Category: 1261675-06-2

Small molecule inhibitors of anthrax lethal factor toxin was written by Williams, John D.;Khan, Atiyya R.;Cardinale, Steven C.;Butler, Michelle M.;Bowlin, Terry L.;Peet, Norton P.. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Synthetic Route of C10H11BrO3 The following contents are mentioned in the article:

This manuscript describes the preparation of new small mol. inhibitors of Bacillus anthracis lethal factor. The authors’ starting point was the sym., bis-quinolinyl compound (I) (NSC 12155). Optimization of one half of this mol. led to new LF inhibitors that were desymmetrized to afford more drug-like compounds This study involved multiple reactions and reactants, such as 3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2Synthetic Route of C10H11BrO3).

3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Synthetic Route of C10H11BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Non-target screening analysis of river water as compound-related base for monitoring measures was written by Schwarzbauer, Jan;Ricking, Mathias. And the article was included in Environmental Science and Pollution Research in 2010.Reference of 1261675-06-2 The following contents are mentioned in the article:

Building up a comprehensive accurate monitoring program requires the knowledge on the contamination in principal, complemented by detailed information on individual contaminants. The selection of pollutants to be considered in monitoring actions is based dominantly on the information available about their environmental relevance (e.g., persistence, bioaccumulation potential, toxicol. and ecotoxicol. properties) and their occurrence within the affected environmental system. Therefore, this study focused on the identification of organic contaminants in selected German and European rivers to demonstrate the usefulness of a screening approach as complementary base for the compound selection process within monitoring activities. Gas chromatog.-mass spectrometry-based screening analyses were performed on five and six samples from German and European rivers, resp. Identification of individual contaminants was based on the investigation of mass spectral and gas chromatog. properties compared with databases and reference materials. This study summarized the results of non-target screening analyses applied to river water samples and focused dominantly on, so far, unnoticed organic contaminants. Numerous compounds have been identified belonging to the groups of pharmaceuticals, tech. additives, pesticides, personal care products, and oxygen-, nitrogen-, and sulfur-containing compounds of obviously anthropogenic origin. They are discussed in terms of their structural properties, their possible application or usage, and the environmental information available so far. Generally, two different groups of compounds have been differentiated that might contribute to potential monitoring programs. Firstly, more specific contaminants characterizing the individual riverine systems have been depicted (e.g., 4-chloro-2-(trifluoromethyl)aniline, di-iso-propylurea). The consideration of these substances in monitoring analyses to be applied to the corresponding catchment areas is recommended in order to monitor the real state of pollution. Secondly, contaminants have been introduced that appeared with higher multiplicity throughout the different river systems (e.g., TMDD, TXIB). Since these compounds tend to obviously have an elevated environmental stability accompanied by a widespread distribution, it is recommended to consider them in international high-scale monitoring programs. For monitoring purposes, a fundamental knowledge on the diversity of pollutants is an important precondition, which can be supported by screening analyses. Obviously, numerous organic contaminants have been neglected so far in environmental studies on river water, comprising also investigation on potential harmful effects and, therefore, their implementation in monitoring activities has been hindered. Therefore, based on the results of this study, screening analyses should be established as principle tools to improve and complement the substance spectra for monitoring purposes. Secondly, scientific efforts should be strengthened to expand our knowledge on actually appearing organic contaminants in riverine systems. This study involved multiple reactions and reactants, such as 3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2Reference of 1261675-06-2).

3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Reference of 1261675-06-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary