Category: 128-08-5

Structure-based design of high-affinity fluorescent probes for the neuropeptide Y Y₁ receptor was written by Mueller, Christoph;Gleixner, Jakob;Tahk, Maris-Johanna;Kopanchuk, Sergei;Laasfeld, Tonis;Weinhart, Michael;Schollmeyer, Dieter;Betschart, Martin U.;Luedeke, Steffen;Koch, Pierre;Rinken, Ago;Keller, Max. And the article was included in Journal of Medicinal Chemistry in 2022.Recommanded Product: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The recent crystallization of the neuropeptide Y Y₁ receptor (Y₁R) in complex with the argininamide-type Y₁R selective antagonist UR-MK299 (2) opened up a new approach toward structure-based design of nonpeptidic Y₁R ligands. We designed novel fluorescent probes showing excellent Y₁R selectivity and, in contrast to previously described fluorescent Y₁R ligands, considerably higher (~100-fold) binding affinity. This was achieved through the attachment of different fluorescent dyes to the diphenylacetyl moiety in 2 via an amine-functionalized linker. The fluorescent ligands exhibited picomolar Y₁R binding affinities (pK_i values of 9.36-9.95) and proved to be Y₁R antagonists, as validated in a Fura-2 calcium assay. The versatile applicability of the probes as tool compounds was demonstrated by flow cytometry- and fluorescence anisotropy-based Y₁R binding studies (saturation and competition binding and association and dissociation kinetics) as well as by widefield and total internal reflection fluorescence (TIRF) microscopy of live tumor cells, revealing that fluorescence was mainly localized at the plasma membrane. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Study on synthesis technology of sodium ozagrel was written by Wang, Yuting. And the article was included in Jinzhou Yikedaxue Xuebao in 2022.Application of 128-08-5 This article mentions the following:

Objective In response to the deficiency of existing synthesis process, to explore an industrial preparation of sodium ozagrel, which features safe and environmental protection, low production cost, easy operation, and recycle of solvent. Methods Me cinnamate and sodium imidazolate were used resp. as the starting materials. The reaction material ratio, solvent selection, reaction temperature, reaction time, post-treatment method and product purification and other conditions were studied. Results The sodium ozagrel prepared by this method can meet the quality standard Conclusion The production process has been determined to be reasonable and feasible, and the optimal production conditions have been obtained, which are convenient for production In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Multifunctional Two-Dimensional Polymers for Perovskite Solar Cells with Efficiency Exceeding 24% was written by Fu, Qiang;Liu, Hang;Tang, Xingchen;Wang, Rui;Chen, Mingqian;Liu, Yongsheng. And the article was included in ACS Energy Letters in 2022.Recommanded Product: 128-08-5 This article mentions the following:

The passivation of the intrinsic surface defects of perovskites by organic functional materials has a great potential to retard charge recombination and enhance charge extraction However, unsatisfactory device performance and a lack of in-depth understanding of the defect passivation mechanism make rational mol. design for efficient solar cells a great challenge. Herein, two solution-processable two-dimensional (2D) conjugated polymers, namely, 2DP-F and 2DP-O, have been synthesized for perovskite solar cells (PSCs). It is found that these materials could passivate surface defects, transport and extract hole carriers, hamper moisture invasion, and impede diffusion of Li⁺ cations into the perovskite film. As a result, champion efficiencies of 23.31% and 24.08% were achieved for 2DP-F- and 2DP-O-based devices, resp., coupled with dramatically improved stability. These results indicate that our proposed 2D polymers could be promising multifunctional materials for further boosting the efficiency and improving the stability of PSCs. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Removal of photoredox catalysts from polymers synthesized by organocatalyzed atom transfer radical polymerization was written by Chism, Katherine A.;Corbin, Daniel A.;Miyake, Garret M.. And the article was included in Journal of Polymer Science (Hoboken, NJ, United States) in 2022.Formula: C4H4BrNO2 This article mentions the following:

Organocatalyzed atom transfer radical polymerization (O-ATRP) is a method of producing polymers with precise structures under mild conditions using organic photoredox catalysts (PCs). Due to the unknown toxicity of PCs and their propensity to introduce color in polymers synthesized by this method, removal of the PC from the polymer product can be important for certain applications of polymers produced using O-ATRP. Current purification methods largely rely on precipitation to remove the PC from the polymer, but a more effective and efficient purification method is needed. In this work, an alternative purification method relying on oxidation of the PC to PC^·+ followed by filtration through a plug to remove PC^·+ from the polymer and removal of the volatiles was developed. A range of chem. oxidants and stationary phases were tested for their ability to remove PCs from polymers, revealing chem. oxidation by N-bromosuccinimide followed by a filtration through a silica plug can remove up to 99% of the PC from poly(Me methacrylate). Characterization of the polymer before and after purification demonstrated that polymer mol. weight, dispersity, and chain-end fidelity are not signficantly impacted by this purification method. Finally, this purification method was tested on a range of dihydrophenazine, phenoxazine, dihydroacridines, and phenothiazine PCs, revealing the strength of the chem. oxidant must match the oxidation potential of the PC for effective purification In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors was written by Nasli Esfahani, Anita;Iraji, Aida;Alamir, Amir;Moradi, Shahram;Asgari, Mohammad Sadegh;Hosseini, Samanesadat;Mojtabavi, Somayeh;Nasli-Esfahani, Ensieh;Faramarzi, Mohammad Ali;Bandarian, Fatemeh;Larijani, Bagher;Hamedifar, Haleh;Hajimiri, Mir Hamed;Mahdavi, Mohammad. And the article was included in Molecular Diversity in 2022.Category: bromides-buliding-blocks This article mentions the following:

A novel series of phenoxymethybenzimidazole derivatives I (R¹ = H, 4-F, 4-Br, 4-CH₃, 3-OCH₃, 4-OCH₃; R² = H, CH₃; R³ = H, OCH₃) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC₅₀ values in the range of 6.31 to 49.89μM compared to standard drug acarbose (IC₅₀ = 750.0 ± 10.0μM). Enzyme kinetic studies on I (R¹ = 4-Br, R² = R³ = H; R¹ = R² = H, R³ = OCH₃; R¹ = 4-CH₃, R² = CH₃, R³ = H) as the most potent compounds revealed that these compounds were uncompetitive inhibitors into α-glycosidase. Docking studies confirmed the important role of benzimidazole and triazole rings of the synthesized compounds I to fit properly into the α-glycosidase active site. This study showed that this scaffold can be considered as a highly potent α-glycosidase inhibitor. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Category: bromides-buliding-blocks).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of selective nanomolar inhibitors for insulin-regulated aminopeptidase based on α-hydroxy-β-amino acid derivatives of Bestatin was written by Vourloumis, Dionisios;Mavridis, Ioannis;Athanasoulis, Alexandros;Temponeras, Ioannis;Koumantou, Despoina;Giastas, Petros;Mpakali, Anastasia;Magrioti, Victoria;Leib, Jacqueline;van Endert, Peter;Stratikos, Efstratios;Papakyriakou, Athanasios. And the article was included in Journal of Medicinal Chemistry in 2022.COA of Formula: C4H4BrNO2 This article mentions the following:

The oxytocinase subfamily of M1 zinc aminopeptidases comprises emerging drug targets, including the ER-resident aminopeptidases 1 and 2 (ERAP1 and ERAP2) and insulin-regulated aminopeptidase (IRAP); however, reports on clin. relevant inhibitors are limited. Here we report a new synthetic approach of high diastereo- and regioselectivity for functionalization of the α-hydroxy-β-amino acid scaffold of bestatin. Stereochem. and mechanism of inhibition were investigated by a high-resolution X-ray crystal structure of ERAP1 in complex with a micromolar inhibitor. By exploring the P1 side-chain functionalities, we achieve significant potency and selectivity, and we report a cell-active, low-nanomolar inhibitor of IRAP with >120-fold selectivity over homologous enzymes. X-ray crystallog. anal. of IRAP in complex with this inhibitor suggest that interactions with the GAMEN loop is an unappreciated key determinant for potency and selectivity. Overall, our results suggest that α-hydroxy-β-amino acid derivatives may constitute useful chem. tools and drug leads for this group of aminopeptidases. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5COA of Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.COA of Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Simultaneous Tuning of Alkyl Chains and End Groups in Non-fused Ring Electron Acceptors for Efficient and Stable Organic Solar Cells was written by Luo, Dou;Jiang, Zhengyan;Shan, Chengwei;Li, Lanqing;Duan, Chenghao;Liu, Qian;Wang, Zhaojin;Wang, Kai;Xu, Baomin;Kyaw, Aung Ko Ko. And the article was included in ACS Applied Materials & Interfaces in 2022.Recommanded Product: 128-08-5 This article mentions the following:

Fine-tuning the alkyl chains and end groups of non-fused ring electron acceptors (NFREAs) plays vital roles in the promotion of charge transfer (CT) and power conversion efficiency (PCE). In this work, we developed a series of A-D-A′-D-A-type NFREAs, which possess the same terminals (A), the cyclopentadithiophene unit (D), and the thieno[3,4-c]pyrrole-4,6-dione (A′). Despite the subtle difference in side chains and halogenated end groups, the six acceptors exhibit a considerable difference in the efficiency and device stability of the organic solar cells (OSCs). Among the mols., chlorinated NFREAs show a broader light absorption than the fluorinated ones do. Compared with C8C8-4F (1-octylnonyl and fluorination) and C6C4-4Cl (2-butyloctyl and chlorination), C8C8-4Cl (1-octylnonyl and chlorination) exhibits a lower HOMO level, higher electron mobility, and denser mol. packing. The OSCs based on PM6:C8C8-4Cl yield the best PCE of 14.11%, which is attributed to the faster charge transport, high miscibility, and preferable morphol. Moreover, the PM6:C8C8-4Cl devices retain 91.1% of the initial PCE after being placed in air with 67% relative humidity for 50 days. This work shows that the simultaneous optimization of side chains and end groups facilitates the CT and improves the stability in the OSCs, offering a novel view into the mol. design of A-D-A′-D-A-type NFREAs. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Porphyrazines with bulky peripheral pyrrolyl substituents – Synthesis via microwave-assisted Suzuki-Miyaura cross-coupling reaction, optical and electrochemical properties was written by Szczolko, Wojciech;Koczorowski, Tomasz;Wicher, Barbara;Kryjewski, Michal;Krakowska, Zuzanna;Tykarska, Ewa;Goslinski, Tomasz. And the article was included in Dyes and Pigments in 2022.Synthetic Route of C4H4BrNO2 This article mentions the following:

Synthesis of novel aminoporphyrazines with peripheral 3,4-dihalide-2,5-dimethylpyrrol-1-yl and dimethylamino peripheral groups is reported. Cross-coupling Suzuki-Miyaura reaction with phenylboronic acid was used to convert magnesium(II) porphyrazine with dimethylamino and 3,4-dibromo-2,5-dimethylpyrrol-1-yl groups to an analog with bulky 2,5-dimethyl-3,4-diphenylpyrrol-1-yl moieties. Microwave-assisted organic synthesis approaches were used in the Paal-Knorr reaction leading to the modified diaminomaleonitrile intermediates and the Suzuki-Miyaura reaction, which allowed the obtaining of porphyrazine derivative All compounds were characterized using UV-Vis, ¹H and ¹³C NMR, including 2D techniques, as well as MS (ES or MALDI). An X-ray anal. of magnesium(II) porphyrazine with peripheral 3,4-dibromo-2,5-dimethylpyrrol-1-yl and dimethylamino substituents was also performed. The electrochem. properties of all obtained porphyrazine macrocycles were assessed using cyclic and differential pulse voltammetry. The susceptibility of new macrocycles to oxidation/reduction processes depended on the presence of halide substituents in their macrocyclic periphery. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Synthetic Route of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary