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The Absolute Best Science Experiment for 1,3-Dibromo-5-(tert-butyl)benzene

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 129316-09-2 help many people in the next few years. Category: bromides-buliding-blocks.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 129316-09-2, Name is 1,3-Dibromo-5-(tert-butyl)benzene, formurla is C10H12Br2. In a document, author is Dolai, Malay, introducing its new discovery. Category: bromides-buliding-blocks.

DNA intercalative trinuclear Cu(II) complex with new trans axial nitrato ligation as an efficient catalyst for atmospheric CO2 fixation to epoxides

A trinuclear octahedral Cu-II complex [Cu-3(II)(L)(2)(mu(2)-N-3)(2)(trans-NO3)(2)(H2O)(2)(CH3OH)(2)] (1) (L = 3-[{2-(2-pyridinyl) ethyl}imino]-2-butanone oximate) was synthesized and structurally characterized by single crystal X-ray diffraction studies and geometry optimization using DFT/B3LYP. The crystal structure analysis of 1 showed that the two Cu atoms and the central Cu atom are linearly connected through two oximato and two azido (EO-N-3(-)) co-ligands, and the angle between three Cu-II atoms was Category: bromides-buliding-blocks.

Discovery of 1,3-Dibromo-5-(tert-butyl)benzene

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 129316-09-2. Recommanded Product: 1,3-Dibromo-5-(tert-butyl)benzene.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 1,3-Dibromo-5-(tert-butyl)benzene, 129316-09-2, Name is 1,3-Dibromo-5-(tert-butyl)benzene, SMILES is CC(C)(C)C1=CC(Br)=CC(Br)=C1, belongs to bromides-buliding-blocks compound. In a document, author is Kong, Y-J, introduce the new discover.

MiR-141 promotes cell proliferation and invasion in non-small cell lung cancer by targeting KLF9

OBJECTIVE: Non-small cell lung cancer is the cancer with the highest mortality rate in the whole world. MicroRNA-141 (miR-141) has been reported to be an abnormal expression in multiple tumors including in non-small cell lung cancer. The aim of this study was to verify the potential roles of miR-141 in non-small cell lung cancer and evaluate the effects on cell proliferative and invasive abilities. PATIENTS AND METHODS: MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) and transwell assays were conducted to calculate the tissues and cell lines’ proliferative and invasive abilities. Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) and Western blotting were utilized to evaluate the mRNA and protein levels of specific genes. RESULTS: MiR-141 was significantly upregulated, while kruppel-like factor 9 (KLF9) downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. MiR-141 and KLF9 mRNA levels had a negative correlation in NSCLC tissues. The overexpression of miR-141 promoted the proliferation and invasion of A549 cells, while caused contrast results when knockdown miR-141. In addition. KLF9 was a direct target gene of miR-141 and KLF9 partially reversed the roles of miR-141 in A549 cells. MiR-141 promoted the proliferation and invasion by binding to KLF9 in NSCLC. CONCLUSIONS: MiR-141 promoted the proliferation and invasion by targeting the KLF9 in nonsmall cell lung cancer, and the newly identified miR-141/KLF9 axis provides novel insight into the pathogenesis of non-small cell lung cancer.

Discovery of 1,3-Dibromo-5-(tert-butyl)benzene

MiR-141 promotes cell proliferation and invasion in non-small cell lung cancer by targeting KLF9

Interesting scientific research on 1,3-Dibromo-5-(tert-butyl)benzene

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 129316-09-2, you can contact me at any time and look forward to more communication. Computed Properties of C10H12Br2.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C10H12Br2, 129316-09-2, Name is 1,3-Dibromo-5-(tert-butyl)benzene, SMILES is CC(C)(C)C1=CC(Br)=CC(Br)=C1, in an article , author is Song, Yu, once mentioned of 129316-09-2.

HHIP Overexpression Suppresses Human Gastric Cancer Progression and Metastasis by Reducing Its CpG Island Methylation

Human hedgehog-interacting protein (HHIP), a negative regulator of hedgehog (HH) signaling pathway, has been reported to be dysregulated in many types of cancer, including gastric cancer. However, the inhibitory role of HHIP as well as the underlying molecular mechanism of HHIP regulation in gastric cancer haven’t been fully elucidated yet. In this study, we demonstrated that HHIP overexpression significantly suppressed the proliferation and invasion of AGS cells evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and transwell assays, respectively. Interestingly, methylation-specific polymerase chain reaction (MS-PCR, MSP) showed that HHIP overexpression dramatically decreased its de novo promoter methylation levels in AGS cells. Furthermore, HHIP expression was higher in adjacent non-cancerous tissue compared to matched gastric cancer tissue. High HHIP level was negatively correlated with metastasis (p = 0.035) but not local recurrence (p = 0.58). Taken together, our study suggested that HHIP can modulate gastric cancer progression and metastasis via regulation of its de novo promoter methylation levels in a feedback manner. Lower HHIP levels is positively associated with gastric cancer metastasis, which not only indicates HHIP could be served as a protective marker for gastric cancer, but also suggests restoring HHIP expression might be a potential therapeutic strategy for clinical treatment.

Simple exploration of 129316-09-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3-Dibromo-5-(tert-butyl)benzene, its application will become more common.

Reference of 129316-09-2,Some common heterocyclic compound, 129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, molecular formula is C10H12Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 : tert-Butyl 3-bromo-5-(tert-butvnbenzoate (P11a)n-BuLi (7.2 mL, 18.0 mmol, 2.5M in THF) was added to a flask under N2 containing toluene (9 mL) at -10C. >BuMgCI (4.5 mL, 9.0 mmol, 2M in THF) was then added at such a rate to keep the temperature below -5C. The resulting milky slurry was aged at -10C for 30 min, then 1 ,3- dibromo-5-(terf-butyl)benzene (6.2 g, 21.2 mmol) dissolved in toluene (20 mL) was added. The rate of addition was such that the temperature did not increase above -5C. After addition was complete, the mixture was kept at -10C until the metal-halogen reaction was complete. A solution of di-tert-butyl dicarbonate (5.89 g, 27 mmol) in toluene (7.5 mL) was then charged such at a rate to keep the temperature below -5C. After the addition was complete, the mixture was kept at -10C until the aryl-Mg intermediate was completely consumed. The mixture was quenched by the addition of 10% aq. citric acid (40 mL). The phases were separated and the organic layer was washed with another 10% aq. citric acid (40 mL). The organic extracts were dried over MgS04 and concentrated. Compound P11a (4.0 g, 60%) was obtained as a brown oil.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Extracurricular laboratory: Synthetic route of 129316-09-2

The synthetic route of 129316-09-2 has been constantly updated, and we look forward to future research findings.

129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 129316-09-2

(4) (Suzuki) by Suzuki coupling reaction to obtain the final product f: the 9 – benzene anthracene -10 borate 10 mmol, 1, 3 – dibromo – 4, 6 – dihydro -5 – tert butyl 2 mmol, four (triphenylphosphine) palladium 0.4 mmol, toluene 80 ml, ethanol 20 ml, K2CO344 MmoL (for 20 ml distilled water into the solution), is added to the reaction bottle, then the system vacuum, in 110 C under the protection of nitrogen reflux 24 hours. After the completion of the reaction, methanol hot washing and filtering, toluene recrystallization, distillation to obtain the final product f. Yield 66%.

The synthetic route of 129316-09-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shaanxi Normal University; Hu Jianyong; Zhang Jiali; Zhao Zhen; Duan Xuewei; (18 pag.)CN109678645; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

The important role of 129316-09-2

The synthetic route of 129316-09-2 has been constantly updated, and we look forward to future research findings.

Related Products of 129316-09-2, A common heterocyclic compound, 129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, molecular formula is C10H12Br2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 : 1-(3-Bromo-5-(terf-butyl)phenyl)cvclobutanol (P23a) To an oven dried 100 mL 3-neck flask was added 1 ,3-dibromo-5-(terf-butyl)benzene (500 mg, 1.72 mmol) in dry THF (30 mL) under N2 and the mixture was cooled to -78C. n-BuLi (2.5M, 1 mL) was added and the mixture was stirred at -78C for 1 h. Then cyclobutanone (181 mg, 2.58 mmol) was added. After the reaction was complete (monitored by LC-MS) the mixture was quenched with aq. NH4CI and extracted with EA. The organic layer was dried over MgS04, filtered and evaporated to give compound P23a (243 mg, 50%) as a yellow solid.

The synthetic route of 129316-09-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2013/79223; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

The important role of 129316-09-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-5-(tert-butyl)benzene, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 129316-09-2, Formula: C10H12Br2

Step 1 : 3-(3-bromo-5-(teit-butyl)ohenvnoxetan-3-ol (P29a)To a solution of 1 ,3-dibromo-5-(terf-butyl)benzene (316 mg, 1.05 mmol) in dry THF (15 mL), n- BuLi (1 mL, 2.5M) was added dropwise under N2 at -78C. The mixture was stirred at this temperature for 1h. Then oxetan-3-one (91 mg, 1.27 mmol) was added and the mixture was stirred at rt overnight, diluted with aq. NH4CI (20 mL) and extracted with EA. The combined organic layers were washed with brine, dried over Na2S04 and concentrated to give the product P29a (120 mg, 40%) as a yellow solid.

A new synthetic route of 129316-09-2

Reference of 129316-09-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-phenyl-3,5-dimethylpyrazole (2.0680 g, 12 mmol, 1.0 eq.) was added sequentially to a dry three-necked flask with a magnetic rotor.1,3-Dibromo-5-tert-butylbenzene (7.1513 g, 24 mmol, 98%, 2.0 eq.), cuprous iodide (0.2971 g, 1.56 mmol, 0.13 eq.),Potassium phosphate (5.0945g, 24mmol, 2.0 equivalents) and trans-N,N’-Dimethyl-1,2-cyclohexanediamine (0.4528 g, 3.12 mmol, 98%, 0.26 eq.).Nitrogen was purged three times, then dimethyl sulfoxide (18 mL) was added under nitrogen.The reaction vial was then placed in a 120 C oil bath.After stirring for 5 days, it was cooled to room temperature, filtered through Celite, and ethyl acetate (30 mL¡Á3) was washed thoroughly.The obtained filtrate was washed with brine (20 mL¡Á2), and then evaporated and evaporated.All organic phases were combined and dried over anhydrous sodium sulfate. Filtration, concentration, and purification of the crude product by flash chromatography on silica gel column chromatography(Eluent: petroleum ether / ethyl acetate = 30/1 to 15/1) Intermediate 5 was obtained as a pale yellow oil, 2.5293 g, yield 55%.

Reference:
Patent; Zhejiang University of Technology; Ruisheng Optoelectric Science And Technology (Changzhou) Co., Ltd.; Li Guijie; Dai Jianxin; Zhao Xiangdong; She Yuanbin; Chen Shaohai; (53 pag.)CN108424426; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

The important role of 129316-09-2

According to the analysis of related databases, 129316-09-2, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 129316-09-2 as follows. category: bromides-buliding-blocks

Step 1 : Ethyl 5-(3-bromo-5-(teff-butyl)phenyl)-1-(cvclohexylmethyl)-2-iTiethyl-1 -/-pyrrole-3- carboxylate (12a) To a solution of compound P18a (643 mg, 1.71 mmol ) in 1 ,4-dioxane/H20 (3 mlJ0.8 ml_) 1 ,3-dibromo-5-(tert-butyl)benzene (595 mg, 2.05 mmol), Cs2C03 (1.11 g, 3.42 mmol) and Pd(PPh3)4 (66 mg, 0.17 mmol) were added under N2. The mixture was stirred under microwave at about 110C for 2.5 h. Removal of the solvents and purification by prep. TLC (PE/EA = 20/1) yielded compound 12a (275 mg, 35%) as yellow solid.

According to the analysis of related databases, 129316-09-2, the application of this compound in the production field has become more and more popular.