in 0.5 cc. CDCl3 and 0.10 cc. MeI kept 6 weeks at room temperature in a N.M.R. tube and evaporated left 44 mg. III, m. 78-85鎺? a similar run gave during 48 hrs. 53% II. V (92 mg.) in 4 cc. N NaOH heated 16 hrs. at 100鎺?in a sealed tube and neutralized with N HCl, and the crude product chromatographed on silica gel yielded 22 mg. VI, m. 141鎺? III (112 mg.) in 1 cc. CHCl3 treated with 0.05 cc. Br in 5 cc. cold CHCl3 and filtered after 10 min., and the residue stirred 1 hr. in H2O with excess Amberlite IR-4B gave 84 mg. VI, m. 141鎺? the mother liquor residue treated similarly with Amberlite yielded 48 mg. VI, m. 141鎺? In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Reference of 13273-53-5).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 13273-53-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Elguero, Jose et al. published their research in Bulletin de la Societe Chimique de France in 1967 | CAS: 13273-53-5

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C3H4BrN3

Research in the azole series. XXVI. Nuclear magnetic resonance study and the reaction of 1,2,3-triazole with halo nitrobenzenes was written by Elguero, Jose;Gonzalez, Emmanuel;Jacquier, Robert. And the article was included in Bulletin de la Societe Chimique de France in 1967.Formula: C3H4BrN3 This article mentions the following:

Nucleophilic aromatic substitution of 1,2,3-triazole (I) is studied. An equimolar mixture of I and p-fluoronitrobenzene is heated 2 hrs. at 210鎺?in the presence of anhydrous KF to give a mixture of II, m. 206鎺? and III, m. 185鎺? With 1-fluoro-2,4-dinitrobenzene refluxed 6 hrs. with an equimolar amount of I, the only product isolated is IV, m. 127鎺? The same reaction with 1-chloro-2,4,6-trinitrobenzene leads only to V, m. 230鎺? The products are studied by N.M.R. in CDCl3, C6H6, Me2SO, (NMe2)3PO, C5D5N, CF3CO2H, and H2NNH2 solution, together with 1-methyl-1,2,3-triazole and 1-methyl-1,2,5-triazole. The chem. shifts are compared with calculated electron densities. 13C-1H coupling constants are determined for I and for its 1-Me derivative In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Formula: C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lian, Yajing et al. published their research in Tetrahedron in 2015 | CAS: 13273-53-5

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C3H4BrN3

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation was written by Lian, Yajing;Burford, Kristen;Londregan, Allyn T.. And the article was included in Tetrahedron in 2015.Computed Properties of C3H4BrN3 This article mentions the following:

A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like mols. containing heterocyclic diversity and in the study of the gem-dialkyl effect. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Computed Properties of C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Begtrup, Mikael et al. published their research in Acta Chemica Scandinavica (1947-1973) in 1966 | CAS: 13273-53-5

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 13273-53-5

Methylated 1,2,3-triazoles. II was written by Begtrup, Mikael;Pedersen, Christian. And the article was included in Acta Chemica Scandinavica (1947-1973) in 1966.Reference of 13273-53-5 This article mentions the following:

1-Methyl-5-methoxy-1,2,3-triazole (I) with MeI yielded 1,3-dimethyl-4-methoxy-1,2,3-triazolium iodide (II) which was also prepared from 1,3-dimethyl-1,2,3-triazol-4-one (III) with MeI or from 1,3-dimethyl-4-bromo-1,2,3-triazolium iodide (IV) with NaOMe. II heated or kept in CHCl3 at room temperature lost MeI to give III. The chloride analog (V) of IV with NaOH gave a compound believed to be the 5-Br derivative (VI) of III; it was also obtained by the bromination of III. 1-Methyl-4-bromo-1,2,3-triazole (417 mg.) and 2.5 cc. MeI heated 6 hrs. in a sealed tube, and the product stirred 2 hrs. in EtOH with excess AgCl gave 440 mg. V, m. 193° (EtOH-Et2O). IV (98 mg.), 8.0 mg. Na, and 3.5 cc. MeOH heated 2 hrs. at 75°, treated with 70 mg. NaI, stirred 15 min., and filtered gave 3 mg. II; the mother liquors yielded 35 mg. III. V (70 mg.) and 0.17 cc. soln, of 220 mg. Na in 5 cc. EtOH heated 3 hrs. at 70°, neutralized with CO2, and worked up gave 63 mg. 1,3-dimethyl-4-ethoxy-1,2,3-triazolium chloride (VII), yellow, hygroscopic oil. III (30 mg.) refluxed 3 hrs. with 2 cc. EtI, and the product (74 mg.) stirred 1 hr. in EtOH with excess AgCl yielded 49 mg. yellowish, oily, hygroscopic VII. III (217 mg.) refluxed 3 hrs. with 2 cc. MeI gave 455 mg. yellow II, m. 111° (MeOH-Et2O). II (19 mg.) in 0.5 cc. CDCl3 in an N.M.R. tube kept at room temperature showed after 4 days the spectrum of III; the solution evaporated gave 9 mg. III, m. 78-85°. VII in CHCl3 was unchanged, after 4 days at room temperature, but heated 1 hr. at 80° gave III. I (50 mg.) in 0.5 cc. CDCl3 and 0.10 cc. MeI kept 6 weeks at room temperature in a N.M.R. tube and evaporated left 44 mg. III, m. 78-85°; a similar run gave during 48 hrs. 53% II. V (92 mg.) in 4 cc. N NaOH heated 16 hrs. at 100° in a sealed tube and neutralized with N HCl, and the crude product chromatographed on silica gel yielded 22 mg. VI, m. 141°. III (112 mg.) in 1 cc. CHCl3 treated with 0.05 cc. Br in 5 cc. cold CHCl3 and filtered after 10 min., and the residue stirred 1 hr. in H2O with excess Amberlite IR-4B gave 84 mg. VI, m. 141°; the mother liquor residue treated similarly with Amberlite yielded 48 mg. VI, m. 141°. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Reference of 13273-53-5).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 13273-53-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Elguero, Jose et al. published their research in Bulletin de la Societe Chimique de France in 1967 | CAS: 13273-53-5

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C3H4BrN3

Research in the azole series. XXVI. Nuclear magnetic resonance study and the reaction of 1,2,3-triazole with halo nitrobenzenes was written by Elguero, Jose;Gonzalez, Emmanuel;Jacquier, Robert. And the article was included in Bulletin de la Societe Chimique de France in 1967.Formula: C3H4BrN3 This article mentions the following:

Nucleophilic aromatic substitution of 1,2,3-triazole (I) is studied. An equimolar mixture of I and p-fluoronitrobenzene is heated 2 hrs. at 210° in the presence of anhydrous KF to give a mixture of II, m. 206°, and III, m. 185°. With 1-fluoro-2,4-dinitrobenzene refluxed 6 hrs. with an equimolar amount of I, the only product isolated is IV, m. 127°. The same reaction with 1-chloro-2,4,6-trinitrobenzene leads only to V, m. 230°. The products are studied by N.M.R. in CDCl3, C6H6, Me2SO, (NMe2)3PO, C5D5N, CF3CO2H, and H2NNH2 solution, together with 1-methyl-1,2,3-triazole and 1-methyl-1,2,5-triazole. The chem. shifts are compared with calculated electron densities. 13C-1H coupling constants are determined for I and for its 1-Me derivative In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Formula: C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lian, Yajing et al. published their research in Tetrahedron in 2015 | CAS: 13273-53-5

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C3H4BrN3

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation was written by Lian, Yajing;Burford, Kristen;Londregan, Allyn T.. And the article was included in Tetrahedron in 2015.Computed Properties of C3H4BrN3 This article mentions the following:

A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like mols. containing heterocyclic diversity and in the study of the gem-dialkyl effect. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Computed Properties of C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary