Reference of 128259-71-2, A common heterocyclic compound, 128259-71-2, name is 2,5-Dibromo-1,3-difluorobenzene, molecular formula is C6H2Br2F2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
45 mL of an N-methylpyrrolidone suspension of 10.0 g (36.8 mmol) of 2,5-dibromo-1,3-difluorobenzene, 16.6 g (110.4 mmol) of 4-(tert-butyl)phenol, and 15.3 g (110.4 mmol) of K2CO3 was stirred at a temperature of 170 C. for 20 hours under a nitrogen atmosphere. The reaction mixture was diluted with toluene, and water was poured to extract an organic layer therefrom. The organic layer was washed with water, dried by using MgSO4, and filtered and concentrated by silica gel. The residue obtained therefrom was diluted with ethanol and filtered to obtain 15.7 g (80%) of Intermediate 1.
The synthetic route of 128259-71-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samsung Display Co., Ltd.; Industry Academic Cooperation Foundation Kyunghee University; PARK, Miehwa; KWON, Janghyuk; KIM, Taekyung; LEE, Juyoung; JEONG, Hyein; AHN, Daehyun; SHIN, Daeyup; KIM, Siwoo; MOON, Jisu; (85 pag.)US2019/315776; (2019); A1;,
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