Category: 1295502-53-2

Related Products of 1295502-53-2, A common heterocyclic compound, 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, molecular formula is C6Br2F2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 100 mLthree-neck round-bottom flask was added with 4-nitro-N-phenyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)aniline(1.2 mmol, 0.5 g), 4,7-dibromo-5,6-difluorobenzo[c] [1,2,5]thiadiazole(0.5 mmol, 0.17 g), potassium carbonate (2.17 mmol, 0.3 g),toluene (20 mL), H2O (20 mL) and ethanol (8 mL). Under N2 protection,tetrakis (triphenylphosphine) palladium (0.04 mmol,47 mg) was added quickly to the mixture. The reactionwas refluxedat 70 C for 24 h and then water was added. The water phase wasextracted with ethyl acetate before the organic phase was washedwith water and brine. The solvent was removed under reducedpressure after the extract dried over sodium sulfate. Purificationwas done by column chromatography on silica gel usingdichloromethane-petroleum ether as eluent. Yellow solidNTPA2BTF2 was produced (0.20 g, 53%). 1H NMR (400 MHz, DMSO) delta (ppm): 8.15 (d, J 8.9 Hz, 4H), 7.90 (d, J 8.0 Hz, 4H), 7.52 (t,J 7.5 Hz, 4H), 7.44 (d, J 8.2 Hz, 4H), 7.34 (d, J 7.7 Hz, 6H), 6.99(d, J 8.9 Hz, 4H).

The synthetic route of 1295502-53-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bao, Qing; Li, Hua; Li, Yang; He, Jinghui; Xu, Qingfeng; Li, Najun; Chen, Dongyun; Wang, Lihua; Lu, Jianmei; Dyes and Pigments; vol. 130; (2016); p. 306 – 313;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1295502-53-2,Some common heterocyclic compound, 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, molecular formula is C6Br2F2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 25 mL dry two-necked flask was added 4,7-dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole (327 mg, 1 mmol). Tributyl(4-hexyl-2-thienyl)stannane (1.130 g, 2.5 mmol), and dissolved in dry and deoxygenated tetrahydrofuran (15 mL), The system replaces the air three times with nitrogen. Then tetrakis(triphenylphosphine)palladium Pd(PPh3)4 (50 mg, 0.04 mmol) was added to the system. Replace the air three times with nitrogen again, Heating to 110 C reflux for 72 hours; After cooling, the substance is loaded onto the silica gel. Purification using hexane/chloroform (4:1) as mobile phase silica gel column chromatography. Obtained 0.232 g of a yellow solid;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, its application will become more common.

Reference:
Patent; Nanchang Hangkong University; Qin Yuancheng; He Anwang; Du Wanjun; Zhou Dan; (21 pag.)CN109836437; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1295502-53-2, The chemical industry reduces the impact on the environment during synthesis 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, I believe this compound will play a more active role in future production and life.

(1) Formula (IIb) the compounds of formula [brief records compound (IIb), the cartridge] (3.68 g, 11 . 60 mmol) dissolved in 200 ml anhydrous alcohol, under stirring at room temperature slowly adding NaBH4(4.52 G, 116.0 mmol), room temperature reaction 6 h. Adding water steaming and remove the anhydrous ethanol (100 ml) and methylene chloride (100 ml), the standing liquid, organic phase dried with anhydrous sodium sulfate, rotary evaporated to remove the dichloromethane to obtain white solid [compound IIIc] 2.84 g, yield 81.0%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; East China University of Science and Technology; Zhu Weihong; Wu Yongzhen; Zhang Hao; Li Erpeng; Shen Chao; Jiang Huiyun; Yang Zhuoran; Xu Zixing; (14 pag.)CN108191777; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1295502-53-2, A common heterocyclic compound, 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, molecular formula is C6Br2F2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 100 mLthree-neck round-bottom flask was added with 4-nitro-N-phenyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)aniline(1.2 mmol, 0.5 g), 4,7-dibromo-5,6-difluorobenzo[c] [1,2,5]thiadiazole(0.5 mmol, 0.17 g), potassium carbonate (2.17 mmol, 0.3 g),toluene (20 mL), H2O (20 mL) and ethanol (8 mL). Under N2 protection,tetrakis (triphenylphosphine) palladium (0.04 mmol,47 mg) was added quickly to the mixture. The reactionwas refluxedat 70 C for 24 h and then water was added. The water phase wasextracted with ethyl acetate before the organic phase was washedwith water and brine. The solvent was removed under reducedpressure after the extract dried over sodium sulfate. Purificationwas done by column chromatography on silica gel usingdichloromethane-petroleum ether as eluent. Yellow solidNTPA2BTF2 was produced (0.20 g, 53%). 1H NMR (400 MHz, DMSO) delta (ppm): 8.15 (d, J 8.9 Hz, 4H), 7.90 (d, J 8.0 Hz, 4H), 7.52 (t,J 7.5 Hz, 4H), 7.44 (d, J 8.2 Hz, 4H), 7.34 (d, J 7.7 Hz, 6H), 6.99(d, J 8.9 Hz, 4H).

The synthetic route of 1295502-53-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bao, Qing; Li, Hua; Li, Yang; He, Jinghui; Xu, Qingfeng; Li, Najun; Chen, Dongyun; Wang, Lihua; Lu, Jianmei; Dyes and Pigments; vol. 130; (2016); p. 306 – 313;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole

A mixture of 3,4-difluoro-4,7-dibromobenzothiadiazole (2.9 mmol, 0.92 g) and absolute ethanol (30 mL) were mixed into a 250 mL one-necked flask and NaBH4 (2.9 mmol, 1.13 g) was added at room temperature for 6 h, and the reaction was quenched with 100 mL of distilled water after the reaction. Extracted with methylene chloride, the organic phase washed three times to remove water-soluble impurities and unreacted raw materials, rotary evaporator rotary dry solvent, vacuum drying in white crystalline solid 5. Do not use the purification directly to the next step. (0.75 g, yield: 86%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1295502-53-2.

Reference:
Patent; Central South University; Zou Yingping; Xu Shutao; Chen Guohui; Peng Hongjian; Yuan Jun; Feng Liuliu; (15 pag.)CN106905306; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole

Dry 250mL three-necked flask was added compound 2 (3.87g, 5mmol), 4,7- dibromo-5,6-difluorobenzo [c] [1,2,5] thiadiazole (1.65g, 5mmol) , 120mL THF, and Pd (PPh3)Cl2(105mg, 0.15mmol); and dissolved with stirring, using a vacuum pump with nitrogen 3 times; the reaction temperature was raised to 70 24 hours; direct cooling to room temperature rotary evaporation, and dichloromethane: petroleum ether (1: 5) as eluent agent over a silica gel column to give an orange solid component is the desired product (1.97 g of, 46% yield);

The synthetic route of 1295502-53-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; National Center for Nanoscience and Technology (NCNST); Wei, Zhixiang; Yuan, liu; (22 pag.)CN105315273; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1295502-53-2, A common heterocyclic compound, 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, molecular formula is C6Br2F2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dried 50 mL three-necked flask, 25 mL of re-distilled toluene was added,Compound 2 (1. 05 g, 2 mmol),Pd (PPh3) 4 (46. 2 mg, 0.04 mmol) was added to the solution of 4,7-dimethoxy-5,6-dioxo benzo [c] [1,2,5] thiadiazole (221 mg, 0.67 mmol) Stirring dissolved; after nitrogen after 5 minutes,Using vacuum chestnut nitrogen 3 times;The solution was heated to 110 C for 72 hours. After cooling to room temperature, the solution was poured into 200 mL of methanol,The crude product was precipitated on a silica gel column using dichloromethane: petroleum ether (1: 1 by volume) as eluant,The red solid component was obtained as the object product (642 mg, yield 69%);

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; National Center for Nanoscience and Technology (NCNST); Wei, Zhixiang; Yuan, liu; (22 pag.)CN105315273; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary