Application of 1268954-77-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1268954-77-3, name is 1-(4′-Bromo-[1,1′-biphenyl]-3-yl)naphthalene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Into a 200-mL four-necked flask were introduced the compound 8 (5.0 g; 615.0 mmol), the compound 7 (4.8 g; 13.5 mmol), NaOtBu (4.88 g; 50 mmol), and 100 mL of toluene. Nitrogen bubbling was conducted for 30 minutes (solution A). On the other hand, tri-t-butylphosphine (121 mg) was added to a toluene solution (6 mL) of a tris(dibenzylideneacetone)dipalladium chloroform complex (77 mg), and the mixture was heated to 65C (solution B). In a nitrogen stream, solution B was added to solution A, and this mixture was reacted with heating and refluxing for 4 hours. The organic layer was washed with purified water and dried with magnesium sulfate. Thereafter, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to obtain compound 9 (6.4 g).
The synthetic route of 1-(4′-Bromo-[1,1′-biphenyl]-3-yl)naphthalene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Chemical Corporation; EP2471772; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary