Category: 128-08-5

Copper-mediated Intermolecular C-H aminohalogenation of Indoles at Room Temperature was written by Lu, Yuanhui;Zhang, Xiaoxiang;Xiao, Xiaoyu;Huang, Ninghua;Dou, Yadong;Liu, Chenrui;Wei, Wanxing;Zhang, Zhuan;Liang, Taoyuan. And the article was included in Asian Journal of Organic Chemistry in 2022.Electric Literature of C4H4BrNO2 This article mentions the following:

An efficient intermol. C-H aminohalogenation of indoles with azoles and NXS (X=F, Cl, Br, I) was developed to provide 2-azolyl-3-halogenated indoles I [R = H, 6-Me, 5-OMe, etc.; R¹ = 4-Br-1H-pyrazol-1-yl, 4-Cl-1H-pyrazol-1-yl, 4-Br-3,5-(Me)₂-1H-pyrazol-1-yl, etc.; R² = Me, Et, Bn, etc.; R³ = F, Cl, Br, I] in one single operation. In addition, this attractive route for the synthesis of compounds I was of great significance due to the product’s versatile reactivity for further transformations. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Electric Literature of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists was written by Yang, Yifang;Lee, Candy;Reddy, Reddy Rajasekhar;Huang, David J.;Zhong, Weixia;Nguyen-Tran, Van T. B.;Shen, Weijun;Lin, Qing. And the article was included in ACS Chemical Biology in 2022.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Recent clin. trials have revealed that the chimeric peptide hormones simultaneously activating glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) demonstrate superior efficacy in glycemic control and body weight reduction, better than those activating the GLP-1R alone. However, the linear peptide-based GLP-1R/GIPR dual agonists are susceptible to proteolytic cleavage by common digestive enzymes present in the gastrointestinal tract and thus not suitable for oral administration. Here, we report the design and synthesis of biaryl-stapled peptides, with and without fatty diacid attachment, that showed potent GLP-1R/GIPR dual agonist activities. Compared to a linear peptide dual agonist and semaglutide, the biaryl-stapled peptides displayed drastically improved proteolytic stability against the common digestive enzymes. Furthermore, two stapled peptides showed excellent efficacy in an oral glucose tolerance test in mice, owing to their potent receptor activity in vitro and good pharmacokinetics exposure upon s.c. injection. By exploring a more comprehensive set of biaryl staplers, we expect that this stapling method could facilitate the design of the stapled peptide-based dual agonists suitable for oral administration. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application In Synthesis of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mechanochemical Aliphatic Iodination (and Bromination) by Cascaded Cyclization was written by Bal, Ankita;Kumar Dinda, Tarun;Mal, Prasenjit. And the article was included in Asian Journal of Organic Chemistry in 2022.Category: bromides-buliding-blocks This article mentions the following:

Herein, the synthesis of oxazoline derivatives I [Ar = Ph, 4-MeC₆H₄, 3-BrC₆H₄, etc.] from N-allyl benzamides via mechanochem. cascaded cyclization and halogenation using N-iodo- and N-bromosuccinimides, resp., as bifunctional reagents was demonstrated. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Category: bromides-buliding-blocks).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Enhanced Reactivity for Aromatic Bromination via Halogen Bonding with Lactic Acid Derivatives was written by Baker, Sarah I.;Yaghoubi, Mahshid;Bidwell, Samantha L.;Pierce, Savannah L.;Hratchian, Hrant P.;Baxter, Ryan D.. And the article was included in Journal of Organic Chemistry in 2022.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Herein, a new method for regioselective aromatic bromination using lactic acid derivatives as halogen bond acceptors with N-bromosuccinimide (NBS) is reported. Several structural analogs of lactic acid affected the efficiency of aromatic brominations, presumably via Lewis acid/base halogen-bonding interactions. Rate comparisons of aromatic brominations demonstrated the reactivity enhancement available via catalytic additives capable of halogen bonding. Computational results demonstrated that Lewis basic additives interact with NBS to increase the electropos. character of bromine prior to electrophilic transfer. An optimized procedure using catalytic mandelic acid under aqueous conditions at room temperature has been developed to promote aromatic bromination on a variety of arene substrates with complete regioselectivity. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application In Synthesis of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photoswitching of Local (Anti)Aromaticity in Biphenylene-Based Diarylethene Molecular Switches was written by Kalapos, Peter Pal;Mayer, Peter J.;Gazdag, Tamas;Demeter, Attila;Oruganti, Baswanth;Durbeej, Bo;London, Gabor. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Photoinduced tuning of (anti)aromaticity and associated mol. properties is currently in the focus of attention for both tailoring photochem. reactivity and designing new materials. Here, we report on the synthesis and spectroscopic characterization of diarylethene-based mol. switches embedded in a biphenylene structure composed of rings with different levels of local (anti)aromaticity. We show that it is possible to modulate and control the (anti)aromatic character of each ring through reversible photoswitching of the aryl units of the system between open and closed forms. Remarkably, it is shown that the irreversible formation of an annulated bis(dihydro-thiopyran) side-product that hampers the photoswitching can be efficiently suppressed when the aryl core formed by thienyl groups in one switch is replaced by thiazolyl groups in another. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On-Surface Debromination of 2,3-Bis(dibromomethyl)- and 2,3-Bis(bromomethyl)naphthalene: Dimerization or Polymerization? was written by Tang, Yanning;Ejlli, Barbara;Niu, Kaifeng;Li, Xuechao;Hao, Zhengming;Xu, Chaojie;Zhang, Haiming;Rominger, Frank;Freudenberg, Jan;Bunz, Uwe H. F.;Muellen, Klaus;Chi, Lifeng. And the article was included in Angewandte Chemie, International Edition in 2022.Electric Literature of C4H4BrNO2 This article mentions the following:

We describe the on-surface dehalogenative homocoupling of benzylic bromides, namely bis-bromomethyl- and bis-gem-(dibromomethyl) naphthalene as a potential route to either hydrocarbon dimers or conjugated polymers on Au(111). While bis-gem-(dibromomethyl) naphthalene affords different dimers with naphthocyclobutadiene as the key intermediate, bis-bromomethyl naphthalene furnishes a poly(o-naphthylene vinylidene) as a non-conjugated polymer which undergoes dehydrogenation toward its conjugated derivative poly(o-naphthylene vinylene) upon mild annealing. A combination of scanning tunneling microscopy, non-contact at. force microscopy and d. functional theory calculations provides deep insights into the prevailing mechanisms. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Electric Literature of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Electric Literature of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Formal Dehydration Polymerization of Propargylic Alcohols via Cumulene Intermediates was written by Wu, Bin;Su, Hao-Ze;Wang, Zi-Yuan;Yu, Zi-Di;Sun, Han-Li;Yang, Fan;Dou, Jin-Hu;Zhu, Rong. And the article was included in Journal of the American Chemical Society in 2022.HPLC of Formula: 128-08-5 This article mentions the following:

Here we report a copper-catalyzed formal dehydration polymerization of propargylic alcs. Copper catalysis allows for efficient in situ generation of [n]cumulenes (n = 3, 5) by a soft deprotonation/灏?elimination pathway and subsequent polymerization via organocopper species. Alkyne polymers (M_n up to 36.2 kg/mol) were produced with high efficiency (up to 95% yield) and excellent functional group tolerance. One-pot synthesis of semiconducting head-to-head poly(phenylacetylene) was demonstrated through a polymerization-isomerization sequence. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.HPLC of Formula: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Ladder-Type 9,9′-Bifluorenylidene-Based Conjugated Oligomers via a Pd-Catalyzed Tandem Suzuki Coupling/Heck Cyclization Approach was written by Zhu, Xiaoyan;Liu, Feng;Ba, Xinwu;Wu, Yonggang. And the article was included in Organic Letters in 2022.Computed Properties of C4H4BrNO2 This article mentions the following:

For new ladder-type oligomers and polymers with versatile and robust synthetic strategies, in this study, four fully conjugated ladder-type overcrowded 9,9′-bifluorenylidene-based compounds and oligomers (BFY1, BFY2, BFY3, and BFY4) were synthesized via a Pd-catalyzed tandem Suzuki coupling/Heck cyclization reaction. By monomer screening and route optimization, the target products were obtained in high yields and characterized by ¹H and ¹³C NMR spectroscopy and high resolution mass spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Computed Properties of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Reactivity of Cobalt-Dinitrogen Complexes Bearing Anionic PCP-Type Pincer Ligands toward Catalytic Silylamine Formation from Dinitrogen was written by Kuriyama, Shogo;Wei, Shenglan;Tanaka, Hiromasa;Konomi, Asuka;Yoshizawa, Kazunari;Nishibayashi, Yoshiaki. And the article was included in Inorganic Chemistry in 2022.Product Details of 128-08-5 This article mentions the following:

A series of cobalt(I)-dinitrogen complexes bearing anionic 4-substituted benzene-based PCP-type pincer ligands are synthesized and characterized. These complexes work as highly efficient catalysts for the formation of silylamine from dinitrogen under ambient reaction conditions to produce up to 371 equiv of silylamine based on the cobalt atom of the catalyst. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Product Details of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Deciphering a novel chloramphenicols resistance mechanism: Oxidative inactivation of the propanediol pharmacophore was written by Zhang, Jiayu;Yang, Chao;Hu, Jiahui;Zhang, Yiting;Lai, Yuezheng;Gong, Hongri;Guo, Fangliang;Li, Xiaoyan;Ye, Lin;Li, Bing. And the article was included in Water Research in 2022.Category: bromides-buliding-blocks This article mentions the following:

Expanding knowledge about new types of antibiotic resistance genes is of great significance in dealing with the global antibiotic resistance crisis. Herein, a novel oxidoreductase capO was discovered to be responsible for oxidative inactivation of chloramphenicol and thiamphenicol. The antibiotic resistance mechanism was comprehensively deciphered using multi-omics and multiscale computational approaches. A 66,383 bp DNA fragment carrying capO was shared among four chloramphenicol-resistant strains, and the co-occurrence of capO with a mobile genetic element cluster revealed its potential mobility among different taxa. Metagenomic anal. of 772 datasets indicated that chloramphenicol was the crucial driving factor for the development and accumulation of capO in activated sludge bioreactors treating antibiotic production wastewater. Therefore, we should pay sufficient attention to its possible prevalence and transfer to pathogens, especially in some hotspot environments contaminated with high concentrations of chloramphenicols. This finding significantly expands our knowledge boundary about chloramphenicols resistance mechanisms. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Category: bromides-buliding-blocks).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary